ENSG00000078142

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262039 ENSG00000078142 HEK293_OSMI2_6hA HEK293_TMG_6hB PIK3C3 protein_coding protein_coding 10.70453 1.423758 21.3394 0.4801763 1.088579 3.896322 1.707971 0.4566012 2.987954 0.02563875 0.02395399 2.683716 0.2328750 0.4416000 0.1407333 -0.30086667 4.565895e-01 2.131767e-07 FALSE TRUE
ENST00000589550 ENSG00000078142 HEK293_OSMI2_6hA HEK293_TMG_6hB PIK3C3 protein_coding retained_intron 10.70453 1.423758 21.3394 0.4801763 1.088579 3.896322 4.054400 0.4441582 8.376066 0.22271284 1.25843193 4.206727 0.2691333 0.2496333 0.3884667 0.13883333 7.800696e-01 2.131767e-07 FALSE FALSE
ENST00000590013 ENSG00000078142 HEK293_OSMI2_6hA HEK293_TMG_6hB PIK3C3 protein_coding processed_transcript 10.70453 1.423758 21.3394 0.4801763 1.088579 3.896322 2.335388 0.0000000 5.251550 0.00000000 0.26125873 9.039344 0.1935500 0.0000000 0.2487000 0.24870000 2.131767e-07 2.131767e-07 FALSE FALSE
ENST00000597477 ENSG00000078142 HEK293_OSMI2_6hA HEK293_TMG_6hB PIK3C3 protein_coding protein_coding 10.70453 1.423758 21.3394 0.4801763 1.088579 3.896322 2.146430 0.4514233 4.335128 0.29552858 0.18817517 3.235236 0.2281542 0.2294667 0.2034000 -0.02606667 1.000000e+00 2.131767e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000078142 E001 5.3920275 0.0053962084 4.437434e-01 6.611839e-01 18 41955234 41955253 20 + 0.684 0.538 -0.645
ENSG00000078142 E002 5.7126460 0.0051399422 3.739540e-01 6.073176e-01 18 41955254 41955255 2 + 0.706 0.538 -0.738
ENSG00000078142 E003 10.1088403 0.0035538608 7.947765e-02 2.437976e-01 18 41955256 41955261 6 + 0.924 0.630 -1.181
ENSG00000078142 E004 30.0340257 0.0070568162 1.951393e-02 9.423363e-02 18 41955262 41955359 98 + 1.357 1.096 -0.925
ENSG00000078142 E005 0.3393995 0.0274424043 1.000000e+00   18 41955418 41955444 27 + 0.099 0.000 -9.397
ENSG00000078142 E006 35.1641944 0.0179900116 1.211492e-02 6.691800e-02 18 41957570 41957638 69 + 1.428 1.125 -1.063
ENSG00000078142 E007 23.3351834 0.0093724768 3.190200e-01 5.587333e-01 18 41957639 41957666 28 + 1.241 1.123 -0.419
ENSG00000078142 E008 20.2157362 0.0020370844 8.286355e-01 9.130367e-01 18 41957667 41957688 22 + 1.174 1.148 -0.092
ENSG00000078142 E009 30.4168231 0.0013675733 5.830656e-01 7.590406e-01 18 41957689 41957758 70 + 1.348 1.296 -0.182
ENSG00000078142 E010 49.6414171 0.0009037854 2.538206e-01 4.921906e-01 18 41962489 41962632 144 + 1.557 1.471 -0.296
ENSG00000078142 E011 55.1087742 0.0032928082 1.429851e-01 3.519459e-01 18 41970327 41970456 130 + 1.605 1.494 -0.382
ENSG00000078142 E012 0.1614157 0.0329098924 8.643764e-01   18 41970457 41971443 987 + 0.052 0.000 -8.424
ENSG00000078142 E013 0.9854382 0.2747761507 7.876763e-01   18 41984880 41985107 228 + 0.218 0.256 0.299
ENSG00000078142 E014 46.0596940 0.0009093245 1.130553e-02 6.362683e-02 18 41987812 41987898 87 + 1.540 1.330 -0.723
ENSG00000078142 E015 39.1503475 0.0013402181 1.752884e-01 3.975518e-01 18 41990459 41990554 96 + 1.463 1.347 -0.402
ENSG00000078142 E016 0.1779838 0.0333852001 8.644609e-01   18 41990555 41990602 48 + 0.052 0.000 -8.426
ENSG00000078142 E017 32.9324630 0.0012855823 1.509620e-01 3.636669e-01 18 41993270 41993341 72 + 1.393 1.259 -0.468
ENSG00000078142 E018 40.6573964 0.0069637457 9.370303e-02 2.706403e-01 18 41995890 41995994 105 + 1.486 1.329 -0.542
ENSG00000078142 E019 34.6675824 0.0089586774 2.334915e-03 1.928235e-02 18 41996638 41996730 93 + 1.434 1.094 -1.197
ENSG00000078142 E020 51.6251791 0.0037911014 3.003992e-02 1.274635e-01 18 42004356 42004541 186 + 1.585 1.407 -0.612
ENSG00000078142 E021 39.9552431 0.0010772793 9.423617e-01 9.734511e-01 18 42013442 42013596 155 + 1.455 1.459 0.011
ENSG00000078142 E022 33.6247660 0.0011324380 5.871039e-01 7.616939e-01 18 42015476 42015566 91 + 1.377 1.420 0.147
ENSG00000078142 E023 33.7441803 0.0010524937 7.270304e-01 8.524405e-01 18 42020638 42020705 68 + 1.380 1.406 0.092
ENSG00000078142 E024 1.6538261 0.0121989077 7.473395e-01 8.651026e-01 18 42025331 42025781 451 + 0.332 0.259 -0.493
ENSG00000078142 E025 0.9231097 0.0395620306 8.175711e-01   18 42025782 42025939 158 + 0.214 0.259 0.363
ENSG00000078142 E026 2.3969113 0.0809573417 6.894860e-02 2.226734e-01 18 42025940 42027442 1503 + 0.354 0.709 1.708
ENSG00000078142 E027 42.3027396 0.0011901341 4.220153e-01 6.451519e-01 18 42027443 42027548 106 + 1.486 1.420 -0.227
ENSG00000078142 E028 45.6862224 0.0010519140 1.424405e-01 3.511005e-01 18 42029325 42029441 117 + 1.524 1.406 -0.404
ENSG00000078142 E029 29.9884697 0.0018267673 3.660083e-01 6.007688e-01 18 42033826 42033841 16 + 1.346 1.258 -0.306
ENSG00000078142 E030 51.8841167 0.0052571425 1.523682e-01 3.657768e-01 18 42033842 42033957 116 + 1.578 1.460 -0.407
ENSG00000078142 E031 41.4386453 0.0009298940 6.615018e-01 8.108125e-01 18 42037692 42037749 58 + 1.463 1.494 0.105
ENSG00000078142 E032 29.1166046 0.0019280420 7.083163e-01 8.407191e-01 18 42037750 42037771 22 + 1.315 1.347 0.110
ENSG00000078142 E033 36.5140491 0.0106531915 9.458987e-01 9.753268e-01 18 42037772 42037820 49 + 1.416 1.406 -0.032
ENSG00000078142 E034 44.5696081 0.0008049642 8.961580e-01 9.498794e-01 18 42038781 42038850 70 + 1.498 1.505 0.025
ENSG00000078142 E035 41.7175927 0.0038064582 5.494907e-01 7.359319e-01 18 42040677 42040741 65 + 1.462 1.507 0.154
ENSG00000078142 E036 45.6330131 0.0008179981 8.871750e-03 5.325088e-02 18 42043733 42043817 85 + 1.482 1.654 0.588
ENSG00000078142 E037 0.4986023 0.0294066254 1.000000e+00   18 42049292 42049530 239 + 0.141 0.000 -9.970
ENSG00000078142 E038 41.7254081 0.0008723799 3.645611e-02 1.454926e-01 18 42049531 42049605 75 + 1.450 1.595 0.497
ENSG00000078142 E039 0.6434498 0.0195892099 7.547215e-01   18 42049606 42049867 262 + 0.179 0.000 -10.349
ENSG00000078142 E040 3.9075551 0.0071005573 3.264762e-01 5.656820e-01 18 42049868 42051313 1446 + 0.535 0.706 0.751
ENSG00000078142 E041 0.3150090 0.0268621155 1.779643e-01   18 42057638 42057834 197 + 0.052 0.259 2.680
ENSG00000078142 E042 0.0000000       18 42057835 42057882 48 +      
ENSG00000078142 E043 45.6859932 0.0049905386 1.182031e-04 1.717896e-03 18 42057883 42058051 169 + 1.466 1.733 0.907
ENSG00000078142 E044 0.1308682 0.0316121675 5.472598e-02   18 42059795 42059894 100 + 0.000 0.259 12.889
ENSG00000078142 E045 0.3503582 0.0285900014 1.787465e-01   18 42064695 42064739 45 + 0.052 0.259 2.677
ENSG00000078142 E046 28.0898121 0.0015218945 1.128724e-02 6.355545e-02 18 42064740 42064830 91 + 1.275 1.483 0.719
ENSG00000078142 E047 42.7206439 0.0010370936 1.912249e-04 2.577332e-03 18 42067388 42067513 126 + 1.438 1.685 0.843
ENSG00000078142 E048 100.1134029 0.0005085219 3.142836e-06 7.732916e-05 18 42081123 42087830 6708 + 1.810 2.013 0.684