ENSG00000085721

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000198767 ENSG00000085721 HEK293_OSMI2_6hA HEK293_TMG_6hB RRN3 protein_coding protein_coding 23.30732 8.780319 37.97826 1.718441 1.245351 2.111566 18.868931 7.9452588 28.988748 1.462902 0.6049879 1.86601 0.8512042 0.91000000 0.7642000 -0.1458 0.001854642 0.001854642 FALSE TRUE
ENST00000429751 ENSG00000085721 HEK293_OSMI2_6hA HEK293_TMG_6hB RRN3 protein_coding protein_coding 23.30732 8.780319 37.97826 1.718441 1.245351 2.111566 3.615761 0.6293839 7.508601 0.182871 1.0857931 3.55571 0.1125208 0.06876667 0.1963667 0.1276 0.003933703 0.001854642 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000085721 E001 0.2735028 0.0257987054 0.373540309   16 15060033 15060034 2 - 0.069 0.205 1.813
ENSG00000085721 E002 47.9063708 0.0063452392 0.036373501 0.145253659 16 15060035 15060173 139 - 1.570 1.734 0.559
ENSG00000085721 E003 699.4426889 0.0032326313 0.000096395 0.001449707 16 15060174 15061427 1254 - 2.737 2.855 0.393
ENSG00000085721 E004 202.7746308 0.0003084758 0.845014843 0.922154184 16 15061428 15061628 201 - 2.227 2.251 0.081
ENSG00000085721 E005 196.2192514 0.0003217242 0.288324120 0.529066723 16 15061629 15061788 160 - 2.208 2.257 0.164
ENSG00000085721 E006 170.4543312 0.0004390999 0.357207711 0.593440536 16 15061789 15061905 117 - 2.147 2.194 0.158
ENSG00000085721 E007 127.1636492 0.0004480945 0.806817357 0.900242304 16 15063196 15063283 88 - 2.030 2.039 0.029
ENSG00000085721 E008 141.9414354 0.0006968654 0.810459973 0.902487403 16 15065219 15065371 153 - 2.077 2.086 0.032
ENSG00000085721 E009 81.7213520 0.0079004206 0.864453139 0.932847880 16 15068169 15068277 109 - 1.834 1.857 0.079
ENSG00000085721 E010 82.4720459 0.0022323662 0.625808986 0.787772107 16 15070070 15070254 185 - 1.846 1.841 -0.017
ENSG00000085721 E011 101.4481799 0.0004600285 0.639676054 0.796717919 16 15071121 15071251 131 - 1.927 1.965 0.127
ENSG00000085721 E012 136.4453764 0.0003184454 0.891056315 0.947176448 16 15072950 15073080 131 - 2.060 2.073 0.045
ENSG00000085721 E013 1.4119707 0.0130641266 0.485301278 0.690737828 16 15074677 15074722 46 - 0.308 0.449 0.813
ENSG00000085721 E014 152.7510997 0.0011944593 0.011250512 0.063405423 16 15074723 15074861 139 - 2.128 2.050 -0.260
ENSG00000085721 E015 0.6622309 0.2065783189 0.400553505   16 15076435 15076557 123 - 0.229 0.000 -10.524
ENSG00000085721 E016 100.8022340 0.0005653289 0.001561476 0.014049722 16 15076558 15076650 93 - 1.955 1.833 -0.409
ENSG00000085721 E017 94.0011343 0.0021580327 0.037693527 0.148817311 16 15079998 15080096 99 - 1.917 1.834 -0.281
ENSG00000085721 E018 91.5672395 0.0005163462 0.075626138 0.236070608 16 15083513 15083582 70 - 1.902 1.841 -0.206
ENSG00000085721 E019 1.1586203 0.0362287423 0.122847381   16 15083583 15083750 168 - 0.344 0.000 -11.322
ENSG00000085721 E020 100.4879266 0.0006407637 0.099542492 0.280924986 16 15084642 15084705 64 - 1.943 1.891 -0.175
ENSG00000085721 E021 84.4644757 0.0004965392 0.024595515 0.110966342 16 15085639 15085698 60 - 1.876 1.789 -0.294
ENSG00000085721 E022 90.3329039 0.0006119897 0.001711488 0.015096354 16 15086129 15086258 130 - 1.913 1.784 -0.433
ENSG00000085721 E023 50.8999049 0.0015369449 0.727351050 0.852656506 16 15086365 15086454 90 - 1.645 1.642 -0.009
ENSG00000085721 E024 62.2057538 0.0008855570 0.265843108 0.505263163 16 15091315 15091371 57 - 1.736 1.694 -0.144
ENSG00000085721 E025 94.3185979 0.0004192520 0.072456831 0.229700186 16 15092509 15092614 106 - 1.917 1.856 -0.204
ENSG00000085721 E026 0.1614157 0.0335726656 1.000000000   16 15093952 15094144 193 - 0.069 0.000 -8.511
ENSG00000085721 E027 73.6816194 0.0013048618 0.076069035 0.236884727 16 15094145 15094311 167 - 1.812 1.739 -0.248