ENSG00000077463

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337491 ENSG00000077463 HEK293_OSMI2_6hA HEK293_TMG_6hB SIRT6 protein_coding protein_coding 35.80876 52.99919 23.25477 8.440088 0.8770637 -1.188095 18.674499 30.602818 9.403100 6.0712300 0.3827912 -1.7013940 0.49122500 0.56880000 0.40673333 -0.16206667 0.11880474 1.188631e-06 FALSE TRUE
ENST00000594341 ENSG00000077463 HEK293_OSMI2_6hA HEK293_TMG_6hB SIRT6 protein_coding retained_intron 35.80876 52.99919 23.25477 8.440088 0.8770637 -1.188095 2.272812 2.314538 2.555387 1.1586934 0.6656884 0.1422322 0.07330000 0.05156667 0.10843333 0.05686667 0.79636636 1.188631e-06 FALSE FALSE
ENST00000596298 ENSG00000077463 HEK293_OSMI2_6hA HEK293_TMG_6hB SIRT6 protein_coding retained_intron 35.80876 52.99919 23.25477 8.440088 0.8770637 -1.188095 1.817238 2.289792 1.905920 0.6974201 0.3659018 -0.2634660 0.05178750 0.04130000 0.08143333 0.04013333 0.24212556 1.188631e-06 FALSE TRUE
ENST00000599394 ENSG00000077463 HEK293_OSMI2_6hA HEK293_TMG_6hB SIRT6 protein_coding retained_intron 35.80876 52.99919 23.25477 8.440088 0.8770637 -1.188095 2.443168 1.734394 2.975119 0.4515134 0.1938550 0.7750627 0.08601250 0.03736667 0.12806667 0.09070000 0.04875744 1.188631e-06 FALSE FALSE
ENST00000601069 ENSG00000077463 HEK293_OSMI2_6hA HEK293_TMG_6hB SIRT6 protein_coding retained_intron 35.80876 52.99919 23.25477 8.440088 0.8770637 -1.188095 1.848530 2.166515 1.555485 0.2369719 0.2616017 -0.4754104 0.06225833 0.04173333 0.06620000 0.02446667 0.37570822 1.188631e-06 TRUE TRUE
ENST00000601571 ENSG00000077463 HEK293_OSMI2_6hA HEK293_TMG_6hB SIRT6 protein_coding protein_coding 35.80876 52.99919 23.25477 8.440088 0.8770637 -1.188095 3.100127 4.941284 1.493517 0.9251132 0.5639608 -1.7194616 0.08395417 0.09263333 0.06623333 -0.02640000 0.73445060 1.188631e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000077463 E001 0.000000       19 4174109 4174109 1 -      
ENSG00000077463 E002 23.907346 0.0016748189 0.0015161369 0.013729066 19 4174110 4174140 31 - 1.501 1.249 -0.875
ENSG00000077463 E003 255.144700 0.0002639333 0.5847661997 0.760185731 19 4174141 4174335 195 - 2.324 2.330 0.020
ENSG00000077463 E004 360.180459 0.0007751345 0.0197500543 0.095052170 19 4174336 4174619 284 - 2.438 2.486 0.161
ENSG00000077463 E005 79.492098 0.0006149866 0.0659680645 0.216071876 19 4174620 4174635 16 - 1.764 1.847 0.278
ENSG00000077463 E006 98.198798 0.0024870444 0.0317451533 0.132477937 19 4174636 4174703 68 - 1.836 1.936 0.337
ENSG00000077463 E007 86.672851 0.0141303500 0.1207245689 0.316997425 19 4174704 4174860 157 - 1.765 1.879 0.385
ENSG00000077463 E008 30.289689 0.0114207914 0.0685222064 0.221785122 19 4174861 4174877 17 - 1.276 1.445 0.586
ENSG00000077463 E009 111.630388 0.0004929944 0.0156023131 0.080369802 19 4174878 4174946 69 - 1.894 1.986 0.310
ENSG00000077463 E010 20.176030 0.0090003266 0.2593768653 0.498310508 19 4174947 4175027 81 - 1.163 1.267 0.370
ENSG00000077463 E011 153.799915 0.0012450971 0.1376100996 0.343872090 19 4175028 4175111 84 - 2.071 2.116 0.150
ENSG00000077463 E012 141.850312 0.0003690273 0.8616294014 0.931205643 19 4175112 4175151 40 - 2.075 2.073 -0.008
ENSG00000077463 E013 60.716001 0.0393647608 0.0962781291 0.275223060 19 4175152 4175571 420 - 1.854 1.653 -0.680
ENSG00000077463 E014 27.582399 0.0395872395 0.1392261771 0.346354951 19 4175572 4175679 108 - 1.518 1.322 -0.677
ENSG00000077463 E015 212.794176 0.0007315018 0.5937857315 0.766218903 19 4175680 4175760 81 - 2.269 2.242 -0.091
ENSG00000077463 E016 10.609889 0.0737577346 0.8589946796 0.929844387 19 4175761 4175790 30 - 1.031 0.973 -0.213
ENSG00000077463 E017 13.194629 0.0210371758 0.1525498793 0.365983078 19 4175791 4175841 51 - 1.214 1.026 -0.674
ENSG00000077463 E018 237.591942 0.0002574875 0.7708395500 0.879173421 19 4175842 4175937 96 - 2.312 2.296 -0.054
ENSG00000077463 E019 188.106677 0.0003254580 0.6809263200 0.823249733 19 4177079 4177138 60 - 2.214 2.193 -0.069
ENSG00000077463 E020 283.197729 0.0002386697 0.9761677106 0.989865406 19 4179104 4179286 183 - 2.380 2.372 -0.026
ENSG00000077463 E021 20.387570 0.1377876183 0.0007465649 0.007832451 19 4179287 4179503 217 - 1.655 1.009 -2.260
ENSG00000077463 E022 15.558840 0.0800396023 0.0534787852 0.187856594 19 4180580 4180611 32 - 1.366 1.048 -1.126
ENSG00000077463 E023 28.969325 0.0608039853 0.0503740495 0.180569744 19 4180612 4180781 170 - 1.598 1.316 -0.974
ENSG00000077463 E024 224.628950 0.0003109493 0.2118416260 0.443896359 19 4180782 4180909 128 - 2.306 2.264 -0.143
ENSG00000077463 E025 6.486268 0.1088757199 0.6057159069 0.774012079 19 4182211 4182473 263 - 0.728 0.806 0.314
ENSG00000077463 E026 157.463555 0.0015500435 0.8439437108 0.921554342 19 4182474 4182566 93 - 2.133 2.115 -0.061