ENSG00000079819

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337057 ENSG00000079819 HEK293_OSMI2_6hA HEK293_TMG_6hB EPB41L2 protein_coding protein_coding 35.26354 28.10873 42.31206 4.718867 0.9804039 0.5898785 14.767840 12.775964 11.183492 2.3414050 0.53491106 -0.19190084 0.42369167 0.45150000 0.2640333 -0.18746667 1.189936e-05 9.574535e-17 FALSE TRUE
ENST00000530481 ENSG00000079819 HEK293_OSMI2_6hA HEK293_TMG_6hB EPB41L2 protein_coding protein_coding 35.26354 28.10873 42.31206 4.718867 0.9804039 0.5898785 1.542193 2.523172 2.443956 0.4046257 0.09773581 -0.04583557 0.05251250 0.09036667 0.0577000 -0.03266667 1.568880e-01 9.574535e-17 FALSE TRUE
ENST00000628542 ENSG00000079819 HEK293_OSMI2_6hA HEK293_TMG_6hB EPB41L2 protein_coding protein_coding 35.26354 28.10873 42.31206 4.718867 0.9804039 0.5898785 11.614398 9.354345 18.477983 2.7256251 0.65652147 0.98133782 0.32906250 0.31760000 0.4365000 0.11890000 4.440250e-01 9.574535e-17 FALSE TRUE
MSTRG.28960.21 ENSG00000079819 HEK293_OSMI2_6hA HEK293_TMG_6hB EPB41L2 protein_coding   35.26354 28.10873 42.31206 4.718867 0.9804039 0.5898785 1.314269 0.000000 3.208860 0.0000000 0.40136089 8.33040588 0.03047083 0.00000000 0.0760000 0.07600000 9.574535e-17 9.574535e-17 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000079819 E001 0.8098394 0.0168408311 1.171909e-01   6 130839347 130839349 3 - 0.110 0.387 2.317
ENSG00000079819 E002 0.8098394 0.0168408311 1.171909e-01   6 130839350 130839351 2 - 0.110 0.387 2.317
ENSG00000079819 E003 0.8098394 0.0168408311 1.171909e-01   6 130839352 130839352 1 - 0.110 0.387 2.317
ENSG00000079819 E004 520.8514997 0.0019676245 4.423669e-12 4.076112e-10 6 130839353 130839883 531 - 2.613 2.812 0.663
ENSG00000079819 E005 333.1852872 0.0060902982 1.723490e-04 2.361151e-03 6 130839884 130840134 251 - 2.426 2.612 0.617
ENSG00000079819 E006 102.5130188 0.0152852632 1.434063e-01 3.525502e-01 6 130840135 130840167 33 - 1.942 2.079 0.460
ENSG00000079819 E007 114.8078053 0.0075768171 2.742077e-01 5.141807e-01 6 130840168 130840168 1 - 2.018 2.100 0.274
ENSG00000079819 E008 130.3014921 0.0053071345 1.648716e-01 3.838476e-01 6 130840169 130840181 13 - 2.071 2.156 0.287
ENSG00000079819 E009 133.1885740 0.0032197445 8.707874e-02 2.584180e-01 6 130840182 130840187 6 - 2.080 2.166 0.288
ENSG00000079819 E010 287.4970281 0.0033642226 5.221681e-02 1.848652e-01 6 130840188 130840372 185 - 2.413 2.501 0.293
ENSG00000079819 E011 94.1784967 0.0027987953 1.720844e-02 8.621378e-02 6 130840373 130840375 3 - 1.915 2.036 0.406
ENSG00000079819 E012 313.2663316 0.0005284135 2.396065e-03 1.966209e-02 6 130840376 130840594 219 - 2.455 2.537 0.275
ENSG00000079819 E013 114.9776685 0.0006108111 7.380908e-02 2.323825e-01 6 130840595 130840598 4 - 2.028 2.102 0.248
ENSG00000079819 E014 112.0826220 0.0004778668 3.029411e-02 1.282440e-01 6 130858131 130858135 5 - 2.009 2.096 0.292
ENSG00000079819 E015 244.9767184 0.0001922673 4.706722e-02 1.726930e-01 6 130858136 130858224 89 - 2.359 2.418 0.196
ENSG00000079819 E016 161.0378092 0.0003233999 1.527830e-01 3.663484e-01 6 130858225 130858243 19 - 2.180 2.234 0.180
ENSG00000079819 E017 4.0634876 0.2426874188 7.634617e-02 2.374386e-01 6 130858244 130858328 85 - 0.443 0.891 1.935
ENSG00000079819 E018 273.8455105 0.0002079787 3.427475e-01 5.804330e-01 6 130863638 130863718 81 - 2.440 2.432 -0.026
ENSG00000079819 E019 307.0964542 0.0014986253 2.389522e-01 4.754101e-01 6 130865536 130865634 99 - 2.496 2.475 -0.070
ENSG00000079819 E020 1.3097971 0.1882967994 8.111428e-01   6 130865635 130865833 199 - 0.383 0.325 -0.351
ENSG00000079819 E021 304.1429522 0.0011222031 3.010812e-01 5.415393e-01 6 130867459 130867581 123 - 2.489 2.474 -0.051
ENSG00000079819 E022 12.1875310 0.1329749853 8.603213e-01 9.305467e-01 6 130867582 130868907 1326 - 1.112 1.115 0.009
ENSG00000079819 E023 232.2830813 0.0003700534 5.441805e-01 7.320877e-01 6 130869563 130869658 96 - 2.352 2.380 0.092
ENSG00000079819 E024 254.7793577 0.0024820506 1.493913e-01 3.613816e-01 6 130869659 130869811 153 - 2.379 2.437 0.194
ENSG00000079819 E025 142.5570474 0.0082450582 2.095255e-01 4.413276e-01 6 130869812 130869851 40 - 2.120 2.196 0.253
ENSG00000079819 E026 216.5593364 0.0038589554 6.518612e-01 8.046947e-01 6 130869852 130869944 93 - 2.340 2.334 -0.019
ENSG00000079819 E027 187.4683913 0.0057078656 6.051606e-01 7.736290e-01 6 130869945 130870038 94 - 2.280 2.269 -0.040
ENSG00000079819 E028 166.0725207 0.0002846573 6.286943e-01 7.896657e-01 6 130870039 130870076 38 - 2.208 2.235 0.088
ENSG00000079819 E029 172.6766029 0.0034134026 5.156904e-01 7.120528e-01 6 130870077 130870126 50 - 2.219 2.255 0.118
ENSG00000079819 E030 6.7016612 0.0436424426 6.383634e-01 7.959529e-01 6 130870328 130870381 54 - 0.916 0.851 -0.249
ENSG00000079819 E031 5.2910689 0.0617660435 6.302396e-02 2.095057e-01 6 130872371 130872538 168 - 0.912 0.593 -1.300
ENSG00000079819 E032 9.1797995 0.0632341952 4.523535e-01 6.674315e-01 6 130876674 130876775 102 - 1.051 0.934 -0.433
ENSG00000079819 E033 114.5904425 0.0058373740 2.229868e-04 2.926226e-03 6 130878104 130878250 147 - 1.962 2.155 0.647
ENSG00000079819 E034 9.1218949 0.0705889983 9.419636e-01 9.732370e-01 6 130878251 130878625 375 - 0.997 1.015 0.069
ENSG00000079819 E035 63.1372125 0.0009605371 2.461186e-06 6.262601e-05 6 130880144 130880206 63 - 1.685 1.915 0.777
ENSG00000079819 E036 3.6334161 0.1524413442 2.539610e-01 4.923351e-01 6 130880454 130880489 36 - 0.750 0.509 -1.053
ENSG00000079819 E037 12.1894341 0.2512751995 4.246990e-01 6.470621e-01 6 130880601 130881581 981 - 1.173 1.040 -0.480
ENSG00000079819 E038 21.1333918 0.2488733970 3.873278e-01 6.183845e-01 6 130881582 130883167 1586 - 1.385 1.284 -0.354
ENSG00000079819 E039 235.4226022 0.0004575774 1.525186e-02 7.901566e-02 6 130885096 130885268 173 - 2.391 2.344 -0.156
ENSG00000079819 E040 222.0795039 0.0002782037 8.572565e-03 5.192306e-02 6 130890294 130890466 173 - 2.368 2.317 -0.171
ENSG00000079819 E041 159.1508681 0.0003433473 2.394367e-01 4.759567e-01 6 130894344 130894441 98 - 2.210 2.189 -0.068
ENSG00000079819 E042 225.3296597 0.0023082446 3.607696e-02 1.444227e-01 6 130894967 130895119 153 - 2.372 2.321 -0.169
ENSG00000079819 E043 95.3208380 0.0005392655 1.676868e-02 8.461968e-02 6 130899491 130899493 3 - 2.010 1.933 -0.258
ENSG00000079819 E044 161.9738481 0.0008289610 9.757269e-03 5.707769e-02 6 130899494 130899552 59 - 2.235 2.169 -0.219
ENSG00000079819 E045 120.1191990 0.0006447765 2.061486e-03 1.747032e-02 6 130899553 130899574 22 - 2.117 2.025 -0.309
ENSG00000079819 E046 109.6765613 0.0009167433 6.912426e-04 7.369045e-03 6 130899575 130899578 4 - 2.085 1.974 -0.371
ENSG00000079819 E047 294.6269656 0.0004972769 8.025224e-04 8.303106e-03 6 130900962 130901180 219 - 2.493 2.430 -0.210
ENSG00000079819 E048 184.6751031 0.0002982389 1.219819e-02 6.724883e-02 6 130904465 130904540 76 - 2.289 2.235 -0.180
ENSG00000079819 E049 161.8217508 0.0014331691 1.005069e-03 9.952995e-03 6 130908821 130908863 43 - 2.250 2.155 -0.318
ENSG00000079819 E050 215.2823923 0.0002720332 6.809764e-05 1.084041e-03 6 130926605 130926709 105 - 2.369 2.282 -0.291
ENSG00000079819 E051 277.6530234 0.0005670097 2.817277e-06 7.035860e-05 6 130955105 130955272 168 - 2.486 2.386 -0.332
ENSG00000079819 E052 148.7032203 0.0003315977 1.468447e-03 1.339363e-02 6 130955273 130955317 45 - 2.209 2.126 -0.276
ENSG00000079819 E053 105.2500982 0.0004228023 8.371407e-02 2.522012e-01 6 130955994 130955997 4 - 2.046 1.998 -0.160
ENSG00000079819 E054 131.6622242 0.0003535133 1.073259e-01 2.945603e-01 6 130955998 130956024 27 - 2.136 2.098 -0.127
ENSG00000079819 E055 191.3504832 0.0003204601 2.378609e-04 3.087301e-03 6 130956025 130956103 79 - 2.318 2.233 -0.284
ENSG00000079819 E056 140.6819265 0.0005553121 3.005270e-04 3.735373e-03 6 130956104 130956131 28 - 2.192 2.090 -0.341
ENSG00000079819 E057 362.1622597 0.0003893550 9.916238e-06 2.081589e-04 6 130956132 130956499 368 - 2.590 2.513 -0.259
ENSG00000079819 E058 0.2027342 0.0321600421 4.050219e-01   6 130970283 130970483 201 - 0.000 0.134 10.266
ENSG00000079819 E059 0.0000000       6 130978605 130978796 192 -      
ENSG00000079819 E060 0.1426347 0.0319897391 5.863176e-01   6 131000620 131000767 148 - 0.110 0.000 -9.665
ENSG00000079819 E061 0.0000000       6 131013562 131013595 34 -      
ENSG00000079819 E062 0.0000000       6 131014103 131014191 89 -      
ENSG00000079819 E063 0.2027342 0.0321600421 4.050219e-01   6 131015281 131015333 53 - 0.000 0.134 10.266
ENSG00000079819 E064 0.0000000       6 131015819 131015842 24 -      
ENSG00000079819 E065 0.3807181 0.0299058903 8.916789e-01   6 131062380 131062576 197 - 0.110 0.134 0.317
ENSG00000079819 E066 19.6332869 0.0055736200 6.465425e-01 8.012098e-01 6 131063142 131063154 13 - 1.327 1.302 -0.089
ENSG00000079819 E067 82.2917112 0.0045288259 4.976162e-01 6.992147e-01 6 131063155 131063322 168 - 1.926 1.906 -0.068