ENSG00000085719

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000517490 ENSG00000085719 HEK293_OSMI2_6hA HEK293_TMG_6hB CPNE3 protein_coding protein_coding 40.92885 7.313387 77.1888 2.246966 3.954655 3.397995 32.916806 6.854112 63.417469 2.07997 1.880354 3.207963 0.84546667 0.9413 0.8235333 -0.1177667 5.336120e-02 6.247836e-11 FALSE TRUE
ENST00000621783 ENSG00000085719 HEK293_OSMI2_6hA HEK293_TMG_6hB CPNE3 protein_coding protein_coding 40.92885 7.313387 77.1888 2.246966 3.954655 3.397995 1.715091 0.000000 8.421398 0.00000 1.412844 9.719628 0.02237083 0.0000 0.1078333 0.1078333 6.247836e-11 6.247836e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000085719 E001 1.6450802 0.1194271179 3.862583e-01 6.174976e-01 8 86514435 86514436 2 + 0.317 0.000 -11.015
ENSG00000085719 E002 1.8064959 0.1701434289 3.679659e-01 6.023855e-01 8 86514437 86514437 1 + 0.339 0.000 -12.488
ENSG00000085719 E003 1.8064959 0.1701434289 3.679659e-01 6.023855e-01 8 86514438 86514438 1 + 0.339 0.000 -12.488
ENSG00000085719 E004 3.2917743 0.0069749672 3.701283e-01 6.040796e-01 8 86514439 86514442 4 + 0.495 0.296 -1.120
ENSG00000085719 E005 5.5475440 0.0048423709 3.378477e-01 5.761499e-01 8 86514443 86514445 3 + 0.654 0.471 -0.844
ENSG00000085719 E006 28.7261958 0.0015109343 2.322375e-02 1.066681e-01 8 86514446 86514458 13 + 1.283 1.033 -0.895
ENSG00000085719 E007 101.9397458 0.0004734670 1.939144e-03 1.666282e-02 8 86514459 86514503 45 + 1.808 1.634 -0.590
ENSG00000085719 E008 127.5853598 0.0003406196 1.010897e-02 5.861169e-02 8 86514504 86514541 38 + 1.901 1.783 -0.398
ENSG00000085719 E009 6.4067325 0.0119475769 2.246859e-01 4.590159e-01 8 86514542 86514561 20 + 0.711 0.471 -1.079
ENSG00000085719 E010 4.6318293 0.0128150598 1.629512e-01 3.811479e-01 8 86514562 86514573 12 + 0.610 0.296 -1.653
ENSG00000085719 E011 5.8587314 0.0052577672 6.587067e-01 8.091798e-01 8 86514574 86514722 149 + 0.664 0.595 -0.299
ENSG00000085719 E012 2.8818436 0.0141386063 4.187104e-01 6.426472e-01 8 86515142 86515461 320 + 0.415 0.595 0.875
ENSG00000085719 E013 140.8512521 0.0015257700 3.258208e-02 1.349175e-01 8 86515462 86515499 38 + 1.940 1.847 -0.313
ENSG00000085719 E014 0.5845677 0.2671672161 8.328090e-02   8 86521604 86521714 111 + 0.084 0.462 3.152
ENSG00000085719 E015 2.0671871 0.0103387113 5.729923e-01 7.523096e-01 8 86524709 86524814 106 + 0.336 0.471 0.743
ENSG00000085719 E016 3.4108760 0.0071070050 6.287806e-01 7.897040e-01 8 86524877 86524997 121 + 0.480 0.595 0.537
ENSG00000085719 E017 267.4275801 0.0002409472 7.826092e-04 8.137289e-03 8 86528536 86528677 142 + 2.218 2.114 -0.346
ENSG00000085719 E018 278.5302379 0.0001941582 9.417447e-03 5.560798e-02 8 86528945 86529062 118 + 2.234 2.164 -0.236
ENSG00000085719 E019 254.7171816 0.0008892285 1.208977e-02 6.682033e-02 8 86529063 86529124 62 + 2.196 2.118 -0.262
ENSG00000085719 E020 258.9770713 0.0001893564 9.286677e-02 2.690502e-01 8 86531155 86531229 75 + 2.199 2.161 -0.128
ENSG00000085719 E021 231.4304998 0.0003618375 4.552478e-02 1.688634e-01 8 86532509 86532580 72 + 2.154 2.098 -0.187
ENSG00000085719 E022 246.7195782 0.0003808412 9.151600e-02 2.664916e-01 8 86537563 86537646 84 + 2.179 2.137 -0.140
ENSG00000085719 E023 174.7178859 0.0061091137 5.840782e-01 7.597266e-01 8 86540245 86540274 30 + 2.027 2.006 -0.071
ENSG00000085719 E024 237.0275716 0.0029574397 3.866236e-02 1.512727e-01 8 86540275 86540334 60 + 2.164 2.085 -0.267
ENSG00000085719 E025 281.3727727 0.0018136720 1.751603e-01 3.973797e-01 8 86544740 86544838 99 + 2.234 2.200 -0.114
ENSG00000085719 E026 1.9491306 0.0755213913 2.746291e-01 5.146029e-01 8 86544839 86545333 495 + 0.358 0.000 -12.871
ENSG00000085719 E027 199.3401192 0.0002680048 2.547179e-01 4.932265e-01 8 86546595 86546627 33 + 2.084 2.059 -0.083
ENSG00000085719 E028 202.9555090 0.0002516094 1.765819e-01 3.991755e-01 8 86546628 86546681 54 + 2.092 2.059 -0.112
ENSG00000085719 E029 2.6588531 0.0575509530 1.533405e-01 3.671175e-01 8 86547306 86547710 405 + 0.434 0.000 -13.382
ENSG00000085719 E030 185.6332539 0.0002554143 6.088239e-01 7.761136e-01 8 86547711 86547770 60 + 2.051 2.051 0.003
ENSG00000085719 E031 256.4869501 0.0160089925 7.778372e-01 8.833931e-01 8 86548301 86548434 134 + 2.192 2.168 -0.080
ENSG00000085719 E032 0.0000000       8 86551005 86551045 41 +      
ENSG00000085719 E033 177.6802678 0.0013918953 6.682780e-01 8.150836e-01 8 86551046 86551100 55 + 2.031 2.032 0.002
ENSG00000085719 E034 1.5486360 0.0122482196 3.696747e-01 6.037559e-01 8 86551101 86551182 82 + 0.267 0.470 1.199
ENSG00000085719 E035 176.8747020 0.0002551736 2.756057e-02 1.199800e-01 8 86551183 86551234 52 + 2.037 1.959 -0.261
ENSG00000085719 E036 1.3056807 0.0918651983 5.112825e-01   8 86551235 86551512 278 + 0.268 0.000 -12.226
ENSG00000085719 E037 249.2354436 0.0003074171 4.865742e-01 6.916448e-01 8 86554851 86554984 134 + 2.179 2.175 -0.011
ENSG00000085719 E038 308.4209907 0.0004052912 1.589153e-01 3.751281e-01 8 86556102 86556338 237 + 2.264 2.333 0.228
ENSG00000085719 E039 0.2852693 0.3420930642 1.000000e+00   8 86557195 86557222 28 + 0.082 0.000 -9.774
ENSG00000085719 E040 2601.7176916 0.0006310961 1.966515e-17 4.112801e-15 8 86558288 86561498 3211 + 3.181 3.300 0.395