ENSG00000077585

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366592 ENSG00000077585 HEK293_OSMI2_6hA HEK293_TMG_6hB GPR137B protein_coding protein_coding 6.692094 8.199987 5.127993 0.3662573 0.3733607 -0.6761749 4.5110761 5.3620916 4.0732946 0.6855009 0.3053175 -0.39575022 0.68266250 0.64900000 0.79890000 0.14990000 6.017917e-01 9.173808e-08 FALSE TRUE
ENST00000419162 ENSG00000077585 HEK293_OSMI2_6hA HEK293_TMG_6hB GPR137B protein_coding nonsense_mediated_decay 6.692094 8.199987 5.127993 0.3662573 0.3733607 -0.6761749 0.4237823 0.3880528 0.0695151 0.1568704 0.0695151 -2.32365919 0.06500417 0.04756667 0.01473333 -0.03283333 5.449996e-01 9.173808e-08 TRUE TRUE
ENST00000477559 ENSG00000077585 HEK293_OSMI2_6hA HEK293_TMG_6hB GPR137B protein_coding processed_transcript 6.692094 8.199987 5.127993 0.3662573 0.3733607 -0.6761749 0.6174352 1.1247022 0.0000000 0.1805871 0.0000000 -6.82616996 0.08199167 0.13953333 0.00000000 -0.13953333 9.173808e-08 9.173808e-08   FALSE
MSTRG.3326.5 ENSG00000077585 HEK293_OSMI2_6hA HEK293_TMG_6hB GPR137B protein_coding   6.692094 8.199987 5.127993 0.3662573 0.3733607 -0.6761749 0.6195245 0.7501664 0.7211446 0.3105831 0.3796713 -0.05615848 0.09100833 0.09533333 0.13490000 0.03956667 1.000000e+00 9.173808e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000077585 E001 0.7844689 0.0211828099 4.090680e-01   1 236142505 236142538 34 + 0.151 0.301 1.269
ENSG00000077585 E002 0.7844689 0.0211828099 4.090680e-01   1 236142539 236142543 5 + 0.151 0.301 1.269
ENSG00000077585 E003 61.6626876 0.0006309967 2.146582e-01 0.4471334438 1 236142544 236143036 493 + 1.743 1.802 0.200
ENSG00000077585 E004 2.2293156 0.0356849982 5.116934e-01 0.7092846726 1 236145734 236145848 115 + 0.425 0.544 0.592
ENSG00000077585 E005 0.1308682 0.0308028073 7.705913e-01   1 236168701 236168705 5 + 0.000 0.097 8.589
ENSG00000077585 E006 32.3060176 0.0022924889 2.163046e-01 0.4490621899 1 236168706 236168755 50 + 1.447 1.531 0.288
ENSG00000077585 E007 71.3124888 0.0008036288 2.420963e-01 0.4789217050 1 236178414 236178636 223 + 1.809 1.862 0.177
ENSG00000077585 E008 66.5849446 0.0006767023 2.238120e-01 0.4579914570 1 236179879 236180028 150 + 1.847 1.800 -0.157
ENSG00000077585 E009 2.0892065 0.0198805553 7.824269e-01 0.8861049238 1 236180029 236180188 160 + 0.488 0.442 -0.234
ENSG00000077585 E010 61.9207459 0.0008706059 9.809291e-01 0.9922584521 1 236183778 236183906 129 + 1.784 1.788 0.016
ENSG00000077585 E011 65.3757403 0.0007089010 3.221528e-01 0.5615947681 1 236205126 236205250 125 + 1.829 1.790 -0.129
ENSG00000077585 E012 29.2537064 0.0021084375 9.962214e-01 0.9997595227 1 236208050 236208060 11 + 1.466 1.470 0.015
ENSG00000077585 E013 48.4909590 0.0009030739 8.183074e-02 0.2484502348 1 236208061 236208154 94 + 1.733 1.652 -0.277
ENSG00000077585 E014 81.8467678 0.0006203426 5.183767e-01 0.7139451007 1 236208155 236208907 753 + 1.918 1.897 -0.068
ENSG00000077585 E015 1.4866132 0.0128920032 8.144477e-02 0.2477066188 1 236213314 236213410 97 + 0.543 0.244 -1.727
ENSG00000077585 E016 1.6725190 0.0645888662 6.230120e-01 0.7858589503 1 236214641 236214764 124 + 0.350 0.443 0.517
ENSG00000077585 E017 1.6074798 0.0115763382 5.148608e-02 0.1832715645 1 236221791 236221865 75 + 0.151 0.513 2.442
ENSG00000077585 E018 3.1252224 0.0073671838 5.410106e-05 0.0008910489 1 236238997 236239077 81 + 0.000 0.761 12.840