ENSG00000077684

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000226319 ENSG00000077684 HEK293_OSMI2_6hA HEK293_TMG_6hB JADE1 protein_coding protein_coding 10.59519 8.776258 16.11376 1.453174 0.161201 0.8758674 0.3635967 0.0000000 1.0289512 0.0000000 0.5605465 6.6989841 0.03128750 0.00000000 0.06413333 0.064133333 3.860259e-01 1.365513e-07 FALSE TRUE
ENST00000413543 ENSG00000077684 HEK293_OSMI2_6hA HEK293_TMG_6hB JADE1 protein_coding protein_coding 10.59519 8.776258 16.11376 1.453174 0.161201 0.8758674 0.8014832 0.0000000 0.2641506 0.0000000 0.1342416 4.7768966 0.10609583 0.00000000 0.01646667 0.016466667 4.142576e-01 1.365513e-07 FALSE TRUE
ENST00000511647 ENSG00000077684 HEK293_OSMI2_6hA HEK293_TMG_6hB JADE1 protein_coding protein_coding 10.59519 8.776258 16.11376 1.453174 0.161201 0.8758674 2.9197685 4.9368779 3.3003889 0.6462806 0.1209592 -0.5795176 0.29447083 0.57310000 0.20476667 -0.368333333 1.365513e-07 1.365513e-07 FALSE TRUE
ENST00000512960 ENSG00000077684 HEK293_OSMI2_6hA HEK293_TMG_6hB JADE1 protein_coding protein_coding 10.59519 8.776258 16.11376 1.453174 0.161201 0.8758674 0.6687471 0.5635103 1.0876567 0.1503635 0.1284975 0.9365356 0.06238750 0.06210000 0.06756667 0.005466667 9.690915e-01 1.365513e-07 FALSE TRUE
ENST00000610919 ENSG00000077684 HEK293_OSMI2_6hA HEK293_TMG_6hB JADE1 protein_coding protein_coding 10.59519 8.776258 16.11376 1.453174 0.161201 0.8758674 3.7770468 2.7356136 7.2456407 0.4782248 1.0805750 1.4019744 0.33779167 0.31053333 0.45100000 0.140466667 5.179806e-01 1.365513e-07 FALSE TRUE
MSTRG.25460.16 ENSG00000077684 HEK293_OSMI2_6hA HEK293_TMG_6hB JADE1 protein_coding   10.59519 8.776258 16.11376 1.453174 0.161201 0.8758674 0.8156809 0.3216518 1.7377535 0.1770299 1.7377535 2.3977606 0.06648333 0.03313333 0.10633333 0.073200000 7.814077e-01 1.365513e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000077684 E001 0.4762370 0.021768165 4.019423e-01   4 128809700 128809702 3 + 0.103 0.250 1.537
ENSG00000077684 E002 7.3941622 0.109789242 5.397646e-01 0.7288035393 4 128809703 128809814 112 + 0.841 0.992 0.569
ENSG00000077684 E003 8.7617937 0.086298151 5.475111e-01 0.7344796262 4 128809815 128809843 29 + 0.918 1.052 0.495
ENSG00000077684 E004 13.6119795 0.042076147 7.517572e-01 0.8678299685 4 128809844 128809877 34 + 1.159 1.153 -0.022
ENSG00000077684 E005 0.0000000       4 128809919 128809919 1 +      
ENSG00000077684 E006 0.1779838 0.067041893 6.371801e-01   4 128809920 128810030 111 + 0.103 0.000 -9.407
ENSG00000077684 E007 0.9514940 0.097028409 7.669654e-01   4 128810031 128810088 58 + 0.258 0.333 0.511
ENSG00000077684 E008 7.7991079 0.003772564 7.227666e-01 0.8497929075 4 128810089 128810291 203 + 0.943 0.924 -0.072
ENSG00000077684 E009 0.0000000       4 128810292 128810386 95 +      
ENSG00000077684 E010 0.0000000       4 128811028 128811056 29 +      
ENSG00000077684 E011 0.0000000       4 128811270 128811270 1 +      
ENSG00000077684 E012 0.4043710 0.075359195 4.228398e-01   4 128811271 128811287 17 + 0.103 0.248 1.525
ENSG00000077684 E013 0.5470056 0.238995013 7.890293e-01   4 128811288 128811291 4 + 0.184 0.244 0.516
ENSG00000077684 E014 6.6698337 0.013309385 3.184861e-01 0.5583616860 4 128811292 128811325 34 + 0.915 0.810 -0.407
ENSG00000077684 E015 13.3083121 0.048465225 5.477244e-01 0.7346554237 4 128811326 128811396 71 + 1.165 1.119 -0.166
ENSG00000077684 E016 0.4514866 0.021604023 7.620733e-01   4 128811397 128811403 7 + 0.186 0.142 -0.466
ENSG00000077684 E017 0.5363366 0.024377415 4.763993e-02   4 128811806 128811841 36 + 0.000 0.336 12.029
ENSG00000077684 E018 0.1779838 0.067041893 6.371801e-01   4 128811844 128811974 131 + 0.103 0.000 -9.407
ENSG00000077684 E019 2.4392048 0.187536329 9.932074e-01 0.9982801116 4 128816367 128816463 97 + 0.504 0.532 0.133
ENSG00000077684 E020 0.2922838 0.026186337 8.176375e-01   4 128831433 128831553 121 + 0.103 0.142 0.533
ENSG00000077684 E021 53.2289045 0.030709250 3.889388e-01 0.6196560563 4 128831733 128831810 78 + 1.743 1.701 -0.140
ENSG00000077684 E022 0.2735028 0.025731552 8.167319e-01   4 128831811 128831811 1 + 0.103 0.142 0.535
ENSG00000077684 E023 67.8165925 0.030417278 1.853847e-01 0.4110550029 4 128842953 128843038 86 + 1.863 1.780 -0.281
ENSG00000077684 E024 88.4026947 0.021813121 2.391397e-01 0.4756047745 4 128846375 128846532 158 + 1.964 1.915 -0.164
ENSG00000077684 E025 56.0883658 0.017893230 1.961149e-01 0.4246817340 4 128848980 128849015 36 + 1.773 1.711 -0.207
ENSG00000077684 E026 116.1197957 0.010520071 8.527823e-02 0.2551443929 4 128849016 128849167 152 + 2.085 2.025 -0.202
ENSG00000077684 E027 149.3931929 0.010190499 2.241232e-01 0.4582982779 4 128852057 128852268 212 + 2.181 2.154 -0.091
ENSG00000077684 E028 118.6382892 0.017802214 5.433847e-01 0.7314459269 4 128855630 128855797 168 + 2.071 2.071 0.003
ENSG00000077684 E029 91.8222145 0.026194759 8.920827e-01 0.9476327891 4 128857338 128857454 117 + 1.943 1.983 0.133
ENSG00000077684 E030 124.7372946 0.027318824 9.124351e-01 0.9583451522 4 128861704 128861958 255 + 2.076 2.113 0.125
ENSG00000077684 E031 133.8358987 0.020532678 6.713852e-01 0.8171889355 4 128861959 128862225 267 + 2.091 2.163 0.242
ENSG00000077684 E032 269.3922717 0.039385825 3.414495e-05 0.0006024517 4 128862226 128864630 2405 + 2.207 2.617 1.367
ENSG00000077684 E033 45.1699599 0.041720583 1.022364e-02 0.0590768313 4 128867856 128867973 118 + 1.760 1.469 -0.993
ENSG00000077684 E034 518.5794021 1.889039568 8.363549e-01 0.9174285752 4 128871355 128875224 3870 + 2.731 2.676 -0.182