ENSG00000089053

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261819 ENSG00000089053 HEK293_OSMI2_6hA HEK293_TMG_6hB ANAPC5 protein_coding protein_coding 126.9802 90.16792 135.4451 8.53403 2.628164 0.5869686 60.694214 47.4833095 60.22374347 3.6237982 2.46944165 0.3428476 0.48199167 0.530900000 0.4447333333 -0.08616667 0.52196075 0.03668766 FALSE TRUE
ENST00000441917 ENSG00000089053 HEK293_OSMI2_6hA HEK293_TMG_6hB ANAPC5 protein_coding protein_coding 126.9802 90.16792 135.4451 8.53403 2.628164 0.5869686 20.735972 12.2723836 21.13210420 4.7102581 3.00778898 0.7835284 0.15873750 0.131933333 0.1554333333 0.02350000 0.87804149 0.03668766 FALSE TRUE
ENST00000541652 ENSG00000089053 HEK293_OSMI2_6hA HEK293_TMG_6hB ANAPC5 protein_coding retained_intron 126.9802 90.16792 135.4451 8.53403 2.628164 0.5869686 4.090868 0.3468564 10.59393345 0.2406469 3.50520683 4.8931119 0.03081250 0.003866667 0.0774666667 0.07360000 0.03668766 0.03668766 FALSE TRUE
ENST00000541887 ENSG00000089053 HEK293_OSMI2_6hA HEK293_TMG_6hB ANAPC5 protein_coding protein_coding 126.9802 90.16792 135.4451 8.53403 2.628164 0.5869686 10.244355 6.1160702 6.70049692 3.5659177 3.36024545 0.1314577 0.08313333 0.070066667 0.0504000000 -0.01966667 1.00000000 0.03668766 FALSE TRUE
ENST00000544314 ENSG00000089053 HEK293_OSMI2_6hA HEK293_TMG_6hB ANAPC5 protein_coding processed_transcript 126.9802 90.16792 135.4451 8.53403 2.628164 0.5869686 6.977114 5.3103329 0.07653718 3.1389877 0.07653718 -5.9420526 0.05295833 0.058900000 0.0005666667 -0.05833333 0.44785885 0.03668766 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000089053 E001 3.6280651 4.100089e-02 5.791356e-01 7.565888e-01 12 121308245 121308331 87 - 0.714 0.615 -0.420
ENSG00000089053 E002 3.8060489 2.592342e-02 4.447937e-01 6.619924e-01 12 121308332 121308346 15 - 0.740 0.615 -0.525
ENSG00000089053 E003 4.2117051 1.242281e-02 4.518095e-01 6.669639e-01 12 121308347 121308356 10 - 0.763 0.651 -0.467
ENSG00000089053 E004 6.7976557 5.594681e-02 3.552565e-01 5.919533e-01 12 121308357 121308357 1 - 0.824 0.968 0.548
ENSG00000089053 E005 7.4766270 3.524030e-02 2.069546e-01 4.381378e-01 12 121308358 121308360 3 - 0.843 1.015 0.647
ENSG00000089053 E006 7.6192617 4.875832e-02 2.742336e-01 5.142121e-01 12 121308361 121308365 5 - 0.860 1.015 0.581
ENSG00000089053 E007 9.3558447 3.106095e-02 2.332670e-01 4.689059e-01 12 121308366 121308366 1 - 0.943 1.093 0.549
ENSG00000089053 E008 1015.6931152 2.103233e-04 2.570561e-16 4.624368e-14 12 121308367 121308691 325 - 2.951 3.052 0.337
ENSG00000089053 E009 1097.2048653 1.886362e-04 1.847436e-18 4.507717e-16 12 121309701 121309863 163 - 2.982 3.086 0.346
ENSG00000089053 E010 17.2959607 8.876802e-02 3.240782e-01 5.633848e-01 12 121309864 121309969 106 - 1.133 1.369 0.830
ENSG00000089053 E011 12.4893277 3.751964e-02 2.398615e-01 4.764768e-01 12 121309970 121310011 42 - 1.036 1.208 0.618
ENSG00000089053 E012 17.1807012 1.533695e-01 8.524155e-01 9.264150e-01 12 121310012 121310394 383 - 1.175 1.336 0.567
ENSG00000089053 E013 7.4832335 2.229353e-01 2.952743e-01 5.357761e-01 12 121317890 121318154 265 - 0.709 1.086 1.442
ENSG00000089053 E014 639.1816863 1.816335e-03 1.435749e-04 2.023261e-03 12 121318277 121318351 75 - 2.755 2.850 0.314
ENSG00000089053 E015 515.7167257 4.962443e-04 4.312245e-09 2.195857e-07 12 121318352 121318404 53 - 2.654 2.762 0.357
ENSG00000089053 E016 385.5602869 4.186637e-04 6.817252e-07 2.037174e-05 12 121318405 121318424 20 - 2.532 2.630 0.327
ENSG00000089053 E017 42.4364095 8.515255e-02 5.991834e-01 7.696593e-01 12 121318425 121318500 76 - 1.645 1.628 -0.056
ENSG00000089053 E018 516.1491940 3.492958e-04 1.441986e-03 1.320334e-02 12 121318501 121318534 34 - 2.681 2.735 0.179
ENSG00000089053 E019 624.3308502 1.288665e-03 3.697906e-01 6.038418e-01 12 121318535 121318608 74 - 2.781 2.803 0.072
ENSG00000089053 E020 466.9317945 5.626737e-04 7.178538e-01 8.468722e-01 12 121319697 121319733 37 - 2.662 2.667 0.018
ENSG00000089053 E021 595.0539236 1.171148e-04 8.402785e-02 2.528369e-01 12 121319734 121319818 85 - 2.758 2.781 0.076
ENSG00000089053 E022 481.8312637 1.258650e-04 1.133833e-04 1.659090e-03 12 121320385 121320459 75 - 2.648 2.709 0.203
ENSG00000089053 E023 2.2331441 9.395073e-03 8.031892e-01 8.981792e-01 12 121320460 121321111 652 - 0.532 0.488 -0.209
ENSG00000089053 E024 0.6356275 2.192342e-02 3.898481e-01   12 121326353 121326485 133 - 0.279 0.129 -1.378
ENSG00000089053 E025 1.5464231 1.153470e-02 8.850488e-02 2.610083e-01 12 121326486 121326642 157 - 0.532 0.228 -1.798
ENSG00000089053 E026 761.6901341 2.641794e-04 6.417967e-02 2.120959e-01 12 121327096 121327231 136 - 2.866 2.890 0.083
ENSG00000089053 E027 63.7162677 1.858503e-01 2.142033e-01 4.466077e-01 12 121327232 121328256 1025 - 1.852 1.758 -0.316
ENSG00000089053 E028 10.6339117 1.736429e-01 7.960530e-01 8.940431e-01 12 121328257 121328315 59 - 1.031 1.095 0.233
ENSG00000089053 E029 890.5286936 8.539942e-05 5.626224e-01 7.451159e-01 12 121328316 121328458 143 - 2.949 2.938 -0.034
ENSG00000089053 E030 454.9524966 1.415110e-04 2.804784e-01 5.206721e-01 12 121328459 121328497 39 - 2.645 2.660 0.050
ENSG00000089053 E031 13.0417931 1.439622e-01 5.530310e-02 1.920119e-01 12 121328773 121328835 63 - 1.263 0.949 -1.136
ENSG00000089053 E032 15.3771514 3.697914e-02 1.921809e-02 9.321318e-02 12 121328999 121329185 187 - 1.320 1.035 -1.014
ENSG00000089053 E033 689.2035857 2.773505e-04 2.783131e-01 5.184338e-01 12 121330583 121330672 90 - 2.827 2.841 0.046
ENSG00000089053 E034 54.8149100 1.214988e-01 5.486211e-02 1.910325e-01 12 121330673 121331226 554 - 1.840 1.607 -0.787
ENSG00000089053 E035 24.8651989 5.994768e-02 3.768934e-02 1.488104e-01 12 121331227 121331346 120 - 1.506 1.266 -0.831
ENSG00000089053 E036 674.9646912 3.064210e-04 2.046566e-01 4.354876e-01 12 121331347 121331428 82 - 2.836 2.813 -0.076
ENSG00000089053 E037 138.4516808 1.615683e-01 3.409810e-02 1.391299e-01 12 121331429 121335172 3744 - 2.252 1.975 -0.928
ENSG00000089053 E038 4.4446920 1.115695e-01 1.046643e-01 2.900523e-01 12 121335517 121335532 16 - 0.852 0.534 -1.337
ENSG00000089053 E039 912.7627592 8.899439e-04 2.360686e-01 4.720090e-01 12 121335533 121335723 191 - 2.968 2.945 -0.075
ENSG00000089053 E040 557.5131896 6.518470e-04 2.369038e-01 4.730026e-01 12 121337291 121337392 102 - 2.755 2.730 -0.083
ENSG00000089053 E041 0.1426347 3.170854e-02 5.588876e-01   12 121337393 121337395 3 - 0.114 0.000 -10.199
ENSG00000089053 E042 538.3276742 1.287766e-04 7.988189e-03 4.925132e-02 12 121342003 121342069 67 - 2.748 2.702 -0.152
ENSG00000089053 E043 0.3228314 4.360055e-01 3.584169e-01   12 121342070 121342071 2 - 0.205 0.000 -11.208
ENSG00000089053 E044 334.4177845 1.890732e-04 6.786455e-05 1.080634e-03 12 121345839 121345839 1 - 2.557 2.473 -0.281
ENSG00000089053 E045 705.1146472 1.490696e-04 1.496785e-12 1.489968e-10 12 121345840 121345923 84 - 2.889 2.784 -0.349
ENSG00000089053 E046 531.7435056 4.890477e-04 1.288986e-12 1.292968e-10 12 121345924 121345951 28 - 2.779 2.644 -0.448
ENSG00000089053 E047 581.3539768 1.698681e-04 1.337339e-14 1.924668e-12 12 121345952 121345998 47 - 2.813 2.688 -0.416
ENSG00000089053 E048 495.7529514 1.438959e-04 1.023124e-07 3.785401e-06 12 121345999 121346031 33 - 2.730 2.638 -0.307
ENSG00000089053 E049 25.1375971 1.741001e-01 4.196813e-01 6.434250e-01 12 121346032 121346035 4 - 1.435 1.393 -0.146
ENSG00000089053 E050 40.0601760 2.018102e-01 3.697048e-01 6.037714e-01 12 121346036 121346126 91 - 1.636 1.584 -0.178
ENSG00000089053 E051 84.8609672 2.263636e-01 2.172233e-01 4.501301e-01 12 121346127 121346565 439 - 1.977 1.877 -0.336
ENSG00000089053 E052 57.7792619 1.141380e-01 9.290920e-02 2.691441e-01 12 121346566 121346794 229 - 1.855 1.645 -0.710
ENSG00000089053 E053 33.6662439 8.509570e-02 8.505432e-02 2.547160e-01 12 121346795 121346895 101 - 1.626 1.410 -0.742
ENSG00000089053 E054 591.2595874 1.775420e-04 9.371476e-11 6.689753e-09 12 121346896 121347005 110 - 2.812 2.707 -0.349
ENSG00000089053 E055 3.1889600 3.938522e-02 1.057431e-01 2.918988e-01 12 121347006 121347801 796 - 0.719 0.437 -1.287
ENSG00000089053 E056 435.0667454 3.470694e-04 8.563497e-01 9.284389e-01 12 121347802 121347881 80 - 2.639 2.632 -0.021
ENSG00000089053 E057 1.3108423 1.369686e-02 6.241273e-01   12 121347882 121347883 2 - 0.398 0.310 -0.532
ENSG00000089053 E058 0.3337900 2.700189e-02 9.139833e-01   12 121351060 121351203 144 - 0.114 0.129 0.206
ENSG00000089053 E059 601.1473717 1.957003e-03 9.679795e-01 9.858419e-01 12 121352134 121352446 313 - 2.778 2.777 -0.001
ENSG00000089053 E060 2.4156015 9.497763e-02 5.039805e-03 3.484691e-02 12 121399611 121399896 286 - 0.204 0.759 2.983