ENSG00000078304

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328724 ENSG00000078304 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP2R5C protein_coding protein_coding 55.43219 29.24838 77.82747 4.229552 3.004503 1.411615 4.099028 2.7373822 8.172535 0.6203365 0.2070722 1.5744902 0.07410833 0.09163333 0.10516667 0.01353333 0.822015646 0.002180096 FALSE TRUE
ENST00000350249 ENSG00000078304 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP2R5C protein_coding protein_coding 55.43219 29.24838 77.82747 4.229552 3.004503 1.411615 4.186621 0.6601186 4.517752 0.1417057 0.4455477 2.7563066 0.06560417 0.02203333 0.05803333 0.03600000 0.002180096 0.002180096 FALSE TRUE
ENST00000445439 ENSG00000078304 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP2R5C protein_coding protein_coding 55.43219 29.24838 77.82747 4.229552 3.004503 1.411615 21.033862 10.4698224 29.121410 1.9776589 2.8167965 1.4749613 0.36540000 0.35463333 0.37253333 0.01790000 0.951004510 0.002180096 FALSE TRUE
ENST00000553730 ENSG00000078304 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP2R5C protein_coding retained_intron 55.43219 29.24838 77.82747 4.229552 3.004503 1.411615 3.518477 1.9667686 7.458536 0.5187593 0.4778746 1.9176816 0.06197083 0.07690000 0.09646667 0.01956667 0.813529904 0.002180096 FALSE TRUE
ENST00000556260 ENSG00000078304 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP2R5C protein_coding protein_coding 55.43219 29.24838 77.82747 4.229552 3.004503 1.411615 7.519787 5.1494399 7.640933 0.5545579 0.5721553 0.5684213 0.15973750 0.17980000 0.09796667 -0.08183333 0.019203327 0.002180096   FALSE
ENST00000694906 ENSG00000078304 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP2R5C protein_coding protein_coding 55.43219 29.24838 77.82747 4.229552 3.004503 1.411615 3.606689 1.6769608 5.255419 0.1089861 0.4443402 1.6421219 0.05952083 0.05896667 0.06726667 0.00830000 0.849687568 0.002180096 FALSE TRUE
MSTRG.10194.19 ENSG00000078304 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP2R5C protein_coding   55.43219 29.24838 77.82747 4.229552 3.004503 1.411615 4.651438 2.2658333 7.307484 1.2672267 1.1707889 1.6849529 0.07672500 0.06786667 0.09526667 0.02740000 0.856256129 0.002180096 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000078304 E001 2.2729874 0.0762877389 5.388568e-01 7.282024e-01 14 101761709 101761797 89 + 0.429 0.548 0.583
ENSG00000078304 E002 2.4335953 0.0668226850 1.546179e-01 3.688757e-01 14 101761798 101761841 44 + 0.394 0.655 1.251
ENSG00000078304 E003 6.5266303 0.0483785950 1.098709e-01 2.988023e-01 14 101761842 101761861 20 + 0.765 1.012 0.943
ENSG00000078304 E004 10.1445713 0.0822222093 4.321170e-02 1.631141e-01 14 101761862 101761869 8 + 0.888 1.227 1.240
ENSG00000078304 E005 22.3709504 0.0031953724 3.078114e-03 2.388443e-02 14 101761870 101761884 15 + 1.255 1.487 0.805
ENSG00000078304 E006 48.2434579 0.0031579305 8.798882e-03 5.293925e-02 14 101761885 101761920 36 + 1.607 1.762 0.527
ENSG00000078304 E007 63.8169995 0.0116752902 1.947483e-02 9.409563e-02 14 101762905 101762927 23 + 1.723 1.884 0.546
ENSG00000078304 E008 88.2297434 0.0007618493 7.764528e-05 1.209943e-03 14 101762928 101762970 43 + 1.862 2.025 0.549
ENSG00000078304 E009 65.8232675 0.0198534444 3.461317e-03 2.611218e-02 14 101765154 101765291 138 + 1.705 1.936 0.779
ENSG00000078304 E010 51.6178446 0.0193775486 9.190651e-03 5.466652e-02 14 101765292 101765386 95 + 1.611 1.822 0.715
ENSG00000078304 E011 43.6027018 0.0356204430 6.955973e-02 2.238973e-01 14 101765387 101765448 62 + 1.546 1.738 0.652
ENSG00000078304 E012 150.7892999 0.0035104064 1.645542e-11 1.365173e-09 14 101765449 101766124 676 + 2.041 2.314 0.913
ENSG00000078304 E013 124.5485360 0.0139818292 9.847967e-08 3.660344e-06 14 101766125 101766616 492 + 1.926 2.270 1.154
ENSG00000078304 E014 27.6422081 0.0075639768 1.132230e-05 2.333479e-04 14 101766617 101767049 433 + 1.280 1.623 1.183
ENSG00000078304 E015 71.6896333 0.0133330364 8.828681e-01 9.427885e-01 14 101786018 101786110 93 + 1.829 1.832 0.012
ENSG00000078304 E016 52.9698137 0.0020612128 6.217817e-02 2.076964e-01 14 101786111 101786120 10 + 1.729 1.629 -0.341
ENSG00000078304 E017 71.1571370 0.0007364743 6.502587e-01 8.037505e-01 14 101786121 101786183 63 + 1.829 1.813 -0.056
ENSG00000078304 E018 0.0000000       14 101789681 101789896 216 +      
ENSG00000078304 E019 4.1461183 0.0065640010 1.959419e-01 4.244750e-01 14 101797211 101797701 491 + 0.618 0.810 0.793
ENSG00000078304 E020 2.9763174 0.0079082013 3.920980e-01 6.221153e-01 14 101809803 101809833 31 + 0.617 0.475 -0.664
ENSG00000078304 E021 2.9763174 0.0079082013 3.920980e-01 6.221153e-01 14 101809834 101809834 1 + 0.617 0.475 -0.664
ENSG00000078304 E022 3.1071855 0.0077254216 6.300890e-01 7.904401e-01 14 101809835 101809836 2 + 0.617 0.541 -0.343
ENSG00000078304 E023 5.9080377 0.0047548444 7.007012e-01 8.360924e-01 14 101809837 101809865 29 + 0.824 0.775 -0.191
ENSG00000078304 E024 6.2120880 0.0044819488 5.597016e-01 7.430473e-01 14 101809866 101809868 3 + 0.850 0.775 -0.294
ENSG00000078304 E025 37.7671607 0.0012138513 1.919312e-01 4.193006e-01 14 101809869 101809894 26 + 1.574 1.495 -0.271
ENSG00000078304 E026 65.7633052 0.0006945632 3.259604e-01 5.652046e-01 14 101809895 101809904 10 + 1.803 1.760 -0.145
ENSG00000078304 E027 150.7771124 0.0003590529 1.998596e-01 4.295047e-01 14 101809905 101810036 132 + 2.157 2.120 -0.124
ENSG00000078304 E028 0.7143205 0.0273732959 6.845757e-02   14 101818027 101818991 965 + 0.083 0.396 2.828
ENSG00000078304 E029 1.8044553 0.0109895417 8.486631e-01 9.241466e-01 14 101818992 101819085 94 + 0.428 0.396 -0.172
ENSG00000078304 E030 1.2075010 0.0240038958 4.733693e-01   14 101819086 101821098 2013 + 0.265 0.397 0.830
ENSG00000078304 E031 0.0000000       14 101823653 101823877 225 +      
ENSG00000078304 E032 0.0000000       14 101823878 101823881 4 +      
ENSG00000078304 E033 0.1723744 0.0427861790 2.034099e-01   14 101823882 101823941 60 + 0.000 0.175 9.914
ENSG00000078304 E034 4.5105757 0.0063911539 4.611852e-02 1.702909e-01 14 101824014 101824161 148 + 0.618 0.899 1.138
ENSG00000078304 E035 2.0807345 0.0111883913 9.507258e-01 9.773252e-01 14 101824162 101824169 8 + 0.461 0.475 0.071
ENSG00000078304 E036 2.1123820 0.1170200098 2.298986e-01 4.650634e-01 14 101824170 101824478 309 + 0.389 0.645 1.234
ENSG00000078304 E037 0.0000000       14 101824838 101824922 85 +      
ENSG00000078304 E038 1.7033268 0.0115020433 9.912960e-01 9.974159e-01 14 101831701 101831804 104 + 0.392 0.396 0.022
ENSG00000078304 E039 11.1266638 0.0120120523 1.230867e-09 7.071365e-08 14 101836169 101836701 533 + 0.732 1.395 2.441
ENSG00000078304 E040 365.2003237 0.0002326043 1.841893e-05 3.564219e-04 14 101856686 101856885 200 + 2.553 2.467 -0.286
ENSG00000078304 E041 0.0000000       14 101879222 101879363 142 +      
ENSG00000078304 E042 188.6633656 0.0002968503 2.185492e-07 7.457240e-06 14 101882161 101882204 44 + 2.282 2.132 -0.502
ENSG00000078304 E043 219.6281901 0.0014978348 3.598349e-04 4.335174e-03 14 101882205 101882271 67 + 2.337 2.226 -0.370
ENSG00000078304 E044 87.5879849 0.0965603575 5.319711e-01 7.234365e-01 14 101882272 101883016 745 + 1.932 1.857 -0.251
ENSG00000078304 E045 147.4203902 0.0032113094 1.739903e-01 3.958570e-01 14 101883257 101883301 45 + 2.151 2.102 -0.166
ENSG00000078304 E046 166.0865512 0.0015767237 6.913338e-02 2.230538e-01 14 101883302 101883349 48 + 2.205 2.147 -0.196
ENSG00000078304 E047 187.8902468 0.0003552124 4.975085e-03 3.449773e-02 14 101883432 101883536 105 + 2.263 2.185 -0.260
ENSG00000078304 E048 108.8971070 0.0005141275 1.420146e-01 3.504561e-01 14 101883537 101883562 26 + 2.017 1.965 -0.174
ENSG00000078304 E049 1.8923892 0.0107123138 4.673718e-02 1.719092e-01 14 101889793 101889981 189 + 0.312 0.650 1.724
ENSG00000078304 E050 2.2227354 0.1085042874 9.502929e-01 9.771875e-01 14 101889982 101890192 211 + 0.463 0.479 0.081
ENSG00000078304 E051 1.1384679 0.0153787590 9.368629e-01   14 101890193 101890236 44 + 0.312 0.299 -0.080
ENSG00000078304 E052 141.6281510 0.0003443847 1.656310e-01 3.846819e-01 14 101890237 101890296 60 + 2.128 2.087 -0.139
ENSG00000078304 E053 221.4953654 0.0024098764 4.293302e-02 1.623641e-01 14 101893000 101893108 109 + 2.330 2.267 -0.211
ENSG00000078304 E054 197.4905295 0.0053093786 2.881178e-01 5.288709e-01 14 101894507 101894560 54 + 2.273 2.237 -0.119
ENSG00000078304 E055 311.6982716 0.0002676908 4.535135e-01 6.683463e-01 14 101901719 101901856 138 + 2.453 2.475 0.072
ENSG00000078304 E056 182.1359313 0.0003112475 7.608234e-03 4.751593e-02 14 101901857 101901889 33 + 2.203 2.283 0.269
ENSG00000078304 E057 290.6947862 0.0007245084 3.899915e-01 6.204519e-01 14 101906402 101906504 103 + 2.421 2.448 0.091
ENSG00000078304 E058 222.4810004 0.0003150185 8.622887e-01 9.315820e-01 14 101906505 101906529 25 + 2.312 2.312 0.001
ENSG00000078304 E059 1.1957345 0.0201990304 1.432521e-01   14 101906530 101906647 118 + 0.212 0.475 1.656
ENSG00000078304 E060 267.1234999 0.0003145208 9.669293e-01 9.853491e-01 14 101909589 101909647 59 + 2.389 2.395 0.020
ENSG00000078304 E061 238.2022428 0.0004311051 9.013207e-01 9.525265e-01 14 101909648 101909690 43 + 2.341 2.343 0.006
ENSG00000078304 E062 182.2998534 0.0002990389 6.218438e-01 7.850502e-01 14 101912401 101912404 4 + 2.228 2.218 -0.033
ENSG00000078304 E063 251.0029400 0.0011888640 7.707174e-01 8.790923e-01 14 101912405 101912473 69 + 2.360 2.372 0.039
ENSG00000078304 E064 111.6882668 0.0004655181 3.177059e-04 3.908561e-03 14 101912474 101912628 155 + 1.969 2.102 0.447
ENSG00000078304 E065 1.2802947 0.0129057993 2.439964e-01   14 101914175 101914572 398 + 0.265 0.475 1.241
ENSG00000078304 E066 0.6536007 0.0680343385 7.413657e-02   14 101917769 101917830 62 + 0.083 0.396 2.822
ENSG00000078304 E067 33.9597442 0.0018764255 3.619321e-02 1.447581e-01 14 101917831 101917947 117 + 1.546 1.403 -0.491
ENSG00000078304 E068 0.6258862 0.0193874923 6.759007e-02   14 101921093 101921382 290 + 0.083 0.396 2.825
ENSG00000078304 E069 1.3684393 0.0128699300 6.038235e-01   14 101921984 101922042 59 + 0.392 0.299 -0.568
ENSG00000078304 E070 1.7623289 0.0105398911 6.542074e-01 8.062078e-01 14 101922043 101922129 87 + 0.392 0.475 0.434
ENSG00000078304 E071 1.2920612 0.0128126289 6.502391e-01   14 101922165 101922198 34 + 0.311 0.396 0.506
ENSG00000078304 E072 794.6723652 0.0017362217 6.729930e-04 7.208887e-03 14 101925141 101927989 2849 + 2.885 2.809 -0.252