ENSG00000087495

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355648 ENSG00000087495 HEK293_OSMI2_6hA HEK293_TMG_6hB PHACTR3 protein_coding protein_coding 0.7674345 0.2605464 1.091871 0.0066217 0.1376312 2.026007 0.03832514 0.03140793 0.00000000 0.03140793 0.00000000 -2.0499070 0.0689500 0.1147000 0.00000000 -0.1147000 0.67381847 0.02584553 FALSE TRUE
ENST00000361300 ENSG00000087495 HEK293_OSMI2_6hA HEK293_TMG_6hB PHACTR3 protein_coding protein_coding 0.7674345 0.2605464 1.091871 0.0066217 0.1376312 2.026007 0.07830891 0.08474343 0.07212848 0.04286698 0.02338296 -0.2061433 0.1309000 0.3337333 0.06913333 -0.2646000 0.33865246 0.02584553 FALSE TRUE
ENST00000492611 ENSG00000087495 HEK293_OSMI2_6hA HEK293_TMG_6hB PHACTR3 protein_coding protein_coding 0.7674345 0.2605464 1.091871 0.0066217 0.1376312 2.026007 0.59586264 0.13857272 0.95370986 0.02055154 0.12764343 2.6974296 0.7327208 0.5286333 0.87186667 0.3432333 0.02584553 0.02584553 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000087495 E001 0.1426347 0.032633907 1.0000000000   20 59577509 59577617 109 + 0.075 0.000 -8.084
ENSG00000087495 E002 0.0000000       20 59603505 59603606 102 +      
ENSG00000087495 E003 0.0000000       20 59603717 59603945 229 +      
ENSG00000087495 E004 0.0000000       20 59604540 59604931 392 +      
ENSG00000087495 E005 0.0000000       20 59604932 59605132 201 +      
ENSG00000087495 E006 0.0000000       20 59628609 59628816 208 +      
ENSG00000087495 E007 0.0000000       20 59676661 59676764 104 +      
ENSG00000087495 E008 0.0000000       20 59721210 59721438 229 +      
ENSG00000087495 E009 0.7990684 0.023512843 0.5324565424   20 59743107 59743268 162 + 0.195 0.323 0.959
ENSG00000087495 E010 0.7990684 0.023512843 0.5324565424   20 59747758 59747835 78 + 0.195 0.323 0.959
ENSG00000087495 E011 0.9299365 0.070064573 0.2607402139   20 59755182 59755364 183 + 0.195 0.422 1.539
ENSG00000087495 E012 0.4054685 0.679554694 0.1325979197   20 59767186 59767395 210 + 0.000 0.339 12.383
ENSG00000087495 E013 1.2140381 0.150232249 0.6443152141   20 59773279 59773453 175 + 0.290 0.416 0.757
ENSG00000087495 E014 1.2603460 0.179092214 0.2661630300   20 59774243 59774490 248 + 0.248 0.498 1.480
ENSG00000087495 E015 0.6479912 0.057880794 0.0030673536   20 59806041 59806194 154 + 0.000 0.506 13.583
ENSG00000087495 E016 8.5417308 0.006314922 0.0001441577 0.00202979 20 59835853 59836504 652 + 1.012 0.505 -2.074
ENSG00000087495 E017 3.9814600 0.010321338 0.8882238542 0.94570466 20 59836505 59836560 56 + 0.644 0.686 0.180
ENSG00000087495 E018 4.1603219 0.042329974 0.3719393157 0.60556688 20 59840369 59840430 62 + 0.710 0.572 -0.595
ENSG00000087495 E019 6.3173075 0.007190118 0.1599397077 0.37669812 20 59841395 59841535 141 + 0.743 0.941 0.770
ENSG00000087495 E020 1.5455656 0.017117566 0.1899846768 0.41692156 20 59843455 59845188 1734 + 0.431 0.191 -1.623
ENSG00000087495 E021 3.6703791 0.036259246 0.6911033405 0.82978581 20 59845189 59845265 77 + 0.602 0.688 0.370
ENSG00000087495 E022 9.7857102 0.004217527 0.9581441192 0.98099627 20 59847115 59847711 597 + 0.969 0.992 0.084