ENSG00000088538

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
MSTRG.23009.1 ENSG00000088538 HEK293_OSMI2_6hA HEK293_TMG_6hB DOCK3 protein_coding   4.52084 5.678795 3.324218 0.3176922 0.2938543 -0.7707749 0.39217912 0.5636413 0.03689992 0.09563496 0.03689992 -3.6124916 0.08090833 0.09803333 0.01340000 -0.08463333 0.03154147 0.03154147 FALSE TRUE
MSTRG.23009.10 ENSG00000088538 HEK293_OSMI2_6hA HEK293_TMG_6hB DOCK3 protein_coding   4.52084 5.678795 3.324218 0.3176922 0.2938543 -0.7707749 0.33387076 0.6122044 0.50796670 0.16253952 0.02659442 -0.2645291 0.07400000 0.10576667 0.15610000 0.05033333 0.69021906 0.03154147 FALSE TRUE
MSTRG.23009.12 ENSG00000088538 HEK293_OSMI2_6hA HEK293_TMG_6hB DOCK3 protein_coding   4.52084 5.678795 3.324218 0.3176922 0.2938543 -0.7707749 0.08180827 0.0000000 0.36761540 0.00000000 0.36761540 5.2388457 0.01974167 0.00000000 0.09836667 0.09836667 0.81603379 0.03154147 FALSE FALSE
MSTRG.23009.13 ENSG00000088538 HEK293_OSMI2_6hA HEK293_TMG_6hB DOCK3 protein_coding   4.52084 5.678795 3.324218 0.3176922 0.2938543 -0.7707749 0.43678563 0.7598947 0.29361564 0.30770814 0.19240806 -1.3424150 0.09382083 0.13063333 0.08296667 -0.04766667 0.80266446 0.03154147 FALSE TRUE
MSTRG.23009.14 ENSG00000088538 HEK293_OSMI2_6hA HEK293_TMG_6hB DOCK3 protein_coding   4.52084 5.678795 3.324218 0.3176922 0.2938543 -0.7707749 1.34194254 2.3943724 0.43139389 0.10105700 0.32646447 -2.4455218 0.28227083 0.42543333 0.12960000 -0.29583333 0.36663732 0.03154147 FALSE TRUE
MSTRG.23009.3 ENSG00000088538 HEK293_OSMI2_6hA HEK293_TMG_6hB DOCK3 protein_coding   4.52084 5.678795 3.324218 0.3176922 0.2938543 -0.7707749 0.93824914 0.3628359 0.60786175 0.18223294 0.07759027 0.7287433 0.21814167 0.06626667 0.19043333 0.12416667 0.58639818 0.03154147 FALSE TRUE
MSTRG.23009.7 ENSG00000088538 HEK293_OSMI2_6hA HEK293_TMG_6hB DOCK3 protein_coding   4.52084 5.678795 3.324218 0.3176922 0.2938543 -0.7707749 0.26626963 0.4175828 0.18446376 0.21254336 0.18446376 -1.1367024 0.06466250 0.07590000 0.05303333 -0.02286667 0.81966413 0.03154147 FALSE TRUE
MSTRG.23009.9 ENSG00000088538 HEK293_OSMI2_6hA HEK293_TMG_6hB DOCK3 protein_coding   4.52084 5.678795 3.324218 0.3176922 0.2938543 -0.7707749 0.16974793 0.2018505 0.55612463 0.20185049 0.29472363 1.4180732 0.04632500 0.03330000 0.18066667 0.14736667 0.64916179 0.03154147 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

No results under this category.

Splicing

All exons whithin this gene region are shown and numbering below.

No results under this category.

Transcripts

All isoforms whithin this gene region are shown below.

No results under this category.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000088538 E001 0.1723744 0.031008559 1.000000e+00   3 50674922 50674926 5 +      
ENSG00000088538 E002 0.1723744 0.031008559 1.000000e+00   3 50674927 50674949 23 +      
ENSG00000088538 E003 0.7962354 0.017267182 5.936258e-01   3 50674950 50674992 43 +      
ENSG00000088538 E004 1.1298377 0.014129308 9.896814e-01   3 50674993 50675042 50 +      
ENSG00000088538 E005 0.9574634 0.015880722 8.121012e-01   3 50675043 50675051 9 +      
ENSG00000088538 E006 0.9574634 0.015880722 8.121012e-01   3 50675052 50675079 28 +      
ENSG00000088538 E007 0.9574634 0.015880722 8.121012e-01   3 50675080 50675167 88 +      
ENSG00000088538 E008 3.1291820 0.007728934 4.508367e-01 6.662664e-01 3 50675168 50675276 109 +      
ENSG00000088538 E009 3.6564265 0.025571628 8.306431e-01 9.141456e-01 3 50675277 50675300 24 +      
ENSG00000088538 E010 11.8221864 0.002971620 9.712059e-08 3.614576e-06 3 50778675 50778758 84 +      
ENSG00000088538 E011 13.7199975 0.003742783 1.715671e-07 6.022333e-06 3 50841675 50841715 41 +      
ENSG00000088538 E012 15.5606706 0.028491819 2.482202e-05 4.587886e-04 3 50890026 50890081 56 +      
ENSG00000088538 E013 18.8010617 0.034523937 2.528158e-03 2.051703e-02 3 50933981 50934077 97 +      
ENSG00000088538 E014 21.4837215 0.008740599 4.680563e-03 3.290683e-02 3 51064448 51064596 149 +      
ENSG00000088538 E015 18.2591743 0.004011231 9.292670e-03 5.506088e-02 3 51075356 51075440 85 +      
ENSG00000088538 E016 4.7702082 0.308845094 2.289081e-01 4.638891e-01 3 51081175 51081398 224 +      
ENSG00000088538 E017 8.4956964 0.007441794 3.998371e-01 6.280957e-01 3 51089243 51089284 42 +      
ENSG00000088538 E018 9.1103189 0.063202681 7.697834e-01 8.785470e-01 3 51090230 51090280 51 +      
ENSG00000088538 E019 12.4813520 0.027629728 7.197030e-01 8.480279e-01 3 51090281 51090384 104 +      
ENSG00000088538 E020 12.4197296 0.020867122 4.248023e-01 6.471322e-01 3 51146549 51146630 82 +      
ENSG00000088538 E021 10.7185112 0.014793657 1.469650e-01 3.579548e-01 3 51159244 51159304 61 +      
ENSG00000088538 E022 14.5535256 0.002509221 1.149261e-01 3.073478e-01 3 51160555 51160702 148 +      
ENSG00000088538 E023 0.1779838 0.040164841 1.958839e-01   3 51170656 51170668 13 +      
ENSG00000088538 E024 2.2315285 0.009604508 9.891169e-01 9.963569e-01 3 51174636 51174756 121 +      
ENSG00000088538 E025 6.3144378 0.017793336 2.810804e-01 5.213460e-01 3 51208774 51208787 14 +      
ENSG00000088538 E026 10.3384835 0.003379890 5.907682e-02 2.006962e-01 3 51208788 51208862 75 +      
ENSG00000088538 E027 7.1040413 0.004589139 2.991520e-02 1.270866e-01 3 51214122 51214141 20 +      
ENSG00000088538 E028 10.9314210 0.002831747 4.081936e-02 1.568447e-01 3 51214142 51214247 106 +      
ENSG00000088538 E029 12.9062073 0.004165525 8.843973e-02 2.608841e-01 3 51225649 51225773 125 +      
ENSG00000088538 E030 15.5686173 0.011949214 1.349309e-01 3.395727e-01 3 51227283 51227445 163 +      
ENSG00000088538 E031 15.6494032 0.002725262 3.851238e-01 6.166011e-01 3 51227982 51228088 107 +      
ENSG00000088538 E032 18.3792652 0.004972373 9.892255e-02 2.799048e-01 3 51228661 51228832 172 +      
ENSG00000088538 E033 16.4951832 0.002516650 1.308978e-01 3.332054e-01 3 51229512 51229609 98 +      
ENSG00000088538 E034 13.5502123 0.006912816 3.033523e-02 1.283702e-01 3 51236345 51236428 84 +      
ENSG00000088538 E035 16.0117139 0.002442700 1.140564e-03 1.097379e-02 3 51237490 51237590 101 +      
ENSG00000088538 E036 17.1394019 0.002419146 2.123538e-01 4.445067e-01 3 51246726 51246807 82 +      
ENSG00000088538 E037 24.7339744 0.001479501 4.725070e-01 6.818881e-01 3 51260156 51260326 171 +      
ENSG00000088538 E038 20.8673076 0.010697555 6.467003e-01 8.012884e-01 3 51270815 51271007 193 +      
ENSG00000088538 E039 13.7569149 0.005975822 8.772433e-01 9.398470e-01 3 51275079 51275206 128 +      
ENSG00000088538 E040 3.3323169 0.109075932 4.372933e-01 6.566844e-01 3 51275207 51275220 14 +      
ENSG00000088538 E041 5.4604314 0.104660354 3.004735e-01 5.409333e-01 3 51275282 51275373 92 +      
ENSG00000088538 E042 14.1726772 0.003237309 4.143936e-01 6.393703e-01 3 51277608 51277712 105 +      
ENSG00000088538 E043 2.0880388 0.206472222 5.525333e-01 7.380686e-01 3 51277713 51277754 42 +      
ENSG00000088538 E044 3.2962749 0.183733887 2.024676e-01 4.327145e-01 3 51278401 51278436 36 +      
ENSG00000088538 E045 9.1557305 0.003888390 5.647697e-02 1.947746e-01 3 51278437 51278528 92 +      
ENSG00000088538 E046 16.3416801 0.002474538 5.763994e-01 7.547099e-01 3 51280106 51280204 99 +      
ENSG00000088538 E047 15.0618333 0.002661865 9.486075e-01 9.765563e-01 3 51310232 51310326 95 +      
ENSG00000088538 E048 16.3415696 0.002216813 3.077943e-01 5.484114e-01 3 51312004 51312079 76 +      
ENSG00000088538 E049 19.5673681 0.002101690 6.506742e-01 8.039753e-01 3 51312476 51312576 101 +      
ENSG00000088538 E050 18.9065104 0.002458995 2.572606e-01 4.960132e-01 3 51312844 51312902 59 +      
ENSG00000088538 E051 28.2355131 0.023819926 6.753639e-01 8.197872e-01 3 51314980 51315128 149 +      
ENSG00000088538 E052 23.5053138 0.051933997 8.161888e-01 9.059440e-01 3 51330138 51330223 86 +      
ENSG00000088538 E053 0.6487990 0.031029592 3.813482e-01   3 51333001 51333027 27 +      
ENSG00000088538 E054 18.7787108 0.002368725 8.735128e-01 9.378857e-01 3 51333158 51333253 96 +      
ENSG00000088538 E055 16.3738691 0.021065207 8.047434e-01 8.990339e-01 3 51338359 51338419 61 +      
ENSG00000088538 E056 19.3635055 0.053082414 8.272344e-01 9.122310e-01 3 51338935 51339028 94 +      
ENSG00000088538 E057 25.6666611 0.014872511 4.600612e-01 6.731890e-01 3 51341237 51341385 149 +      
ENSG00000088538 E058 17.7238933 0.002143316 9.528482e-01 9.784260e-01 3 51348852 51348938 87 +      
ENSG00000088538 E059 22.9738066 0.001658371 7.268698e-01 8.523453e-01 3 51350288 51350392 105 +      
ENSG00000088538 E060 23.4451714 0.003012824 1.661846e-01 3.854301e-01 3 51354882 51355023 142 +      
ENSG00000088538 E061 33.3999704 0.002799861 7.471541e-01 8.650098e-01 3 51356089 51356255 167 +      
ENSG00000088538 E062 28.2684499 0.001361979 8.779770e-01 9.402404e-01 3 51356407 51356493 87 +      
ENSG00000088538 E063 36.1546078 0.001227205 7.634207e-02 2.374372e-01 3 51356962 51357141 180 +      
ENSG00000088538 E064 22.1613284 0.002074303 6.813910e-01 8.235301e-01 3 51357758 51357841 84 +      
ENSG00000088538 E065 22.8269330 0.006474309 6.066669e-01 7.746835e-01 3 51357961 51358077 117 +      
ENSG00000088538 E066 23.7678286 0.003818454 2.491635e-02 1.119617e-01 3 51360511 51360632 122 +      
ENSG00000088538 E067 17.6452406 0.009571288 8.206057e-01 9.084302e-01 3 51361859 51361921 63 +      
ENSG00000088538 E068 23.8844612 0.001584922 8.720022e-01 9.370059e-01 3 51361922 51361997 76 +      
ENSG00000088538 E069 30.7981683 0.001471954 8.005676e-01 8.966395e-01 3 51362527 51362674 148 +      
ENSG00000088538 E070 12.2356405 0.002637072 1.916811e-01 4.190043e-01 3 51374469 51374486 18 +      
ENSG00000088538 E071 25.4505686 0.001415134 9.279412e-01 9.660048e-01 3 51374487 51374587 101 +      
ENSG00000088538 E072 21.4144852 0.001592359 9.565701e-01 9.801669e-01 3 51375748 51375835 88 +      
ENSG00000088538 E073 14.7002695 0.003914392 1.907742e-01 4.178589e-01 3 51379449 51379571 123 +      
ENSG00000088538 E074 14.2257090 0.015827821 2.086066e-01 4.401974e-01 3 51380125 51380207 83 +      
ENSG00000088538 E075 340.4473845 1.330502077 2.882190e-01 5.289595e-01 3 51381050 51384198 3149 +