ENSG00000083520

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377767 ENSG00000083520 HEK293_OSMI2_6hA HEK293_TMG_6hB DIS3 protein_coding protein_coding 42.24985 7.717659 83.56357 1.266114 2.945173 3.434943 2.024291 0.7108649 2.746919 0.1440949 0.0860136 1.935256 0.07219583 0.09116667 0.03293333 -0.05823333 0.0004467337 0.0004467337 FALSE TRUE
ENST00000377780 ENSG00000083520 HEK293_OSMI2_6hA HEK293_TMG_6hB DIS3 protein_coding protein_coding 42.24985 7.717659 83.56357 1.266114 2.945173 3.434943 9.751368 2.9676115 18.497436 0.5542251 0.7339024 2.635878 0.33963333 0.38290000 0.22130000 -0.16160000 0.0159225913 0.0004467337 FALSE TRUE
MSTRG.8876.1 ENSG00000083520 HEK293_OSMI2_6hA HEK293_TMG_6hB DIS3 protein_coding   42.24985 7.717659 83.56357 1.266114 2.945173 3.434943 29.665113 3.9683585 60.721107 0.7204513 1.8571300 3.932190 0.57283750 0.51803333 0.72693333 0.20890000 0.0137611230 0.0004467337 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000083520 E001 0.000000       13 72744481 72744531 51 -      
ENSG00000083520 E002 160.306730 0.0086916141 6.811457e-15 1.023666e-12 13 72752169 72756678 4510 - 1.931 2.379 1.497
ENSG00000083520 E003 38.420562 0.0014140011 2.751270e-05 5.002451e-04 13 72756679 72756935 257 - 1.350 1.678 1.123
ENSG00000083520 E004 36.304205 0.0021617975 2.939158e-06 7.306934e-05 13 72756936 72757442 507 - 1.316 1.686 1.270
ENSG00000083520 E005 91.820196 0.0005034083 1.059152e-06 2.988344e-05 13 72757443 72758906 1464 - 1.733 1.995 0.883
ENSG00000083520 E006 7.454582 0.0577069237 1.691393e-01 3.894218e-01 13 72758907 72758908 2 - 0.720 0.999 1.080
ENSG00000083520 E007 56.928100 0.0007321646 3.240856e-05 5.766680e-04 13 72758909 72759043 135 - 1.530 1.807 0.940
ENSG00000083520 E008 203.427189 0.0011197370 8.615191e-11 6.191526e-09 13 72759044 72759163 120 - 2.076 2.332 0.856
ENSG00000083520 E009 507.503543 0.0001622475 1.691856e-19 4.626667e-17 13 72759164 72759472 309 - 2.479 2.694 0.716
ENSG00000083520 E010 355.504306 0.0084710243 3.805988e-06 9.100877e-05 13 72759473 72759674 202 - 2.317 2.568 0.835
ENSG00000083520 E011 357.215563 0.0096636493 3.498591e-04 4.238114e-03 13 72759675 72759878 204 - 2.327 2.536 0.697
ENSG00000083520 E012 286.958587 0.0007068430 8.009965e-03 4.935633e-02 13 72760529 72760651 123 - 2.251 2.356 0.351
ENSG00000083520 E013 308.019499 0.0020334672 3.662789e-02 1.458956e-01 13 72761363 72761521 159 - 2.283 2.380 0.323
ENSG00000083520 E014 394.493559 0.0001442726 8.849044e-01 9.438401e-01 13 72761646 72761814 169 - 2.398 2.422 0.080
ENSG00000083520 E015 455.483437 0.0001428122 7.508989e-01 8.673112e-01 13 72761923 72762137 215 - 2.461 2.473 0.039
ENSG00000083520 E016 361.598769 0.0001936426 5.270497e-01 7.198826e-01 13 72763451 72763607 157 - 2.359 2.397 0.127
ENSG00000083520 E017 299.092273 0.0015331923 5.025927e-01 7.025805e-01 13 72765972 72766058 87 - 2.276 2.320 0.146
ENSG00000083520 E018 370.196017 0.0001616065 7.303429e-02 2.309020e-01 13 72768785 72768912 128 - 2.377 2.345 -0.107
ENSG00000083520 E019 339.412241 0.0001910466 4.145831e-01 6.394999e-01 13 72770904 72770988 85 - 2.336 2.332 -0.014
ENSG00000083520 E020 274.862047 0.0002735005 8.896470e-01 9.465138e-01 13 72771081 72771145 65 - 2.242 2.267 0.082
ENSG00000083520 E021 330.227388 0.0002400618 2.122662e-02 1.000741e-01 13 72771795 72771896 102 - 2.329 2.277 -0.174
ENSG00000083520 E022 419.377422 0.0002176378 3.519653e-05 6.179880e-04 13 72772159 72772275 117 - 2.437 2.338 -0.330
ENSG00000083520 E023 478.400970 0.0001749258 1.078208e-03 1.051720e-02 13 72772693 72772839 147 - 2.491 2.425 -0.220
ENSG00000083520 E024 409.551161 0.0019029295 5.994707e-05 9.730828e-04 13 72773684 72773821 138 - 2.429 2.303 -0.422
ENSG00000083520 E025 359.477219 0.0017258864 2.670699e-07 8.908781e-06 13 72773946 72774059 114 - 2.377 2.197 -0.601
ENSG00000083520 E026 437.514477 0.0001607908 2.628892e-09 1.405688e-07 13 72775211 72775375 165 - 2.460 2.308 -0.507
ENSG00000083520 E027 404.106637 0.0001885155 3.886129e-12 3.618169e-10 13 72775925 72776092 168 - 2.428 2.233 -0.650
ENSG00000083520 E028 277.841178 0.0002164464 1.367078e-13 1.655930e-11 13 72777420 72777493 74 - 2.271 2.003 -0.898
ENSG00000083520 E029 408.749963 0.0004890235 1.423069e-13 1.715186e-11 13 72778187 72778380 194 - 2.436 2.216 -0.732
ENSG00000083520 E030 248.685991 0.0029345946 6.863405e-07 2.047568e-05 13 72780846 72781003 158 - 2.221 2.004 -0.724
ENSG00000083520 E031 22.702946 0.0015454482 1.604839e-02 8.199070e-02 13 72781289 72781356 68 - 1.214 0.920 -1.070
ENSG00000083520 E032 185.820170 0.0027781677 2.314491e-03 1.914627e-02 13 72781605 72782096 492 - 2.091 1.959 -0.442