ENSG00000085224

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373344 ENSG00000085224 HEK293_OSMI2_6hA HEK293_TMG_6hB ATRX protein_coding protein_coding 10.13118 3.496431 19.27322 0.2974166 1.2148 2.459271 1.1451227 0.4387984 2.6296102 0.12937375 0.20279292 2.5561855 0.128275000 0.12773333 0.13850000 0.010766667 9.478700e-01 1.900713e-09 FALSE TRUE
ENST00000395603 ENSG00000085224 HEK293_OSMI2_6hA HEK293_TMG_6hB ATRX protein_coding protein_coding 10.13118 3.496431 19.27322 0.2974166 1.2148 2.459271 3.1164280 0.6317466 7.4017684 0.20022911 0.39599461 3.5297421 0.217291667 0.17716667 0.38596667 0.208800000 9.728605e-02 1.900713e-09 FALSE TRUE
ENST00000460639 ENSG00000085224 HEK293_OSMI2_6hA HEK293_TMG_6hB ATRX protein_coding retained_intron 10.13118 3.496431 19.27322 0.2974166 1.2148 2.459271 0.5280134 0.3830461 0.2465984 0.19967269 0.17251890 -0.6151864 0.054533333 0.11473333 0.01393333 -0.100800000 6.420971e-01 1.900713e-09 FALSE FALSE
ENST00000493470 ENSG00000085224 HEK293_OSMI2_6hA HEK293_TMG_6hB ATRX protein_coding protein_coding 10.13118 3.496431 19.27322 0.2974166 1.2148 2.459271 0.7862143 0.1992458 1.1331612 0.05546369 0.09038783 2.4497583 0.093862500 0.05553333 0.05980000 0.004266667 9.676068e-01 1.900713e-09 FALSE TRUE
ENST00000636152 ENSG00000085224 HEK293_OSMI2_6hA HEK293_TMG_6hB ATRX protein_coding processed_transcript 10.13118 3.496431 19.27322 0.2974166 1.2148 2.459271 0.1541216 0.0000000 1.2329728 0.00000000 1.23297276 6.9576509 0.007141667 0.00000000 0.05713333 0.057133333 1.000000e+00 1.900713e-09   FALSE
ENST00000675732 ENSG00000085224 HEK293_OSMI2_6hA HEK293_TMG_6hB ATRX protein_coding protein_coding 10.13118 3.496431 19.27322 0.2974166 1.2148 2.459271 1.0587856 1.4887277 0.5768984 0.35062821 0.05667004 -1.3525556 0.263670833 0.41713333 0.02993333 -0.387200000 1.900713e-09 1.900713e-09 FALSE TRUE
MSTRG.34503.2 ENSG00000085224 HEK293_OSMI2_6hA HEK293_TMG_6hB ATRX protein_coding   10.13118 3.496431 19.27322 0.2974166 1.2148 2.459271 0.5576351 0.1171205 1.6765414 0.06329225 0.50001423 3.7297995 0.042704167 0.03540000 0.08743333 0.052033333 5.992840e-01 1.900713e-09 FALSE TRUE
MSTRG.34503.6 ENSG00000085224 HEK293_OSMI2_6hA HEK293_TMG_6hB ATRX protein_coding   10.13118 3.496431 19.27322 0.2974166 1.2148 2.459271 0.7299640 0.0000000 1.4983107 0.00000000 0.18515582 7.2367898 0.044029167 0.00000000 0.07866667 0.078666667 2.308070e-05 1.900713e-09 FALSE TRUE
MSTRG.34503.9 ENSG00000085224 HEK293_OSMI2_6hA HEK293_TMG_6hB ATRX protein_coding   10.13118 3.496431 19.27322 0.2974166 1.2148 2.459271 0.6106135 0.0000000 1.2811274 0.00000000 0.33578995 7.0124876 0.035054167 0.00000000 0.06830000 0.068300000 2.326155e-03 1.900713e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000085224 E001 13.3250266 0.6154686860 1.213340e-01 3.179977e-01 X 77504880 77505712 833 - 0.845 1.463 2.222
ENSG00000085224 E002 183.5872839 1.5758030113 2.281751e-01 4.631491e-01 X 77505713 77506904 1192 - 1.934 2.574 2.140
ENSG00000085224 E003 187.7193899 1.6098517339 3.006594e-01 5.411359e-01 X 77506905 77508194 1290 - 1.980 2.514 1.786
ENSG00000085224 E004 71.4859487 1.0441769149 3.423227e-01 5.800576e-01 X 77508195 77508480 286 - 1.616 1.972 1.203
ENSG00000085224 E005 54.2373409 0.9757446874 3.753830e-01 6.084805e-01 X 77508481 77508629 149 - 1.509 1.823 1.067
ENSG00000085224 E006 67.6963700 0.0510391362 6.169931e-01 7.817564e-01 X 77520788 77520916 129 - 1.631 1.820 0.638
ENSG00000085224 E007 5.0468781 0.0051564762 1.859709e-02 9.105400e-02 X 77520917 77521035 119 - 0.557 0.991 1.754
ENSG00000085224 E008 2.7295336 0.0085349158 3.590709e-02 1.439632e-01 X 77521036 77521102 67 - 0.362 0.798 2.019
ENSG00000085224 E009 7.3506888 0.0327057268 8.648345e-01 9.330571e-01 X 77521103 77521402 300 - 0.743 0.855 0.444
ENSG00000085224 E010 63.7363975 0.0007289643 2.098119e-02 9.929465e-02 X 77521403 77521498 96 - 1.600 1.831 0.782
ENSG00000085224 E011 7.2359114 0.0125217145 5.029706e-01 7.028387e-01 X 77521499 77522262 764 - 0.760 0.731 -0.114
ENSG00000085224 E012 69.3121754 0.0013775470 5.787201e-02 1.980294e-01 X 77522263 77522388 126 - 1.636 1.842 0.700
ENSG00000085224 E013 0.1614157 0.0331837797 1.000000e+00   X 77522389 77522468 80 - 0.049 0.000 -8.891
ENSG00000085224 E014 84.2941327 0.0063191743 9.586697e-01 9.812268e-01 X 77523252 77523401 150 - 1.736 1.837 0.342
ENSG00000085224 E015 96.6011884 0.0060877432 5.066585e-01 7.053974e-01 X 77557451 77557645 195 - 1.788 1.930 0.475
ENSG00000085224 E016 67.7365386 0.0007045642 9.342253e-01 9.692517e-01 X 77558669 77558808 140 - 1.641 1.744 0.352
ENSG00000085224 E017 43.7695117 0.0008931041 2.388616e-01 4.752910e-01 X 77558809 77558846 38 - 1.470 1.477 0.024
ENSG00000085224 E018 0.0000000       X 77561647 77561708 62 -      
ENSG00000085224 E019 36.0223534 0.0010504176 7.562707e-01 8.703843e-01 X 77574250 77574256 7 - 1.380 1.451 0.247
ENSG00000085224 E020 51.0143097 0.0007291037 9.120410e-01 9.581679e-01 X 77574257 77574310 54 - 1.521 1.627 0.360
ENSG00000085224 E021 47.0191951 0.0040329301 1.701569e-01 3.906470e-01 X 77574311 77574358 48 - 1.502 1.490 -0.044
ENSG00000085224 E022 0.5470056 0.2345986850 1.428524e-01   X 77575554 77575605 52 - 0.091 0.433 2.873
ENSG00000085224 E023 0.1614157 0.0331837797 1.000000e+00   X 77575693 77575753 61 - 0.049 0.000 -8.891
ENSG00000085224 E024 61.9837926 0.0007412911 6.517546e-01 8.046253e-01 X 77589834 77589940 107 - 1.608 1.678 0.237
ENSG00000085224 E025 68.0971526 0.0007357398 9.627127e-01 9.833202e-01 X 77593696 77593849 154 - 1.643 1.744 0.344
ENSG00000085224 E026 6.8189011 0.0045601897 7.014179e-01 8.365202e-01 X 77593850 77595711 1862 - 0.711 0.855 0.572
ENSG00000085224 E027 4.1642313 0.0824011473 8.034388e-01 8.982988e-01 X 77595712 77595785 74 - 0.545 0.660 0.512
ENSG00000085224 E028 1.4382802 0.0153894743 7.829739e-01 8.864083e-01 X 77595786 77596875 1090 - 0.289 0.274 -0.106
ENSG00000085224 E029 75.9891679 0.0093724288 2.529688e-02 1.131239e-01 X 77599411 77599580 170 - 1.664 1.917 0.853
ENSG00000085224 E030 27.9307949 0.0108368687 8.481231e-02 2.543008e-01 X 77599732 77599734 3 - 1.241 1.502 0.906
ENSG00000085224 E031 50.1535063 0.0014298425 1.983259e-01 4.275034e-01 X 77599735 77599820 86 - 1.501 1.685 0.630
ENSG00000085224 E032 74.8284905 0.0079538739 8.047052e-01 8.990089e-01 X 77600434 77600564 131 - 1.682 1.796 0.387
ENSG00000085224 E033 0.3393995 0.0249771230 1.000000e+00   X 77600565 77600755 191 - 0.092 0.000 -9.861
ENSG00000085224 E034 0.0000000       X 77613261 77616244 2984 -      
ENSG00000085224 E035 0.4341107 0.0217681645 1.296478e-03   X 77616245 77616511 267 - 0.000 0.560 14.983
ENSG00000085224 E036 0.8205084 0.5666116057 2.026442e-01   X 77616512 77616612 101 - 0.128 0.538 2.841
ENSG00000085224 E037 72.7788983 0.0160304241 5.847931e-01 7.602018e-01 X 77616613 77616730 118 - 1.680 1.734 0.183
ENSG00000085224 E038 84.4333393 0.0018278978 5.869316e-01 7.615581e-01 X 77618806 77618981 176 - 1.733 1.863 0.441
ENSG00000085224 E039 73.2787031 0.0071968965 6.119536e-01 7.781524e-01 X 77620395 77620532 138 - 1.682 1.749 0.227
ENSG00000085224 E040 77.8106634 0.0157280269 6.010579e-01 7.708729e-01 X 77633207 77633352 146 - 1.708 1.776 0.227
ENSG00000085224 E041 41.8877528 0.0367184252 5.746661e-01 7.534413e-01 X 77633353 77633384 32 - 1.450 1.483 0.112
ENSG00000085224 E042 64.1128640 0.0067192622 2.267284e-01 4.614286e-01 X 77633566 77633712 147 - 1.632 1.643 0.035
ENSG00000085224 E043 4.0554706 0.0212055422 4.732410e-02 1.733322e-01 X 77633713 77634256 544 - 0.495 0.904 1.719
ENSG00000085224 E044 3.6754181 0.0075860777 1.056494e-03 1.034163e-02 X 77634422 77634593 172 - 0.405 0.991 2.513
ENSG00000085224 E045 45.3084505 0.0010002045 5.230045e-01 7.170772e-01 X 77634594 77634703 110 - 1.485 1.536 0.175
ENSG00000085224 E046 49.1488207 0.0007604386 2.444997e-01 4.816635e-01 X 77635915 77636056 142 - 1.522 1.537 0.048
ENSG00000085224 E047 0.3040503 0.0244411696 1.000000e+00   X 77651983 77652113 131 - 0.092 0.000 -9.858
ENSG00000085224 E048 90.8045117 0.0061073013 2.025681e-01 4.328017e-01 X 77652114 77652353 240 - 1.778 1.795 0.058
ENSG00000085224 E049 57.0150091 0.0160704297 2.808067e-01 5.210489e-01 X 77654098 77654157 60 - 1.581 1.579 -0.009
ENSG00000085224 E050 52.2895574 0.0174559602 3.399630e-02 1.388599e-01 X 77654158 77654200 43 - 1.556 1.438 -0.404
ENSG00000085224 E051 73.6442231 0.0023752199 1.342189e-02 7.209288e-02 X 77656560 77656653 94 - 1.698 1.635 -0.215
ENSG00000085224 E052 78.9999338 0.0024536383 1.020405e-01 2.854361e-01 X 77663382 77663558 177 - 1.722 1.722 0.000
ENSG00000085224 E053 71.2478222 0.0006964500 3.821312e-02 1.501495e-01 X 77664645 77664778 134 - 1.682 1.653 -0.101
ENSG00000085224 E054 35.4839383 0.0293250922 4.546426e-01 6.692448e-01 X 77673954 77676225 2272 - 1.354 1.537 0.627
ENSG00000085224 E055 57.9507214 0.0069777060 2.384810e-03 1.959150e-02 X 77676226 77676298 73 - 1.605 1.450 -0.532
ENSG00000085224 E056 223.6056015 0.0046827996 2.489132e-06 6.320452e-05 X 77681520 77682304 785 - 2.182 2.050 -0.442
ENSG00000085224 E057 259.3766831 0.0023113051 1.501801e-10 1.026319e-08 X 77682305 77683451 1147 - 2.249 2.081 -0.562
ENSG00000085224 E058 33.9526326 0.0020445685 5.026710e-02 1.803234e-01 X 77683452 77683506 55 - 1.373 1.289 -0.293
ENSG00000085224 E059 23.5827937 0.0016890916 4.028869e-02 1.554564e-01 X 77683507 77683538 32 - 1.227 1.095 -0.473
ENSG00000085224 E060 193.9839333 0.0067337672 1.895349e-10 1.267719e-08 X 77683539 77684477 939 - 2.131 1.844 -0.964
ENSG00000085224 E061 48.6869562 0.0009281591 4.558989e-05 7.689920e-04 X 77684478 77684593 116 - 1.538 1.289 -0.859
ENSG00000085224 E062 32.5163274 0.0011472578 1.952011e-03 1.674731e-02 X 77684939 77684997 59 - 1.366 1.152 -0.754
ENSG00000085224 E063 20.8426613 0.0016868988 3.000747e-03 2.340387e-02 X 77684998 77685006 9 - 1.189 0.905 -1.037
ENSG00000085224 E064 38.2141773 0.0009496907 8.255467e-06 1.776442e-04 X 77688818 77688901 84 - 1.445 1.094 -1.233
ENSG00000085224 E065 30.3504743 0.0012417499 7.907358e-07 2.316858e-05 X 77688902 77688924 23 - 1.360 0.855 -1.831
ENSG00000085224 E066 16.2035980 0.0021005514 4.898312e-04 5.581423e-03 X 77688925 77688927 3 - 1.100 0.655 -1.722
ENSG00000085224 E067 0.0000000       X 77690803 77690925 123 -      
ENSG00000085224 E068 0.0000000       X 77691225 77691291 67 -      
ENSG00000085224 E069 33.7464557 0.0011989328 3.713258e-04 4.450223e-03 X 77693824 77693937 114 - 1.388 1.124 -0.929
ENSG00000085224 E070 48.5512162 0.0007860568 8.556091e-04 8.737349e-03 X 77696577 77696687 111 - 1.533 1.361 -0.593
ENSG00000085224 E071 27.9244791 0.0018176817 3.430833e-02 1.397003e-01 X 77696688 77696704 17 - 1.297 1.178 -0.422
ENSG00000085224 E072 26.2882664 0.0052852798 4.220858e-02 1.604546e-01 X 77697583 77697602 20 - 1.274 1.151 -0.435
ENSG00000085224 E073 26.5461760 0.0232335231 1.009425e-01 2.834854e-01 X 77697603 77697635 33 - 1.276 1.173 -0.364
ENSG00000085224 E074 25.7044388 0.0159739797 6.376805e-02 2.111716e-01 X 77698574 77698629 56 - 1.266 1.148 -0.420
ENSG00000085224 E075 0.0000000       X 77699510 77699547 38 -      
ENSG00000085224 E076 30.9656980 0.0457599791 3.595565e-03 2.690622e-02 X 77717131 77717243 113 - 1.357 1.020 -1.200
ENSG00000085224 E077 5.9506815 0.0107144436 7.635764e-02 2.374409e-01 X 77785845 77785981 137 - 0.721 0.441 -1.275
ENSG00000085224 E078 32.4197243 0.0192113943 2.355794e-04 3.064246e-03 X 77785982 77786233 252 - 1.376 0.989 -1.380