ENSG00000080503

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000349721 ENSG00000080503 HEK293_OSMI2_6hA HEK293_TMG_6hB SMARCA2 protein_coding protein_coding 10.60346 9.647696 11.73029 0.6250609 1.367903 0.2817174 0.4246304 0.2640306 1.0015416 0.2640306 0.2352085 1.8841467 0.03706667 0.02880000 0.08376667 0.054966667 3.670862e-01 1.380997e-22 FALSE TRUE
ENST00000357248 ENSG00000080503 HEK293_OSMI2_6hA HEK293_TMG_6hB SMARCA2 protein_coding protein_coding 10.60346 9.647696 11.73029 0.6250609 1.367903 0.2817174 1.4534478 1.4723264 1.7031249 0.5184166 0.7695867 0.2087671 0.14513333 0.15083333 0.16156667 0.010733333 1.000000e+00 1.380997e-22 FALSE TRUE
ENST00000382194 ENSG00000080503 HEK293_OSMI2_6hA HEK293_TMG_6hB SMARCA2 protein_coding protein_coding 10.60346 9.647696 11.73029 0.6250609 1.367903 0.2817174 1.4819771 1.4556631 1.7909288 0.7730917 0.8979659 0.2971876 0.14246667 0.14890000 0.14356667 -0.005333333 1.000000e+00 1.380997e-22 FALSE TRUE
ENST00000416751 ENSG00000080503 HEK293_OSMI2_6hA HEK293_TMG_6hB SMARCA2 protein_coding protein_coding 10.60346 9.647696 11.73029 0.6250609 1.367903 0.2817174 1.0708258 0.5189867 2.0828557 0.5189867 0.5098388 1.9841696 0.09876667 0.05836667 0.17360000 0.115233333 3.048095e-01 1.380997e-22 FALSE FALSE
ENST00000634925 ENSG00000080503 HEK293_OSMI2_6hA HEK293_TMG_6hB SMARCA2 protein_coding processed_transcript 10.60346 9.647696 11.73029 0.6250609 1.367903 0.2817174 1.1568380 0.7490320 1.4431502 0.7490320 0.2213723 0.9369512 0.10144583 0.08423333 0.12216667 0.037933333 4.226650e-01 1.380997e-22 FALSE TRUE
ENST00000635273 ENSG00000080503 HEK293_OSMI2_6hA HEK293_TMG_6hB SMARCA2 protein_coding processed_transcript 10.60346 9.647696 11.73029 0.6250609 1.367903 0.2817174 1.5354121 1.8902602 0.0000000 0.1266289 0.0000000 -7.5700532 0.14367500 0.19606667 0.00000000 -0.196066667 1.380997e-22 1.380997e-22 FALSE TRUE
ENST00000636157 ENSG00000080503 HEK293_OSMI2_6hA HEK293_TMG_6hB SMARCA2 protein_coding processed_transcript 10.60346 9.647696 11.73029 0.6250609 1.367903 0.2817174 0.9007760 1.3166490 0.8694948 0.6771249 0.5319103 -0.5930399 0.09613333 0.13073333 0.07966667 -0.051066667 9.506576e-01 1.380997e-22 FALSE TRUE
ENST00000638139 ENSG00000080503 HEK293_OSMI2_6hA HEK293_TMG_6hB SMARCA2 protein_coding processed_transcript 10.60346 9.647696 11.73029 0.6250609 1.367903 0.2817174 0.3303585 0.7632277 0.0000000 0.4420770 0.0000000 -6.2728214 0.03260000 0.07446667 0.00000000 -0.074466667 2.954117e-01 1.380997e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000080503 E001 0.0000000       9 1980290 1980386 97 +      
ENSG00000080503 E002 0.0000000       9 2015186 2015218 33 +      
ENSG00000080503 E003 0.0000000       9 2015219 2015220 2 +      
ENSG00000080503 E004 0.4576437 0.2218081494 6.160694e-01   9 2015221 2015280 60 + 0.219 0.119 -1.060
ENSG00000080503 E005 2.9824202 0.1515496578 3.084996e-02 0.129897687 9 2015281 2015346 66 + 0.783 0.288 -2.426
ENSG00000080503 E006 7.8870554 0.0568067839 2.050458e-01 0.435977225 9 2015347 2015404 58 + 1.032 0.827 -0.773
ENSG00000080503 E007 2.6546332 0.0089725427 5.319728e-01 0.723436478 9 2015971 2016141 171 + 0.602 0.504 -0.452
ENSG00000080503 E008 1.7247669 0.0118236822 3.179981e-01 0.557926595 9 2016142 2016143 2 + 0.522 0.352 -0.896
ENSG00000080503 E009 0.0000000       9 2016144 2016213 70 +      
ENSG00000080503 E010 0.0000000       9 2016370 2016424 55 +      
ENSG00000080503 E011 1.5266914 0.8301856038 6.491453e-01 0.802934138 9 2017087 2017207 121 + 0.312 0.463 0.856
ENSG00000080503 E012 1.3106546 0.0137602880 9.226443e-01   9 2017412 2017429 18 + 0.368 0.352 -0.089
ENSG00000080503 E013 1.4109752 0.0132575618 3.776275e-01 0.610325375 9 2017430 2017487 58 + 0.301 0.458 0.908
ENSG00000080503 E014 0.7567544 0.0280642447 2.030951e-01   9 2017488 2017497 10 + 0.125 0.352 1.905
ENSG00000080503 E015 0.9594886 0.0179700779 1.113079e-01   9 2017498 2017502 5 + 0.125 0.409 2.231
ENSG00000080503 E016 1.3707542 0.0394978885 5.649357e-01   9 2017503 2017585 83 + 0.301 0.410 0.650
ENSG00000080503 E017 1.7329988 0.0129001103 1.664262e-01 0.385774455 9 2017586 2017799 214 + 0.301 0.544 1.322
ENSG00000080503 E018 0.1426347 0.0317930720 4.626383e-01   9 2017990 2018039 50 + 0.125 0.000 -13.939
ENSG00000080503 E019 0.5474829 0.1333799242 1.073023e-01   9 2021945 2022117 173 + 0.000 0.291 14.632
ENSG00000080503 E020 0.1779838 0.0347844496 4.617492e-01   9 2027720 2027775 56 + 0.125 0.000 -13.938
ENSG00000080503 E021 40.3994519 0.0009864853 6.554852e-04 0.007055978 9 2028987 2029247 261 + 1.701 1.513 -0.639
ENSG00000080503 E022 0.0000000       9 2032520 2032642 123 +      
ENSG00000080503 E023 33.8515344 0.0025682291 2.704460e-02 0.118447328 9 2032952 2033081 130 + 1.608 1.470 -0.473
ENSG00000080503 E024 0.0000000       9 2033082 2033188 107 +      
ENSG00000080503 E025 39.7533625 0.0180059444 8.566422e-01 0.928619606 9 2039466 2039900 435 + 1.622 1.605 -0.058
ENSG00000080503 E026 11.9830093 0.0836145628 5.861247e-02 0.199669942 9 2039901 2041330 1430 + 1.256 0.931 -1.177
ENSG00000080503 E027 48.4553581 0.0091929918 7.522799e-05 0.001178764 9 2041331 2046037 4707 + 1.813 1.546 -0.903
ENSG00000080503 E028 1.1138898 0.0152265162 7.763730e-01   9 2047229 2047314 86 + 0.300 0.352 0.328
ENSG00000080503 E029 11.4943573 0.0053539172 1.132505e-01 0.304562879 9 2047315 2047484 170 + 1.175 1.017 -0.571
ENSG00000080503 E030 0.3337900 0.0326187688 9.653700e-01   9 2047485 2047954 470 + 0.125 0.118 -0.088
ENSG00000080503 E031 23.5475312 0.0014464761 3.758197e-02 0.148532253 9 2054597 2054723 127 + 1.462 1.316 -0.504
ENSG00000080503 E032 0.0000000       9 2055573 2055682 110 +      
ENSG00000080503 E033 40.1669757 0.0009176134 2.858682e-02 0.123112595 9 2056672 2056845 174 + 1.668 1.549 -0.405
ENSG00000080503 E034 0.2027342 0.0330867783 5.130021e-01   9 2058161 2058290 130 + 0.000 0.118 13.329
ENSG00000080503 E035 45.6991994 0.0017726332 1.389815e-01 0.345957331 9 2058291 2058464 174 + 1.701 1.624 -0.263
ENSG00000080503 E036 49.6680013 0.0008711372 1.959873e-01 0.424536128 9 2060816 2060986 171 + 1.732 1.669 -0.211
ENSG00000080503 E037 0.0000000       9 2060987 2061008 22 +      
ENSG00000080503 E038 0.0000000       9 2068953 2069059 107 +      
ENSG00000080503 E039 20.0046401 0.0019549335 8.087184e-01 0.901422858 9 2070418 2070432 15 + 1.308 1.329 0.075
ENSG00000080503 E040 25.5623148 0.0026894244 4.303328e-01 0.651356901 9 2070433 2070471 39 + 1.391 1.450 0.204
ENSG00000080503 E041 0.3641499 0.0289558549 9.634693e-01   9 2072032 2072067 36 + 0.125 0.118 -0.086
ENSG00000080503 E042 0.0000000       9 2073097 2073211 115 +      
ENSG00000080503 E043 50.1528233 0.0041752405 1.233774e-01 0.321118315 9 2073212 2073342 131 + 1.753 1.666 -0.294
ENSG00000080503 E044 39.7510225 0.0031064837 1.049964e-01 0.290629248 9 2073566 2073623 58 + 1.659 1.564 -0.324
ENSG00000080503 E045 0.0000000       9 2075068 2075133 66 +      
ENSG00000080503 E046 0.0000000       9 2075225 2075259 35 +      
ENSG00000080503 E047 0.0000000       9 2075349 2075396 48 +      
ENSG00000080503 E048 34.9896882 0.0093213267 6.683749e-01 0.815131542 9 2076229 2076283 55 + 1.578 1.549 -0.097
ENSG00000080503 E049 30.8645244 0.0218545713 3.865299e-01 0.617730364 9 2076284 2076329 46 + 1.547 1.468 -0.273
ENSG00000080503 E050 41.6951735 0.0067529776 2.884993e-01 0.529228000 9 2077629 2077776 148 + 1.668 1.603 -0.222
ENSG00000080503 E051 0.1308682 0.0307713072 5.146950e-01   9 2079906 2080158 253 + 0.000 0.118 13.330
ENSG00000080503 E052 45.5108050 0.0071993246 9.752800e-01 0.989481381 9 2081832 2081995 164 + 1.669 1.669 -0.001
ENSG00000080503 E053 34.0366858 0.0018769466 9.916242e-01 0.997570115 9 2083347 2083413 67 + 1.547 1.549 0.006
ENSG00000080503 E054 36.2672867 0.0012566723 3.252810e-02 0.134791069 9 2084086 2084196 111 + 1.504 1.632 0.437
ENSG00000080503 E055 0.0000000       9 2085728 2085744 17 +      
ENSG00000080503 E056 0.0000000       9 2085975 2086107 133 +      
ENSG00000080503 E057 31.5961160 0.0010804041 1.950246e-01 0.423389851 9 2086829 2086897 69 + 1.467 1.549 0.284
ENSG00000080503 E058 37.9061553 0.0069016488 9.139554e-01 0.959120565 9 2086898 2087021 124 + 1.587 1.600 0.044
ENSG00000080503 E059 27.0463506 0.0047487272 8.326651e-01 0.915294558 9 2087022 2087071 50 + 1.461 1.449 -0.043
ENSG00000080503 E060 0.1723744 0.0394581063 5.124441e-01   9 2087301 2087350 50 + 0.000 0.118 13.308
ENSG00000080503 E061 50.3565543 0.0073167317 4.104507e-01 0.636403311 9 2088500 2088613 114 + 1.735 1.683 -0.175
ENSG00000080503 E062 0.0000000       9 2096601 2096656 56 +      
ENSG00000080503 E063 47.3526444 0.0065016377 3.084614e-01 0.549056519 9 2096657 2096764 108 + 1.711 1.647 -0.216
ENSG00000080503 E064 0.0000000       9 2097117 2097185 69 +      
ENSG00000080503 E065 0.0000000       9 2097236 2097260 25 +      
ENSG00000080503 E066 48.2654296 0.0044744333 5.932933e-01 0.765829671 9 2097385 2097471 87 + 1.702 1.671 -0.103
ENSG00000080503 E067 36.4320414 0.0019403375 9.465205e-01 0.975569462 9 2101570 2101616 47 + 1.563 1.569 0.018
ENSG00000080503 E068 62.5584781 0.0047678552 2.712199e-01 0.511211677 9 2104003 2104169 167 + 1.766 1.826 0.204
ENSG00000080503 E069 48.2368664 0.0026406463 4.595243e-01 0.672794646 9 2110254 2110356 103 + 1.665 1.707 0.140
ENSG00000080503 E070 39.6961101 0.0016642362 6.133348e-01 0.779173554 9 2110357 2110417 61 + 1.590 1.620 0.103
ENSG00000080503 E071 75.0116015 0.0005542919 5.154640e-01 0.711948597 9 2115822 2116049 228 + 1.866 1.895 0.097
ENSG00000080503 E072 46.5595985 0.0009834746 2.752480e-01 0.515282078 9 2119458 2119535 78 + 1.646 1.705 0.202
ENSG00000080503 E073 57.9967950 0.0007749386 2.001230e-01 0.429842444 9 2123719 2123849 131 + 1.734 1.797 0.211
ENSG00000080503 E074 44.6925420 0.0032185053 5.911479e-01 0.764484008 9 2123850 2123937 88 + 1.640 1.674 0.116
ENSG00000080503 E075 0.0000000       9 2157680 2157682 3 +      
ENSG00000080503 E076 0.2027342 0.0330867783 5.130021e-01   9 2157683 2157890 208 + 0.000 0.118 13.329
ENSG00000080503 E077 0.1779838 0.0347844496 4.617492e-01   9 2158239 2158302 64 + 0.125 0.000 -13.938
ENSG00000080503 E078 0.1779838 0.0347844496 4.617492e-01   9 2158303 2158350 48 + 0.125 0.000 -13.938
ENSG00000080503 E079 0.1779838 0.0347844496 4.617492e-01   9 2158351 2158392 42 + 0.125 0.000 -13.938
ENSG00000080503 E080 0.1779838 0.0347844496 4.617492e-01   9 2158449 2158451 3 + 0.125 0.000 -13.938
ENSG00000080503 E081 0.1779838 0.0347844496 4.617492e-01   9 2158452 2158452 1 + 0.125 0.000 -13.938
ENSG00000080503 E082 0.1779838 0.0347844496 4.617492e-01   9 2158453 2158455 3 + 0.125 0.000 -13.938
ENSG00000080503 E083 0.1779838 0.0347844496 4.617492e-01   9 2158456 2158457 2 + 0.125 0.000 -13.938
ENSG00000080503 E084 0.1779838 0.0347844496 4.617492e-01   9 2158458 2158460 3 + 0.125 0.000 -13.938
ENSG00000080503 E085 0.0000000       9 2158461 2158469 9 +      
ENSG00000080503 E086 0.0000000       9 2158470 2158472 3 +      
ENSG00000080503 E087 0.0000000       9 2158473 2158474 2 +      
ENSG00000080503 E088 0.0000000       9 2158475 2158475 1 +      
ENSG00000080503 E089 0.0000000       9 2158476 2158492 17 +      
ENSG00000080503 E090 0.0000000       9 2158493 2158496 4 +      
ENSG00000080503 E091 0.0000000       9 2158497 2158553 57 +      
ENSG00000080503 E092 0.0000000       9 2158554 2158563 10 +      
ENSG00000080503 E093 0.0000000       9 2158564 2158581 18 +      
ENSG00000080503 E094 0.0000000       9 2158582 2158587 6 +      
ENSG00000080503 E095 0.0000000       9 2158588 2158594 7 +      
ENSG00000080503 E096 0.1308682 0.0307713072 5.146950e-01   9 2158595 2158955 361 + 0.000 0.118 13.330
ENSG00000080503 E097 0.1308682 0.0307713072 5.146950e-01   9 2158956 2158978 23 + 0.000 0.118 13.330
ENSG00000080503 E098 0.0000000       9 2159429 2159466 38 +      
ENSG00000080503 E099 0.0000000       9 2159672 2159778 107 +      
ENSG00000080503 E100 0.0000000       9 2159779 2159813 35 +      
ENSG00000080503 E101 0.0000000       9 2159814 2159904 91 +      
ENSG00000080503 E102 0.0000000       9 2159905 2159909 5 +      
ENSG00000080503 E103 0.0000000       9 2159945 2159972 28 +      
ENSG00000080503 E104 0.0000000       9 2160235 2160263 29 +      
ENSG00000080503 E105 0.1614157 0.0329605653 4.622589e-01   9 2160264 2160612 349 + 0.125 0.000 -13.939
ENSG00000080503 E106 0.0000000       9 2160613 2160619 7 +      
ENSG00000080503 E107 0.0000000       9 2160620 2160975 356 +      
ENSG00000080503 E108 0.0000000       9 2160976 2161000 25 +      
ENSG00000080503 E109 0.1614157 0.0329605653 4.622589e-01   9 2161001 2161035 35 + 0.125 0.000 -13.939
ENSG00000080503 E110 68.4399527 0.0007439861 8.218501e-01 0.909025636 9 2161686 2161903 218 + 1.832 1.844 0.042
ENSG00000080503 E111 3.7442523 0.0070922377 3.041155e-01 0.544694720 9 2170419 2170472 54 + 0.601 0.755 0.646
ENSG00000080503 E112 0.5363366 0.0256519552 9.544708e-02   9 2181233 2181327 95 + 0.000 0.288 14.895
ENSG00000080503 E113 48.4563638 0.0011655157 4.130502e-01 0.638402091 9 2181571 2181676 106 + 1.671 1.716 0.152
ENSG00000080503 E114 20.5974395 0.0018352877 4.290185e-01 0.650337824 9 2182141 2182145 5 + 1.367 1.309 -0.201
ENSG00000080503 E115 54.6991417 0.0007160797 6.880990e-01 0.827925280 9 2182146 2182242 97 + 1.732 1.753 0.074
ENSG00000080503 E116 77.7940183 0.0065978121 1.439160e-02 0.075847233 9 2186096 2186228 133 + 1.819 1.955 0.459
ENSG00000080503 E117 72.9592543 0.0068216590 5.601626e-03 0.037740419 9 2191266 2191408 143 + 1.777 1.934 0.531
ENSG00000080503 E118 5.1865892 0.3539970047 4.619341e-01 0.674451116 9 2191409 2192703 1295 + 0.843 0.727 -0.461
ENSG00000080503 E119 173.0373040 0.0037146779 4.045868e-04 0.004774051 9 2192704 2193624 921 + 2.159 2.300 0.473