ENSG00000083223

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375957 ENSG00000083223 HEK293_OSMI2_6hA HEK293_TMG_6hB TUT7 protein_coding protein_coding 4.842192 1.974958 8.647376 0.2764337 0.2485384 2.124821 0.3809746 0.5802981 0.02949276 0.10287288 0.02949276 -3.901784 0.2229000 0.2919667 0.003366667 -0.2886000 1.167294e-13 1.167294e-13 FALSE TRUE
ENST00000375963 ENSG00000083223 HEK293_OSMI2_6hA HEK293_TMG_6hB TUT7 protein_coding protein_coding 4.842192 1.974958 8.647376 0.2764337 0.2485384 2.124821 2.3136610 0.8931198 5.11936613 0.03884049 0.27672457 2.505791 0.4247833 0.4700667 0.592033333 0.1219667 6.015689e-01 1.167294e-13 FALSE TRUE
MSTRG.32929.5 ENSG00000083223 HEK293_OSMI2_6hA HEK293_TMG_6hB TUT7 protein_coding   4.842192 1.974958 8.647376 0.2764337 0.2485384 2.124821 1.5086114 0.1939093 2.54649117 0.07926842 0.38489461 3.648166 0.2500167 0.0954000 0.293733333 0.1983333 7.450692e-02 1.167294e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000083223 E001 0.0000000       9 86287733 86287734 2 -      
ENSG00000083223 E002 46.1496187 0.8725648520 0.1829309832 0.407776224 9 86287735 86288402 668 - 1.435 1.892 1.554
ENSG00000083223 E003 14.1274056 0.4850205069 0.1304432649 0.332531735 9 86288403 86288561 159 - 0.966 1.376 1.466
ENSG00000083223 E004 22.2565748 0.3551452643 0.0980491778 0.278342508 9 86288562 86288744 183 - 1.139 1.581 1.539
ENSG00000083223 E005 9.8108444 0.0661743023 0.8087261631 0.901425601 9 86298767 86298830 64 - 0.917 0.999 0.304
ENSG00000083223 E006 72.3889535 0.0005940571 0.0097085118 0.056862514 9 86301276 86301601 326 - 1.718 1.883 0.560
ENSG00000083223 E007 42.1296357 0.0127044539 0.1310888241 0.333546550 9 86303086 86303201 116 - 1.487 1.650 0.556
ENSG00000083223 E008 34.5295331 0.0125634567 0.1983997053 0.427612011 9 86304856 86304947 92 - 1.408 1.565 0.539
ENSG00000083223 E009 29.3807660 0.0110739695 0.2477847459 0.485598763 9 86305192 86305239 48 - 1.339 1.485 0.506
ENSG00000083223 E010 48.7603363 0.0045905884 0.1039752564 0.288807307 9 86308429 86308606 178 - 1.555 1.702 0.500
ENSG00000083223 E011 25.0169397 0.0014937033 0.6341156407 0.793030990 9 86309212 86309289 78 - 1.292 1.372 0.279
ENSG00000083223 E012 32.8306283 0.0012260468 0.9229740831 0.963806957 9 86309463 86309576 114 - 1.411 1.444 0.113
ENSG00000083223 E013 35.0738194 0.0010455175 0.7286778946 0.853406172 9 86309928 86310017 90 - 1.431 1.496 0.224
ENSG00000083223 E014 36.8985040 0.0137129034 0.9772458849 0.990373260 9 86310706 86310809 104 - 1.455 1.496 0.140
ENSG00000083223 E015 29.8277372 0.0026282599 0.2922779814 0.532976019 9 86317219 86317276 58 - 1.381 1.332 -0.171
ENSG00000083223 E016 34.2013625 0.0012364261 0.3139153543 0.554123934 9 86318958 86319058 101 - 1.436 1.398 -0.131
ENSG00000083223 E017 29.5959870 0.0029381009 0.8792545597 0.940927376 9 86319584 86319670 87 - 1.359 1.410 0.179
ENSG00000083223 E018 36.3364213 0.0036822641 0.6679323050 0.814886834 9 86322325 86322475 151 - 1.443 1.515 0.250
ENSG00000083223 E019 25.9837692 0.0024052284 0.9685596031 0.986115264 9 86322873 86322953 81 - 1.308 1.346 0.130
ENSG00000083223 E020 113.4510988 0.0004781341 0.1791281308 0.402786883 9 86322954 86323627 674 - 1.947 1.932 -0.048
ENSG00000083223 E021 55.9325424 0.0007459863 0.0019125392 0.016490310 9 86323628 86323960 333 - 1.665 1.506 -0.544
ENSG00000083223 E022 1.2589410 0.2830314751 0.7609309707   9 86324362 86324653 292 - 0.278 0.374 0.604
ENSG00000083223 E023 28.5459942 0.0014266789 0.3042727876 0.544827372 9 86325334 86325514 181 - 1.364 1.317 -0.163
ENSG00000083223 E024 2.3855225 0.0631102748 0.6865539211 0.826850423 9 86326371 86326491 121 - 0.444 0.385 -0.324
ENSG00000083223 E025 28.5585484 0.0013092756 0.0219731303 0.102495204 9 86328340 86328492 153 - 1.383 1.218 -0.577
ENSG00000083223 E026 1.3381815 0.0136968632 0.0072998430   9 86336879 86337418 540 - 0.159 0.656 2.994
ENSG00000083223 E027 27.5952543 0.0030263272 0.0008331533 0.008551226 9 86337419 86337538 120 - 1.383 1.090 -1.035
ENSG00000083223 E028 26.0494799 0.0014066399 0.0020710871 0.017542056 9 86338823 86338949 127 - 1.353 1.090 -0.932
ENSG00000083223 E029 26.4210145 0.0238916667 0.0076518659 0.047728746 9 86340036 86340105 70 - 1.362 1.065 -1.051
ENSG00000083223 E030 24.8977987 0.0192695544 0.0210165828 0.099406727 9 86341002 86341053 52 - 1.330 1.091 -0.847
ENSG00000083223 E031 30.3723847 0.0020059515 0.1215186080 0.318265345 9 86343075 86343163 89 - 1.394 1.302 -0.318
ENSG00000083223 E032 0.1614157 0.0334436329 1.0000000000   9 86344870 86344976 107 - 0.060 0.000 -7.022
ENSG00000083223 E033 45.6611290 0.0057527864 0.5092304703 0.707337201 9 86344977 86345154 178 - 1.552 1.544 -0.030
ENSG00000083223 E034 32.7760432 0.0014171737 0.7243615199 0.850756511 9 86345669 86345785 117 - 1.399 1.466 0.230
ENSG00000083223 E035 46.6053148 0.0009700130 0.1472055010 0.358314411 9 86346299 86346480 182 - 1.572 1.515 -0.194
ENSG00000083223 E036 75.9597111 0.0006053245 0.0017261377 0.015204247 9 86352680 86353230 551 - 1.793 1.664 -0.437
ENSG00000083223 E037 18.1479358 0.0023025096 0.2749502122 0.514949793 9 86354271 86354488 218 - 1.189 1.113 -0.270