ENSG00000078124

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000531352 ENSG00000078124 HEK293_OSMI2_6hA HEK293_TMG_6hB ACER3 protein_coding nonsense_mediated_decay 5.691253 1.153707 9.686118 0.1632147 0.3414532 3.058679 0.25865639 0.00000000 1.28805278 0.00000000 0.788547206 7.0202052 0.02694583 0.00000000 0.12973333 0.12973333 6.281924e-01 7.353016e-09 FALSE TRUE
ENST00000532485 ENSG00000078124 HEK293_OSMI2_6hA HEK293_TMG_6hB ACER3 protein_coding protein_coding 5.691253 1.153707 9.686118 0.1632147 0.3414532 3.058679 2.83840919 0.09813348 5.50521199 0.09813348 0.090439783 5.6725312 0.44057500 0.11113333 0.56950000 0.45836667 1.329764e-01 7.353016e-09 FALSE TRUE
ENST00000533873 ENSG00000078124 HEK293_OSMI2_6hA HEK293_TMG_6hB ACER3 protein_coding protein_coding 5.691253 1.153707 9.686118 0.1632147 0.3414532 3.058679 0.19543742 0.00000000 0.88398390 0.00000000 0.883983898 6.4821769 0.02008750 0.00000000 0.09186667 0.09186667 1.000000e+00 7.353016e-09 FALSE TRUE
ENST00000534206 ENSG00000078124 HEK293_OSMI2_6hA HEK293_TMG_6hB ACER3 protein_coding protein_coding 5.691253 1.153707 9.686118 0.1632147 0.3414532 3.058679 0.48322923 0.11527410 0.33475549 0.11527410 0.190897017 1.4604853 0.10444583 0.07966667 0.03390000 -0.04576667 1.000000e+00 7.353016e-09   FALSE
ENST00000679754 ENSG00000078124 HEK293_OSMI2_6hA HEK293_TMG_6hB ACER3 protein_coding protein_coding 5.691253 1.153707 9.686118 0.1632147 0.3414532 3.058679 0.17779900 0.14016820 0.23859617 0.02685659 0.238596174 0.7272248 0.04311667 0.12793333 0.02613333 -0.10180000 2.735970e-01 7.353016e-09 FALSE TRUE
ENST00000680583 ENSG00000078124 HEK293_OSMI2_6hA HEK293_TMG_6hB ACER3 protein_coding protein_coding 5.691253 1.153707 9.686118 0.1632147 0.3414532 3.058679 0.01222257 0.09778055 0.00000000 0.09778055 0.000000000 -3.4300250 0.01080417 0.08643333 0.00000000 -0.08643333 5.451482e-01 7.353016e-09 FALSE TRUE
ENST00000681375 ENSG00000078124 HEK293_OSMI2_6hA HEK293_TMG_6hB ACER3 protein_coding nonsense_mediated_decay 5.691253 1.153707 9.686118 0.1632147 0.3414532 3.058679 0.25441561 0.40942606 0.05910184 0.14542216 0.002149862 -2.6016205 0.11966667 0.33240000 0.00610000 -0.32630000 7.353016e-09 7.353016e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000078124 E001 0.1779838 0.0333332215 8.754329e-01   11 76860859 76860866 8 + 0.052 0.000 -8.677
ENSG00000078124 E002 0.1779838 0.0333332215 8.754329e-01   11 76860867 76860869 3 + 0.052 0.000 -10.741
ENSG00000078124 E003 0.3206185 0.0274424043 1.000000e+00   11 76860870 76860872 3 + 0.099 0.000 -11.713
ENSG00000078124 E004 0.3206185 0.0274424043 1.000000e+00   11 76860873 76860876 4 + 0.099 0.000 -11.713
ENSG00000078124 E005 0.3206185 0.0274424043 1.000000e+00   11 76860877 76860883 7 + 0.099 0.000 -11.713
ENSG00000078124 E006 0.4929928 0.0217681645 3.485153e-01   11 76860884 76860887 4 + 0.099 0.259 1.679
ENSG00000078124 E007 0.6957271 0.0193874923 8.099371e-02   11 76860888 76860895 8 + 0.099 0.421 2.681
ENSG00000078124 E008 0.8265952 0.0168989497 1.641243e-02   11 76860896 76860905 10 + 0.099 0.538 3.264
ENSG00000078124 E009 1.1601976 0.0141366181 5.573346e-04   11 76860906 76860917 12 + 0.099 0.706 4.001
ENSG00000078124 E010 1.4808161 0.0130871630 3.430289e-03 2.593571e-02 11 76860918 76860923 6 + 0.179 0.706 3.001
ENSG00000078124 E011 2.7018191 0.0080393081 2.551885e-02 1.137988e-01 11 76860924 76860934 11 + 0.381 0.771 1.804
ENSG00000078124 E012 2.7018191 0.0080393081 2.551885e-02 1.137988e-01 11 76860935 76860935 1 + 0.381 0.771 1.804
ENSG00000078124 E013 2.7018191 0.0080393081 2.551885e-02 1.137988e-01 11 76860936 76860936 1 + 0.381 0.771 1.804
ENSG00000078124 E014 3.3914594 0.0132527585 9.060163e-03 5.409500e-02 11 76860937 76860938 2 + 0.444 0.876 1.871
ENSG00000078124 E015 3.5340940 0.0299272462 1.605828e-02 8.202324e-02 11 76860939 76860939 1 + 0.463 0.875 1.772
ENSG00000078124 E016 3.8844522 0.0097843875 5.771316e-03 3.859886e-02 11 76860940 76860941 2 + 0.482 0.921 1.848
ENSG00000078124 E017 3.8844522 0.0097843875 5.771316e-03 3.859886e-02 11 76860942 76860942 1 + 0.482 0.921 1.848
ENSG00000078124 E018 5.4979398 0.0060997697 2.239186e-02 1.038778e-01 11 76860943 76860949 7 + 0.622 0.962 1.358
ENSG00000078124 E019 22.6111449 0.0022770617 2.890819e-02 1.240907e-01 11 76860950 76861062 113 + 1.191 1.392 0.703
ENSG00000078124 E020 18.0167260 0.0062593020 1.040271e-01 2.888671e-01 11 76861063 76861079 17 + 1.104 1.277 0.613
ENSG00000078124 E021 2.8979484 0.0083483285 4.024289e-06 9.546261e-05 11 76868120 76868156 37 + 0.277 0.999 3.331
ENSG00000078124 E022 3.0300339 0.0086953587 2.649110e-10 1.717098e-08 11 76868157 76868267 111 + 0.179 1.122 4.584
ENSG00000078124 E023 0.0000000       11 76920079 76920255 177 +      
ENSG00000078124 E024 15.7305646 0.0043855210 6.851102e-01 8.259619e-01 11 76926557 76926565 9 + 1.082 1.033 -0.179
ENSG00000078124 E025 25.1098265 0.0316983419 8.436857e-01 9.214326e-01 11 76926566 76926667 102 + 1.263 1.278 0.056
ENSG00000078124 E026 0.5067846 0.0217681645 3.483893e-01   11 76957465 76957586 122 + 0.099 0.259 1.682
ENSG00000078124 E027 15.9776813 0.3277897311 5.922169e-01 7.651293e-01 11 76958979 76959031 53 + 1.068 1.145 0.277
ENSG00000078124 E028 0.9475002 0.0165455417 4.308971e-01   11 76959077 76959200 124 + 0.247 0.000 -13.171
ENSG00000078124 E029 11.9030629 0.1339881667 9.833160e-01 9.934480e-01 11 76976289 76976303 15 + 0.970 0.931 -0.147
ENSG00000078124 E030 14.5197245 0.0879455505 8.942829e-01 9.488482e-01 11 76976304 76976341 38 + 1.046 1.010 -0.133
ENSG00000078124 E031 1.6311009 0.0455728075 7.423215e-01 8.618355e-01 11 76976342 76980663 4322 + 0.333 0.259 -0.504
ENSG00000078124 E032 0.0000000       11 76981797 76981922 126 +      
ENSG00000078124 E033 2.0769780 0.0109125860 3.620439e-01 5.973726e-01 11 76982678 76985642 2965 + 0.357 0.537 0.938
ENSG00000078124 E034 24.4556723 0.0278728111 6.546582e-01 8.064883e-01 11 76985643 76985724 82 + 1.255 1.203 -0.184
ENSG00000078124 E035 1.1905729 0.1751380826 9.473733e-01   11 76989513 76990538 1026 + 0.250 0.260 0.075
ENSG00000078124 E036 23.0123435 0.0364329688 4.062201e-01 6.332025e-01 11 76990539 76990574 36 + 1.234 1.130 -0.372
ENSG00000078124 E037 0.9287192 0.0160640744 4.316335e-01   11 76990575 76991789 1215 + 0.247 0.000 -13.173
ENSG00000078124 E038 0.0000000       11 76994156 76994226 71 +      
ENSG00000078124 E039 0.6072928 0.0198130331 8.146625e-02   11 76997206 76997273 68 + 0.099 0.420 2.678
ENSG00000078124 E040 1.1067030 0.0140106655 3.419929e-01   11 76998554 76998762 209 + 0.277 0.000 -13.367
ENSG00000078124 E041 27.2621448 0.0019513570 5.301353e-01 7.221710e-01 11 76998763 76998821 59 + 1.298 1.239 -0.209
ENSG00000078124 E042 0.0000000       11 77010761 77011057 297 +      
ENSG00000078124 E043 0.5008152 0.0377261723 1.000000e+00   11 77011330 77011375 46 + 0.141 0.000 -12.202
ENSG00000078124 E044 2.1292553 0.0108647759 2.760508e-02 1.201306e-01 11 77013435 77015015 1581 + 0.306 0.706 1.999
ENSG00000078124 E045 38.9826056 0.0010219745 7.606638e-02 2.368847e-01 11 77015016 77015117 102 + 1.463 1.314 -0.518
ENSG00000078124 E046 0.6787990 0.0536644712 7.564664e-01   11 77015118 77015638 521 + 0.180 0.000 -12.517
ENSG00000078124 E047 0.3337900 0.0262411914 1.788001e-01   11 77015639 77015659 21 + 0.052 0.259 2.679
ENSG00000078124 E048 0.3228314 0.3704013773 1.000000e+00   11 77015660 77015979 320 + 0.099 0.000 -11.117
ENSG00000078124 E049 2.2800020 0.1258040724 1.519972e-02 7.884121e-02 11 77016013 77016674 662 + 0.280 0.778 2.463
ENSG00000078124 E050 39.8725930 0.0009140500 9.570283e-01 9.803859e-01 11 77016675 77016779 105 + 1.453 1.459 0.018
ENSG00000078124 E051 0.5227326 0.3672886882 7.326311e-02   11 77018042 77019536 1495 + 0.053 0.425 3.683
ENSG00000078124 E052 0.3206185 0.0274424043 1.000000e+00   11 77019537 77019730 194 + 0.099 0.000 -11.713
ENSG00000078124 E053 38.4027398 0.0009446653 4.838072e-01 6.896453e-01 11 77019731 77019776 46 + 1.448 1.392 -0.192
ENSG00000078124 E054 314.5416411 0.0003251129 1.088458e-06 3.058326e-05 11 77020274 77022835 2562 + 2.354 2.226 -0.427
ENSG00000078124 E055 98.3030880 0.0031277679 7.003317e-01 8.358512e-01 11 77022836 77024003 1168 + 1.841 1.821 -0.067
ENSG00000078124 E056 192.1165729 0.0025390433 6.363189e-01 7.945354e-01 11 77024004 77026797 2794 + 2.127 2.111 -0.054