ENSG00000083857

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000441802 ENSG00000083857 HEK293_OSMI2_6hA HEK293_TMG_6hB FAT1 protein_coding protein_coding 11.73692 12.89719 11.35041 3.029914 1.052713 -0.1841599 2.4549481 1.1864687 4.558595 0.17707458 0.29881402 1.9329678 0.21908750 0.09796667 0.40366667 0.30570000 1.617828e-11 1.617828e-11 FALSE TRUE
ENST00000500085 ENSG00000083857 HEK293_OSMI2_6hA HEK293_TMG_6hB FAT1 protein_coding retained_intron 11.73692 12.89719 11.35041 3.029914 1.052713 -0.1841599 4.0017379 5.8990872 1.218826 1.66715453 0.68038857 -2.2656541 0.32572500 0.44176667 0.09863333 -0.34313333 3.431027e-01 1.617828e-11 FALSE TRUE
ENST00000507105 ENSG00000083857 HEK293_OSMI2_6hA HEK293_TMG_6hB FAT1 protein_coding protein_coding 11.73692 12.89719 11.35041 3.029914 1.052713 -0.1841599 0.2384344 0.9225876 0.000000 0.06900956 0.00000000 -6.5431673 0.01924583 0.08346667 0.00000000 -0.08346667 7.992016e-07 1.617828e-11 FALSE TRUE
MSTRG.25836.2 ENSG00000083857 HEK293_OSMI2_6hA HEK293_TMG_6hB FAT1 protein_coding   11.73692 12.89719 11.35041 3.029914 1.052713 -0.1841599 2.1926208 3.1065641 2.044100 1.00595196 0.08236686 -0.6014502 0.18461667 0.22890000 0.18400000 -0.04490000 7.984812e-01 1.617828e-11 FALSE TRUE
MSTRG.25836.4 ENSG00000083857 HEK293_OSMI2_6hA HEK293_TMG_6hB FAT1 protein_coding   11.73692 12.89719 11.35041 3.029914 1.052713 -0.1841599 0.4341162 0.1693072 0.737381 0.13630224 0.13625390 2.0594106 0.04038333 0.01260000 0.06806667 0.05546667 2.352399e-01 1.617828e-11 FALSE TRUE
MSTRG.25836.6 ENSG00000083857 HEK293_OSMI2_6hA HEK293_TMG_6hB FAT1 protein_coding   11.73692 12.89719 11.35041 3.029914 1.052713 -0.1841599 0.2403720 0.0000000 1.029401 0.00000000 0.73302851 6.6996087 0.02317500 0.00000000 0.09913333 0.09913333 3.508024e-01 1.617828e-11 FALSE TRUE
MSTRG.25836.9 ENSG00000083857 HEK293_OSMI2_6hA HEK293_TMG_6hB FAT1 protein_coding   11.73692 12.89719 11.35041 3.029914 1.052713 -0.1841599 1.3071894 1.3563122 1.181547 0.28998563 0.59878089 -0.1974507 0.11214583 0.10756667 0.09756667 -0.01000000 9.161883e-01 1.617828e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000083857 E001 13.9249861 0.149179133 9.449392e-02 2.720759e-01 4 186587794 186587826 33 - 0.988 1.340 1.260
ENSG00000083857 E002 54.6388744 0.566809615 1.437285e-01 3.529828e-01 4 186587827 186587988 162 - 1.483 1.948 1.577
ENSG00000083857 E003 119.3674151 1.031921029 1.902291e-01 4.172623e-01 4 186587989 186588391 403 - 1.759 2.308 1.844
ENSG00000083857 E004 152.5441117 1.156127881 2.390205e-01 4.754958e-01 4 186588392 186588806 415 - 1.900 2.399 1.670
ENSG00000083857 E005 72.8796135 0.667539445 1.671649e-01 3.867768e-01 4 186588807 186588880 74 - 1.607 2.071 1.565
ENSG00000083857 E006 79.0896692 0.676168374 1.470639e-01 3.581032e-01 4 186588881 186588989 109 - 1.623 2.114 1.657
ENSG00000083857 E007 69.5690272 0.624585257 1.238890e-01 3.218824e-01 4 186588990 186589071 82 - 1.561 2.062 1.692
ENSG00000083857 E008 90.7834342 0.750551830 1.815168e-01 4.060024e-01 4 186589072 186589220 149 - 1.714 2.159 1.497
ENSG00000083857 E009 1.1416042 0.028815082 5.999346e-01   4 186590368 186590403 36 - 0.259 0.403 0.909
ENSG00000083857 E010 1.7163107 0.016426703 8.574819e-01 9.290851e-01 4 186590505 186590695 191 - 0.373 0.465 0.494
ENSG00000083857 E011 0.8649651 0.116750295 2.593440e-01   4 186592693 186592752 60 - 0.321 0.142 -1.506
ENSG00000083857 E012 84.6991997 0.021601269 1.122467e-03 1.083811e-02 4 186595689 186595826 138 - 1.740 2.100 1.209
ENSG00000083857 E013 171.5908868 0.013307655 7.090472e-02 2.265226e-01 4 186596540 186597033 494 - 2.127 2.342 0.721
ENSG00000083857 E014 75.1203564 0.011211882 5.196386e-01 7.147839e-01 4 186597034 186597110 77 - 1.808 1.952 0.484
ENSG00000083857 E015 67.8383592 0.024644798 5.581649e-01 7.419669e-01 4 186597111 186597171 61 - 1.761 1.913 0.513
ENSG00000083857 E016 2.0318379 0.010541383 1.757526e-02 8.755307e-02 4 186597172 186597271 100 - 0.601 0.247 -1.968
ENSG00000083857 E017 62.4881561 0.023107639 1.038550e-01 2.886149e-01 4 186597682 186597729 48 - 1.679 1.917 0.804
ENSG00000083857 E018 66.6643216 0.014724099 1.940964e-01 4.222545e-01 4 186597730 186597792 63 - 1.726 1.928 0.681
ENSG00000083857 E019 100.6809105 0.027753649 4.542073e-01 6.688997e-01 4 186597972 186598125 154 - 1.918 2.094 0.590
ENSG00000083857 E020 0.2027342 0.034877839 4.352438e-01   4 186598126 186598127 2 - 0.000 0.141 10.164
ENSG00000083857 E021 0.0000000       4 186598527 186598821 295 -      
ENSG00000083857 E022 157.1380596 0.023071892 4.036006e-01 6.312167e-01 4 186599898 186600330 433 - 2.102 2.292 0.633
ENSG00000083857 E023 38.0115224 0.001149615 8.975190e-01 9.505714e-01 4 186600331 186600360 30 - 1.544 1.634 0.307
ENSG00000083857 E024 80.2682590 0.011538433 2.742957e-01 5.142602e-01 4 186601269 186601426 158 - 1.819 2.001 0.613
ENSG00000083857 E025 0.9654734 0.064764115 5.278845e-01   4 186601427 186601700 274 - 0.321 0.246 -0.519
ENSG00000083857 E026 73.7535097 0.020481165 2.640774e-01 5.033381e-01 4 186602903 186603034 132 - 1.767 1.979 0.713
ENSG00000083857 E027 240.2740458 0.024228637 7.415395e-01 8.614304e-01 4 186603176 186603977 802 - 2.337 2.427 0.299
ENSG00000083857 E028 72.5090026 0.030534574 2.715977e-01 5.114581e-01 4 186604377 186604574 198 - 1.860 1.859 -0.005
ENSG00000083857 E029 71.9600778 0.016920789 1.219265e-01 3.189551e-01 4 186606070 186606213 144 - 1.865 1.847 -0.062
ENSG00000083857 E030 60.5942792 0.021849548 7.287377e-02 2.305681e-01 4 186609183 186609249 67 - 1.806 1.750 -0.187
ENSG00000083857 E031 61.6033975 0.004723007 5.658592e-02 1.950473e-01 4 186609250 186609320 71 - 1.796 1.794 -0.005
ENSG00000083857 E032 90.1386033 0.006225961 3.500329e-02 1.415999e-01 4 186609801 186610015 215 - 1.958 1.953 -0.018
ENSG00000083857 E033 0.1308682 0.032649190 4.376768e-01   4 186610016 186610070 55 - 0.000 0.140 10.157
ENSG00000083857 E034 96.7848757 0.014584099 3.847010e-02 1.507867e-01 4 186611386 186611775 390 - 2.002 1.962 -0.135
ENSG00000083857 E035 69.4028131 0.015488401 5.656478e-01 7.471212e-01 4 186613109 186613342 234 - 1.815 1.872 0.193
ENSG00000083857 E036 63.1207504 0.028503341 3.731950e-01 6.066826e-01 4 186614191 186614344 154 - 1.790 1.811 0.070
ENSG00000083857 E037 73.9846032 0.002119559 1.188911e-02 6.597259e-02 4 186617005 186617201 197 - 1.882 1.860 -0.075
ENSG00000083857 E038 72.7351390 0.845497638 5.194677e-01 7.146709e-01 4 186617708 186617986 279 - 1.807 1.929 0.409
ENSG00000083857 E039 379.0206220 1.730574295 7.860976e-01 8.881534e-01 4 186617987 186621775 3789 - 2.578 2.570 -0.026
ENSG00000083857 E040 37.6543421 0.004938477 3.737933e-05 6.512640e-04 4 186628154 186628364 211 - 1.654 1.481 -0.593
ENSG00000083857 E041 48.7678976 0.012705243 9.623404e-08 3.587084e-06 4 186628488 186628763 276 - 1.797 1.491 -1.039
ENSG00000083857 E042 34.6929952 0.012924512 1.068502e-06 3.012220e-05 4 186633684 186633823 140 - 1.657 1.341 -1.083
ENSG00000083857 E043 33.6910751 0.015823228 2.383687e-06 6.082718e-05 4 186636025 186636235 211 - 1.648 1.324 -1.113
ENSG00000083857 E044 46.6394450 0.014432482 3.979959e-07 1.266895e-05 4 186636585 186636914 330 - 1.779 1.477 -1.027
ENSG00000083857 E045 24.2016427 0.012805131 2.476078e-03 2.016956e-02 4 186639722 186639783 62 - 1.464 1.299 -0.572
ENSG00000083857 E046 48.7650456 0.039174531 1.011319e-03 9.995651e-03 4 186663299 186663613 315 - 1.783 1.536 -0.838
ENSG00000083857 E047 31.6787472 0.009449518 1.467654e-07 5.238364e-06 4 186706563 186706720 158 - 1.619 1.301 -1.097
ENSG00000083857 E048 151.7623254 0.017559214 9.301323e-12 8.038568e-10 4 186706721 186708362 1642 - 2.304 1.919 -1.289
ENSG00000083857 E049 89.7270441 0.058618293 7.370651e-06 1.609704e-04 4 186708363 186709615 1253 - 2.096 1.625 -1.586
ENSG00000083857 E050 20.3247685 0.030310393 2.266100e-05 4.252800e-04 4 186709616 186709845 230 - 1.453 1.049 -1.425
ENSG00000083857 E051 5.2373661 0.015834249 5.805286e-03 3.877261e-02 4 186723664 186723784 121 - 0.893 0.566 -1.348
ENSG00000083857 E052 1.0125891 0.159866871 1.836247e-01   4 186723785 186723856 72 - 0.376 0.141 -1.843
ENSG00000083857 E053 5.0136900 0.187460690 3.583908e-01 5.945046e-01 4 186726354 186726722 369 - 0.812 0.750 -0.247