ENSG00000081177

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312994 ENSG00000081177 HEK293_OSMI2_6hA HEK293_TMG_6hB EXD2 protein_coding protein_coding 12.82128 8.656217 16.70471 1.136901 0.492784 0.9476438 0.2076610 0.6434445 0.2500543 0.3550937 0.1258152 -1.3292516 0.01763333 0.07993333 0.01536667 -0.06456667 0.82222879 0.03398848 FALSE TRUE
ENST00000409018 ENSG00000081177 HEK293_OSMI2_6hA HEK293_TMG_6hB EXD2 protein_coding protein_coding 12.82128 8.656217 16.70471 1.136901 0.492784 0.9476438 2.5090343 1.3986364 3.8632896 0.2421793 0.4997701 1.4592601 0.21475833 0.16083333 0.22990000 0.06906667 0.48794125 0.03398848 FALSE TRUE
ENST00000409949 ENSG00000081177 HEK293_OSMI2_6hA HEK293_TMG_6hB EXD2 protein_coding protein_coding 12.82128 8.656217 16.70471 1.136901 0.492784 0.9476438 0.8591018 1.3233361 0.8114528 0.2016197 0.1884210 -0.6987909 0.07259167 0.15660000 0.04830000 -0.10830000 0.03398848 0.03398848 FALSE TRUE
ENST00000494629 ENSG00000081177 HEK293_OSMI2_6hA HEK293_TMG_6hB EXD2 protein_coding processed_transcript 12.82128 8.656217 16.70471 1.136901 0.492784 0.9476438 2.4234861 0.8970505 3.4883118 0.8970505 0.1519239 1.9474041 0.14797917 0.08276667 0.20896667 0.12620000 0.32300447 0.03398848 FALSE FALSE
ENST00000685843 ENSG00000081177 HEK293_OSMI2_6hA HEK293_TMG_6hB EXD2 protein_coding protein_coding 12.82128 8.656217 16.70471 1.136901 0.492784 0.9476438 5.8087239 3.9607686 7.3975176 0.1672132 0.1920136 0.8995718 0.46712500 0.47193333 0.44423333 -0.02770000 0.95577965 0.03398848 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000081177 E001 0.4576437 0.1185717485 0.788391266   14 69191498 69191510 13 + 0.190 0.139 -0.536
ENSG00000081177 E002 2.2544643 0.0308770341 0.323475919 0.56279865 14 69191511 69191528 18 + 0.574 0.400 -0.863
ENSG00000081177 E003 2.7965980 0.0088252410 0.284027124 0.52450293 14 69191529 69191530 2 + 0.635 0.461 -0.812
ENSG00000081177 E004 2.9274662 0.0081249502 0.446630104 0.66316831 14 69191531 69191532 2 + 0.635 0.514 -0.550
ENSG00000081177 E005 15.7027892 0.0201211628 0.440878564 0.65938035 14 69191533 69191554 22 + 1.239 1.168 -0.253
ENSG00000081177 E006 28.3246829 0.0045082487 0.149008920 0.36084075 14 69191555 69191591 37 + 1.497 1.395 -0.352
ENSG00000081177 E007 3.0146489 0.0371503636 0.214442486 0.44686504 14 69191766 69191805 40 + 0.506 0.711 0.908
ENSG00000081177 E008 3.3897575 0.0181828194 0.087748180 0.25952488 14 69191806 69191812 7 + 0.506 0.771 1.151
ENSG00000081177 E009 4.6623497 0.0675689742 0.018156520 0.08954506 14 69191813 69191834 22 + 0.540 0.945 1.659
ENSG00000081177 E010 11.3864221 0.1093724031 0.001614471 0.01442838 14 69191835 69192039 205 + 0.768 1.325 2.052
ENSG00000081177 E011 42.3080492 0.0008714079 0.271790116 0.51164944 14 69203917 69204000 84 + 1.602 1.661 0.204
ENSG00000081177 E012 0.9722506 0.0675259746 0.209287055   14 69208830 69209082 253 + 0.376 0.139 -1.863
ENSG00000081177 E013 171.0686753 0.0005750541 0.718740577 0.84740486 14 69209424 69209803 380 + 2.232 2.223 -0.030
ENSG00000081177 E014 3.3668104 0.0648646236 0.510693463 0.70851597 14 69210112 69210201 90 + 0.686 0.562 -0.539
ENSG00000081177 E015 0.0000000       14 69224130 69224279 150 +      
ENSG00000081177 E016 0.3150090 0.0263484159 0.820703478   14 69227950 69228012 63 + 0.106 0.139 0.450
ENSG00000081177 E017 155.1902292 0.0003092250 0.634794826 0.79342107 14 69228816 69229072 257 + 2.191 2.178 -0.042
ENSG00000081177 E018 104.5989418 0.0003791674 0.967369783 0.98564646 14 69230472 69230598 127 + 2.016 2.015 -0.003
ENSG00000081177 E019 80.3044432 0.0005721301 0.202694679 0.43293487 14 69234700 69234773 74 + 1.921 1.870 -0.170
ENSG00000081177 E020 156.3029104 0.0003938269 0.663873939 0.81232573 14 69234774 69235031 258 + 2.195 2.183 -0.040
ENSG00000081177 E021 2.9719861 0.1858716119 0.985409638 0.99449191 14 69235612 69236045 434 + 0.582 0.604 0.100
ENSG00000081177 E022 94.6823932 0.0004180210 0.142831836 0.35169614 14 69236046 69236152 107 + 1.949 2.002 0.180
ENSG00000081177 E023 111.0604467 0.0007693309 0.672828428 0.81811879 14 69236407 69236542 136 + 2.048 2.034 -0.046
ENSG00000081177 E024 0.0000000       14 69236543 69236543 1 +      
ENSG00000081177 E025 179.9005211 0.0019870215 0.059540352 0.20175935 14 69237575 69237931 357 + 2.220 2.284 0.212
ENSG00000081177 E026 647.5440421 0.0008978123 0.224654376 0.45898995 14 69240884 69244020 3137 + 2.813 2.798 -0.051