ENSG00000087301

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281741 ENSG00000087301 HEK293_OSMI2_6hA HEK293_TMG_6hB TXNDC16 protein_coding protein_coding 8.551355 2.587753 15.7481 0.5011137 0.5389697 2.600757 7.636673 2.3385749 13.5943902 0.58903351 0.48035766 2.5342148 0.90974583 0.87933333 0.86320000 -0.01613333 0.8881371211 6.47215e-05 FALSE  
ENST00000555312 ENSG00000087301 HEK293_OSMI2_6hA HEK293_TMG_6hB TXNDC16 protein_coding nonsense_mediated_decay 8.551355 2.587753 15.7481 0.5011137 0.5389697 2.600757 0.249218 0.1738909 0.3361763 0.08870272 0.03642601 0.9126568 0.03849167 0.08146667 0.02126667 -0.06020000 0.7630223971 6.47215e-05 TRUE  
MSTRG.9542.3 ENSG00000087301 HEK293_OSMI2_6hA HEK293_TMG_6hB TXNDC16 protein_coding   8.551355 2.587753 15.7481 0.5011137 0.5389697 2.600757 0.423409 0.0000000 1.3889048 0.00000000 0.16352686 7.1281539 0.02812083 0.00000000 0.08853333 0.08853333 0.0000647215 6.47215e-05 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000087301 E001 2.388142 0.2106598044 0.0050949152 0.035133544 14 52429765 52429909 145 - 0.246 0.920 3.265
ENSG00000087301 E002 119.910764 1.3850237692 0.2559221982 0.494656114 14 52430596 52431365 770 - 1.810 2.309 1.672
ENSG00000087301 E003 150.100552 1.4970903047 0.3606683565 0.596168761 14 52431366 52432295 930 - 1.942 2.327 1.290
ENSG00000087301 E004 72.261712 0.4772462712 0.2431892342 0.480245063 14 52432296 52432587 292 - 1.652 1.949 1.001
ENSG00000087301 E005 39.984796 0.0384585013 0.3759610971 0.608971018 14 52439204 52439258 55 - 1.429 1.630 0.690
ENSG00000087301 E006 58.865081 0.0014529741 0.9256338009 0.964983664 14 52439259 52439394 136 - 1.611 1.711 0.338
ENSG00000087301 E007 57.406603 0.0009001392 0.6691809461 0.815692764 14 52440564 52440724 161 - 1.595 1.725 0.441
ENSG00000087301 E008 18.752197 0.0019719251 0.3538567531 0.590693437 14 52455324 52455327 4 - 1.123 1.312 0.670
ENSG00000087301 E009 61.515586 0.0029683265 0.3694397132 0.603587744 14 52455328 52455440 113 - 1.615 1.775 0.541
ENSG00000087301 E010 39.545820 0.0032747014 0.5452175998 0.732838150 14 52455441 52455462 22 - 1.446 1.504 0.197
ENSG00000087301 E011 61.221537 0.0325023220 0.2596609316 0.498613700 14 52457090 52457174 85 - 1.638 1.616 -0.075
ENSG00000087301 E012 2.005164 0.0143399662 0.4647514423 0.676392062 14 52462812 52462970 159 - 0.332 0.538 1.090
ENSG00000087301 E013 73.262423 0.0168565473 0.7069913801 0.839897846 14 52470037 52470173 137 - 1.703 1.773 0.237
ENSG00000087301 E014 81.284681 0.0101784506 0.8256794124 0.911319132 14 52470512 52470680 169 - 1.744 1.835 0.305
ENSG00000087301 E015 46.189576 0.0009439119 0.0671977010 0.218816444 14 52482230 52482289 60 - 1.523 1.493 -0.101
ENSG00000087301 E016 72.101111 0.0040755352 0.0028667683 0.022603918 14 52482822 52482965 144 - 1.720 1.628 -0.313
ENSG00000087301 E017 68.509120 0.0007888290 0.0001279486 0.001835032 14 52488363 52488486 124 - 1.705 1.566 -0.472
ENSG00000087301 E018 46.082757 0.0009517128 0.0107006285 0.061113598 14 52490391 52490451 61 - 1.531 1.445 -0.296
ENSG00000087301 E019 88.875332 0.0142523879 0.0217674161 0.101823363 14 52490839 52491005 167 - 1.805 1.735 -0.234
ENSG00000087301 E020 85.151217 0.0108187404 0.0040971211 0.029712832 14 52511240 52511390 151 - 1.791 1.687 -0.353
ENSG00000087301 E021 55.952647 0.0051699928 0.0445808710 0.166558403 14 52514880 52514970 91 - 1.607 1.565 -0.144
ENSG00000087301 E022 54.524830 0.0544840693 0.0263518616 0.116346511 14 52519172 52519278 107 - 1.608 1.461 -0.505
ENSG00000087301 E023 25.698850 0.0274559627 0.0296224686 0.126221967 14 52519279 52519293 15 - 1.296 1.140 -0.553
ENSG00000087301 E024 40.846834 0.0338119998 0.0164522009 0.083477827 14 52536719 52536793 75 - 1.488 1.320 -0.581
ENSG00000087301 E025 42.599644 0.0289967409 0.0031762268 0.024465749 14 52537599 52537672 74 - 1.511 1.271 -0.831
ENSG00000087301 E026 42.250698 0.0115858787 0.0024131717 0.019768079 14 52542371 52542453 83 - 1.505 1.325 -0.622
ENSG00000087301 E027 64.340773 0.0040454629 0.0069944093 0.044609290 14 52543398 52543630 233 - 1.671 1.593 -0.266
ENSG00000087301 E028 32.509739 0.0082158836 0.7876086436 0.889138959 14 52544264 52544371 108 - 1.359 1.443 0.290
ENSG00000087301 E029 24.822226 0.0481997762 0.6887793677 0.828332856 14 52552316 52552522 207 - 1.235 1.376 0.493