ENSG00000080839

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373664 ENSG00000080839 HEK293_OSMI2_6hA HEK293_TMG_6hB RBL1 protein_coding protein_coding 6.632882 1.850818 11.6969 0.2798231 0.4743207 2.653351 4.6559338 1.710503 7.8169688 0.3945493 0.09903512 2.185623 0.80654167 0.8966333 0.6710000 -0.2256333 3.205316e-01 1.963441e-08 FALSE TRUE
MSTRG.20669.2 ENSG00000080839 HEK293_OSMI2_6hA HEK293_TMG_6hB RBL1 protein_coding   6.632882 1.850818 11.6969 0.2798231 0.4743207 2.653351 0.4333241 0.000000 0.6905609 0.0000000 0.38235652 6.130439 0.03897917 0.0000000 0.0566000 0.0566000 6.051375e-01 1.963441e-08 FALSE TRUE
MSTRG.20669.3 ENSG00000080839 HEK293_OSMI2_6hA HEK293_TMG_6hB RBL1 protein_coding   6.632882 1.850818 11.6969 0.2798231 0.4743207 2.653351 0.8882266 0.000000 2.3814245 0.0000000 0.16505416 7.901726 0.08108750 0.0000000 0.2040333 0.2040333 1.963441e-08 1.963441e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000080839 E001 174.242062 1.5726846445 0.385346832 0.61673240 20 36996349 36998560 2212 - 2.028 2.392 1.216
ENSG00000080839 E002 17.473932 0.5227219017 0.228862175 0.46386319 20 36998561 36998676 116 - 1.072 1.396 1.144
ENSG00000080839 E003 47.061635 0.8543384385 0.297412912 0.53792671 20 36998677 36998929 253 - 1.481 1.804 1.098
ENSG00000080839 E004 1.722671 0.4670821164 0.456818702 0.67088383 20 37003574 37003701 128 - 0.303 0.521 1.205
ENSG00000080839 E005 37.763198 0.0172594977 0.005972114 0.03959590 20 37003702 37003866 165 - 1.399 1.704 1.042
ENSG00000080839 E006 45.216951 0.0070284846 0.182261702 0.40693793 20 37007411 37007559 149 - 1.505 1.684 0.610
ENSG00000080839 E007 40.378323 0.0229632259 0.749153480 0.86626310 20 37018279 37018369 91 - 1.480 1.533 0.181
ENSG00000080839 E008 35.350995 0.0130262582 0.737552941 0.85898996 20 37020659 37020730 72 - 1.424 1.475 0.177
ENSG00000080839 E009 64.547848 0.0059417701 0.851084465 0.92564906 20 37022650 37022826 177 - 1.669 1.765 0.323
ENSG00000080839 E010 79.999672 0.0028158339 0.041762349 0.15930385 20 37032665 37032876 212 - 1.783 1.748 -0.116
ENSG00000080839 E011 80.746670 0.0006082527 0.016264775 0.08276550 20 37035242 37035508 267 - 1.792 1.748 -0.149
ENSG00000080839 E012 46.119247 0.0010958122 0.069838772 0.22447418 20 37040153 37040285 133 - 1.553 1.508 -0.155
ENSG00000080839 E013 53.937126 0.0204061484 0.141217721 0.34932729 20 37044086 37044250 165 - 1.618 1.557 -0.207
ENSG00000080839 E014 45.120270 0.0297685110 0.188525954 0.41511349 20 37047053 37047190 138 - 1.542 1.474 -0.232
ENSG00000080839 E015 43.350207 0.0128689069 0.112629273 0.30355112 20 37055553 37055656 104 - 1.526 1.474 -0.178
ENSG00000080839 E016 24.126724 0.0150231100 0.912573193 0.95841631 20 37056146 37056159 14 - 1.262 1.336 0.257
ENSG00000080839 E017 39.471165 0.0192078083 0.441354816 0.65966282 20 37056160 37056258 99 - 1.479 1.492 0.047
ENSG00000080839 E018 55.193011 0.0436106429 0.174000394 0.39586931 20 37061103 37061269 167 - 1.633 1.555 -0.265
ENSG00000080839 E019 1.429534 0.0124957777 0.115761164 0.30878674 20 37061946 37062083 138 - 0.354 0.001 -9.610
ENSG00000080839 E020 62.311281 0.0257628964 0.069562471 0.22389728 20 37062084 37062270 187 - 1.686 1.587 -0.337
ENSG00000080839 E021 29.279894 0.0243706386 0.134130001 0.33828911 20 37065424 37065473 50 - 1.366 1.274 -0.323
ENSG00000080839 E022 51.056179 0.0162932409 0.100683955 0.28302476 20 37066724 37066884 161 - 1.597 1.535 -0.214
ENSG00000080839 E023 27.816545 0.0052558820 0.457024357 0.67105487 20 37066993 37067021 29 - 1.334 1.351 0.060
ENSG00000080839 E024 35.084106 0.0228122874 0.151197622 0.36406672 20 37067022 37067121 100 - 1.440 1.387 -0.184
ENSG00000080839 E025 23.521103 0.0118126315 0.062423767 0.20819324 20 37067233 37067297 65 - 1.281 1.157 -0.440
ENSG00000080839 E026 30.477425 0.0013442116 0.027655010 0.12027394 20 37067986 37068086 101 - 1.387 1.275 -0.392
ENSG00000080839 E027 27.561364 0.0016361700 0.012162102 0.06711525 20 37068087 37068186 100 - 1.353 1.200 -0.538
ENSG00000080839 E028 0.000000       20 37081888 37082029 142 -      
ENSG00000080839 E029 29.997760 0.0016277392 0.813228884 0.90417746 20 37088989 37089122 134 - 1.361 1.419 0.201
ENSG00000080839 E030 20.165808 0.5977563477 0.347650139 0.58507159 20 37095773 37095997 225 - 1.155 1.385 0.808