ENSG00000083457

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000570360 ENSG00000083457 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGAE protein_coding processed_transcript 56.92532 24.25924 59.70865 1.953113 1.57945 1.299053 2.877551 2.125509 1.955450 0.1366547 0.09361472 -0.1197199 0.05526250 0.08966667 0.03273333 -0.05693333 0.001391687 0.001391687 FALSE  
ENST00000572179 ENSG00000083457 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGAE protein_coding processed_transcript 56.92532 24.25924 59.70865 1.953113 1.57945 1.299053 49.117080 17.815442 50.858421 3.0044192 3.94766604 1.5128325 0.84490833 0.72336667 0.84986667 0.12650000 0.575290488 0.001391687 FALSE  
ENST00000572433 ENSG00000083457 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGAE protein_coding retained_intron 56.92532 24.25924 59.70865 1.953113 1.57945 1.299053 3.579030 3.341336 3.061086 0.7824364 0.30260111 -0.1259875 0.07336667 0.14433333 0.05113333 -0.09320000 0.193101106 0.001391687    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000083457 E001 1.1115047 0.015378759 2.601569e-01   17 3705559 3705645 87 - 0.377 0.162 -1.609
ENSG00000083457 E002 1.2639142 0.225459144 7.810844e-01   17 3714628 3714635 8 - 0.332 0.372 0.240
ENSG00000083457 E003 5.3551665 0.029250053 9.254318e-01 9.648720e-01 17 3714636 3714652 17 - 0.798 0.775 -0.092
ENSG00000083457 E004 12.2705615 0.004246568 1.339313e-01 3.379838e-01 17 3714653 3714665 13 - 1.150 0.982 -0.609
ENSG00000083457 E005 45.7423147 0.000958199 2.298628e-01 4.650076e-01 17 3714666 3714691 26 - 1.672 1.596 -0.257
ENSG00000083457 E006 78.2720944 0.005888852 6.656416e-01 8.134398e-01 17 3714692 3714736 45 - 1.888 1.857 -0.104
ENSG00000083457 E007 294.7811421 0.006536169 8.710131e-01 9.364992e-01 17 3714737 3714942 206 - 2.453 2.439 -0.049
ENSG00000083457 E008 237.9897365 0.002306411 7.488238e-01 8.660099e-01 17 3716688 3716798 111 - 2.362 2.343 -0.064
ENSG00000083457 E009 32.5862667 0.154268862 1.893582e-01 4.161636e-01 17 3716799 3718379 1581 - 1.358 1.691 1.140
ENSG00000083457 E010 270.5066056 0.001434635 6.513081e-01 8.044041e-01 17 3720307 3720402 96 - 2.418 2.397 -0.070
ENSG00000083457 E011 25.8852082 0.081199900 4.112051e-03 2.979312e-02 17 3720403 3720619 217 - 1.185 1.651 1.612
ENSG00000083457 E012 26.7667193 0.013807096 6.385186e-07 1.922268e-05 17 3723288 3723383 96 - 1.227 1.646 1.446
ENSG00000083457 E013 225.0826345 0.004774173 9.036248e-01 9.537046e-01 17 3723688 3723744 57 - 2.337 2.323 -0.047
ENSG00000083457 E014 178.9112916 0.004494949 8.273278e-01 9.122521e-01 17 3723745 3723896 152 - 2.239 2.221 -0.062
ENSG00000083457 E015 1.6909248 0.012198908 2.163201e-04 2.855287e-03 17 3723897 3723904 8 - 0.090 0.706 4.152
ENSG00000083457 E016 3.7027755 0.006697122 1.607132e-07 5.676537e-06 17 3723905 3724317 413 - 0.228 1.002 3.716
ENSG00000083457 E017 1.1013154 0.015638887 1.968641e-04   17 3724318 3724744 427 - 0.000 0.620 16.555
ENSG00000083457 E018 3.2918694 0.184655119 5.637253e-01 7.458961e-01 17 3724745 3726807 2063 - 0.584 0.660 0.329
ENSG00000083457 E019 49.9607339 2.698243897 8.183404e-01 9.070912e-01 17 3726808 3727918 1111 - 1.861 0.271 -6.368
ENSG00000083457 E020 3.4842806 0.123687100 1.394348e-01 3.466599e-01 17 3727919 3728013 95 - 0.720 0.370 -1.663
ENSG00000083457 E021 1.0513349 0.469976587 2.006278e-01   17 3728014 3728026 13 - 0.388 0.000 -14.957
ENSG00000083457 E022 1.6018546 1.597091617 6.404423e-01 7.971812e-01 17 3728027 3728104 78 - 0.515 0.000 -15.239
ENSG00000083457 E023 2.2475173 0.555725141 7.092443e-02 2.265608e-01 17 3728105 3728168 64 - 0.620 0.000 -15.944
ENSG00000083457 E024 1.6018546 1.597091617 6.404423e-01 7.971812e-01 17 3728169 3728823 655 - 0.515 0.000 -15.239
ENSG00000083457 E025 0.6456627 0.955413634 5.766812e-01   17 3729478 3729555 78 - 0.285 0.000 -14.161
ENSG00000083457 E026 0.9489052 0.428422503 8.126893e-01   17 3731104 3731183 80 - 0.284 0.277 -0.051
ENSG00000083457 E027 0.1614157 0.031849460 1.000000e+00   17 3732368 3732374 7 - 0.090 0.000 -13.281
ENSG00000083457 E028 0.3228314 0.354989877 5.739614e-01   17 3732375 3732466 92 - 0.165 0.000 -13.462
ENSG00000083457 E029 0.5955263 0.020945749 9.260969e-02   17 3734817 3734949 133 - 0.090 0.372 2.560
ENSG00000083457 E030 0.0000000       17 3738861 3738953 93 -      
ENSG00000083457 E031 0.4231520 0.055041487 2.557578e-01   17 3739805 3739878 74 - 0.090 0.279 1.967
ENSG00000083457 E032 0.9990895 0.140529587 1.272847e-03   17 3743489 3743617 129 - 0.000 0.610 15.927
ENSG00000083457 E033 0.1308682 0.032649190 2.431806e-01   17 3743785 3743813 29 - 0.000 0.162 13.743
ENSG00000083457 E034 0.9043783 0.018317044 1.020270e-01   17 3745764 3745927 164 - 0.164 0.448 1.973
ENSG00000083457 E035 0.6730019 0.019387492 4.943255e-01   17 3747922 3748052 131 - 0.164 0.280 0.978
ENSG00000083457 E036 0.8092192 0.017035737 1.864061e-03   17 3750352 3750482 131 - 0.000 0.514 16.100
ENSG00000083457 E037 0.7788594 0.059140299 2.619481e-03   17 3751650 3751869 220 - 0.000 0.513 15.789
ENSG00000083457 E038 0.1308682 0.032649190 2.431806e-01   17 3751870 3751874 5 - 0.000 0.162 13.743
ENSG00000083457 E039 0.1779838 0.032803560 1.000000e+00   17 3753290 3753430 141 - 0.090 0.000 -13.274
ENSG00000083457 E040 0.3751086 0.025312088 6.934598e-02   17 3753783 3753925 143 - 0.000 0.281 14.779
ENSG00000083457 E041 0.0000000       17 3754632 3754696 65 -      
ENSG00000083457 E042 0.1723744 0.032814177 2.418858e-01   17 3755117 3755261 145 - 0.000 0.162 13.745
ENSG00000083457 E043 0.3807181 0.031371730 6.077246e-01   17 3755830 3755897 68 - 0.090 0.163 0.980
ENSG00000083457 E044 0.3807181 0.031371730 6.077246e-01   17 3756984 3757134 151 - 0.090 0.163 0.980
ENSG00000083457 E045 0.1779838 0.032803560 1.000000e+00   17 3757706 3757859 154 - 0.090 0.000 -13.274
ENSG00000083457 E046 0.4514866 0.021768165 1.000000e+00   17 3759402 3759553 152 - 0.164 0.162 -0.024
ENSG00000083457 E047 0.2735028 0.027442404 6.099030e-01   17 3760172 3760287 116 - 0.090 0.162 0.977
ENSG00000083457 E048 0.1308682 0.032649190 2.431806e-01   17 3761013 3761177 165 - 0.000 0.162 13.743
ENSG00000083457 E049 0.1308682 0.032649190 2.431806e-01   17 3761403 3761520 118 - 0.000 0.162 13.743
ENSG00000083457 E050 0.1723744 0.032814177 2.418858e-01   17 3761915 3761982 68 - 0.000 0.162 13.745
ENSG00000083457 E051 0.1723744 0.032814177 2.418858e-01   17 3763869 3763960 92 - 0.000 0.162 13.745
ENSG00000083457 E052 0.0000000       17 3777540 3777660 121 -      
ENSG00000083457 E053 0.0000000       17 3801111 3801188 78 -