ENSG00000077380

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340296 ENSG00000077380 HEK293_OSMI2_6hA HEK293_TMG_6hB DYNC1I2 protein_coding protein_coding 25.92537 7.073102 44.12804 1.064869 3.357752 2.639569 7.798805 1.872589 14.42986 0.2718935 0.8050359 2.939266 0.3150458 0.2666333 0.32826667 0.06163333 5.017179e-01 5.827667e-06 FALSE TRUE
ENST00000409197 ENSG00000077380 HEK293_OSMI2_6hA HEK293_TMG_6hB DYNC1I2 protein_coding protein_coding 25.92537 7.073102 44.12804 1.064869 3.357752 2.639569 5.117086 1.781144 5.94359 0.2323488 0.2346594 1.732878 0.2220042 0.2558333 0.13563333 -0.12020000 1.548317e-02 5.827667e-06 FALSE TRUE
ENST00000435234 ENSG00000077380 HEK293_OSMI2_6hA HEK293_TMG_6hB DYNC1I2 protein_coding protein_coding 25.92537 7.073102 44.12804 1.064869 3.357752 2.639569 9.870851 2.783566 18.18783 0.7278593 1.6442198 2.703587 0.3526792 0.3778000 0.41173333 0.03393333 9.222646e-01 5.827667e-06 FALSE TRUE
ENST00000452242 ENSG00000077380 HEK293_OSMI2_6hA HEK293_TMG_6hB DYNC1I2 protein_coding protein_coding 25.92537 7.073102 44.12804 1.064869 3.357752 2.639569 1.376079 0.000000 2.50258 0.0000000 0.5370295 7.973026 0.0314375 0.0000000 0.05656667 0.05656667 5.827667e-06 5.827667e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000077380 E001 5.1430309 0.0619843442 8.553196e-01 0.9277961595 2 171687409 171687468 60 + 0.696 0.651 -0.188
ENSG00000077380 E002 5.4989985 0.0925113053 7.999238e-01 0.8963109478 2 171687469 171687470 2 + 0.724 0.652 -0.299
ENSG00000077380 E003 5.4989985 0.0925113053 7.999238e-01 0.8963109478 2 171687471 171687471 1 + 0.724 0.652 -0.299
ENSG00000077380 E004 30.6652031 0.0013742876 3.798591e-04 0.0045380808 2 171687472 171687500 29 + 1.440 1.105 -1.179
ENSG00000077380 E005 80.2177644 0.0006219098 4.474089e-05 0.0007569268 2 171687501 171687627 127 + 1.836 1.606 -0.781
ENSG00000077380 E006 0.4632531 0.0241315165 7.364158e-01   2 171687672 171687704 33 + 0.162 0.000 -11.765
ENSG00000077380 E007 0.4632531 0.0241315165 7.364158e-01   2 171687705 171687707 3 + 0.162 0.000 -11.765
ENSG00000077380 E008 0.9866059 0.0450321176 1.000000e+00   2 171687708 171687743 36 + 0.244 0.228 -0.122
ENSG00000077380 E009 3.1115074 0.0080716657 1.025053e-01 0.2862341250 2 171687744 171687754 11 + 0.570 0.228 -1.977
ENSG00000077380 E010 11.8215986 0.0026756409 5.256684e-02 0.1856498137 2 171687755 171687775 21 + 0.954 1.170 0.787
ENSG00000077380 E011 16.5833299 0.0020609043 6.745338e-03 0.0434446752 2 171687776 171687791 16 + 1.080 1.337 0.911
ENSG00000077380 E012 35.6600927 0.0043305749 3.193581e-02 0.1330220316 2 171687792 171687873 82 + 1.424 1.583 0.544
ENSG00000077380 E013 0.6129023 0.0191202150 7.191262e-01   2 171687881 171688003 123 + 0.162 0.228 0.606
ENSG00000077380 E014 0.0000000       2 171688006 171688010 5 +      
ENSG00000077380 E015 0.0000000       2 171688011 171688166 156 +      
ENSG00000077380 E016 0.1723744 0.0423815871 8.839012e-02   2 171688303 171688309 7 + 0.000 0.228 12.652
ENSG00000077380 E017 0.1723744 0.0423815871 8.839012e-02   2 171688310 171688358 49 + 0.000 0.228 12.652
ENSG00000077380 E018 0.4458772 0.0217681645 6.349834e-02   2 171688471 171688648 178 + 0.061 0.376 3.193
ENSG00000077380 E019 0.4654660 0.0267396063 7.357757e-01   2 171690145 171690146 2 + 0.162 0.000 -11.761
ENSG00000077380 E020 133.7954450 0.0029457672 3.239377e-01 0.5632616668 2 171690147 171690263 117 + 2.029 1.983 -0.155
ENSG00000077380 E021 126.6743840 0.0128664831 4.838378e-01 0.6896600842 2 171692777 171692894 118 + 2.007 1.958 -0.163
ENSG00000077380 E022 0.1779838 0.0357924609 1.000000e+00   2 171692895 171693084 190 + 0.061 0.000 -10.172
ENSG00000077380 E023 0.0000000       2 171706547 171706564 18 +      
ENSG00000077380 E024 0.0000000       2 171706890 171707232 343 +      
ENSG00000077380 E025 0.2852693 0.2588048041 1.000000e+00   2 171707233 171707286 54 + 0.113 0.000 -10.535
ENSG00000077380 E026 136.5152412 0.0003543287 6.879753e-02 0.2223570089 2 171707287 171707377 91 + 2.042 1.970 -0.240
ENSG00000077380 E027 0.3206185 0.0274424043 1.000000e+00   2 171712402 171712766 365 + 0.115 0.000 -11.183
ENSG00000077380 E028 3.4499817 0.0075287991 9.859353e-01 0.9947923675 2 171712767 171712826 60 + 0.570 0.575 0.022
ENSG00000077380 E029 151.9978498 0.0003011521 1.101620e-02 0.0624433928 2 171715328 171715389 62 + 2.091 1.995 -0.321
ENSG00000077380 E030 155.5380633 0.0003924577 1.567254e-01 0.3718505194 2 171715390 171715443 54 + 2.095 2.044 -0.171
ENSG00000077380 E031 223.9027415 0.0002769564 2.559669e-01 0.4947031326 2 171725618 171725713 96 + 2.247 2.214 -0.110
ENSG00000077380 E032 242.7617599 0.0002455299 5.285660e-01 0.7210015462 2 171725919 171726081 163 + 2.273 2.293 0.064
ENSG00000077380 E033 2.0691557 0.0105672526 2.728142e-01 0.5126318842 2 171726082 171726193 112 + 0.373 0.575 1.021
ENSG00000077380 E034 182.4770611 0.0004243283 6.100776e-01 0.7769361793 2 171726194 171726293 100 + 2.150 2.168 0.062
ENSG00000077380 E035 0.9710829 0.1058845497 1.000000e+00   2 171726558 171726790 233 + 0.246 0.227 -0.152
ENSG00000077380 E036 161.8026952 0.0003379166 6.244136e-02 0.2082355433 2 171726791 171726916 126 + 2.090 2.156 0.218
ENSG00000077380 E037 166.0348858 0.0012923576 2.128599e-01 0.4451019511 2 171727821 171727967 147 + 2.105 2.153 0.159
ENSG00000077380 E038 169.6720714 0.0009355368 5.591670e-01 0.7427059739 2 171728305 171728418 114 + 2.119 2.142 0.077
ENSG00000077380 E039 190.6724836 0.0047359168 8.352248e-01 0.9166558627 2 171728717 171728850 134 + 2.170 2.186 0.052
ENSG00000077380 E040 240.3240902 0.0011417222 3.520225e-02 0.1421120623 2 171729709 171729853 145 + 2.259 2.327 0.229
ENSG00000077380 E041 200.9934199 0.0018670966 1.121966e-01 0.3027700513 2 171744049 171744189 141 + 2.181 2.240 0.197
ENSG00000077380 E042 208.7307302 0.0002348460 8.279710e-01 0.9126103579 2 171745802 171745927 126 + 2.210 2.218 0.026
ENSG00000077380 E043 95.2936471 0.0005023931 4.831785e-01 0.6892480536 2 171747776 171747778 3 + 1.881 1.849 -0.108
ENSG00000077380 E044 238.9139510 0.0002858204 9.823728e-01 0.9929381449 2 171747779 171750158 2380 + 2.269 2.271 0.005