ENSG00000079805

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359692 ENSG00000079805 HEK293_OSMI2_6hA HEK293_TMG_6hB DNM2 protein_coding protein_coding 101.0475 146.2931 62.58921 21.55303 1.180744 -1.224744 46.17134 76.78116 19.350419 13.734890 0.9712284 -1.9878301 0.4392708 0.51893333 0.30963333 -0.20930000 1.878653e-04 6.44688e-12 FALSE TRUE
ENST00000408974 ENSG00000079805 HEK293_OSMI2_6hA HEK293_TMG_6hB DNM2 protein_coding protein_coding 101.0475 146.2931 62.58921 21.55303 1.180744 -1.224744 13.81718 10.73696 17.996584 1.588171 1.3982962 0.7445956 0.1479292 0.07433333 0.28700000 0.21266667 6.446880e-12 6.44688e-12 FALSE TRUE
ENST00000585892 ENSG00000079805 HEK293_OSMI2_6hA HEK293_TMG_6hB DNM2 protein_coding protein_coding 101.0475 146.2931 62.58921 21.55303 1.180744 -1.224744 12.16472 21.36905 6.047779 4.985180 0.4440296 -1.8193371 0.1076583 0.14160000 0.09653333 -0.04506667 3.725020e-01 6.44688e-12 FALSE TRUE
MSTRG.16425.3 ENSG00000079805 HEK293_OSMI2_6hA HEK293_TMG_6hB DNM2 protein_coding   101.0475 146.2931 62.58921 21.55303 1.180744 -1.224744 14.09984 19.74351 11.366317 3.172857 0.5693130 -0.7960754 0.1496167 0.13430000 0.18173333 0.04743333 1.454025e-01 6.44688e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000079805 E001 1.2910658 1.311833e-02 9.496916e-01   19 10717958 10717991 34 + 0.314 0.337 0.145
ENSG00000079805 E002 2.5653757 1.192377e-02 5.083211e-01 7.067087e-01 19 10717992 10718000 9 + 0.414 0.549 0.675
ENSG00000079805 E003 7.0272047 5.741687e-02 4.987899e-01 6.999573e-01 19 10718001 10718054 54 + 0.760 0.899 0.541
ENSG00000079805 E004 11.4225144 3.777769e-02 4.322349e-01 6.529160e-01 19 10718055 10718078 24 + 0.952 1.080 0.468
ENSG00000079805 E005 13.9374298 1.006658e-01 9.197979e-01 9.620949e-01 19 10718079 10718091 13 + 1.151 1.120 -0.109
ENSG00000079805 E006 14.1087067 1.293355e-01 9.091404e-01 9.566429e-01 19 10718092 10718092 1 + 1.165 1.122 -0.155
ENSG00000079805 E007 138.2791137 9.732869e-03 2.030437e-06 5.291818e-05 19 10718093 10718207 115 + 1.829 2.159 1.105
ENSG00000079805 E008 397.0325419 2.187727e-03 2.458090e-03 2.005863e-02 19 10718208 10718403 196 + 2.459 2.576 0.388
ENSG00000079805 E009 0.0000000       19 10718561 10718646 86 +      
ENSG00000079805 E010 0.1308682 3.264919e-02 1.000000e+00   19 10755121 10755488 368 + 0.000 0.078 10.541
ENSG00000079805 E011 1.2200075 1.369686e-02 1.526210e-01   19 10759634 10759737 104 + 0.495 0.251 -1.442
ENSG00000079805 E012 370.1090904 1.479993e-04 3.518172e-01 5.888981e-01 19 10759738 10759811 74 + 2.517 2.518 0.002
ENSG00000079805 E013 0.3040503 2.744240e-02 3.964708e-02   19 10763099 10763616 518 + 0.314 0.000 -13.875
ENSG00000079805 E014 0.1723744 4.446844e-02 1.000000e+00   19 10768553 10768862 310 + 0.000 0.078 10.386
ENSG00000079805 E015 0.0000000       19 10769289 10769446 158 +      
ENSG00000079805 E016 724.2176822 1.658640e-04 7.905705e-13 8.251816e-11 19 10772479 10772628 150 + 2.872 2.783 -0.297
ENSG00000079805 E017 1044.7955912 1.016411e-03 4.504765e-10 2.787947e-08 19 10775703 10775906 204 + 3.037 2.937 -0.333
ENSG00000079805 E018 562.5882095 3.715916e-04 3.425254e-12 3.220858e-10 19 10777118 10777168 51 + 2.775 2.667 -0.361
ENSG00000079805 E019 589.5281263 1.326832e-03 7.215837e-05 1.138650e-03 19 10777169 10777216 48 + 2.773 2.696 -0.255
ENSG00000079805 E020 0.0000000       19 10781374 10781567 194 +      
ENSG00000079805 E021 0.1426347 3.219986e-02 1.663288e-01   19 10781568 10781795 228 + 0.185 0.000 -12.769
ENSG00000079805 E022 590.4586338 5.903535e-04 5.627773e-05 9.227820e-04 19 10782960 10783015 56 + 2.763 2.702 -0.202
ENSG00000079805 E023 682.2400722 9.621800e-04 7.817918e-02 2.411746e-01 19 10783016 10783120 105 + 2.796 2.777 -0.063
ENSG00000079805 E024 0.4644705 2.176816e-02 4.058581e-01   19 10786430 10786563 134 + 0.000 0.201 12.344
ENSG00000079805 E025 818.3128337 9.931680e-05 1.381144e-01 3.446426e-01 19 10786564 10786706 143 + 2.862 2.860 -0.005
ENSG00000079805 E026 0.7132229 1.022409e-01 4.858925e-01   19 10786707 10786741 35 + 0.314 0.198 -0.883
ENSG00000079805 E027 801.0988479 1.291764e-03 3.206273e-01 5.602360e-01 19 10793720 10793855 136 + 2.851 2.848 -0.010
ENSG00000079805 E028 0.1426347 3.219986e-02 1.663288e-01   19 10793856 10794734 879 + 0.185 0.000 -12.769
ENSG00000079805 E029 644.7006132 1.048500e-03 3.503282e-02 1.416721e-01 19 10795372 10795439 68 + 2.775 2.747 -0.091
ENSG00000079805 E030 31.5258544 9.558942e-02 6.772509e-01 8.209835e-01 19 10795440 10795715 276 + 1.382 1.484 0.349
ENSG00000079805 E031 43.3346140 8.105880e-02 6.567220e-01 8.077767e-01 19 10795716 10796060 345 + 1.519 1.617 0.336
ENSG00000079805 E032 582.8529222 2.135284e-04 2.945354e-12 2.799043e-10 19 10796061 10796199 139 + 2.597 2.747 0.499
ENSG00000079805 E033 222.2158232 2.003521e-03 1.426223e-44 3.510224e-41 19 10797380 10797518 139 + 2.565 2.129 -1.454
ENSG00000079805 E034 6.4681381 4.825909e-03 8.139938e-01 9.046489e-01 19 10798387 10798485 99 + 0.800 0.849 0.192
ENSG00000079805 E035 747.2717068 1.284596e-04 1.370005e-05 2.753680e-04 19 10798486 10798572 87 + 2.855 2.809 -0.150
ENSG00000079805 E036 752.1219939 1.004414e-04 2.184118e-04 2.876636e-03 19 10802288 10802358 71 + 2.850 2.815 -0.115
ENSG00000079805 E037 47.7957187 5.145350e-02 6.848661e-02 2.217064e-01 19 10802359 10803638 1280 + 1.775 1.572 -0.689
ENSG00000079805 E038 5.7834528 6.188640e-02 1.945737e-01 4.228108e-01 19 10803639 10803668 30 + 0.926 0.724 -0.790
ENSG00000079805 E039 43.9743288 1.349580e-01 2.650754e-01 5.044024e-01 19 10803669 10804912 1244 + 1.705 1.555 -0.508
ENSG00000079805 E040 45.4645603 1.015108e-01 1.201747e-01 3.161255e-01 19 10804980 10805915 936 + 1.769 1.540 -0.777
ENSG00000079805 E041 703.2748179 7.902370e-04 6.608626e-02 2.162909e-01 19 10805916 10805967 52 + 2.806 2.788 -0.060
ENSG00000079805 E042 16.0524736 2.143985e-02 2.704174e-01 5.103983e-01 19 10808519 10808568 50 + 1.257 1.145 -0.397
ENSG00000079805 E043 137.4155974 3.515975e-04 6.692298e-01 8.157290e-01 19 10808569 10808580 12 + 2.062 2.097 0.118
ENSG00000079805 E044 49.9274121 7.810713e-02 2.228447e-01 4.568174e-01 19 10808581 10809207 627 + 1.763 1.606 -0.533
ENSG00000079805 E045 228.0070661 6.397908e-02 5.461486e-01 7.335616e-01 19 10809208 10812263 3056 + 2.342 2.292 -0.169
ENSG00000079805 E046 928.3027342 2.198571e-04 8.820810e-04 8.948485e-03 19 10812264 10812377 114 + 2.935 2.906 -0.096
ENSG00000079805 E047 988.4088979 1.424243e-03 6.523950e-01 8.049848e-01 19 10819980 10820089 110 + 2.934 2.943 0.032
ENSG00000079805 E048 2.4223086 9.016745e-03 2.375615e-01 4.737821e-01 19 10823224 10823787 564 + 0.315 0.550 1.259
ENSG00000079805 E049 1039.9164096 8.077215e-05 8.111481e-01 9.029517e-01 19 10823788 10823899 112 + 2.952 2.969 0.057
ENSG00000079805 E050 4.1523544 1.418607e-02 8.131926e-01 9.041558e-01 19 10823900 10824806 907 + 0.623 0.674 0.222
ENSG00000079805 E051 1271.9110913 6.828483e-05 7.761905e-01 8.824607e-01 19 10825057 10825221 165 + 3.040 3.057 0.056
ENSG00000079805 E052 776.7033528 1.047888e-04 4.205177e-01 6.440597e-01 19 10829036 10829111 76 + 2.814 2.846 0.107
ENSG00000079805 E053 892.6664213 9.052128e-04 8.800522e-04 8.931104e-03 19 10829112 10829268 157 + 2.832 2.919 0.288
ENSG00000079805 E054 872.0305651 3.031351e-03 7.348783e-10 4.388159e-08 19 10830127 10830337 211 + 2.723 2.934 0.699
ENSG00000079805 E055 462.5576045 5.343941e-03 1.938891e-06 5.078950e-05 19 10830338 10830378 41 + 2.440 2.661 0.736
ENSG00000079805 E056 11.9231425 1.116724e-01 8.393023e-01 9.190107e-01 19 10830379 10830534 156 + 1.067 1.063 -0.013
ENSG00000079805 E057 231.3188972 3.337223e-03 4.816379e-05 8.055269e-04 19 10830978 10830980 3 + 2.170 2.355 0.617
ENSG00000079805 E058 1851.7346883 2.090274e-03 1.274122e-14 1.836801e-12 19 10830981 10831903 923 + 3.057 3.259 0.673
ENSG00000079805 E059 350.5151114 1.408904e+00 5.006052e-01 7.011900e-01 19 10832304 10832991 688 + 2.333 2.537 0.679
ENSG00000079805 E060 217.4347449 1.145835e-01 3.855880e-01 6.169080e-01 19 10832992 10833488 497 + 2.202 2.312 0.369