ENSG00000078403

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307729 ENSG00000078403 HEK293_OSMI2_6hA HEK293_TMG_6hB MLLT10 protein_coding protein_coding 15.54435 13.15111 18.47214 1.434636 0.3726603 0.4898503 0.3222627 0.09019176 1.733819 0.09019176 0.4792651 4.1214143 0.01842917 0.005633333 0.09326667 0.08763333 3.686158e-02 5.488754e-20 FALSE TRUE
ENST00000377100 ENSG00000078403 HEK293_OSMI2_6hA HEK293_TMG_6hB MLLT10 protein_coding protein_coding 15.54435 13.15111 18.47214 1.434636 0.3726603 0.4898503 1.5142014 1.71939785 0.000000 0.07409093 0.0000000 -7.4341260 0.10472917 0.132633333 0.00000000 -0.13263333 5.488754e-20 5.488754e-20 FALSE TRUE
ENST00000652497 ENSG00000078403 HEK293_OSMI2_6hA HEK293_TMG_6hB MLLT10 protein_coding protein_coding 15.54435 13.15111 18.47214 1.434636 0.3726603 0.4898503 6.2639016 6.69931487 4.761280 0.88088136 0.1180306 -0.4917891 0.40837500 0.507466667 0.25770000 -0.24976667 9.925056e-09 5.488754e-20 FALSE TRUE
MSTRG.3647.10 ENSG00000078403 HEK293_OSMI2_6hA HEK293_TMG_6hB MLLT10 protein_coding   15.54435 13.15111 18.47214 1.434636 0.3726603 0.4898503 2.0179256 0.42414257 3.378674 0.21245226 0.3147191 2.9644803 0.12668333 0.036200000 0.18340000 0.14720000 2.908342e-01 5.488754e-20 FALSE TRUE
MSTRG.3647.11 ENSG00000078403 HEK293_OSMI2_6hA HEK293_TMG_6hB MLLT10 protein_coding   15.54435 13.15111 18.47214 1.434636 0.3726603 0.4898503 0.7888153 0.77016548 1.479288 0.23802559 0.3154756 0.9327706 0.05231667 0.057433333 0.08010000 0.02266667 8.298383e-01 5.488754e-20 FALSE TRUE
MSTRG.3647.14 ENSG00000078403 HEK293_OSMI2_6hA HEK293_TMG_6hB MLLT10 protein_coding   15.54435 13.15111 18.47214 1.434636 0.3726603 0.4898503 1.5675014 0.80284715 4.183575 0.29691778 0.6816685 2.3671245 0.09592083 0.058933333 0.22770000 0.16876667 7.068894e-02 5.488754e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000078403 E001 1.2623215 0.0132497520 8.072868e-01   10 21524646 21524674 29 + 0.345 0.307 -0.241
ENSG00000078403 E002 2.2263899 0.0090630220 2.021421e-01 4.322765e-01 10 21524675 21524775 101 + 0.535 0.307 -1.241
ENSG00000078403 E003 0.1614157 0.0324123721 1.000000e+00   10 21533349 21533841 493 + 0.080 0.000 -10.840
ENSG00000078403 E004 2.8509501 0.0087192246 2.884327e-03 2.271178e-02 10 21534232 21534344 113 + 0.346 0.823 2.218
ENSG00000078403 E005 2.3449734 0.0096765512 3.183910e-02 1.327255e-01 10 21534345 21534439 95 + 0.346 0.709 1.758
ENSG00000078403 E006 0.0000000       10 21534440 21534440 1 +      
ENSG00000078403 E007 2.0936322 0.4538450428 1.232106e-01 3.208365e-01 10 21534441 21534451 11 + 0.305 0.684 1.910
ENSG00000078403 E008 10.2530775 0.0189265614 6.094420e-03 4.018375e-02 10 21534452 21534465 14 + 0.875 1.217 1.254
ENSG00000078403 E009 11.9618734 0.0031407689 6.359243e-05 1.023433e-03 10 21534466 21534467 2 + 0.908 1.313 1.462
ENSG00000078403 E010 25.5274428 0.0018319175 5.265689e-06 1.205006e-04 10 21534468 21534475 8 + 1.251 1.586 1.160
ENSG00000078403 E011 32.4133672 0.0022182005 2.175273e-06 5.617570e-05 10 21534476 21534489 14 + 1.360 1.679 1.096
ENSG00000078403 E012 35.1804629 0.0042456506 9.584788e-06 2.020754e-04 10 21534490 21534494 5 + 1.400 1.707 1.048
ENSG00000078403 E013 21.9565984 0.0022460927 9.845335e-03 5.745384e-02 10 21534495 21534520 26 + 1.246 1.459 0.740
ENSG00000078403 E014 54.0624264 0.0045927185 2.613206e-08 1.116434e-06 10 21534645 21534701 57 + 1.572 1.902 1.120
ENSG00000078403 E015 55.6968016 0.0075864902 3.022264e-06 7.480688e-05 10 21534702 21534748 47 + 1.597 1.901 1.029
ENSG00000078403 E016 55.3633903 0.0131316067 3.812926e-06 9.112336e-05 10 21534749 21534804 56 + 1.572 1.921 1.178
ENSG00000078403 E017 72.8186822 0.0132476328 2.449223e-07 8.241219e-06 10 21538833 21538912 80 + 1.682 2.049 1.235
ENSG00000078403 E018 0.0000000       10 21538913 21538964 52 +      
ENSG00000078403 E019 0.1308682 0.0308730196 1.950734e-01   10 21541263 21541361 99 + 0.000 0.180 13.487
ENSG00000078403 E020 2.9833956 0.0078653586 6.302452e-09 3.086221e-07 10 21551816 21551921 106 + 0.080 0.989 5.431
ENSG00000078403 E021 102.2765157 0.0127879448 5.713044e-30 4.512588e-27 10 21556643 21557182 540 + 1.608 2.348 2.489
ENSG00000078403 E022 3.7203929 0.0142332815 2.163920e-01 4.491569e-01 10 21557621 21557824 204 + 0.686 0.485 -0.907
ENSG00000078403 E023 0.5008152 0.0381532037 3.419414e-01   10 21571975 21571984 10 + 0.207 0.000 -12.427
ENSG00000078403 E024 0.6622309 0.1650329672 2.548744e-01   10 21571985 21572026 42 + 0.259 0.000 -12.851
ENSG00000078403 E025 24.1359159 0.0427777439 1.475214e-02 7.714644e-02 10 21586294 21586348 55 + 1.425 1.123 -1.058
ENSG00000078403 E026 34.0739107 0.0182232906 1.659905e-02 8.397084e-02 10 21595331 21595440 110 + 1.554 1.350 -0.701
ENSG00000078403 E027 0.1614157 0.0324123721 1.000000e+00   10 21595441 21595582 142 + 0.080 0.000 -10.840
ENSG00000078403 E028 0.1614157 0.0324123721 1.000000e+00   10 21611031 21612347 1317 + 0.080 0.000 -10.840
ENSG00000078403 E029 41.5262830 0.0171238759 5.586313e-03 3.765816e-02 10 21612348 21612451 104 + 1.640 1.416 -0.768
ENSG00000078403 E030 38.5883037 0.0222375563 1.209398e-03 1.150351e-02 10 21614831 21614924 94 + 1.623 1.329 -1.013
ENSG00000078403 E031 26.7358429 0.0183203852 4.524333e-03 3.207011e-02 10 21617112 21617133 22 + 1.463 1.186 -0.967
ENSG00000078403 E032 28.3072406 0.0038991334 2.623583e-05 4.803717e-04 10 21617134 21617207 74 + 1.500 1.157 -1.198
ENSG00000078403 E033 0.0000000       10 21624667 21624690 24 +      
ENSG00000078403 E034 0.0000000       10 21624691 21624749 59 +      
ENSG00000078403 E035 34.9930785 0.0051611586 4.537283e-06 1.058718e-04 10 21651673 21651768 96 + 1.592 1.240 -1.217
ENSG00000078403 E036 0.1614157 0.0324123721 1.000000e+00   10 21663750 21663843 94 + 0.080 0.000 -10.840
ENSG00000078403 E037 1.0971494 0.0401197480 3.783537e-01   10 21668917 21668971 55 + 0.346 0.180 -1.248
ENSG00000078403 E038 1.9539322 0.1127277973 1.189123e-01 3.140643e-01 10 21668972 21669052 81 + 0.513 0.179 -2.145
ENSG00000078403 E039 69.5636671 0.0156723444 1.974340e-05 3.781732e-04 10 21670449 21670704 256 + 1.877 1.558 -1.080
ENSG00000078403 E040 1.4866132 0.0126304494 7.803448e-01 8.849698e-01 10 21670705 21671014 310 + 0.346 0.405 0.343
ENSG00000078403 E041 58.7546229 0.0117575118 3.354602e-03 2.550426e-02 10 21673350 21673528 179 + 1.783 1.584 -0.674
ENSG00000078403 E042 39.4237951 0.0244865650 4.449737e-03 3.166251e-02 10 21673529 21673577 49 + 1.626 1.361 -0.907
ENSG00000078403 E043 36.2277980 0.0213637376 1.017660e-01 2.849357e-01 10 21673578 21673640 63 + 1.562 1.428 -0.460
ENSG00000078403 E044 25.0322733 0.0174593988 5.340000e-02 1.876808e-01 10 21673641 21673643 3 + 1.417 1.242 -0.611
ENSG00000078403 E045 46.3838438 0.0077361150 5.318683e-04 5.966277e-03 10 21673644 21673781 138 + 1.692 1.457 -0.803
ENSG00000078403 E046 47.0030477 0.0268140331 3.925520e-03 2.873092e-02 10 21673782 21673919 138 + 1.702 1.449 -0.867
ENSG00000078403 E047 30.7190253 0.0014877452 1.198459e-04 1.736569e-03 10 21681332 21681376 45 + 1.531 1.254 -0.962
ENSG00000078403 E048 19.6483923 0.0088106356 7.434174e-04 7.808063e-03 10 21682225 21682257 33 + 1.348 1.010 -1.206
ENSG00000078403 E049 7.7656431 0.0152367193 5.473578e-01 7.343823e-01 10 21688491 21688538 48 + 0.920 0.855 -0.249
ENSG00000078403 E050 0.1723744 0.0392006107 1.943884e-01   10 21708588 21708657 70 + 0.000 0.180 13.492
ENSG00000078403 E051 0.3641499 0.0299068691 5.090088e-01   10 21712230 21712340 111 + 0.080 0.180 1.346
ENSG00000078403 E052 67.1955836 0.0079921263 2.580589e-05 4.739155e-04 10 21713772 21713950 179 + 1.852 1.590 -0.889
ENSG00000078403 E053 56.0681963 0.0006391456 1.039849e-06 2.938764e-05 10 21726244 21726355 112 + 1.778 1.517 -0.887
ENSG00000078403 E054 40.1272786 0.0487731920 9.578697e-02 2.744021e-01 10 21727856 21727928 73 + 1.629 1.400 -0.786
ENSG00000078403 E055 50.8367101 0.5670011072 7.689098e-01 8.779614e-01 10 21730900 21731054 155 + 1.694 1.617 -0.263
ENSG00000078403 E056 57.2182267 0.0511685861 1.629400e-01 3.811433e-01 10 21732899 21733087 189 + 1.762 1.625 -0.468
ENSG00000078403 E057 39.3673419 0.0196444678 3.989176e-02 1.544272e-01 10 21733504 21733592 89 + 1.609 1.444 -0.564
ENSG00000078403 E058 97.1654341 0.0307684023 3.904935e-02 1.523252e-01 10 21733768 21734129 362 + 1.993 1.823 -0.571
ENSG00000078403 E059 54.6552341 0.0179267173 1.008555e-02 5.852338e-02 10 21735139 21735235 97 + 1.755 1.560 -0.660
ENSG00000078403 E060 60.8069002 0.0033247246 8.482527e-02 2.543081e-01 10 21740030 21740153 124 + 1.776 1.692 -0.284
ENSG00000078403 E061 45.8575248 0.0259730210 9.589978e-01 9.813959e-01 10 21740154 21740236 83 + 1.635 1.624 -0.035
ENSG00000078403 E062 210.4893931 1.6175729067 5.996322e-01 7.699680e-01 10 21741939 21743630 1692 + 2.253 2.348 0.319