ENSG00000080200

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389622 ENSG00000080200 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYBG3 protein_coding protein_coding 3.586661 1.654559 6.17811 0.2820962 0.3939474 1.894358 2.50160752 0.8567311 5.005413 0.1425537 0.09789129 2.532712 0.6320625 0.5191000 0.8148667 0.2957667 0.009396049 0.009396049 FALSE TRUE
ENST00000485253 ENSG00000080200 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYBG3 protein_coding processed_transcript 3.586661 1.654559 6.17811 0.2820962 0.3939474 1.894358 0.05586408 0.3233117 0.000000 0.3233117 0.00000000 -5.058800 0.0333250 0.1673667 0.0000000 -0.1673667 0.757174561 0.009396049 TRUE TRUE
MSTRG.23329.2 ENSG00000080200 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYBG3 protein_coding   3.586661 1.654559 6.17811 0.2820962 0.3939474 1.894358 1.02918984 0.4745166 1.172696 0.2628699 0.29638366 1.287461 0.3346125 0.3135333 0.1851333 -0.1284000 0.956295262 0.009396049 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000080200 E001 7.6705384 0.254163006 0.042892353 0.16226459 3 97822011 97822355 345 + 0.949 0.440 -2.166
ENSG00000080200 E002 6.0178117 0.112761071 0.026782950 0.11763814 3 97843195 97843261 67 + 0.856 0.438 -1.825
ENSG00000080200 E003 32.1552030 0.084224500 0.001563347 0.01406135 3 97864217 97864647 431 + 1.522 1.092 -1.506
ENSG00000080200 E004 301.6300768 0.156122932 0.648344276 0.80242373 3 97871842 97878037 6196 + 2.436 2.303 -0.444
ENSG00000080200 E005 15.3330715 0.004928299 0.075302851 0.23543803 3 97879704 97879748 45 + 1.098 1.288 0.675
ENSG00000080200 E006 21.7322368 0.002163707 0.586346490 0.76119641 3 97879985 97880100 116 + 1.296 1.274 -0.075
ENSG00000080200 E007 23.7610016 0.045460763 0.254265985 0.49272793 3 97881072 97881219 148 + 1.343 1.249 -0.328
ENSG00000080200 E008 24.6232560 0.083920087 0.379394175 0.61172425 3 97886631 97886767 137 + 1.352 1.288 -0.224
ENSG00000080200 E009 23.2540925 0.134256604 0.508746987 0.70699524 3 97888341 97888455 115 + 1.324 1.294 -0.103
ENSG00000080200 E010 15.7966863 0.084074766 0.594182611 0.76645910 3 97889355 97889390 36 + 1.160 1.168 0.027
ENSG00000080200 E011 23.5587382 0.117512472 0.984773562 0.99421085 3 97892860 97892993 134 + 1.299 1.393 0.325
ENSG00000080200 E012 29.1407031 0.104672830 0.497975799 0.69946989 3 97895959 97896085 127 + 1.420 1.378 -0.146
ENSG00000080200 E013 29.8857792 0.079358444 0.351451481 0.58859202 3 97898883 97899025 143 + 1.438 1.362 -0.262
ENSG00000080200 E014 26.9521563 0.058711308 0.206759614 0.43783403 3 97899137 97899263 127 + 1.403 1.283 -0.416
ENSG00000080200 E015 17.1416100 0.011810675 0.073423771 0.23164608 3 97900453 97900485 33 + 1.229 1.066 -0.582
ENSG00000080200 E016 25.5487822 0.045482597 0.484883376 0.69045496 3 97912167 97912276 110 + 1.363 1.341 -0.076
ENSG00000080200 E017 29.3027734 0.050382810 0.834287028 0.91617011 3 97915610 97915736 127 + 1.404 1.438 0.117
ENSG00000080200 E018 0.1779838 0.256186432 1.000000000   3 97924212 97924411 200 + 0.071 0.000 -11.649
ENSG00000080200 E019 27.5914908 0.051235763 0.633718028 0.79279217 3 97933694 97933833 140 + 1.386 1.383 -0.009
ENSG00000080200 E020 26.3877031 0.048922296 0.711410042 0.84270659 3 97936785 97936908 124 + 1.342 1.438 0.334
ENSG00000080200 E021 35.9472164 0.001137253 0.153752801 0.36769573 3 97941148 97941306 159 + 1.476 1.591 0.394
ENSG00000080200 E022 37.0675831 0.511253717 0.186086029 0.41194160 3 97942284 97942443 160 + 1.434 1.694 0.886
ENSG00000080200 E023 52.5796831 0.612157368 0.165826867 0.38487906 3 97943226 97943570 345 + 1.564 1.872 1.044
ENSG00000080200 E024 102.1292327 1.076633030 0.213151444 0.44542384 3 97943571 97944833 1263 + 1.824 2.192 1.235
ENSG00000080200 E025 6.0560243 0.073930893 0.000140045 0.00198043 3 97944834 97945013 180 + 0.533 1.185 2.568