ENSG00000083097

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000349129 ENSG00000083097 HEK293_OSMI2_6hA HEK293_TMG_6hB DOP1A protein_coding protein_coding 3.412564 1.632162 6.737643 0.2244432 0.4720749 2.038787 1.1240986 0.4624452 2.4955225 0.10773574 0.6184763 2.4068925 0.24845417 0.2745000 0.3694000 0.0949000 8.575131e-01 4.192292e-05 FALSE TRUE
ENST00000484282 ENSG00000083097 HEK293_OSMI2_6hA HEK293_TMG_6hB DOP1A protein_coding processed_transcript 3.412564 1.632162 6.737643 0.2244432 0.4720749 2.038787 0.8542815 0.8696845 1.3510298 0.19687780 0.1982490 0.6296406 0.36051667 0.5173667 0.1985000 -0.3188667 1.425009e-03 4.192292e-05 TRUE TRUE
ENST00000604380 ENSG00000083097 HEK293_OSMI2_6hA HEK293_TMG_6hB DOP1A protein_coding protein_coding 3.412564 1.632162 6.737643 0.2244432 0.4720749 2.038787 0.3051392 0.0000000 1.0290628 0.00000000 0.1023783 6.6991390 0.05500417 0.0000000 0.1556667 0.1556667 4.192292e-05 4.192292e-05 FALSE TRUE
MSTRG.28595.1 ENSG00000083097 HEK293_OSMI2_6hA HEK293_TMG_6hB DOP1A protein_coding   3.412564 1.632162 6.737643 0.2244432 0.4720749 2.038787 0.3011563 0.1893224 0.8467937 0.08940877 0.3133812 2.1038441 0.08193333 0.1391333 0.1298333 -0.0093000 1.000000e+00 4.192292e-05 TRUE TRUE
MSTRG.28595.2 ENSG00000083097 HEK293_OSMI2_6hA HEK293_TMG_6hB DOP1A protein_coding   3.412564 1.632162 6.737643 0.2244432 0.4720749 2.038787 0.5097300 0.0000000 0.4500950 0.00000000 0.2335310 5.5238599 0.14954167 0.0000000 0.0662000 0.0662000 5.773053e-01 4.192292e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000083097 E001 0.0000000       6 83067649 83067651 3 +      
ENSG00000083097 E002 0.1779838 0.0402846800 1.000000e+00   6 83067652 83067665 14 + 0.073 0.000 -8.419
ENSG00000083097 E003 0.1779838 0.0402846800 1.000000e+00   6 83067666 83067670 5 + 0.073 0.000 -10.951
ENSG00000083097 E004 0.1779838 0.0402846800 1.000000e+00   6 83067671 83067678 8 + 0.073 0.000 -10.951
ENSG00000083097 E005 6.0173798 0.1123528205 2.331742e-01 4.688247e-01 6 83067679 83067779 101 + 0.840 0.635 -0.837
ENSG00000083097 E006 0.0000000       6 83096729 83096730 2 +      
ENSG00000083097 E007 5.7670837 0.0507929694 1.291639e-01 3.304459e-01 6 83096731 83096823 93 + 0.828 0.581 -1.028
ENSG00000083097 E008 16.4725701 0.0020467672 5.831776e-05 9.510896e-04 6 83096925 83097115 191 + 1.260 0.825 -1.599
ENSG00000083097 E009 14.1920005 0.0178956906 4.848000e-01 6.903942e-01 6 83100705 83100886 182 + 1.145 1.088 -0.204
ENSG00000083097 E010 15.6426241 0.0024749655 8.330125e-01 9.154660e-01 6 83108910 83109080 171 + 1.157 1.198 0.146
ENSG00000083097 E011 17.5970291 0.1675305147 1.209849e-01 3.174449e-01 6 83110125 83110314 190 + 1.259 0.994 -0.953
ENSG00000083097 E012 10.6002192 0.0034340345 4.033260e-02 1.555693e-01 6 83113323 83113421 99 + 1.058 0.825 -0.879
ENSG00000083097 E013 18.2768808 0.0022353754 4.438347e-02 1.660462e-01 6 83118888 83118987 100 + 1.265 1.092 -0.613
ENSG00000083097 E014 12.4248321 0.0098557779 4.142422e-02 1.584197e-01 6 83119748 83119774 27 + 1.122 0.893 -0.844
ENSG00000083097 E015 15.4505954 0.0025150271 1.001471e-02 5.822122e-02 6 83119775 83119857 83 + 1.209 0.952 -0.932
ENSG00000083097 E016 15.1455490 0.0022677793 1.342005e-02 7.209288e-02 6 83120683 83120791 109 + 1.199 0.952 -0.897
ENSG00000083097 E017 16.8564091 0.0021445114 2.245953e-02 1.041120e-01 6 83121930 83122050 121 + 1.238 1.028 -0.754
ENSG00000083097 E018 13.9374285 0.0027972514 6.581596e-02 2.157447e-01 6 83122863 83122982 120 + 1.157 0.979 -0.648
ENSG00000083097 E019 14.9562067 0.0709685169 8.734674e-02 2.588956e-01 6 83124705 83124819 115 + 1.196 0.945 -0.914
ENSG00000083097 E020 0.0000000       6 83125166 83125195 30 +      
ENSG00000083097 E021 24.6643342 0.0015242640 5.984438e-02 2.024251e-01 6 83125500 83125733 234 + 1.378 1.243 -0.472
ENSG00000083097 E022 35.0863522 0.7986550015 6.112712e-01 7.777738e-01 6 83128887 83129508 622 + 1.492 1.506 0.046
ENSG00000083097 E023 9.7777809 0.0343229686 1.890158e-01 4.157231e-01 6 83130123 83130213 91 + 1.019 0.826 -0.729
ENSG00000083097 E024 20.7557812 0.0241686131 1.560188e-01 3.709282e-01 6 83130214 83130397 184 + 1.305 1.154 -0.532
ENSG00000083097 E025 18.8116080 0.0042664704 3.989134e-02 1.544272e-01 6 83132176 83132328 153 + 1.277 1.093 -0.655
ENSG00000083097 E026 12.2200895 0.1696073449 3.361194e-01 5.745849e-01 6 83134187 83134287 101 + 1.109 0.896 -0.786
ENSG00000083097 E027 0.5008152 0.0283234350 4.285540e-01   6 83134288 83134480 193 + 0.190 0.000 -12.493
ENSG00000083097 E028 20.4592543 0.6451186725 7.309600e-01 8.547807e-01 6 83135619 83135878 260 + 1.284 1.234 -0.179
ENSG00000083097 E029 46.7988559 0.0065128092 3.963607e-02 1.537979e-01 6 83137173 83137675 503 + 1.647 1.529 -0.401
ENSG00000083097 E030 136.6636487 0.0041147762 8.364307e-03 5.099816e-02 6 83137676 83139162 1487 + 2.097 2.008 -0.298
ENSG00000083097 E031 28.0500322 0.0030117133 4.106935e-01 6.365532e-01 6 83140000 83140111 112 + 1.382 1.468 0.297
ENSG00000083097 E032 38.4249989 0.0023625613 8.679735e-01 9.348461e-01 6 83140221 83140403 183 + 1.524 1.559 0.120
ENSG00000083097 E033 34.6005225 0.0204667190 4.898814e-01 6.939064e-01 6 83141921 83142046 126 + 1.465 1.557 0.317
ENSG00000083097 E034 27.3984574 0.0139738670 3.944902e-01 6.239674e-01 6 83145524 83145658 135 + 1.366 1.473 0.373
ENSG00000083097 E035 11.0144883 0.0052478656 8.305906e-01 9.141181e-01 6 83147236 83147291 56 + 1.029 1.027 -0.006
ENSG00000083097 E036 15.9250087 0.0045059737 7.839185e-01 8.868818e-01 6 83148759 83148863 105 + 1.169 1.165 -0.011
ENSG00000083097 E037 17.5102790 0.0073224293 6.021947e-01 7.716247e-01 6 83151593 83151659 67 + 1.210 1.182 -0.099
ENSG00000083097 E038 25.7553315 0.0026905503 1.772174e-01 4.000797e-01 6 83151883 83152027 145 + 1.333 1.460 0.439
ENSG00000083097 E039 23.5579525 0.0030491659 5.107731e-01 7.085709e-01 6 83152288 83152367 80 + 1.310 1.385 0.262
ENSG00000083097 E040 0.2027342 0.0360603262 1.563008e-01   6 83153392 83153510 119 + 0.000 0.196 12.428
ENSG00000083097 E041 29.1054272 0.0013533734 8.770421e-01 9.397457e-01 6 83153511 83153620 110 + 1.413 1.425 0.039
ENSG00000083097 E042 0.3807181 0.0284405533 4.302538e-01   6 83153621 83153893 273 + 0.073 0.196 1.636
ENSG00000083097 E043 33.0227260 0.0014561573 9.268736e-01 9.654946e-01 6 83153894 83154043 150 + 1.468 1.485 0.059
ENSG00000083097 E044 27.8052445 0.0068372987 6.612671e-01 8.107190e-01 6 83154180 83154241 62 + 1.398 1.386 -0.041
ENSG00000083097 E045 0.5008152 0.0283234350 4.285540e-01   6 83154242 83154273 32 + 0.190 0.000 -12.493
ENSG00000083097 E046 37.2371522 0.0009659038 1.134650e-01 3.049320e-01 6 83155951 83156103 153 + 1.489 1.610 0.414
ENSG00000083097 E047 35.8442228 0.0010797050 6.957299e-02 2.239060e-01 6 83157182 83157318 137 + 1.473 1.610 0.468
ENSG00000083097 E048 24.0136859 0.0019118929 4.725822e-01 6.819271e-01 6 83158567 83158622 56 + 1.318 1.396 0.271
ENSG00000083097 E049 39.2348531 0.0012232043 1.805390e-02 8.921773e-02 6 83159796 83159960 165 + 1.502 1.667 0.562
ENSG00000083097 E050 38.0026661 0.0027026178 3.185489e-06 7.820866e-05 6 83162790 83162919 130 + 1.434 1.740 1.047
ENSG00000083097 E051 2.7691910 0.0085633673 2.171644e-01 4.500410e-01 6 83164660 83164719 60 + 0.479 0.697 0.982
ENSG00000083097 E052 0.4161375 0.1272467864 7.527859e-01   6 83164720 83167861 3142 + 0.135 0.194 0.634
ENSG00000083097 E053 67.0144709 0.8822321983 1.966857e-01 4.254024e-01 6 83167862 83168756 895 + 1.634 2.029 1.330
ENSG00000083097 E054 5.2887468 0.2279892292 2.435300e-01 4.805479e-01 6 83168757 83169477 721 + 0.630 0.969 1.347
ENSG00000083097 E055 6.8915248 0.1118842957 3.615357e-01 5.969343e-01 6 83169478 83169534 57 + 0.797 0.955 0.605
ENSG00000083097 E056 33.6859043 0.0321544672 1.946672e-02 9.406457e-02 6 83170289 83171350 1062 + 1.395 1.660 0.906