ENSG00000078674

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325083 ENSG00000078674 HEK293_OSMI2_6hA HEK293_TMG_6hB PCM1 protein_coding protein_coding 16.43441 7.453982 27.9048 0.1459906 2.064231 1.903013 2.4433193 0.89865298 4.7037186 0.48120787 0.78471071 2.3750643 0.12203333 0.119733333 0.16660000 0.04686667 8.468163e-01 2.300944e-10 FALSE TRUE
ENST00000517836 ENSG00000078674 HEK293_OSMI2_6hA HEK293_TMG_6hB PCM1 protein_coding retained_intron 16.43441 7.453982 27.9048 0.1459906 2.064231 1.903013 1.5403689 0.00000000 3.9286133 0.00000000 0.65076356 8.6215440 0.06260000 0.000000000 0.14236667 0.14236667 6.295006e-10 2.300944e-10 FALSE TRUE
ENST00000521338 ENSG00000078674 HEK293_OSMI2_6hA HEK293_TMG_6hB PCM1 protein_coding retained_intron 16.43441 7.453982 27.9048 0.1459906 2.064231 1.903013 0.6525467 0.75299740 0.6705271 0.10462251 0.21166155 -0.1650256 0.06210000 0.101600000 0.02410000 -0.07750000 7.850506e-03 2.300944e-10 FALSE FALSE
ENST00000522275 ENSG00000078674 HEK293_OSMI2_6hA HEK293_TMG_6hB PCM1 protein_coding protein_coding 16.43441 7.453982 27.9048 0.1459906 2.064231 1.903013 0.7843674 0.77097038 0.1764861 0.43863243 0.02412133 -2.0661996 0.11113750 0.102333333 0.00650000 -0.09583333 5.214899e-01 2.300944e-10 FALSE TRUE
ENST00000524203 ENSG00000078674 HEK293_OSMI2_6hA HEK293_TMG_6hB PCM1 protein_coding processed_transcript 16.43441 7.453982 27.9048 0.1459906 2.064231 1.903013 1.1431809 1.76182346 1.3116607 0.15299060 1.06927916 -0.4228830 0.10959583 0.237300000 0.04383333 -0.19346667 3.018775e-01 2.300944e-10 FALSE FALSE
ENST00000524356 ENSG00000078674 HEK293_OSMI2_6hA HEK293_TMG_6hB PCM1 protein_coding retained_intron 16.43441 7.453982 27.9048 0.1459906 2.064231 1.903013 0.5522189 0.00000000 1.7947469 0.00000000 0.46957312 7.4956527 0.02503750 0.000000000 0.06520000 0.06520000 1.923334e-05 2.300944e-10 FALSE FALSE
MSTRG.31218.1 ENSG00000078674 HEK293_OSMI2_6hA HEK293_TMG_6hB PCM1 protein_coding   16.43441 7.453982 27.9048 0.1459906 2.064231 1.903013 0.7856843 0.05349404 1.5628250 0.03063509 0.22894337 4.6305931 0.03401250 0.007133333 0.05770000 0.05056667 8.461523e-03 2.300944e-10 FALSE TRUE
MSTRG.31218.12 ENSG00000078674 HEK293_OSMI2_6hA HEK293_TMG_6hB PCM1 protein_coding   16.43441 7.453982 27.9048 0.1459906 2.064231 1.903013 1.2105050 1.20527593 0.9247536 0.37369820 0.92475362 -0.3786259 0.07748750 0.159933333 0.02980000 -0.13013333 2.058471e-01 2.300944e-10 FALSE TRUE
MSTRG.31218.13 ENSG00000078674 HEK293_OSMI2_6hA HEK293_TMG_6hB PCM1 protein_coding   16.43441 7.453982 27.9048 0.1459906 2.064231 1.903013 1.2830479 0.00000000 2.2444189 0.00000000 0.30962510 7.8166118 0.05028333 0.000000000 0.07993333 0.07993333 2.300944e-10 2.300944e-10 FALSE TRUE
MSTRG.31218.5 ENSG00000078674 HEK293_OSMI2_6hA HEK293_TMG_6hB PCM1 protein_coding   16.43441 7.453982 27.9048 0.1459906 2.064231 1.903013 1.8860371 0.45668479 4.7791684 0.22930370 0.87325513 3.3592548 0.09965417 0.062300000 0.17796667 0.11566667 6.150549e-01 2.300944e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000078674 E001 2.3490056 0.0844698416 5.098643e-01 7.078932e-01 8 17922941 17922957 17 + 0.491 0.344 -0.801
ENSG00000078674 E002 1.9930379 0.0146707737 6.380299e-01 7.957433e-01 8 17922958 17922967 10 + 0.436 0.343 -0.522
ENSG00000078674 E003 2.9736744 0.0276511743 2.419772e-01 4.787586e-01 8 17922968 17922987 20 + 0.577 0.343 -1.204
ENSG00000078674 E004 2.5989257 0.0087061497 3.263853e-01 5.655717e-01 8 17922988 17922989 2 + 0.534 0.343 -1.006
ENSG00000078674 E005 2.5989257 0.0087061497 3.263853e-01 5.655717e-01 8 17922990 17922991 2 + 0.534 0.343 -1.006
ENSG00000078674 E006 3.0643917 0.0074349636 1.900826e-01 4.170324e-01 8 17922992 17922997 6 + 0.595 0.343 -1.285
ENSG00000078674 E007 4.2252249 0.0064909911 4.977388e-02 1.791071e-01 8 17922998 17922998 1 + 0.712 0.343 -1.784
ENSG00000078674 E008 12.4513316 0.0031595821 2.500733e-03 2.033820e-02 8 17922999 17923005 7 + 1.123 0.718 -1.539
ENSG00000078674 E009 14.0148704 0.0043034452 1.148155e-02 6.431688e-02 8 17923006 17923009 4 + 1.160 0.847 -1.160
ENSG00000078674 E010 20.4759190 0.0145868704 1.609747e-02 8.215784e-02 8 17923010 17923027 18 + 1.314 1.026 -1.025
ENSG00000078674 E011 50.5293454 0.0007110904 1.091395e-03 1.061109e-02 8 17923028 17923188 161 + 1.679 1.467 -0.726
ENSG00000078674 E012 34.4342834 0.0033030861 5.617064e-02 1.940215e-01 8 17924713 17924743 31 + 1.507 1.355 -0.524
ENSG00000078674 E013 32.3770322 0.0016228485 1.733444e-03 1.525357e-02 8 17924744 17924780 37 + 1.497 1.237 -0.903
ENSG00000078674 E014 0.6129023 0.0190684206 9.054250e-01   8 17924781 17927953 3173 + 0.181 0.205 0.215
ENSG00000078674 E015 3.8644556 0.0065118774 1.390881e-02 7.398006e-02 8 17934706 17934858 153 + 0.697 0.205 -2.720
ENSG00000078674 E016 64.2778234 0.0080599824 9.143612e-05 1.386301e-03 8 17935589 17935706 118 + 1.792 1.493 -1.018
ENSG00000078674 E017 44.9651059 0.0130864854 1.164890e-02 6.502701e-02 8 17937134 17937175 42 + 1.633 1.400 -0.799
ENSG00000078674 E018 93.6369629 0.0008903543 6.636060e-10 3.997714e-08 8 17937176 17937379 204 + 1.957 1.635 -1.088
ENSG00000078674 E019 65.6620683 0.0006569052 1.980475e-11 1.623215e-09 8 17938740 17938838 99 + 1.817 1.389 -1.460
ENSG00000078674 E020 81.5455973 0.0012858593 5.276471e-11 3.950909e-09 8 17938839 17939009 171 + 1.905 1.525 -1.288
ENSG00000078674 E021 0.4514866 0.0217681645 6.423930e-01   8 17939010 17939016 7 + 0.129 0.205 0.800
ENSG00000078674 E022 68.2605826 0.0006489158 4.389088e-05 7.447668e-04 8 17939691 17939861 171 + 1.810 1.577 -0.791
ENSG00000078674 E023 24.1673281 0.0017776255 8.910791e-02 2.621305e-01 8 17940042 17940158 117 + 1.360 1.206 -0.541
ENSG00000078674 E024 5.2927006 0.0143953359 5.941948e-02 2.015096e-01 8 17941647 17941835 189 + 0.791 0.449 -1.515
ENSG00000078674 E025 66.9090386 0.0006707585 3.866046e-05 6.696691e-04 8 17947186 17947363 178 + 1.802 1.563 -0.810
ENSG00000078674 E026 61.4843128 0.0006713840 7.562788e-03 4.732434e-02 8 17950615 17950724 110 + 1.753 1.597 -0.529
ENSG00000078674 E027 119.3727949 0.0259276432 3.479990e-02 1.410661e-01 8 17952970 17953186 217 + 2.042 1.844 -0.665
ENSG00000078674 E028 107.2775916 0.0007468396 2.086328e-05 3.960196e-04 8 17955470 17955653 184 + 1.997 1.800 -0.663
ENSG00000078674 E029 1.7673182 0.0139011346 2.975787e-01 5.380715e-01 8 17955654 17955955 302 + 0.345 0.532 0.991
ENSG00000078674 E030 93.9763336 0.0004573067 3.788616e-05 6.583384e-04 8 17956604 17956777 174 + 1.940 1.742 -0.669
ENSG00000078674 E031 98.4396616 0.0019437777 2.029495e-02 9.692209e-02 8 17957264 17957421 158 + 1.945 1.828 -0.395
ENSG00000078674 E032 3.3296963 0.0080247377 3.711021e-01 6.047910e-01 8 17957537 17957539 3 + 0.614 0.448 -0.781
ENSG00000078674 E033 78.4676876 0.0086046543 3.351151e-01 5.736804e-01 8 17957540 17957657 118 + 1.841 1.775 -0.225
ENSG00000078674 E034 81.8749809 0.0005980136 4.508876e-03 3.198065e-02 8 17957658 17957775 118 + 1.876 1.732 -0.484
ENSG00000078674 E035 74.4676552 0.0008341842 8.159081e-04 8.411765e-03 8 17960014 17960093 80 + 1.840 1.659 -0.614
ENSG00000078674 E036 81.1721373 0.0005014247 4.419064e-05 7.491850e-04 8 17960094 17960165 72 + 1.882 1.670 -0.715
ENSG00000078674 E037 100.5768932 0.0030736913 1.457450e-03 1.331980e-02 8 17960315 17960444 130 + 1.967 1.795 -0.578
ENSG00000078674 E038 89.7618535 0.0023762565 3.593112e-03 2.689378e-02 8 17962034 17962174 141 + 1.912 1.752 -0.537
ENSG00000078674 E039 0.6600180 0.0193874923 3.547334e-01   8 17962175 17962213 39 + 0.228 0.000 -9.892
ENSG00000078674 E040 1.1137175 0.0147067278 6.063228e-01   8 17962953 17963100 148 + 0.309 0.205 -0.785
ENSG00000078674 E041 111.4307529 0.0003680594 2.101801e-04 2.786154e-03 8 17963101 17963291 191 + 2.008 1.847 -0.542
ENSG00000078674 E042 137.0031497 0.0002915604 3.202463e-03 2.461677e-02 8 17964568 17964768 201 + 2.089 1.975 -0.381
ENSG00000078674 E043 0.9029733 0.0404744922 5.544546e-01   8 17964769 17964770 2 + 0.228 0.342 0.794
ENSG00000078674 E044 148.4589006 0.0026538971 7.162315e-02 2.280759e-01 8 17965999 17966218 220 + 2.117 2.040 -0.261
ENSG00000078674 E045 105.4308927 0.0016855733 1.013723e-01 2.843116e-01 8 17966328 17966473 146 + 1.971 1.895 -0.257
ENSG00000078674 E046 102.8706404 0.0006848273 3.732869e-01 6.067332e-01 8 17966980 17967170 191 + 1.950 1.909 -0.138
ENSG00000078674 E047 0.3337900 0.0319046101 3.566570e-01   8 17969423 17969576 154 + 0.069 0.205 1.803
ENSG00000078674 E048 101.2205577 0.0005666111 6.826145e-01 8.243518e-01 8 17969577 17969748 172 + 1.931 1.946 0.050
ENSG00000078674 E049 148.7651002 0.0003062701 7.391808e-01 8.598704e-01 8 17972329 17972582 254 + 2.099 2.107 0.029
ENSG00000078674 E050 96.4264236 0.0004328215 6.289346e-01 7.897833e-01 8 17972583 17972672 90 + 1.910 1.928 0.060
ENSG00000078674 E051 47.6316150 0.0010244478 2.538288e-01 4.922008e-01 8 17972673 17972687 15 + 1.599 1.664 0.222
ENSG00000078674 E052 0.1426347 0.0321619153 1.000000e+00   8 17980221 17980590 370 + 0.069 0.000 -7.889
ENSG00000078674 E053 38.1676301 0.0011326377 4.381636e-01 6.573635e-01 8 17980591 17980755 165 + 1.513 1.562 0.168
ENSG00000078674 E054 0.0000000       8 17982540 17982637 98 +      
ENSG00000078674 E055 3.9690598 0.0067442784 2.196440e-01 4.529952e-01 8 17983233 17983289 57 + 0.576 0.765 0.802
ENSG00000078674 E056 117.8955286 0.0006325082 9.984920e-01 1.000000e+00 8 17985447 17985619 173 + 2.001 1.999 -0.007
ENSG00000078674 E057 140.7163378 0.0003526099 7.105912e-01 8.422002e-01 8 17985959 17986087 129 + 2.074 2.084 0.035
ENSG00000078674 E058 1.5767104 0.0347479842 2.210365e-01 4.547138e-01 8 17986088 17986263 176 + 0.308 0.533 1.221
ENSG00000078674 E059 127.8667299 0.0005494965 5.489821e-01 7.356182e-01 8 17989859 17989979 121 + 2.031 2.051 0.067
ENSG00000078674 E060 121.6345796 0.0006120945 1.743378e-02 8.704520e-02 8 17991542 17991676 135 + 1.992 2.080 0.293
ENSG00000078674 E061 41.9711109 0.0032640136 2.500365e-01 4.879842e-01 8 17991677 17991700 24 + 1.540 1.616 0.258
ENSG00000078674 E062 101.3511831 0.0005538436 2.459883e-05 4.553142e-04 8 17993483 17993619 137 + 1.892 2.058 0.554
ENSG00000078674 E063 4.9514906 0.0708429627 7.563634e-04 7.910815e-03 8 18006054 18006250 197 + 0.489 1.060 2.330
ENSG00000078674 E064 7.9760256 0.0065040725 3.616459e-01 5.970233e-01 8 18006251 18006262 12 + 0.859 0.974 0.435
ENSG00000078674 E065 97.9383719 0.0015874423 5.851347e-02 1.994367e-01 8 18006263 18006397 135 + 1.902 1.985 0.277
ENSG00000078674 E066 137.7653562 0.0004258573 5.484225e-07 1.680223e-05 8 18009547 18009744 198 + 2.023 2.191 0.563
ENSG00000078674 E067 95.9940614 0.0004626568 8.510100e-06 1.824070e-04 8 18010609 18010668 60 + 1.865 2.041 0.594
ENSG00000078674 E068 155.2375008 0.0003058250 1.705720e-06 4.538867e-05 8 18011237 18011366 130 + 2.078 2.228 0.502
ENSG00000078674 E069 172.6243348 0.0002896652 6.671638e-09 3.250852e-07 8 18011667 18011827 161 + 2.119 2.290 0.573
ENSG00000078674 E070 0.3150090 0.0304538146 3.555278e-01   8 18013828 18013881 54 + 0.069 0.205 1.805
ENSG00000078674 E071 0.1426347 0.0321619153 1.000000e+00   8 18013882 18013963 82 + 0.069 0.000 -7.889
ENSG00000078674 E072 102.1096291 0.0011415435 1.193169e-06 3.308745e-05 8 18013964 18013987 24 + 1.885 2.080 0.654
ENSG00000078674 E073 124.2202203 0.0046058623 3.766723e-05 6.552984e-04 8 18013988 18014036 49 + 1.971 2.158 0.629
ENSG00000078674 E074 221.8069223 0.0002913155 2.094285e-16 3.833939e-14 8 18014584 18014840 257 + 2.212 2.426 0.713
ENSG00000078674 E075 3.0342335 0.1382295901 1.623681e-02 8.266836e-02 8 18015701 18015795 95 + 0.374 0.860 2.189
ENSG00000078674 E076 3.5525942 0.0075188327 4.942001e-05 8.233743e-04 8 18024951 18025360 410 + 0.377 0.974 2.607
ENSG00000078674 E077 131.2012361 0.0018059856 2.007638e-06 5.241830e-05 8 18025361 18025453 93 + 1.994 2.176 0.608
ENSG00000078674 E078 117.3559545 0.0004270470 4.330259e-06 1.016698e-04 8 18025544 18025658 115 + 1.953 2.120 0.557
ENSG00000078674 E079 147.2999128 0.0003901090 3.799406e-11 2.935517e-09 8 18027637 18029948 2312 + 2.040 2.251 0.705