ENSG00000079462

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262890 ENSG00000079462 HEK293_OSMI2_6hA HEK293_TMG_6hB PAFAH1B3 protein_coding protein_coding 95.70887 144.5885 41.64033 32.23239 1.396358 -1.795653 46.72808 71.43435 16.834957 16.401661 1.1577655 -2.084503 0.4801417 0.4930000 0.4033333 -0.08966667 0.121270145 0.002792028 FALSE TRUE
ENST00000538771 ENSG00000079462 HEK293_OSMI2_6hA HEK293_TMG_6hB PAFAH1B3 protein_coding protein_coding 95.70887 144.5885 41.64033 32.23239 1.396358 -1.795653 22.97956 35.99737 8.119576 7.421618 0.3281723 -2.147040 0.2273833 0.2513667 0.1949333 -0.05643333 0.075864994 0.002792028 FALSE TRUE
ENST00000595530 ENSG00000079462 HEK293_OSMI2_6hA HEK293_TMG_6hB PAFAH1B3 protein_coding protein_coding 95.70887 144.5885 41.64033 32.23239 1.396358 -1.795653 19.64253 28.73788 14.278988 7.171772 0.4507715 -1.008552 0.2219458 0.1952000 0.3444333 0.14923333 0.002792028 0.002792028 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000079462 E001 1.8014818 0.3840524097 1.000000e+00 1.000000e+00 19 42297033 42297034 2 - 0.377 0.383 0.032
ENSG00000079462 E002 4.5743886 0.1710931348 9.853944e-01 9.944888e-01 19 42297035 42297035 1 - 0.652 0.646 -0.027
ENSG00000079462 E003 485.8973465 0.0001527643 4.536871e-02 1.684960e-01 19 42297036 42297279 244 - 2.512 2.581 0.228
ENSG00000079462 E004 432.6352750 0.0001553431 7.528137e-01 8.684564e-01 19 42297280 42297315 36 - 2.493 2.525 0.107
ENSG00000079462 E005 511.0023494 0.0044657185 7.192003e-01 8.476773e-01 19 42297316 42297365 50 - 2.575 2.587 0.041
ENSG00000079462 E006 7.2052016 0.0804771168 2.034148e-02 9.709515e-02 19 42299917 42299969 53 - 1.097 0.707 -1.487
ENSG00000079462 E007 528.7051658 0.0063236508 9.420726e-02 2.715542e-01 19 42299970 42300008 39 - 2.634 2.592 -0.140
ENSG00000079462 E008 497.0155174 0.0040980397 3.928962e-03 2.874868e-02 19 42300009 42300041 33 - 2.636 2.559 -0.258
ENSG00000079462 E009 603.6134981 0.0047958616 9.813740e-03 5.732265e-02 19 42300042 42300088 47 - 2.711 2.645 -0.218
ENSG00000079462 E010 401.3166570 0.0002022497 1.345983e-06 3.678449e-05 19 42300089 42300092 4 - 2.554 2.472 -0.276
ENSG00000079462 E011 14.9736001 0.1205516181 2.173576e-01 4.502543e-01 19 42300093 42300170 78 - 1.260 1.039 -0.789
ENSG00000079462 E012 776.6784240 0.0001852030 1.099344e-03 1.066509e-02 19 42300171 42300287 117 - 2.796 2.767 -0.097
ENSG00000079462 E013 617.5013361 0.0001213214 5.498349e-03 3.720845e-02 19 42301950 42302039 90 - 2.608 2.686 0.259
ENSG00000079462 E014 589.8877246 1.3125664966 4.523293e-01 6.674292e-01 19 42302232 42302325 94 - 2.485 2.673 0.626
ENSG00000079462 E015 318.1355345 1.0740687177 4.235370e-01 6.462726e-01 19 42302326 42302436 111 - 2.222 2.405 0.609
ENSG00000079462 E016 392.7285331 0.3399148222 2.003495e-01 4.301765e-01 19 42302437 42302698 262 - 2.284 2.500 0.720
ENSG00000079462 E017 29.0212677 0.0015008252 3.489625e-01 5.863640e-01 19 42302699 42302786 88 - 1.272 1.379 0.373
ENSG00000079462 E018 0.1723744 0.0706590401 1.000000e+00   19 42303468 42303546 79 - 0.001 0.060 6.372