ENSG00000081189

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340208 ENSG00000081189 HEK293_OSMI2_6hA HEK293_TMG_6hB MEF2C protein_coding protein_coding 2.795248 1.03428 6.372868 0.2560815 0.06205316 2.611696 0.04452447 0.09021098 0.0000000 0.04520669 0.00000000 -3.324969 0.02756250 0.06993333 0.00000000 -0.06993333 0.006828905 0.006828905 FALSE TRUE
ENST00000424173 ENSG00000081189 HEK293_OSMI2_6hA HEK293_TMG_6hB MEF2C protein_coding protein_coding 2.795248 1.03428 6.372868 0.2560815 0.06205316 2.611696 0.16555473 0.00000000 0.2766575 0.00000000 0.08833861 4.841256 0.08162917 0.00000000 0.04340000 0.04340000 0.302960213 0.006828905 FALSE TRUE
ENST00000503955 ENSG00000081189 HEK293_OSMI2_6hA HEK293_TMG_6hB MEF2C protein_coding retained_intron 2.795248 1.03428 6.372868 0.2560815 0.06205316 2.611696 0.14847605 0.07345043 0.0000000 0.07345043 0.00000000 -3.060919 0.08336667 0.14010000 0.00000000 -0.14010000 0.696881654 0.006828905   FALSE
ENST00000508569 ENSG00000081189 HEK293_OSMI2_6hA HEK293_TMG_6hB MEF2C protein_coding protein_coding 2.795248 1.03428 6.372868 0.2560815 0.06205316 2.611696 0.22675908 0.00000000 0.6226713 0.00000000 0.62267130 5.983384 0.05480417 0.00000000 0.09583333 0.09583333 1.000000000 0.006828905 FALSE TRUE
ENST00000510942 ENSG00000081189 HEK293_OSMI2_6hA HEK293_TMG_6hB MEF2C protein_coding protein_coding 2.795248 1.03428 6.372868 0.2560815 0.06205316 2.611696 0.23859754 0.22220849 0.8648937 0.16636499 0.49907292 1.913687 0.10537500 0.22173333 0.13436667 -0.08736667 0.950094105 0.006828905 FALSE TRUE
ENST00000627717 ENSG00000081189 HEK293_OSMI2_6hA HEK293_TMG_6hB MEF2C protein_coding protein_coding 2.795248 1.03428 6.372868 0.2560815 0.06205316 2.611696 0.17683798 0.00000000 0.4175615 0.00000000 0.11665683 5.418060 0.05032500 0.00000000 0.06530000 0.06530000 0.122909636 0.006828905 FALSE TRUE
ENST00000636998 ENSG00000081189 HEK293_OSMI2_6hA HEK293_TMG_6hB MEF2C protein_coding protein_coding 2.795248 1.03428 6.372868 0.2560815 0.06205316 2.611696 0.28078065 0.00000000 0.9563985 0.00000000 0.52589268 6.594546 0.11042917 0.00000000 0.14873333 0.14873333 0.604187158 0.006828905 FALSE TRUE
ENST00000637481 ENSG00000081189 HEK293_OSMI2_6hA HEK293_TMG_6hB MEF2C protein_coding protein_coding 2.795248 1.03428 6.372868 0.2560815 0.06205316 2.611696 0.48821844 0.34428283 1.0356272 0.10675566 0.54279976 1.561395 0.18051667 0.31703333 0.16416667 -0.15286667 0.748563345 0.006828905 FALSE TRUE
MSTRG.26568.10 ENSG00000081189 HEK293_OSMI2_6hA HEK293_TMG_6hB MEF2C protein_coding   2.795248 1.03428 6.372868 0.2560815 0.06205316 2.611696 0.34593387 0.23164516 0.6043874 0.23164516 0.60438744 1.346259 0.10460417 0.17423333 0.09590000 -0.07833333 0.909191095 0.006828905 FALSE TRUE
MSTRG.26568.23 ENSG00000081189 HEK293_OSMI2_6hA HEK293_TMG_6hB MEF2C protein_coding   2.795248 1.03428 6.372868 0.2560815 0.06205316 2.611696 0.40971493 0.00000000 1.1710948 0.00000000 0.59871930 6.883981 0.09710000 0.00000000 0.18550000 0.18550000 0.566511799 0.006828905 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000081189 E001 0.3040503 0.0274424043 1.00000000   5 88717117 88718240 1124 - 0.115 0.000 -8.360
ENSG00000081189 E002 0.3453689 0.0281679864 0.26826192   5 88718241 88718273 33 - 0.062 0.226 2.168
ENSG00000081189 E003 65.3226039 0.0011709795 0.35465699 0.59141134 5 88718274 88720025 1752 - 1.705 1.761 0.188
ENSG00000081189 E004 17.1609553 0.0051342732 0.25425746 0.49272266 5 88720026 88720336 311 - 1.173 1.051 -0.439
ENSG00000081189 E005 17.6299490 0.0310429410 0.25492964 0.49351279 5 88720337 88720824 488 - 1.192 1.024 -0.609
ENSG00000081189 E006 3.8250355 0.2582510894 0.45105861 0.66637613 5 88720825 88720828 4 - 0.632 0.377 -1.249
ENSG00000081189 E007 4.6572402 0.0956076709 0.73422298 0.85679697 5 88720829 88720843 15 - 0.674 0.573 -0.439
ENSG00000081189 E008 5.2395950 0.0693135752 0.91278387 0.95849987 5 88720844 88720855 12 - 0.701 0.706 0.021
ENSG00000081189 E009 48.4514918 0.0052399003 0.00689758 0.04417088 5 88720856 88721569 714 - 1.548 1.733 0.630
ENSG00000081189 E010 4.4411855 0.0064407012 0.20015514 0.42989492 5 88721570 88721576 7 - 0.607 0.810 0.843
ENSG00000081189 E011 5.0459056 0.0058628491 0.36978185 0.60383917 5 88721577 88721619 43 - 0.668 0.810 0.578
ENSG00000081189 E012 4.2104223 0.0565022658 0.10846760 0.29647382 5 88721620 88721646 27 - 0.556 0.853 1.239
ENSG00000081189 E013 15.3465200 0.0503819732 0.21199366 0.44408891 5 88721647 88721924 278 - 1.060 1.265 0.731
ENSG00000081189 E014 43.8754163 0.0008685219 0.81205116 0.90345913 5 88721925 88722488 564 - 1.542 1.562 0.070
ENSG00000081189 E015 6.6629614 0.0067685868 0.90666841 0.95543514 5 88722489 88722494 6 - 0.791 0.811 0.079
ENSG00000081189 E016 6.6382110 0.0049945894 0.77746629 0.88319413 5 88722495 88722497 3 - 0.801 0.762 -0.157
ENSG00000081189 E017 11.9452390 0.0851219886 0.72902983 0.85362278 5 88722498 88722566 69 - 1.031 0.934 -0.359
ENSG00000081189 E018 9.3133806 0.1456166241 0.58544136 0.76057932 5 88722567 88722600 34 - 0.949 0.762 -0.724
ENSG00000081189 E019 7.0149370 0.2950387939 0.82860770 0.91302115 5 88722601 88722603 3 - 0.839 0.696 -0.574
ENSG00000081189 E020 16.9026675 0.4582548237 0.75707277 0.87091190 5 88722604 88722729 126 - 1.161 1.116 -0.161
ENSG00000081189 E021 18.0427624 0.6587696254 0.43145406 0.65230510 5 88722730 88722827 98 - 1.148 1.292 0.512
ENSG00000081189 E022 9.2746691 0.4311988701 0.35814243 0.59432280 5 88722828 88722829 2 - 0.882 1.045 0.611
ENSG00000081189 E023 4.2136848 0.2101469540 0.37096094 0.60469093 5 88722830 88722836 7 - 0.599 0.764 0.697
ENSG00000081189 E024 4.3009514 0.0066790483 0.34104326 0.57897884 5 88722837 88722852 16 - 0.607 0.762 0.650
ENSG00000081189 E025 4.2712117 0.0075200869 0.62497230 0.78732495 5 88722853 88722865 13 - 0.623 0.707 0.358
ENSG00000081189 E026 6.7950469 0.0052455123 0.13612486 0.34154500 5 88722866 88722925 60 - 0.757 0.963 0.796
ENSG00000081189 E027 24.4273241 0.0359035437 0.15260334 0.36605266 5 88728493 88728628 136 - 1.267 1.439 0.599
ENSG00000081189 E028 22.1434052 0.0060227045 0.54115276 0.72987051 5 88729218 88729347 130 - 1.256 1.317 0.214
ENSG00000081189 E029 0.1614157 0.0401353154 1.00000000   5 88729348 88729519 172 - 0.062 0.000 -9.887
ENSG00000081189 E030 0.0000000       5 88730211 88730234 24 -      
ENSG00000081189 E031 0.1779838 0.0525869705 1.00000000   5 88731437 88731728 292 - 0.062 0.000 -9.862
ENSG00000081189 E032 16.1637009 0.0037675273 0.82304815 0.90976994 5 88731729 88731804 76 - 1.144 1.123 -0.076
ENSG00000081189 E033 13.7077716 0.0088987758 0.45091307 0.66630769 5 88731805 88731851 47 - 1.088 0.994 -0.342
ENSG00000081189 E034 14.7884548 0.0136946822 0.96302182 0.98346039 5 88731852 88731901 50 - 1.098 1.101 0.010
ENSG00000081189 E035 0.0000000       5 88732472 88732543 72 -      
ENSG00000081189 E036 10.0554677 0.0123848113 0.84660213 0.92306244 5 88749070 88749085 16 - 0.951 0.930 -0.078
ENSG00000081189 E037 10.3726559 0.0031285559 0.18698440 0.41302582 5 88749086 88749117 32 - 0.986 0.810 -0.669
ENSG00000081189 E038 0.1426347 0.0363302849 1.00000000   5 88749118 88749124 7 - 0.062 0.000 -9.894
ENSG00000081189 E039 7.8186330 0.0040185993 0.11671492 0.31035836 5 88751857 88751861 5 - 0.887 0.645 -0.973
ENSG00000081189 E040 6.3407656 0.0048589767 0.05179101 0.18397139 5 88751862 88751865 4 - 0.822 0.484 -1.459
ENSG00000081189 E041 24.5273641 0.0014563770 0.12225967 0.31941848 5 88751866 88752043 178 - 1.325 1.186 -0.489
ENSG00000081189 E042 0.1779838 0.0525869705 1.00000000   5 88760988 88761022 35 - 0.062 0.000 -9.862
ENSG00000081189 E043 0.1426347 0.0363302849 1.00000000   5 88761023 88761125 103 - 0.062 0.000 -9.894
ENSG00000081189 E044 12.1642225 0.0031949807 0.52919783 0.72148780 5 88761185 88761199 15 - 1.000 1.076 0.280
ENSG00000081189 E045 11.1459537 0.0070254315 0.30951947 0.55001178 5 88761200 88761208 9 - 0.951 1.077 0.462
ENSG00000081189 E046 10.3834022 0.0163734280 0.46517728 0.67668126 5 88761209 88761216 8 - 0.929 1.026 0.359
ENSG00000081189 E047 18.6870496 0.0170921158 0.41085573 0.63668242 5 88761217 88761268 52 - 1.204 1.102 -0.365
ENSG00000081189 E048 17.8671071 0.0297317402 0.68605040 0.82653796 5 88761269 88761309 41 - 1.183 1.122 -0.218
ENSG00000081189 E049 13.8302317 0.0214767184 0.27459798 0.51459578 5 88761310 88761324 15 - 1.096 0.960 -0.496
ENSG00000081189 E050 13.2187345 0.0101017630 0.51041126 0.70828468 5 88761325 88761328 4 - 1.068 0.993 -0.273
ENSG00000081189 E051 0.0000000       5 88761718 88761912 195 -      
ENSG00000081189 E052 0.0000000       5 88771779 88771788 10 -      
ENSG00000081189 E053 0.0000000       5 88771789 88771866 78 -      
ENSG00000081189 E054 0.0000000       5 88771973 88772000 28 -      
ENSG00000081189 E055 0.0000000       5 88772266 88772281 16 -      
ENSG00000081189 E056 0.0000000       5 88772282 88772361 80 -      
ENSG00000081189 E057 0.0000000       5 88785339 88785542 204 -      
ENSG00000081189 E058 0.0000000       5 88804526 88804597 72 -      
ENSG00000081189 E059 30.4105760 0.0090431876 0.34328885 0.58096901 5 88804598 88804753 156 - 1.404 1.318 -0.299
ENSG00000081189 E060 11.5246165 0.0044559498 0.10764336 0.29509612 5 88804754 88804769 16 - 1.026 0.810 -0.815
ENSG00000081189 E061 14.9776525 0.0121808121 0.44176853 0.65994420 5 88804770 88804801 32 - 1.116 1.023 -0.338
ENSG00000081189 E062 0.0000000       5 88817805 88817831 27 -      
ENSG00000081189 E063 15.5142630 0.0026951348 0.44608180 0.66279260 5 88823735 88823795 61 - 1.131 1.051 -0.289
ENSG00000081189 E064 14.0802167 0.0030366773 0.99804350 1.00000000 5 88823796 88823860 65 - 1.073 1.076 0.013
ENSG00000081189 E065 8.7172615 0.0124306926 0.91949596 0.96198565 5 88823861 88823862 2 - 0.879 0.895 0.059
ENSG00000081189 E066 14.8313776 0.0046438205 0.44544040 0.66238793 5 88823863 88823900 38 - 1.079 1.166 0.311
ENSG00000081189 E067 14.7405583 0.0188874258 0.98056000 0.99204466 5 88823901 88823927 27 - 1.097 1.097 0.002
ENSG00000081189 E068 5.2376966 0.0050089725 0.32874556 0.56773625 5 88823928 88823930 3 - 0.734 0.572 -0.696
ENSG00000081189 E069 0.0000000       5 88823931 88824275 345 -      
ENSG00000081189 E070 0.0000000       5 88824278 88824309 32 -      
ENSG00000081189 E071 0.0000000       5 88824310 88824340 31 -      
ENSG00000081189 E072 0.0000000       5 88824880 88824914 35 -      
ENSG00000081189 E073 0.0000000       5 88825719 88825864 146 -      
ENSG00000081189 E074 0.1779838 0.0525869705 1.00000000   5 88827036 88827192 157 - 0.062 0.000 -9.862
ENSG00000081189 E075 0.0000000       5 88839240 88839378 139 -      
ENSG00000081189 E076 0.0000000       5 88839379 88839623 245 -      
ENSG00000081189 E077 0.0000000       5 88877938 88877941 4 -      
ENSG00000081189 E078 0.0000000       5 88877942 88877962 21 -      
ENSG00000081189 E079 0.0000000       5 88877963 88878020 58 -      
ENSG00000081189 E080 0.0000000       5 88880844 88880923 80 -      
ENSG00000081189 E081 0.6190593 0.0383903265 0.72401594   5 88880924 88880981 58 - 0.163 0.226 0.583
ENSG00000081189 E082 0.1614157 0.0401353154 1.00000000   5 88880982 88881022 41 - 0.062 0.000 -9.887
ENSG00000081189 E083 0.0000000       5 88881023 88881264 242 -      
ENSG00000081189 E084 11.2651452 0.0301209275 0.90432814 0.95410571 5 88882955 88882959 5 - 0.995 0.989 -0.023
ENSG00000081189 E085 15.7077672 0.0473550394 0.81234240 0.90363554 5 88882960 88882999 40 - 1.129 1.112 -0.061
ENSG00000081189 E086 11.8778220 0.0224801113 0.65986698 0.80991510 5 88883000 88883048 49 - 1.021 0.962 -0.218
ENSG00000081189 E087 18.0643199 0.0274638531 0.16929395 0.38964568 5 88883049 88883466 418 - 1.205 1.022 -0.662
ENSG00000081189 E088 0.6600180 0.0193874923 0.53652053   5 88883652 88883747 96 - 0.207 0.000 -11.723
ENSG00000081189 E089 0.0000000       5 88884328 88884355 28 -      
ENSG00000081189 E090 0.0000000       5 88884356 88884426 71 -      
ENSG00000081189 E091 0.0000000       5 88884489 88884568 80 -      
ENSG00000081189 E092 0.0000000       5 88887392 88887501 110 -      
ENSG00000081189 E093 0.0000000       5 88887502 88887542 41 -      
ENSG00000081189 E094 0.0000000       5 88887543 88887564 22 -      
ENSG00000081189 E095 0.0000000       5 88887565 88887584 20 -      
ENSG00000081189 E096 0.0000000       5 88887585 88887598 14 -      
ENSG00000081189 E097 0.0000000       5 88888167 88888232 66 -      
ENSG00000081189 E098 0.0000000       5 88888879 88888888 10 -      
ENSG00000081189 E099 0.0000000       5 88888889 88889050 162 -      
ENSG00000081189 E100 0.0000000       5 88889051 88889324 274 -      
ENSG00000081189 E101 0.0000000       5 88903916 88904257 342 -