ENSG00000088038

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221232 ENSG00000088038 HEK293_OSMI2_6hA HEK293_TMG_6hB CNOT3 protein_coding protein_coding 69.69363 88.96162 62.38605 16.03843 5.333127 -0.5118905 31.947324 43.793422 20.896829 9.444779 1.1910887 -1.0670693 0.44495000 0.48436667 0.33693333 -0.14743333 9.111415e-02 1.453751e-06 FALSE TRUE
ENST00000644245 ENSG00000088038 HEK293_OSMI2_6hA HEK293_TMG_6hB CNOT3 protein_coding protein_coding 69.69363 88.96162 62.38605 16.03843 5.333127 -0.5118905 14.636243 15.833227 17.359387 2.179472 0.9356113 0.1326806 0.21893750 0.18193333 0.28096667 0.09903333 1.214867e-01 1.453751e-06 FALSE FALSE
ENST00000644707 ENSG00000088038 HEK293_OSMI2_6hA HEK293_TMG_6hB CNOT3 protein_coding retained_intron 69.69363 88.96162 62.38605 16.03843 5.333127 -0.5118905 6.037859 7.674401 11.088063 4.656457 3.8824380 0.5303032 0.08672917 0.07613333 0.16963333 0.09350000 4.935141e-01 1.453751e-06   FALSE
MSTRG.17671.1 ENSG00000088038 HEK293_OSMI2_6hA HEK293_TMG_6hB CNOT3 protein_coding   69.69363 88.96162 62.38605 16.03843 5.333127 -0.5118905 6.553775 10.783097 2.971466 2.317794 0.4393663 -1.8560152 0.08980417 0.11990000 0.04713333 -0.07276667 1.453751e-06 1.453751e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000088038 E001 0.1723744 0.0439252520 1.000000e+00   19 54137594 54137642 49 + 0.000 0.086 9.625
ENSG00000088038 E002 0.5363366 0.0345291034 3.027829e-01   19 54137643 54137724 82 + 0.000 0.220 11.210
ENSG00000088038 E003 12.2968219 0.0027821576 1.005650e-01 2.828179e-01 19 54137725 54137748 24 + 0.957 1.151 0.706
ENSG00000088038 E004 15.5593298 0.0021271257 2.980638e-02 1.267544e-01 19 54137749 54137761 13 + 1.021 1.252 0.831
ENSG00000088038 E005 16.3851172 0.0020701917 1.375769e-02 7.338544e-02 19 54137762 54137762 1 + 1.021 1.278 0.922
ENSG00000088038 E006 29.8120102 0.0020413563 7.160558e-02 2.280451e-01 19 54137763 54137768 6 + 1.358 1.509 0.519
ENSG00000088038 E007 42.6590177 0.0012423027 5.532065e-03 3.738154e-02 19 54137769 54137773 5 + 1.476 1.668 0.654
ENSG00000088038 E008 83.9714786 0.0053951659 3.695132e-02 1.467948e-01 19 54137774 54137781 8 + 1.800 1.940 0.471
ENSG00000088038 E009 247.8228661 0.0010085848 5.121460e-05 8.492742e-04 19 54137782 54137993 212 + 2.266 2.404 0.460
ENSG00000088038 E010 18.1077921 0.0264429263 1.063191e-01 2.928889e-01 19 54139276 54139513 238 + 1.359 1.189 -0.597
ENSG00000088038 E011 44.3303276 0.0964153845 8.164134e-02 2.481223e-01 19 54141396 54142925 1530 + 1.788 1.519 -0.914
ENSG00000088038 E012 28.6355347 0.0040780188 4.330838e-01 6.535205e-01 19 54142926 54142928 3 + 1.384 1.458 0.255
ENSG00000088038 E013 262.1751565 0.0018026058 6.343961e-01 7.931754e-01 19 54142929 54143003 75 + 2.365 2.399 0.113
ENSG00000088038 E014 318.9223826 0.0016487214 1.115184e-01 3.015523e-01 19 54143119 54143186 68 + 2.492 2.464 -0.094
ENSG00000088038 E015 0.1723744 0.0439252520 1.000000e+00   19 54143187 54143339 153 + 0.000 0.086 9.623
ENSG00000088038 E016 401.8256828 0.0015118761 2.177658e-03 1.825718e-02 19 54143442 54143516 75 + 2.615 2.552 -0.210
ENSG00000088038 E017 502.4739931 0.0009966666 2.452907e-07 8.251981e-06 19 54143660 54143736 77 + 2.734 2.639 -0.316
ENSG00000088038 E018 344.4476670 0.0012719138 3.693283e-05 6.444763e-04 19 54143737 54143749 13 + 2.567 2.478 -0.295
ENSG00000088038 E019 6.3937049 0.5832095803 1.725707e-01 3.938883e-01 19 54143750 54144004 255 + 0.978 0.759 -0.843
ENSG00000088038 E020 2.7195320 0.0104108567 7.034589e-01 8.378230e-01 19 54144005 54144005 1 + 0.585 0.533 -0.236
ENSG00000088038 E021 690.1919439 0.0001294072 3.431812e-15 5.361551e-13 19 54144006 54144134 129 + 2.873 2.777 -0.317
ENSG00000088038 E022 409.5763582 0.0002039269 2.285582e-08 9.899117e-07 19 54144237 54144263 27 + 2.643 2.556 -0.291
ENSG00000088038 E023 548.0446310 0.0009296239 1.211277e-05 2.474832e-04 19 54144264 54144332 69 + 2.759 2.685 -0.247
ENSG00000088038 E024 10.0208155 0.0294008236 2.079561e-01 4.393542e-01 19 54145542 54145594 53 + 1.111 0.959 -0.555
ENSG00000088038 E025 71.8946500 0.0033790093 7.949072e-01 8.932727e-01 19 54145595 54145597 3 + 1.813 1.845 0.107
ENSG00000088038 E026 699.3554505 0.0011673939 1.106222e-04 1.625963e-03 19 54145598 54145817 220 + 2.857 2.794 -0.212
ENSG00000088038 E027 327.5965496 0.0017997848 7.185929e-02 2.285145e-01 19 54145910 54146043 134 + 2.511 2.475 -0.119
ENSG00000088038 E028 201.8144699 0.0008544713 9.001022e-01 9.519205e-01 19 54146601 54146657 57 + 2.270 2.283 0.044
ENSG00000088038 E029 542.8482331 0.0009940646 3.001235e-09 1.582362e-07 19 54148148 54148535 388 + 2.597 2.747 0.499
ENSG00000088038 E030 372.5438417 0.0045844706 2.697666e-03 2.155581e-02 19 54148620 54148743 124 + 2.445 2.578 0.441
ENSG00000088038 E031 209.3098274 0.0077064973 1.326200e-01 3.359126e-01 19 54149560 54149569 10 + 2.228 2.318 0.300
ENSG00000088038 E032 544.0199561 0.0033527519 5.029704e-02 1.803813e-01 19 54149570 54149729 160 + 2.647 2.728 0.268
ENSG00000088038 E033 338.2065850 0.0003352420 5.018748e-01 7.021324e-01 19 54149730 54149758 29 + 2.479 2.512 0.111
ENSG00000088038 E034 469.4657601 0.0017194251 8.420496e-02 2.531814e-01 19 54152226 54152325 100 + 2.597 2.659 0.209
ENSG00000088038 E035 1.8987339 0.1185148899 2.556348e-01 4.943256e-01 19 54152326 54152335 10 + 0.584 0.364 -1.114
ENSG00000088038 E036 579.8471162 0.0043137101 3.992141e-02 1.544955e-01 19 54152428 54152626 199 + 2.668 2.757 0.294
ENSG00000088038 E037 182.3122225 0.0019348996 8.951704e-02 2.629113e-01 19 54152867 54152870 4 + 2.177 2.254 0.259
ENSG00000088038 E038 451.5709457 0.0010297622 2.260953e-03 1.880350e-02 19 54152871 54152999 129 + 2.562 2.649 0.291
ENSG00000088038 E039 14.7513980 0.0026765534 4.286132e-01 6.500239e-01 19 54153000 54153082 83 + 1.209 1.151 -0.205
ENSG00000088038 E040 3.7180691 0.1989276286 6.950385e-01 8.323207e-01 19 54153181 54153393 213 + 0.680 0.634 -0.196
ENSG00000088038 E041 7.1831594 0.0913487442 4.692427e-01 6.795534e-01 19 54153497 54153714 218 + 0.974 0.842 -0.500
ENSG00000088038 E042 224.3791755 0.0004757310 6.432597e-01 7.990015e-01 19 54153715 54153723 9 + 2.319 2.324 0.015
ENSG00000088038 E043 442.2856528 0.0258609219 2.417882e-01 4.785296e-01 19 54153724 54153840 117 + 2.549 2.640 0.305
ENSG00000088038 E044 43.0181018 0.0163907969 4.581182e-01 6.718045e-01 19 54153841 54153943 103 + 1.562 1.636 0.250
ENSG00000088038 E045 186.7530040 0.0585909810 5.943084e-01 7.665399e-01 19 54153944 54155257 1314 + 2.272 2.225 -0.156
ENSG00000088038 E046 27.9497153 0.3497814337 3.526572e-01 5.896991e-01 19 54155258 54155308 51 + 1.312 1.475 0.566
ENSG00000088038 E047 335.9636516 1.3918486399 4.258157e-01 6.478833e-01 19 54155309 54155681 373 + 2.294 2.561 0.891