ENSG00000085644

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396878 ENSG00000085644 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF213 protein_coding protein_coding 10.16094 17.00808 5.289867 3.206181 0.183179 -1.68304 5.9291077 10.7496357 1.7265558 1.98865556 0.37403228 -2.6313285 0.54794583 0.6329000 0.3252000 -0.30770000 0.025570554 0.007795141 FALSE TRUE
ENST00000572647 ENSG00000085644 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF213 protein_coding protein_coding 10.16094 17.00808 5.289867 3.206181 0.183179 -1.68304 0.6411673 1.2784455 0.5427891 0.34948096 0.16451921 -1.2208304 0.06505833 0.0723000 0.1009667 0.02866667 0.808874347 0.007795141 FALSE TRUE
ENST00000574575 ENSG00000085644 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF213 protein_coding protein_coding 10.16094 17.00808 5.289867 3.206181 0.183179 -1.68304 0.5776512 1.5025495 0.1535453 0.26404232 0.15354534 -3.2092198 0.05242917 0.0891000 0.0295000 -0.05960000 0.385339890 0.007795141 FALSE TRUE
ENST00000574928 ENSG00000085644 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF213 protein_coding retained_intron 10.16094 17.00808 5.289867 3.206181 0.183179 -1.68304 0.6434284 0.8041593 0.6327196 0.09924496 0.07048907 -0.3411216 0.07480417 0.0544000 0.1198667 0.06546667 0.299028157 0.007795141 FALSE TRUE
ENST00000576863 ENSG00000085644 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF213 protein_coding nonsense_mediated_decay 10.16094 17.00808 5.289867 3.206181 0.183179 -1.68304 1.7514857 1.8572134 1.9949795 0.50163990 0.40315091 0.1027006 0.19243333 0.1071333 0.3790333 0.27190000 0.007795141 0.007795141 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000085644 E001 0.2027342 0.0385684657 1.0000000000   16 3129777 3130056 280 + 0.001 0.068 7.028
ENSG00000085644 E002 0.0000000       16 3134923 3134965 43 +      
ENSG00000085644 E003 0.0000000       16 3134966 3135028 63 +      
ENSG00000085644 E004 0.0000000       16 3135029 3135109 81 +      
ENSG00000085644 E005 0.8451886 0.0185748445 0.9748796882   16 3135110 3135132 23 + 0.209 0.224 0.131
ENSG00000085644 E006 1.7437698 0.0121989077 0.2819500896 0.522285961 16 3135133 3135137 5 + 0.209 0.429 1.450
ENSG00000085644 E007 10.9884220 0.0035010980 0.0146340197 0.076713232 16 3135138 3135158 21 + 0.725 1.059 1.277
ENSG00000085644 E008 45.4228835 0.0010901943 0.0005072977 0.005746069 16 3135159 3135317 159 + 1.388 1.630 0.830
ENSG00000085644 E009 43.6014198 0.0009408381 0.0176728576 0.087905152 16 3135318 3135387 70 + 1.439 1.600 0.549
ENSG00000085644 E010 2.7694130 0.0111369784 0.5292701429 0.721541095 16 3135388 3135445 58 + 0.611 0.504 -0.493
ENSG00000085644 E011 103.6120932 0.0010799257 0.3152275361 0.555297351 16 3137166 3137403 238 + 1.968 1.926 -0.141
ENSG00000085644 E012 109.6233069 0.0005191804 0.1365712533 0.342225140 16 3137404 3137649 246 + 2.006 1.948 -0.195
ENSG00000085644 E013 44.8621482 0.0012271630 0.9082419339 0.956286277 16 3137650 3137679 30 + 1.580 1.586 0.022
ENSG00000085644 E014 11.2057292 0.0551719884 0.0010536722 0.010319725 16 3137680 3138353 674 + 1.330 0.852 -1.739
ENSG00000085644 E015 9.6761216 0.0035078797 0.0115096130 0.064427352 16 3138354 3138417 64 + 1.163 0.880 -1.043
ENSG00000085644 E016 77.1901400 0.0046960167 0.2370446019 0.473144714 16 3138418 3138541 124 + 1.761 1.825 0.218
ENSG00000085644 E017 5.7802626 0.2612911760 0.0906582611 0.264997905 16 3138542 3138744 203 + 1.054 0.621 -1.697
ENSG00000085644 E018 50.0675151 0.0047856984 0.6550523603 0.806730789 16 3138745 3138818 74 + 1.600 1.627 0.092
ENSG00000085644 E019 7.2062918 0.1414879253 0.2206024434 0.454209264 16 3138819 3138974 156 + 1.009 0.771 -0.913
ENSG00000085644 E020 73.0099285 0.0041122544 0.2894446444 0.529957253 16 3138975 3139098 124 + 1.830 1.767 -0.212
ENSG00000085644 E021 38.7425771 0.0293715117 0.0070725946 0.044958750 16 3139099 3140688 1590 + 1.719 1.437 -0.961
ENSG00000085644 E022 545.8123115 0.0026685824 0.0883226557 0.260651983 16 3140689 3142353 1665 + 2.623 2.658 0.117
ENSG00000085644 E023 93.0600488 0.0005761019 0.5060449074 0.704970873 16 3142354 3142463 110 + 1.916 1.887 -0.098
ENSG00000085644 E024 136.3207619 0.0003307802 0.7759003130 0.882326243 16 3142464 3142804 341 + 2.047 2.056 0.032