ENSG00000085760

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263629 ENSG00000085760 HEK293_OSMI2_6hA HEK293_TMG_6hB MTIF2 protein_coding protein_coding 26.60515 12.31336 39.93083 1.120387 1.704334 1.696469 14.651530 4.433847 25.726439 0.7749545 1.9146635 2.5339313 0.47455000 0.3655333 0.6437333 0.27820000 0.07970528 0.02483216 FALSE TRUE
ENST00000394600 ENSG00000085760 HEK293_OSMI2_6hA HEK293_TMG_6hB MTIF2 protein_coding protein_coding 26.60515 12.31336 39.93083 1.120387 1.704334 1.696469 4.497345 4.352232 4.707160 1.0564156 0.6684918 0.1128520 0.25949583 0.3480333 0.1178667 -0.23016667 0.02483216 0.02483216 FALSE TRUE
MSTRG.18425.3 ENSG00000085760 HEK293_OSMI2_6hA HEK293_TMG_6hB MTIF2 protein_coding   26.60515 12.31336 39.93083 1.120387 1.704334 1.696469 1.871584 1.323298 1.998546 0.2059865 0.2038371 0.5911525 0.06922083 0.1073333 0.0506000 -0.05673333 0.10040010 0.02483216 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000085760 E001 8.1468073 0.0214199272 8.574367e-01 9.290479e-01 2 55236595 55236620 26 - 0.907 0.935 0.103
ENSG00000085760 E002 122.8783524 0.0040511437 5.279460e-02 1.862352e-01 2 55236621 55236820 200 - 2.015 2.105 0.302
ENSG00000085760 E003 148.3473716 0.0004184288 3.959901e-07 1.260983e-05 2 55237288 55237428 141 - 2.072 2.235 0.543
ENSG00000085760 E004 180.5184658 0.0010125753 3.676362e-08 1.514999e-06 2 55240011 55240175 165 - 2.154 2.325 0.572
ENSG00000085760 E005 181.5058326 0.0015678114 6.362017e-03 4.150979e-02 2 55242940 55243080 141 - 2.184 2.275 0.306
ENSG00000085760 E006 270.9703633 0.0030641762 2.791102e-02 1.210216e-01 2 55243416 55243668 253 - 2.360 2.432 0.242
ENSG00000085760 E007 189.1026584 0.0015562261 1.321518e-01 3.351965e-01 2 55244029 55244154 126 - 2.211 2.261 0.166
ENSG00000085760 E008 156.8631594 0.0028231232 5.350066e-01 7.256091e-01 2 55244155 55244233 79 - 2.150 2.126 -0.081
ENSG00000085760 E009 193.0009418 0.0047365136 6.499265e-01 8.035154e-01 2 55246337 55246461 125 - 2.239 2.223 -0.053
ENSG00000085760 E010 193.6747105 0.0003345570 5.496375e-01 7.360423e-01 2 55249395 55249534 140 - 2.232 2.252 0.067
ENSG00000085760 E011 130.3676971 0.0004688333 6.186156e-01 7.829023e-01 2 55252477 55252541 65 - 2.072 2.056 -0.051
ENSG00000085760 E012 143.4856995 0.0029673695 8.212825e-01 9.087469e-01 2 55252542 55252653 112 - 2.108 2.098 -0.031
ENSG00000085760 E013 162.5514266 0.0003606375 2.018889e-01 4.319847e-01 2 55254041 55254201 161 - 2.170 2.131 -0.130
ENSG00000085760 E014 139.2720368 0.0003097508 2.226820e-01 4.566549e-01 2 55254654 55254766 113 - 2.104 2.065 -0.132
ENSG00000085760 E015 120.5010198 0.0003401011 4.167483e-02 1.590700e-01 2 55254767 55254825 59 - 2.050 1.977 -0.246
ENSG00000085760 E016 157.3729533 0.0009190093 1.989790e-01 4.284474e-01 2 55262316 55262427 112 - 2.158 2.118 -0.136
ENSG00000085760 E017 74.4621441 0.0007810534 1.140480e-01 3.058400e-01 2 55263640 55263640 1 - 1.846 1.773 -0.245
ENSG00000085760 E018 73.6748038 0.0008005583 4.101068e-01 6.361081e-01 2 55263641 55263646 6 - 1.832 1.796 -0.121
ENSG00000085760 E019 69.8559929 0.0022349804 4.740324e-01 6.828477e-01 2 55263647 55263647 1 - 1.809 1.776 -0.110
ENSG00000085760 E020 166.1738490 0.0003128315 9.078814e-01 9.560775e-01 2 55263648 55263779 132 - 2.171 2.177 0.022
ENSG00000085760 E021 118.9402707 0.0007733558 1.998810e-01 4.295213e-01 2 55263780 55263827 48 - 2.040 1.994 -0.156
ENSG00000085760 E022 98.1966102 0.0005367187 2.137252e-01 4.460350e-01 2 55263828 55263836 9 - 1.957 1.909 -0.162
ENSG00000085760 E023 109.5154427 0.0004361210 1.140427e-02 6.400648e-02 2 55263837 55263865 29 - 2.015 1.918 -0.328
ENSG00000085760 E024 0.0000000       2 55263866 55263868 3 -      
ENSG00000085760 E025 13.9132394 0.0024385091 5.859158e-01 7.609035e-01 2 55266381 55266518 138 - 1.108 1.165 0.204
ENSG00000085760 E026 140.5592858 0.0027896844 2.413939e-03 1.977245e-02 2 55267569 55267635 67 - 2.130 2.005 -0.418
ENSG00000085760 E027 0.3336024 0.0274424043 3.854633e-02   2 55267636 55267787 152 - 0.000 0.320 11.332
ENSG00000085760 E028 115.0248968 0.0031148999 1.263445e-04 1.815398e-03 2 55268578 55268649 72 - 2.054 1.875 -0.604
ENSG00000085760 E029 115.6846620 0.0008746811 1.839323e-02 9.033572e-02 2 55268650 55268739 90 - 2.038 1.946 -0.309
ENSG00000085760 E030 6.5204354 0.0950308726 1.956590e-01 4.241760e-01 2 55268740 55268816 77 - 0.761 0.984 0.858
ENSG00000085760 E031 25.8154430 0.0042807184 1.794079e-01 4.032079e-01 2 55268817 55268991 175 - 1.343 1.451 0.374
ENSG00000085760 E032 18.2061872 0.0018807807 3.531095e-03 2.652781e-02 2 55268992 55269168 177 - 1.151 1.398 0.866
ENSG00000085760 E033 67.7939285 0.0012005065 3.554454e-02 1.430331e-01 2 55269169 55269212 44 - 1.811 1.704 -0.360
ENSG00000085760 E034 27.5394998 0.0192337440 3.808569e-03 2.807216e-02 2 55269213 55269347 135 - 1.464 1.150 -1.097