ENSG00000087470

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000266481 ENSG00000087470 HEK293_OSMI2_6hA HEK293_TMG_6hB DNM1L protein_coding protein_coding 33.51592 11.14621 56.55397 1.251735 1.656725 2.342036 10.465589 3.7067356 20.147444 0.9784181 1.7823569 2.439205 0.32887083 0.32036667 0.35500000 0.034633333 9.214704e-01 1.341724e-06 FALSE TRUE
ENST00000434676 ENSG00000087470 HEK293_OSMI2_6hA HEK293_TMG_6hB DNM1L protein_coding nonsense_mediated_decay 33.51592 11.14621 56.55397 1.251735 1.656725 2.342036 2.826283 0.0000000 5.017771 0.0000000 1.7274972 8.973775 0.05098333 0.00000000 0.08713333 0.087133333 1.341724e-06 1.341724e-06 TRUE FALSE
ENST00000452533 ENSG00000087470 HEK293_OSMI2_6hA HEK293_TMG_6hB DNM1L protein_coding protein_coding 33.51592 11.14621 56.55397 1.251735 1.656725 2.342036 6.427958 2.8337089 10.295735 0.3640231 0.6139589 1.857602 0.20613750 0.25550000 0.18300000 -0.072500000 4.411356e-01 1.341724e-06 FALSE TRUE
ENST00000547312 ENSG00000087470 HEK293_OSMI2_6hA HEK293_TMG_6hB DNM1L protein_coding protein_coding 33.51592 11.14621 56.55397 1.251735 1.656725 2.342036 2.191313 0.9803713 2.847474 0.5225794 0.4681571 1.528699 0.06903333 0.08033333 0.05070000 -0.029633333 9.005838e-01 1.341724e-06 FALSE TRUE
ENST00000547640 ENSG00000087470 HEK293_OSMI2_6hA HEK293_TMG_6hB DNM1L protein_coding retained_intron 33.51592 11.14621 56.55397 1.251735 1.656725 2.342036 3.725863 1.3075820 6.478443 0.2003669 0.3219143 2.299979 0.11646667 0.11980000 0.11443333 -0.005366667 9.941943e-01 1.341724e-06 FALSE FALSE
ENST00000549701 ENSG00000087470 HEK293_OSMI2_6hA HEK293_TMG_6hB DNM1L protein_coding protein_coding 33.51592 11.14621 56.55397 1.251735 1.656725 2.342036 2.218766 1.0881672 2.630514 0.1597472 0.3676231 1.265721 0.07821667 0.09756667 0.04663333 -0.050933333 9.602172e-02 1.341724e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000087470 E001 11.0220167 0.0222164759 0.926843942 0.96549460 12 32679200 32679291 92 + 1.011 1.009 -0.009
ENSG00000087470 E002 16.8289259 0.0159488932 0.741670729 0.86148044 12 32679292 32679300 9 + 1.166 1.214 0.169
ENSG00000087470 E003 17.6728972 0.0206545911 0.755532681 0.86994932 12 32679301 32679302 2 + 1.186 1.230 0.158
ENSG00000087470 E004 30.7648792 0.0101235097 0.505814638 0.70481858 12 32679303 32679315 13 + 1.434 1.387 -0.163
ENSG00000087470 E005 32.8132853 0.0073209743 0.417092326 0.64147682 12 32679316 32679319 4 + 1.463 1.408 -0.188
ENSG00000087470 E006 33.6159379 0.0082714427 0.345500925 0.58310057 12 32679320 32679322 3 + 1.475 1.408 -0.231
ENSG00000087470 E007 70.8264136 0.0005855720 0.057042743 0.19614817 12 32679323 32679335 13 + 1.794 1.711 -0.279
ENSG00000087470 E008 154.4404261 0.0012068089 0.036378391 0.14526977 12 32679336 32679465 130 + 2.125 2.062 -0.212
ENSG00000087470 E009 0.0000000       12 32679708 32679987 280 +      
ENSG00000087470 E010 146.5077901 0.0036046986 0.077532451 0.23991533 12 32701415 32701472 58 + 2.101 2.037 -0.213
ENSG00000087470 E011 155.5735299 0.0040728213 0.047937344 0.17486242 12 32701473 32701562 90 + 2.128 2.054 -0.249
ENSG00000087470 E012 0.3206185 0.0274424043 1.000000000   12 32705825 32705863 39 + 0.127 0.000 -10.851
ENSG00000087470 E013 0.4514866 0.0217681645 0.645348786   12 32705864 32706102 239 + 0.127 0.208 0.860
ENSG00000087470 E014 0.6011358 0.0264273677 0.235393196   12 32706690 32706814 125 + 0.127 0.348 1.856
ENSG00000087470 E015 0.7930990 0.1102628753 1.000000000   12 32706867 32707366 500 + 0.225 0.207 -0.156
ENSG00000087470 E016 126.2427175 0.0055955796 0.052110996 0.18465614 12 32707367 32707413 47 + 2.042 1.958 -0.282
ENSG00000087470 E017 123.6909760 0.0043550960 0.054066839 0.18922958 12 32708153 32708224 72 + 2.033 1.955 -0.260
ENSG00000087470 E018 1.6044975 0.0228365674 0.863583020 0.93237672 12 32709544 32709607 64 + 0.372 0.348 -0.140
ENSG00000087470 E019 149.3343798 0.0002991838 0.038428101 0.15068753 12 32710929 32711015 87 + 2.109 2.053 -0.188
ENSG00000087470 E020 0.9340683 0.3926064220 0.568409297   12 32711180 32711272 93 + 0.220 0.352 0.924
ENSG00000087470 E021 111.9236420 0.0004014877 0.415977304 0.64053927 12 32713209 32713246 38 + 1.976 1.961 -0.052
ENSG00000087470 E022 194.7660201 0.0046350126 0.117931432 0.31244239 12 32713247 32713371 125 + 2.221 2.170 -0.172
ENSG00000087470 E023 210.0770040 0.0049084617 0.047939052 0.17486422 12 32718643 32718763 121 + 2.257 2.188 -0.232
ENSG00000087470 E024 203.9246286 0.0014095329 0.307610370 0.54826582 12 32720664 32720795 132 + 2.235 2.220 -0.050
ENSG00000087470 E025 244.2335884 0.0004659569 0.368688161 0.60296316 12 32722427 32722633 207 + 2.312 2.304 -0.025
ENSG00000087470 E026 0.5893196 0.0749003473 0.384714813   12 32722634 32722772 139 + 0.223 0.000 -11.841
ENSG00000087470 E027 216.8895537 0.0009073370 0.815917509 0.90581464 12 32731014 32731134 121 + 2.252 2.278 0.086
ENSG00000087470 E028 202.9992777 0.0002204791 0.781848205 0.88571615 12 32731356 32731468 113 + 2.224 2.249 0.085
ENSG00000087470 E029 118.6575105 0.0025989144 0.735977153 0.85793091 12 32731469 32731485 17 + 1.998 1.995 -0.008
ENSG00000087470 E030 116.6442977 0.0067083944 0.780053914 0.88478156 12 32731486 32731511 26 + 1.992 1.986 -0.019
ENSG00000087470 E031 176.1263146 0.0205027628 0.626764578 0.78836142 12 32731854 32731943 90 + 2.160 2.194 0.115
ENSG00000087470 E032 1.6785765 0.0121989077 0.867477438 0.93454893 12 32732538 32732610 73 + 0.372 0.349 -0.137
ENSG00000087470 E033 0.0000000       12 32733453 32733565 113 +      
ENSG00000087470 E034 0.4986023 0.0612349424 0.541327401   12 32733566 32733714 149 + 0.179 0.000 -11.439
ENSG00000087470 E035 189.4624075 0.0623640359 0.408602332 0.63495762 12 32733715 32733807 93 + 2.181 2.256 0.248
ENSG00000087470 E036 133.4566523 1.4950404702 0.531441967 0.72303493 12 32737105 32737161 57 + 2.008 2.165 0.527
ENSG00000087470 E037 10.4806333 0.7993765770 0.585377036 0.76053648 12 32737162 32737431 270 + 0.932 1.142 0.768
ENSG00000087470 E038 35.9093903 0.0116360842 0.008843868 0.05311847 12 32737865 32737942 78 + 1.434 1.655 0.755
ENSG00000087470 E039 8.4113221 0.1032100835 0.811762300 0.90330976 12 32737943 32737976 34 + 0.907 0.864 -0.165
ENSG00000087470 E040 18.6800816 0.0576262271 0.268061095 0.50770858 12 32737977 32738263 287 + 1.246 1.084 -0.578
ENSG00000087470 E041 46.0729796 0.0211243937 0.020481324 0.09760902 12 32738264 32738296 33 + 1.538 1.748 0.711
ENSG00000087470 E042 21.2245720 0.0020166418 0.112323375 0.30301938 12 32739845 32740063 219 + 1.296 1.162 -0.472
ENSG00000087470 E043 172.6128902 0.0222471481 0.230187529 0.46534298 12 32740064 32740153 90 + 2.133 2.243 0.369
ENSG00000087470 E044 179.8874373 0.0003490189 0.203613220 0.43407786 12 32740154 32740240 87 + 2.167 2.224 0.191
ENSG00000087470 E045 7.6558054 0.0048586108 0.187991467 0.41443246 12 32740241 32740408 168 + 0.900 0.725 -0.689
ENSG00000087470 E046 229.5257572 0.0002007192 0.304777860 0.54535224 12 32740409 32740518 110 + 2.273 2.319 0.152
ENSG00000087470 E047 281.1252838 0.0009912338 0.054670053 0.19059045 12 32742589 32742748 160 + 2.353 2.424 0.236
ENSG00000087470 E048 988.9413851 0.0057909961 0.290272918 0.53089883 12 32743354 32745650 2297 + 2.902 2.952 0.166