ENSG00000078369

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378609 ENSG00000078369 HEK293_OSMI2_6hA HEK293_TMG_6hB GNB1 protein_coding protein_coding 174.4712 177.3766 153.681 23.5473 6.502032 -0.2068647 76.63742 71.10551 45.21980 13.681866 2.6508162 -0.6528908 0.4265208 0.39376667 0.2945667 -0.09920000 2.893196e-01 2.133459e-19 FALSE TRUE
ENST00000610897 ENSG00000078369 HEK293_OSMI2_6hA HEK293_TMG_6hB GNB1 protein_coding protein_coding 174.4712 177.3766 153.681 23.5473 6.502032 -0.2068647 18.53919 18.94254 12.03305 3.170355 2.3378744 -0.6541904 0.1058000 0.10570000 0.0780000 -0.02770000 6.110220e-01 2.133459e-19 FALSE TRUE
MSTRG.118.12 ENSG00000078369 HEK293_OSMI2_6hA HEK293_TMG_6hB GNB1 protein_coding   174.4712 177.3766 153.681 23.5473 6.502032 -0.2068647 18.66287 16.11339 38.97125 2.338042 0.2306755 1.2736253 0.1119583 0.09056667 0.2544667 0.16390000 2.133459e-19 2.133459e-19 FALSE TRUE
MSTRG.118.8 ENSG00000078369 HEK293_OSMI2_6hA HEK293_TMG_6hB GNB1 protein_coding   174.4712 177.3766 153.681 23.5473 6.502032 -0.2068647 27.82545 45.62583 28.71178 3.888036 3.7820232 -0.6680218 0.1666042 0.26260000 0.1858667 -0.07673333 4.392625e-01 2.133459e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000078369 E001 0.0000000       1 1785285 1785285 1 -      
ENSG00000078369 E002 28.1101557 0.186360715 0.27357893 0.51343197 1 1785286 1785313 28 - 1.333 1.511 0.615
ENSG00000078369 E003 101.2601101 0.518988140 0.29622902 0.53677886 1 1785314 1785341 28 - 1.861 2.061 0.675
ENSG00000078369 E004 399.4457241 1.226963195 0.38537056 0.61675197 1 1785342 1785419 78 - 2.414 2.668 0.847
ENSG00000078369 E005 381.8631866 1.213207446 0.38765491 0.61862963 1 1785420 1785440 21 - 2.397 2.648 0.834
ENSG00000078369 E006 371.8963329 1.195072402 0.37330214 0.60674232 1 1785441 1785457 17 - 2.376 2.639 0.878
ENSG00000078369 E007 780.1056553 1.452009934 0.40234060 0.63026138 1 1785458 1785595 138 - 2.691 2.963 0.905
ENSG00000078369 E008 438.3543463 1.245769392 0.36542060 0.60026719 1 1785596 1785626 31 - 2.436 2.714 0.926
ENSG00000078369 E009 737.0270963 1.443720845 0.41735182 0.64162604 1 1785627 1785789 163 - 2.680 2.933 0.843
ENSG00000078369 E010 1806.7268277 1.793241927 0.54929541 0.73582118 1 1785790 1786362 573 - 3.142 3.295 0.508
ENSG00000078369 E011 3300.1834923 2.003043916 0.59995666 0.77019238 1 1786363 1787053 691 - 3.425 3.547 0.404
ENSG00000078369 E012 684.3478832 1.471992031 0.50632634 0.70515469 1 1787322 1787325 4 - 2.715 2.876 0.536
ENSG00000078369 E013 1501.4133318 1.732065986 0.53895956 0.72828863 1 1787326 1787437 112 - 3.059 3.216 0.521
ENSG00000078369 E014 25.6975584 0.388382558 0.61949842 0.78351519 1 1787987 1789052 1066 - 1.338 1.453 0.399
ENSG00000078369 E015 794.2122464 1.530462953 0.52678777 0.71968181 1 1789053 1789060 8 - 2.791 2.936 0.480
ENSG00000078369 E016 2029.3178785 1.832748204 0.55632766 0.74073012 1 1789061 1789269 209 - 3.196 3.344 0.493
ENSG00000078369 E017 2114.1163015 0.006017510 0.18053992 0.40465943 1 1790395 1790564 170 - 3.288 3.325 0.124
ENSG00000078369 E018 1095.3417724 0.042339082 0.20286715 0.43318338 1 1790565 1790596 32 - 3.040 3.018 -0.074
ENSG00000078369 E019 1197.1321057 0.055025516 0.22117981 0.45490395 1 1793245 1793311 67 - 3.084 3.053 -0.104
ENSG00000078369 E020 7.7290285 0.103317592 0.77902589 0.88418132 1 1793312 1794197 886 - 0.924 0.927 0.011
ENSG00000078369 E021 1426.8944065 0.059652848 0.25556058 0.49422630 1 1804419 1804525 107 - 3.156 3.132 -0.080
ENSG00000078369 E022 1088.4000768 0.056434321 0.26248611 0.50167891 1 1804526 1804581 56 - 3.037 3.015 -0.074
ENSG00000078369 E023 1101.5140490 0.063108325 0.24170763 0.47847865 1 1806475 1806538 64 - 3.050 3.015 -0.116
ENSG00000078369 E024 1370.9330804 0.062724530 0.17138739 0.39236346 1 1815756 1815862 107 - 3.157 3.102 -0.185
ENSG00000078369 E025 1.2847889 0.839435368 0.40438689   1 1817687 1817836 150 - 0.430 0.266 -1.000
ENSG00000078369 E026 890.4270161 0.060391875 0.11610382 0.30932666 1 1817837 1817875 39 - 2.986 2.904 -0.272
ENSG00000078369 E027 1.1603853 0.014649506 0.68045247   1 1817876 1818386 511 - 0.349 0.304 -0.278
ENSG00000078369 E028 6.6390595 0.004156152 0.15586865 0.37073462 1 1824988 1825396 409 - 0.944 0.818 -0.481
ENSG00000078369 E029 964.8566059 0.061366950 0.10376389 0.28849189 1 1825397 1825499 103 - 3.024 2.936 -0.295
ENSG00000078369 E030 1.7349041 0.217131264 0.74869602 0.86590818 1 1825500 1825554 55 - 0.424 0.409 -0.086
ENSG00000078369 E031 1.2484620 0.628138420 0.66422509   1 1832232 1832285 54 - 0.345 0.372 0.159
ENSG00000078369 E032 385.8760014 0.056767437 0.12406959 0.32216572 1 1839190 1839238 49 - 2.620 2.543 -0.257
ENSG00000078369 E033 0.5587019 0.785690150 0.44348982   1 1839629 1839682 54 - 0.268 0.103 -1.678
ENSG00000078369 E034 0.9407076 0.019023187 0.33077178   1 1848461 1848515 55 - 0.149 0.355 1.627
ENSG00000078369 E035 5.5672961 0.005082370 0.08734898 0.25889559 1 1852570 1852680 111 - 0.902 0.726 -0.691
ENSG00000078369 E036 12.9771691 0.002668205 0.68610630 0.82658184 1 1853152 1853297 146 - 1.067 1.160 0.335
ENSG00000078369 E037 2.1144226 0.107737073 0.01790328 0.08871347 1 1873958 1874120 163 - 0.708 0.298 -2.054
ENSG00000078369 E038 10.9294035 0.097253871 0.69242439 0.83062265 1 1879787 1879902 116 - 0.949 1.118 0.620
ENSG00000078369 E039 1.5940186 0.121155114 0.49027623 0.69419103 1 1890364 1890433 70 - 0.483 0.394 -0.467
ENSG00000078369 E040 229.3317840 0.050207491 0.25451373 0.49303076 1 1890820 1891117 298 - 2.362 2.340 -0.072