ENSG00000081320

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263955 ENSG00000081320 HEK293_OSMI2_6hA HEK293_TMG_6hB STK17B protein_coding protein_coding 4.474135 0.8511352 9.021219 0.1761054 0.4733624 3.390609 3.19634859 0.75872300 5.88740484 0.18166060 0.25131806 2.9395445 0.8007083 0.87450000 0.656600000 -0.21790000 0.164973303 0.004529729 FALSE TRUE
MSTRG.19690.2 ENSG00000081320 HEK293_OSMI2_6hA HEK293_TMG_6hB STK17B protein_coding   4.474135 0.8511352 9.021219 0.1761054 0.4733624 3.390609 1.16065910 0.04043579 3.05271900 0.04043579 0.52361306 5.9242213 0.1502542 0.03746667 0.334700000 0.29723333 0.004529729 0.004529729 FALSE TRUE
MSTRG.19690.3 ENSG00000081320 HEK293_OSMI2_6hA HEK293_TMG_6hB STK17B protein_coding   4.474135 0.8511352 9.021219 0.1761054 0.4733624 3.390609 0.08649768 0.05197639 0.04146039 0.03148537 0.04146039 -0.2682564 0.0336375 0.08803333 0.004166667 -0.08386667 0.311403831 0.004529729 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000081320 E001 177.2935642 1.5049912138 0.40555950 0.63271321 2 196133583 196136993 3411 - 1.991 2.307 1.056
ENSG00000081320 E002 52.8943144 0.8054293882 0.47075653 0.68065983 2 196136994 196137430 437 - 1.492 1.712 0.749
ENSG00000081320 E003 15.8486188 0.3816657574 0.55465166 0.73953700 2 196137431 196137446 16 - 1.013 1.138 0.456
ENSG00000081320 E004 52.6785239 0.7728428822 0.58436783 0.75991132 2 196137447 196137729 283 - 1.508 1.604 0.327
ENSG00000081320 E005 45.8279139 0.0009948136 0.01606798 0.08205669 2 196139620 196139799 180 - 1.474 1.416 -0.200
ENSG00000081320 E006 31.6792538 0.0463474284 0.26275252 0.50199467 2 196141249 196141297 49 - 1.308 1.304 -0.016
ENSG00000081320 E007 40.0947913 0.1169752234 0.34000448 0.57795314 2 196143560 196143686 127 - 1.406 1.395 -0.038
ENSG00000081320 E008 37.8608793 0.0882011916 0.22392360 0.45811011 2 196145911 196146055 145 - 1.385 1.356 -0.099
ENSG00000081320 E009 1.3388170 0.2948797573 0.32713231   2 196154968 196155043 76 - 0.275 0.001 -9.132
ENSG00000081320 E010 0.1779838 0.2621136622 0.90675724   2 196156086 196156438 353 - 0.045 0.001 -6.113
ENSG00000081320 E011 35.9549886 0.0838194039 0.19918801 0.42868979 2 196156439 196156571 133 - 1.363 1.324 -0.138
ENSG00000081320 E012 28.2934779 0.1311047205 0.36195387 0.59732272 2 196156572 196156651 80 - 1.262 1.240 -0.078
ENSG00000081320 E013 23.4174996 0.1365409826 0.37194885 0.60556688 2 196163262 196163363 102 - 1.184 1.179 -0.019
ENSG00000081320 E014 16.8378410 0.2379454997 0.75736744 0.87106639 2 196163364 196163427 64 - 1.044 1.094 0.180
ENSG00000081320 E015 0.0000000       2 196165583 196165734 152 -      
ENSG00000081320 E016 0.0000000       2 196166094 196166277 184 -      
ENSG00000081320 E017 0.4646582 0.0244411696 0.03268595   2 196170834 196171000 167 - 0.045 0.466 4.157
ENSG00000081320 E018 28.2321070 0.1608022910 0.96083122 0.98233792 2 196171333 196171587 255 - 1.238 1.415 0.619
ENSG00000081320 E019 0.0000000       2 196174249 196174407 159 -      
ENSG00000081320 E020 0.0000000       2 196176226 196176503 278 -