ENSG00000078177

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261435 ENSG00000078177 HEK293_OSMI2_6hA HEK293_TMG_6hB N4BP2 protein_coding protein_coding 2.149385 0.3191697 4.492631 0.02862982 0.3255484 3.773865 0.5178724 0.09801464 0.4506086 0.098014641 0.4506086 2.092315 0.41531250 0.30380000 0.1151000 -0.1887000 0.84943263 0.04497375 FALSE TRUE
ENST00000511480 ENSG00000078177 HEK293_OSMI2_6hA HEK293_TMG_6hB N4BP2 protein_coding nonsense_mediated_decay 2.149385 0.3191697 4.492631 0.02862982 0.3255484 3.773865 0.4687268 0.19945768 1.0819869 0.104906930 0.1997972 2.382225 0.22729583 0.62506667 0.2383333 -0.3867333 0.61729930 0.04497375 FALSE TRUE
ENST00000513269 ENSG00000078177 HEK293_OSMI2_6hA HEK293_TMG_6hB N4BP2 protein_coding protein_coding 2.149385 0.3191697 4.492631 0.02862982 0.3255484 3.773865 0.3712928 0.00000000 1.1869139 0.000000000 0.3356096 6.903176 0.12070000 0.00000000 0.2559000 0.2559000 0.04497375 0.04497375 FALSE TRUE
ENST00000515550 ENSG00000078177 HEK293_OSMI2_6hA HEK293_TMG_6hB N4BP2 protein_coding protein_coding 2.149385 0.3191697 4.492631 0.02862982 0.3255484 3.773865 0.0605274 0.00000000 0.2132434 0.000000000 0.1200496 4.480546 0.01522500 0.00000000 0.0502000 0.0502000 0.88714333 0.04497375 FALSE TRUE
MSTRG.24769.1 ENSG00000078177 HEK293_OSMI2_6hA HEK293_TMG_6hB N4BP2 protein_coding   2.149385 0.3191697 4.492631 0.02862982 0.3255484 3.773865 0.5853894 0.01331786 1.0506343 0.008308172 0.5296989 5.507348 0.14803750 0.03986667 0.2195000 0.1796333 0.78904662 0.04497375 FALSE TRUE
MSTRG.24769.6 ENSG00000078177 HEK293_OSMI2_6hA HEK293_TMG_6hB N4BP2 protein_coding   2.149385 0.3191697 4.492631 0.02862982 0.3255484 3.773865 0.1021514 0.00000000 0.4272552 0.000000000 0.2580566 5.450404 0.02732917 0.00000000 0.1046667 0.1046667 0.82515241 0.04497375 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000078177 E001 0.1308682 0.030997544 0.0343738294   4 40056850 40056912 63 + 0.000 0.303 16.210
ENSG00000078177 E002 0.0000000       4 40056913 40056928 16 +      
ENSG00000078177 E003 0.1614157 0.032570032 0.6455853459   4 40056929 40056935 7 + 0.043 0.000 -9.665
ENSG00000078177 E004 1.7293802 0.216257986 0.1527946816 0.366355349 4 40056936 40057030 95 + 0.260 0.605 1.886
ENSG00000078177 E005 3.9759225 0.006546256 0.7747083109 0.881572864 4 40073455 40073551 97 + 0.514 0.606 0.423
ENSG00000078177 E006 15.9608852 0.002642016 0.0555097021 0.192513818 4 40097227 40097569 343 + 1.036 0.782 -0.964
ENSG00000078177 E007 2.7783351 0.017416372 0.4997672243 0.700587477 4 40100036 40100126 91 + 0.438 0.304 -0.784
ENSG00000078177 E008 17.7735542 0.008330732 0.0095148247 0.056033120 4 40102075 40102374 300 + 1.083 0.703 -1.456
ENSG00000078177 E009 19.0347553 0.035022044 0.0341136602 0.139174108 4 40102375 40102812 438 + 1.103 0.784 -1.201
ENSG00000078177 E010 10.5310327 0.015855810 0.0291371596 0.124758203 4 40102813 40102906 94 + 0.880 0.480 -1.704
ENSG00000078177 E011 20.8182390 0.001995462 0.0166342403 0.084107677 4 40102907 40103218 312 + 1.145 0.849 -1.094
ENSG00000078177 E012 9.7039280 0.005134690 0.0005360013 0.006002727 4 40106900 40107024 125 + 0.867 0.000 -15.616
ENSG00000078177 E013 9.8535772 0.009692778 0.0070221499 0.044745884 4 40112084 40112172 89 + 0.867 0.303 -2.654
ENSG00000078177 E014 8.3912824 0.003950516 0.0752003477 0.235233496 4 40113432 40113508 77 + 0.802 0.480 -1.402
ENSG00000078177 E015 6.5102615 0.005194721 0.0496937712 0.178905372 4 40117869 40117884 16 + 0.717 0.303 -2.058
ENSG00000078177 E016 9.4025206 0.080305426 0.1146309630 0.306850507 4 40117885 40118024 140 + 0.842 0.480 -1.562
ENSG00000078177 E017 86.2831647 1.427335122 0.6661278500 0.813793666 4 40119932 40122087 2156 + 1.706 1.757 0.173
ENSG00000078177 E018 14.4542614 0.356794074 0.5480440871 0.734915951 4 40122088 40122309 222 + 0.969 1.048 0.292
ENSG00000078177 E019 14.9216687 0.020170030 0.2838771773 0.524334358 4 40123127 40123212 86 + 0.965 1.152 0.681
ENSG00000078177 E020 14.1979332 0.003777861 0.7483115213 0.865706415 4 40124160 40124205 46 + 0.960 1.046 0.317
ENSG00000078177 E021 28.0442241 0.002249840 0.0628785639 0.209192406 4 40126134 40126330 197 + 1.254 1.084 -0.607
ENSG00000078177 E022 20.8652149 0.035883155 0.1560817736 0.371033679 4 40131801 40131919 119 + 1.132 0.960 -0.629
ENSG00000078177 E023 20.7455274 0.042765931 0.8998785062 0.951835640 4 40136944 40137082 139 + 1.109 1.182 0.261
ENSG00000078177 E024 15.2877045 0.007016595 0.4669309724 0.677972115 4 40142673 40142723 51 + 0.979 1.119 0.511
ENSG00000078177 E025 24.3232223 0.002041837 0.2608538737 0.499847531 4 40142724 40142861 138 + 1.167 1.327 0.565
ENSG00000078177 E026 21.8267795 0.008875652 0.8533788816 0.926841553 4 40144632 40144800 169 + 1.135 1.207 0.256
ENSG00000078177 E027 18.7251520 0.002064124 0.7199642892 0.848177587 4 40152780 40152903 124 + 1.083 1.084 0.002
ENSG00000078177 E028 11.6578337 0.003363870 0.3495380233 0.586835611 4 40154192 40154267 76 + 0.874 1.046 0.643
ENSG00000078177 E029 132.4554097 0.024279533 0.0092561018 0.054938451 4 40154268 40157861 3594 + 1.867 2.103 0.794
ENSG00000078177 E030 10.0331073 0.067980800 0.0052724820 0.036041892 4 40157862 40158252 391 + 0.754 1.258 1.871
ENSG00000078177 E031 0.9582712 0.015679889 0.1252988904   4 40185099 40185238 140 + 0.150 0.480 2.298