ENSG00000088247

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000594496 ENSG00000088247 HEK293_OSMI2_6hA HEK293_TMG_6hB KHSRP protein_coding protein_coding 470.6612 693.9232 393.3442 134.482 17.98739 -0.8189677 36.64243 76.39779 9.687402 18.07576 5.235526 -2.9780497 0.07135833 0.1077667 0.0236000 -0.08416667 0.6008191275 0.0006977192 FALSE FALSE
ENST00000595112 ENSG00000088247 HEK293_OSMI2_6hA HEK293_TMG_6hB KHSRP protein_coding retained_intron 470.6612 693.9232 393.3442 134.482 17.98739 -0.8189677 211.83508 296.20496 216.603950 52.32010 8.396157 -0.4515183 0.46120833 0.4308333 0.5510667 0.12023333 0.0006977192 0.0006977192 FALSE FALSE
ENST00000595223 ENSG00000088247 HEK293_OSMI2_6hA HEK293_TMG_6hB KHSRP protein_coding protein_coding 470.6612 693.9232 393.3442 134.482 17.98739 -0.8189677 43.08670 57.01350 32.215876 14.59110 2.107796 -0.8233369 0.09006667 0.0796000 0.0818000 0.00220000 0.9773885598 0.0006977192 FALSE TRUE
ENST00000600480 ENSG00000088247 HEK293_OSMI2_6hA HEK293_TMG_6hB KHSRP protein_coding protein_coding 470.6612 693.9232 393.3442 134.482 17.98739 -0.8189677 168.71760 256.05113 118.877752 51.97228 4.052816 -1.1068882 0.35257917 0.3672333 0.3027333 -0.06450000 0.0720806498 0.0006977192 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000088247 E001 116.540139 0.593095092 2.230945e-01 4.570829e-01 19 6413102 6413243 142 - 1.772 2.102 1.109
ENSG00000088247 E002 427.445592 1.318520906 3.828702e-01 6.146212e-01 19 6413244 6413347 104 - 2.350 2.660 1.033
ENSG00000088247 E003 631.484810 1.458675358 4.092899e-01 6.355027e-01 19 6413348 6413410 63 - 2.528 2.827 0.994
ENSG00000088247 E004 1177.237878 1.665439543 4.417278e-01 6.599343e-01 19 6413411 6413549 139 - 2.807 3.095 0.958
ENSG00000088247 E005 1020.514203 1.626389265 4.457241e-01 6.625661e-01 19 6413550 6413640 91 - 2.753 3.032 0.927
ENSG00000088247 E006 868.220456 1.539247381 3.913503e-01 6.215017e-01 19 6413641 6413738 98 - 2.634 2.971 1.123
ENSG00000088247 E007 1145.850148 1.672551309 4.658486e-01 6.771981e-01 19 6413739 6413964 226 - 2.816 3.079 0.873
ENSG00000088247 E008 1693.341201 1.807837978 5.030904e-01 7.029077e-01 19 6413965 6414120 156 - 3.008 3.243 0.783
ENSG00000088247 E009 4003.677760 2.051579064 5.097401e-01 7.077846e-01 19 6414121 6414456 336 - 3.366 3.621 0.848
ENSG00000088247 E010 5925.265125 2.152292337 5.000891e-01 7.008131e-01 19 6414457 6415140 684 - 3.516 3.795 0.926
ENSG00000088247 E011 1526.933969 1.765283219 4.846521e-01 6.902645e-01 19 6415141 6415215 75 - 2.946 3.202 0.851
ENSG00000088247 E012 1446.020478 1.761181930 5.012450e-01 7.016802e-01 19 6415216 6415301 86 - 2.941 3.175 0.778
ENSG00000088247 E013 1177.950222 0.069745946 1.502353e-01 3.626600e-01 19 6415380 6415457 78 - 2.899 3.074 0.583
ENSG00000088247 E014 19.416347 0.035886855 8.876739e-01 9.454357e-01 19 6415458 6415533 76 - 1.264 1.272 0.029
ENSG00000088247 E015 717.457547 0.001523107 8.745272e-07 2.527052e-05 19 6415534 6415608 75 - 2.696 2.859 0.542
ENSG00000088247 E016 1261.758549 0.007165858 2.626099e-03 2.112510e-02 19 6415609 6415734 126 - 2.921 3.106 0.616
ENSG00000088247 E017 1603.244390 0.007126549 2.698594e-02 1.182594e-01 19 6415808 6415896 89 - 3.053 3.202 0.494
ENSG00000088247 E018 1881.056116 0.005175709 5.312986e-01 7.229790e-01 19 6416298 6416407 110 - 3.178 3.254 0.251
ENSG00000088247 E019 14.199194 0.072333329 6.776357e-02 2.200641e-01 19 6416410 6416489 80 - 1.303 1.059 -0.868
ENSG00000088247 E020 3099.902821 0.008792377 3.417827e-01 5.795291e-01 19 6416490 6416650 161 - 3.443 3.452 0.030
ENSG00000088247 E021 2654.502315 0.009408007 2.673277e-01 5.069557e-01 19 6416738 6416882 145 - 3.382 3.382 -0.001
ENSG00000088247 E022 3176.796453 0.009152615 8.235992e-02 2.493957e-01 19 6416987 6417087 101 - 3.481 3.451 -0.099
ENSG00000088247 E023 3349.124307 0.008826511 8.259328e-03 5.051770e-02 19 6417739 6417841 103 - 3.532 3.461 -0.235
ENSG00000088247 E024 2754.585343 0.010967372 6.852465e-03 4.396487e-02 19 6417981 6418019 39 - 3.460 3.370 -0.300
ENSG00000088247 E025 2929.781127 0.008341688 4.619708e-03 3.257485e-02 19 6418020 6418079 60 - 3.479 3.401 -0.260
ENSG00000088247 E026 3374.647606 0.008944567 4.850747e-02 1.762068e-01 19 6418483 6418581 99 - 3.516 3.474 -0.140
ENSG00000088247 E027 8.727359 0.004315222 4.970755e-04 5.646856e-03 19 6418701 6418701 1 - 1.160 0.809 -1.307
ENSG00000088247 E028 3900.274812 0.010454623 7.043925e-02 2.255870e-01 19 6418702 6418876 175 - 3.576 3.538 -0.127
ENSG00000088247 E029 2618.001297 0.009385890 1.834092e-02 9.015457e-02 19 6419203 6419256 54 - 3.419 3.357 -0.207
ENSG00000088247 E030 1691.365394 0.008073492 1.564525e-02 8.052410e-02 19 6419257 6419260 4 - 3.227 3.169 -0.194
ENSG00000088247 E031 2990.088571 0.008331463 2.365439e-03 1.947382e-02 19 6420073 6420144 72 - 3.493 3.407 -0.284
ENSG00000088247 E032 2537.388787 0.007242349 4.904752e-04 5.587949e-03 19 6420422 6420471 50 - 3.429 3.332 -0.321
ENSG00000088247 E033 27.485492 0.184087968 3.038656e-01 5.444543e-01 19 6421001 6421277 277 - 1.507 1.368 -0.478
ENSG00000088247 E034 2114.830504 0.006933661 4.751846e-04 5.451046e-03 19 6421278 6421317 40 - 3.348 3.254 -0.313
ENSG00000088247 E035 43.055275 0.612732313 3.878600e-02 1.515939e-01 19 6421318 6421649 332 - 1.913 1.363 -1.873
ENSG00000088247 E036 1795.403047 0.006041298 1.285154e-04 1.842694e-03 19 6421650 6421688 39 - 3.280 3.182 -0.325
ENSG00000088247 E037 9.382227 0.027525724 1.154079e-01 3.081468e-01 19 6421689 6421698 10 - 1.094 0.913 -0.666
ENSG00000088247 E038 2024.292675 0.010646005 2.402553e-02 1.091545e-01 19 6422340 6422436 97 - 3.307 3.246 -0.204
ENSG00000088247 E039 1.853540 0.298059159 1.274098e-01 3.277605e-01 19 6424138 6424216 79 - 0.659 0.266 -2.072
ENSG00000088247 E040 1.906932 0.347364141 3.107952e-01 5.512538e-01 19 6424217 6424452 236 - 0.606 0.346 -1.316
ENSG00000088247 E041 1392.112157 0.014662505 7.249704e-01 8.510937e-01 19 6424453 6425390 938 - 3.081 3.111 0.099