ENSG00000085788

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397166 ENSG00000085788 HEK293_OSMI2_6hA HEK293_TMG_6hB DDHD2 protein_coding protein_coding 22.51951 10.56404 33.9205 1.507286 0.7739299 1.682056 6.152355 3.0675066 4.666207 0.2951826 0.3012401 0.6035768 0.27729167 0.29580000 0.13730000 -0.15850000 0.0001217777 0.0001217777 FALSE TRUE
ENST00000526144 ENSG00000085788 HEK293_OSMI2_6hA HEK293_TMG_6hB DDHD2 protein_coding protein_coding 22.51951 10.56404 33.9205 1.507286 0.7739299 1.682056 1.503091 1.1233620 2.309174 0.3197428 0.5906943 1.0330025 0.07915417 0.10153333 0.06843333 -0.03310000 0.7456503291 0.0001217777 FALSE TRUE
ENST00000528504 ENSG00000085788 HEK293_OSMI2_6hA HEK293_TMG_6hB DDHD2 protein_coding retained_intron 22.51951 10.56404 33.9205 1.507286 0.7739299 1.682056 1.690056 0.7538785 2.083388 0.2615178 0.5105467 1.4544245 0.07531250 0.06636667 0.06096667 -0.00540000 0.9878165957 0.0001217777 FALSE FALSE
ENST00000531344 ENSG00000085788 HEK293_OSMI2_6hA HEK293_TMG_6hB DDHD2 protein_coding retained_intron 22.51951 10.56404 33.9205 1.507286 0.7739299 1.682056 2.631286 1.4483367 4.616964 0.3056125 0.4666833 1.6657420 0.11750833 0.13693333 0.13663333 -0.00030000 1.0000000000 0.0001217777   FALSE
ENST00000532222 ENSG00000085788 HEK293_OSMI2_6hA HEK293_TMG_6hB DDHD2 protein_coding protein_coding 22.51951 10.56404 33.9205 1.507286 0.7739299 1.682056 1.521739 0.3688483 4.236406 0.2049642 0.2967180 3.4865502 0.05452917 0.03030000 0.12473333 0.09443333 0.2859070150 0.0001217777 FALSE TRUE
MSTRG.31415.11 ENSG00000085788 HEK293_OSMI2_6hA HEK293_TMG_6hB DDHD2 protein_coding   22.51951 10.56404 33.9205 1.507286 0.7739299 1.682056 2.394107 1.1410577 7.835493 0.6701482 0.1686166 2.7689039 0.11880833 0.09650000 0.23106667 0.13456667 0.6346556766 0.0001217777 FALSE TRUE
MSTRG.31415.15 ENSG00000085788 HEK293_OSMI2_6hA HEK293_TMG_6hB DDHD2 protein_coding   22.51951 10.56404 33.9205 1.507286 0.7739299 1.682056 1.798437 0.1968704 3.770172 0.1478953 0.2964780 4.1916525 0.06466250 0.01746667 0.11093333 0.09346667 0.0667420242 0.0001217777 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000085788 E001 0.0000000       8 38225218 38225308 91 +      
ENSG00000085788 E002 1.7425524 0.0121989077 2.158699e-02 1.012530e-01 8 38231484 38231584 101 + 0.261 0.657 2.103
ENSG00000085788 E003 4.5910860 0.0064567200 7.518075e-06 1.637479e-04 8 38231585 38231670 86 + 0.422 1.046 2.621
ENSG00000085788 E004 7.0916231 0.0292049273 1.128132e-06 3.153625e-05 8 38231671 38231694 24 + 0.564 1.233 2.595
ENSG00000085788 E005 8.4191534 0.0430548119 3.167011e-06 7.783692e-05 8 38231695 38231714 20 + 0.631 1.299 2.529
ENSG00000085788 E006 12.4877260 0.0030236957 1.815672e-09 1.008173e-07 8 38231715 38231746 32 + 0.843 1.419 2.080
ENSG00000085788 E007 10.6244269 0.0170130032 2.511989e-05 4.629840e-04 8 38231747 38231751 5 + 0.831 1.322 1.793
ENSG00000085788 E008 17.7429837 0.0148374471 1.572731e-03 1.412854e-02 8 38231752 38231816 65 + 1.125 1.440 1.107
ENSG00000085788 E009 16.4769628 0.0023904586 1.810004e-01 4.052636e-01 8 38231817 38231838 22 + 1.170 1.294 0.440
ENSG00000085788 E010 19.9498550 0.0017907847 7.960385e-03 4.913698e-02 8 38231839 38231859 21 + 1.210 1.428 0.759
ENSG00000085788 E011 0.0000000       8 38231953 38232144 192 +      
ENSG00000085788 E012 17.7504667 0.0021601646 9.474430e-02 2.725129e-01 8 38232987 38232998 12 + 1.188 1.337 0.524
ENSG00000085788 E013 60.2994952 0.0006322153 9.240881e-01 9.644453e-01 8 38232999 38233138 140 + 1.745 1.757 0.042
ENSG00000085788 E014 69.7347548 0.0006128666 9.962599e-02 2.810843e-01 8 38233139 38233214 76 + 1.830 1.761 -0.236
ENSG00000085788 E015 49.4905361 0.0008719071 5.514983e-02 1.916692e-01 8 38234394 38234399 6 + 1.695 1.596 -0.339
ENSG00000085788 E016 112.3890428 0.0004268342 3.671677e-03 2.732766e-02 8 38234400 38234510 111 + 2.045 1.944 -0.338
ENSG00000085788 E017 98.5666227 0.0004317380 5.251310e-03 3.594636e-02 8 38234511 38234584 74 + 1.989 1.885 -0.348
ENSG00000085788 E018 0.0000000       8 38234585 38234585 1 +      
ENSG00000085788 E019 97.3889878 0.0004242767 1.021214e-01 2.855729e-01 8 38237538 38237627 90 + 1.972 1.916 -0.190
ENSG00000085788 E020 101.9251851 0.0004814253 1.826971e-01 4.075436e-01 8 38238089 38238209 121 + 1.987 1.944 -0.145
ENSG00000085788 E021 5.8756071 0.0051897279 2.078809e-02 9.864145e-02 8 38238210 38239058 849 + 0.891 0.547 -1.426
ENSG00000085788 E022 72.9980881 0.0004858726 8.668905e-01 9.343018e-01 8 38240275 38240364 90 + 1.830 1.831 0.002
ENSG00000085788 E023 2.1107185 0.0795972825 6.802337e-01 8.228751e-01 8 38240365 38240367 3 + 0.485 0.403 -0.428
ENSG00000085788 E024 2.9737511 0.2018704012 3.982192e-02 1.542842e-01 8 38241965 38242227 263 + 0.352 0.852 2.289
ENSG00000085788 E025 1.6001054 0.0116892628 4.872431e-02 1.766343e-01 8 38242228 38242249 22 + 0.261 0.606 1.880
ENSG00000085788 E026 113.0737153 0.0012359963 7.097099e-01 8.416320e-01 8 38242250 38242385 136 + 2.020 2.015 -0.019
ENSG00000085788 E027 153.1131166 0.0010273482 8.658726e-01 9.336789e-01 8 38245742 38245950 209 + 2.143 2.157 0.047
ENSG00000085788 E028 16.9055520 0.0109137006 7.795326e-01 8.844567e-01 8 38245951 38246157 207 + 1.217 1.195 -0.080
ENSG00000085788 E029 8.1564960 0.0047184949 4.831863e-01 6.892481e-01 8 38246184 38246232 49 + 0.892 0.982 0.340
ENSG00000085788 E030 69.7719509 0.0151495221 9.696461e-01 9.866457e-01 8 38246233 38246300 68 + 1.806 1.811 0.017
ENSG00000085788 E031 14.5605160 0.0022789720 8.242167e-01 9.104024e-01 8 38246804 38247712 909 + 1.164 1.150 -0.047
ENSG00000085788 E032 95.7136944 0.0012469132 1.945654e-01 4.227982e-01 8 38247713 38247835 123 + 1.956 1.908 -0.160
ENSG00000085788 E033 0.2852693 0.2909701782 6.800907e-01   8 38247836 38247836 1 + 0.147 0.000 -9.581
ENSG00000085788 E034 74.4102012 0.0005249974 7.820766e-02 2.412095e-01 8 38249708 38249774 67 + 1.859 1.786 -0.243
ENSG00000085788 E035 43.6209728 0.0010509528 1.911520e-01 4.183463e-01 8 38249775 38249778 4 + 1.635 1.567 -0.234
ENSG00000085788 E036 51.5666748 0.0007510207 2.615167e-01 5.005933e-01 8 38249779 38249803 25 + 1.700 1.648 -0.178
ENSG00000085788 E037 1.3144265 0.0135570030 2.662595e-01   8 38249804 38251911 2108 + 0.388 0.178 -1.510
ENSG00000085788 E038 74.2250289 0.0007394441 7.506778e-01 8.671620e-01 8 38251912 38252028 117 + 1.836 1.859 0.078
ENSG00000085788 E039 0.1614157 0.0331737524 1.000000e+00   8 38252098 38252131 34 + 0.081 0.000 -9.610
ENSG00000085788 E040 49.3368865 0.0008520851 1.012091e-01 2.839804e-01 8 38252132 38252165 34 + 1.633 1.729 0.325
ENSG00000085788 E041 61.3097367 0.0007329400 8.503663e-01 9.252087e-01 8 38252166 38252210 45 + 1.751 1.768 0.059
ENSG00000085788 E042 84.7614319 0.0013827706 8.073263e-01 9.005519e-01 8 38252211 38252287 77 + 1.887 1.906 0.062
ENSG00000085788 E043 61.1301857 0.0037647875 8.565257e-01 9.285683e-01 8 38252722 38252741 20 + 1.753 1.750 -0.010
ENSG00000085788 E044 97.6913210 0.0005867430 6.940682e-01 8.317485e-01 8 38252742 38252824 83 + 1.948 1.971 0.079
ENSG00000085788 E045 143.6902618 0.0004225915 8.301734e-01 9.138747e-01 8 38252957 38253127 171 + 2.120 2.121 0.002
ENSG00000085788 E046 0.6600180 0.0193874923 2.051656e-01   8 38253128 38253475 348 + 0.261 0.000 -11.690
ENSG00000085788 E047 53.4212387 0.0007198425 2.783164e-01 5.184338e-01 8 38253556 38253560 5 + 1.713 1.663 -0.170
ENSG00000085788 E048 122.1471964 0.0028556143 7.212031e-01 8.489093e-01 8 38253561 38253718 158 + 2.055 2.048 -0.024
ENSG00000085788 E049 55.7111153 0.0097983436 4.209944e-01 6.444550e-01 8 38260040 38260060 21 + 1.732 1.683 -0.165
ENSG00000085788 E050 52.2990351 0.0038465840 8.663298e-01 9.339572e-01 8 38260061 38260072 12 + 1.691 1.689 -0.006
ENSG00000085788 E051 82.0202105 0.0053310628 6.269293e-01 7.884751e-01 8 38260073 38260147 75 + 1.871 1.904 0.113
ENSG00000085788 E052 2.7902533 0.0082780779 5.990885e-01 7.696072e-01 8 38260148 38260254 107 + 0.514 0.606 0.424
ENSG00000085788 E053 3.2055984 0.0083374613 6.742669e-01 8.190767e-01 8 38260564 38260599 36 + 0.612 0.547 -0.289
ENSG00000085788 E054 271.0138338 0.0058802380 8.728833e-02 2.587687e-01 8 38260600 38261537 938 + 2.411 2.348 -0.211
ENSG00000085788 E055 54.2480141 0.0009507747 7.220316e-01 8.492992e-01 8 38261538 38261599 62 + 1.695 1.721 0.089
ENSG00000085788 E056 252.9235313 0.0002444200 5.723737e-01 7.519529e-01 8 38261600 38262836 1237 + 2.366 2.360 -0.019
ENSG00000085788 E057 19.0559439 0.4806811368 6.131289e-02 2.057571e-01 8 38267613 38269027 1415 + 1.029 1.567 1.890
ENSG00000085788 E058 18.8960489 0.4370868284 2.888144e-02 1.240260e-01 8 38269707 38270977 1271 + 0.967 1.601 2.233
ENSG00000085788 E059 2.2520450 0.3775171199 1.597950e-01 3.764879e-01 8 38271122 38271393 272 + 0.349 0.723 1.798
ENSG00000085788 E060 0.6487990 0.1804600978 4.216081e-01   8 38273370 38273372 3 + 0.149 0.305 1.317
ENSG00000085788 E061 3.2132600 0.3914915913 1.791249e-01 4.027869e-01 8 38273373 38273442 70 + 0.414 0.858 1.959
ENSG00000085788 E062 2.0055012 0.1320186812 1.459660e-03 1.333282e-02 8 38273443 38273626 184 + 0.149 0.788 3.647
ENSG00000085788 E063 1.9765694 0.1104222939 6.774346e-02 2.200241e-01 8 38275359 38275558 200 + 0.305 0.663 1.820