ENSG00000079435

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000597620 ENSG00000079435 HEK293_OSMI2_6hA HEK293_TMG_6hB LIPE protein_coding protein_coding 3.944545 5.857186 2.309111 1.160242 0.3125331 -1.339097 1.62873206 2.7992941 0.2650239 0.6000412 0.1848691 -3.352579 0.37695417 0.47356667 0.1134000 -0.36016667 1.769071e-01 6.732458e-09 FALSE TRUE
ENST00000599211 ENSG00000079435 HEK293_OSMI2_6hA HEK293_TMG_6hB LIPE protein_coding protein_coding 3.944545 5.857186 2.309111 1.160242 0.3125331 -1.339097 0.32899778 0.3042557 0.0000000 0.3042557 0.0000000 -4.973867 0.07774167 0.04096667 0.0000000 -0.04096667 9.493500e-01 6.732458e-09 FALSE FALSE
ENST00000599918 ENSG00000079435 HEK293_OSMI2_6hA HEK293_TMG_6hB LIPE protein_coding protein_coding 3.944545 5.857186 2.309111 1.160242 0.3125331 -1.339097 0.19861230 0.0000000 0.9685491 0.0000000 0.3299021 6.612572 0.06125000 0.00000000 0.3955333 0.39553333 6.732458e-09 6.732458e-09 FALSE TRUE
ENST00000600224 ENSG00000079435 HEK293_OSMI2_6hA HEK293_TMG_6hB LIPE protein_coding retained_intron 3.944545 5.857186 2.309111 1.160242 0.3125331 -1.339097 0.04290017 0.0000000 0.1007127 0.0000000 0.1007127 3.468749 0.01500833 0.00000000 0.0598000 0.05980000 7.811120e-01 6.732458e-09 FALSE FALSE
ENST00000602000 ENSG00000079435 HEK293_OSMI2_6hA HEK293_TMG_6hB LIPE protein_coding processed_transcript 3.944545 5.857186 2.309111 1.160242 0.3125331 -1.339097 0.34567506 0.1408357 0.3046310 0.1408357 0.1557356 1.060683 0.08456250 0.03920000 0.1161667 0.07696667 6.257441e-01 6.732458e-09   FALSE
MSTRG.17236.1 ENSG00000079435 HEK293_OSMI2_6hA HEK293_TMG_6hB LIPE protein_coding   3.944545 5.857186 2.309111 1.160242 0.3125331 -1.339097 1.27360789 2.6128002 0.5524599 0.5262669 0.1462355 -2.221286 0.33459583 0.44623333 0.2701667 -0.17606667 5.127939e-01 6.732458e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000079435 E001 0.3559677 0.6399241702 0.053944366   19 42400811 42401513 703 - 0.408 0.000 -12.155
ENSG00000079435 E002 1.5825418 0.0120992332 0.625725970 0.78770264 19 42401514 42401815 302 - 0.244 0.351 0.721
ENSG00000079435 E003 22.0289760 0.0017872476 0.010522488 0.06035194 19 42401816 42402036 221 - 0.968 1.259 1.049
ENSG00000079435 E004 16.6987216 0.0022934391 0.429714759 0.65079489 19 42402037 42402075 39 - 1.033 1.124 0.330
ENSG00000079435 E005 24.7627406 0.0016245283 0.015714448 0.08077440 19 42402607 42402672 66 - 1.437 1.238 -0.693
ENSG00000079435 E006 60.9685888 0.0007579679 0.008076248 0.04966981 19 42402673 42403031 359 - 1.771 1.630 -0.475
ENSG00000079435 E007 0.5587019 0.4578716741 0.110945590   19 42403032 42403055 24 - 0.406 0.058 -3.440
ENSG00000079435 E008 31.8362554 0.0015117142 0.939192445 0.97189644 19 42405385 42405561 177 - 1.373 1.379 0.022
ENSG00000079435 E009 0.3559677 0.6399241702 0.053944366   19 42405562 42405906 345 - 0.408 0.000 -14.577
ENSG00000079435 E010 32.2364498 0.0013400659 0.829341241 0.91342641 19 42406161 42406388 228 - 1.399 1.384 -0.054
ENSG00000079435 E011 39.3127729 0.0197843141 0.278295220 0.51843151 19 42407174 42407399 226 - 1.361 1.480 0.411
ENSG00000079435 E012 17.7978968 0.0021440444 0.618903705 0.78305344 19 42407400 42407468 69 - 1.090 1.146 0.202
ENSG00000079435 E013 30.7610842 0.0012346858 0.358846754 0.59486580 19 42407606 42407791 186 - 1.297 1.377 0.277
ENSG00000079435 E014 24.5795450 0.0780587347 0.601578648 0.77117181 19 42407976 42408086 111 - 1.237 1.280 0.150
ENSG00000079435 E015 15.3640248 0.0032196607 0.771183204 0.87937638 19 42408087 42408094 8 - 1.062 1.095 0.121
ENSG00000079435 E016 16.5529844 0.0224955449 0.553356312 0.73861440 19 42408095 42408121 27 - 1.060 1.131 0.256
ENSG00000079435 E017 21.7289802 0.0105624719 0.767630222 0.87720977 19 42408232 42408310 79 - 1.204 1.230 0.091
ENSG00000079435 E018 12.1236135 0.0064757914 0.657736703 0.80848023 19 42408311 42408322 12 - 1.032 0.975 -0.210
ENSG00000079435 E019 30.4034764 0.0016238483 0.272296289 0.51220838 19 42410307 42410581 275 - 1.280 1.378 0.342
ENSG00000079435 E020 37.0596968 0.0197488546 0.829137207 0.91331365 19 42410582 42410842 261 - 1.451 1.440 -0.040
ENSG00000079435 E021 0.0000000       19 42412274 42412364 91 -      
ENSG00000079435 E022 0.1308682 0.0326491905 1.000000000   19 42412365 42412448 84 - 0.000 0.056 10.082
ENSG00000079435 E023 0.3032425 0.0274424043 1.000000000   19 42422993 42423222 230 - 0.000 0.106 11.054
ENSG00000079435 E024 28.2693964 0.0017078387 0.632842848 0.79218126 19 42423419 42424123 705 - 1.359 1.320 -0.135
ENSG00000079435 E025 0.0000000       19 42426267 42427388 1122 -