ENSG00000077150

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000189444 ENSG00000077150 HEK293_OSMI2_6hA HEK293_TMG_6hB NFKB2 protein_coding protein_coding 12.34028 19.69241 5.457566 2.276091 0.1170467 -1.849402 1.4184442 2.1796883 0.0000000 1.3949922 0.00000000 -7.7745817 0.07906250 0.10533333 0.00000000 -0.105333333 0.44640669 0.02607468 FALSE TRUE
ENST00000336486 ENSG00000077150 HEK293_OSMI2_6hA HEK293_TMG_6hB NFKB2 protein_coding processed_transcript 12.34028 19.69241 5.457566 2.276091 0.1170467 -1.849402 0.7527939 1.1237021 0.3209250 0.3740079 0.05203809 -1.7764655 0.06350417 0.06163333 0.05890000 -0.002733333 0.97703591 0.02607468 FALSE TRUE
ENST00000428099 ENSG00000077150 HEK293_OSMI2_6hA HEK293_TMG_6hB NFKB2 protein_coding protein_coding 12.34028 19.69241 5.457566 2.276091 0.1170467 -1.849402 0.8613953 1.4866057 0.4195994 0.3506068 0.07234545 -1.8006303 0.07064583 0.07336667 0.07683333 0.003466667 0.98578195 0.02607468 FALSE TRUE
ENST00000467116 ENSG00000077150 HEK293_OSMI2_6hA HEK293_TMG_6hB NFKB2 protein_coding retained_intron 12.34028 19.69241 5.457566 2.276091 0.1170467 -1.849402 0.4568012 0.4551796 0.8022386 0.2014171 0.06004175 0.8041156 0.05370000 0.02533333 0.14690000 0.121566667 0.02607468 0.02607468 FALSE TRUE
ENST00000652277 ENSG00000077150 HEK293_OSMI2_6hA HEK293_TMG_6hB NFKB2 protein_coding protein_coding 12.34028 19.69241 5.457566 2.276091 0.1170467 -1.849402 3.1474893 5.1217222 2.2357599 0.6651647 0.25682777 -1.1922394 0.27524583 0.26136667 0.41200000 0.150633333 0.33297015 0.02607468 FALSE TRUE
ENST00000661543 ENSG00000077150 HEK293_OSMI2_6hA HEK293_TMG_6hB NFKB2 protein_coding protein_coding 12.34028 19.69241 5.457566 2.276091 0.1170467 -1.849402 4.6065642 8.3350007 1.1776020 1.8327523 0.25230970 -2.8128608 0.36517500 0.41800000 0.21403333 -0.203966667 0.29741140 0.02607468 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000077150 E001 6.1541742 0.0048677250 0.334690998 0.57326652 10 102394110 102394328 219 + 0.871 0.730 -0.559
ENSG00000077150 E002 6.8801934 0.0052352694 0.819949261 0.90804694 10 102394329 102394502 174 + 0.827 0.795 -0.127
ENSG00000077150 E003 4.1435932 0.0065417273 0.491258343 0.69480348 10 102394503 102394555 53 + 0.497 0.624 0.583
ENSG00000077150 E004 4.1739531 0.0074583837 0.492258168 0.69551408 10 102394556 102394600 45 + 0.497 0.624 0.584
ENSG00000077150 E005 0.2617363 0.0728009538 1.000000000   10 102394601 102394774 174 + 0.001 0.110 7.036
ENSG00000077150 E006 3.1965539 0.1365504107 0.791686798 0.89143846 10 102395693 102395704 12 + 0.586 0.521 -0.296
ENSG00000077150 E007 3.5413026 0.2029961227 0.912968784 0.95857686 10 102395705 102395705 1 + 0.585 0.559 -0.121
ENSG00000077150 E008 3.5413026 0.2029961227 0.912968784 0.95857686 10 102395706 102395706 1 + 0.585 0.559 -0.121
ENSG00000077150 E009 12.7032014 0.0762377710 0.715096893 0.84502268 10 102395707 102395796 90 + 1.072 1.007 -0.236
ENSG00000077150 E010 12.7592152 0.0038964336 0.008766741 0.05278663 10 102395797 102395887 91 + 1.241 0.955 -1.034
ENSG00000077150 E011 45.4038163 0.0052388929 0.236774661 0.47288381 10 102395888 102395980 93 + 1.613 1.521 -0.314
ENSG00000077150 E012 64.3955872 0.0008684580 0.060918135 0.20485415 10 102396253 102396334 82 + 1.775 1.670 -0.355
ENSG00000077150 E013 63.1964377 0.0006242392 0.044986423 0.16755888 10 102396449 102396489 41 + 1.775 1.664 -0.375
ENSG00000077150 E014 4.7883572 0.0877015657 0.039179495 0.15263654 10 102396490 102396724 235 + 0.950 0.562 -1.580
ENSG00000077150 E015 87.2543062 0.0005769353 0.178389265 0.40176916 10 102396725 102396823 99 + 1.877 1.811 -0.220
ENSG00000077150 E016 117.4257739 0.0024522963 0.123906664 0.32191356 10 102396904 102397055 152 + 2.010 1.940 -0.236
ENSG00000077150 E017 65.4782814 0.0006388277 0.227477857 0.46234184 10 102397302 102397341 40 + 1.759 1.692 -0.227
ENSG00000077150 E018 56.4064567 0.0006515430 0.382244648 0.61404889 10 102397342 102397373 32 + 1.682 1.630 -0.178
ENSG00000077150 E019 53.6873552 0.0007884054 0.260303088 0.49927192 10 102397374 102397408 35 + 1.556 1.628 0.247
ENSG00000077150 E020 114.9709517 0.0003936840 0.315290640 0.55536819 10 102397527 102397685 159 + 1.979 1.936 -0.144
ENSG00000077150 E021 108.7696309 0.0004128371 0.099829297 0.28144809 10 102397981 102398072 92 + 1.976 1.904 -0.239
ENSG00000077150 E022 64.1860828 0.0027205368 0.098528344 0.27924531 10 102398073 102398085 13 + 1.770 1.668 -0.347
ENSG00000077150 E023 101.9887771 0.0029741872 0.053187134 0.18723878 10 102398212 102398297 86 + 1.969 1.867 -0.344
ENSG00000077150 E024 113.9423103 0.0004885911 0.473642169 0.68253183 10 102398385 102398523 139 + 1.962 1.930 -0.109
ENSG00000077150 E025 81.2055513 0.0005040153 0.320396788 0.56005212 10 102398739 102398864 126 + 1.748 1.799 0.171
ENSG00000077150 E026 4.0075925 0.0999528218 0.033959170 0.13875438 10 102398865 102399218 354 + 0.913 0.501 -1.730
ENSG00000077150 E027 64.7391602 0.0111384641 0.001486761 0.01352001 10 102399288 102399497 210 + 1.462 1.728 0.907
ENSG00000077150 E028 69.7214853 0.0005674580 0.053223944 0.18729071 10 102399577 102399718 142 + 1.635 1.746 0.378
ENSG00000077150 E029 16.7554134 0.2328908548 0.136871689 0.34271502 10 102399927 102400079 153 + 1.384 1.053 -1.173
ENSG00000077150 E030 92.1220425 0.0038632026 0.428901748 0.65026267 10 102400080 102400194 115 + 1.885 1.836 -0.166
ENSG00000077150 E031 118.8604459 0.0004381410 0.669213180 0.81572034 10 102400278 102400491 214 + 1.969 1.949 -0.066
ENSG00000077150 E032 8.0486422 0.1789200639 0.360299030 0.59593531 10 102400578 102400654 77 + 0.984 0.812 -0.653
ENSG00000077150 E033 121.3863885 0.0005216160 0.974491253 0.98910117 10 102400655 102400824 170 + 1.966 1.963 -0.008
ENSG00000077150 E034 105.7969654 0.0004829219 0.201956113 0.43202027 10 102400947 102401049 103 + 1.860 1.918 0.196
ENSG00000077150 E035 1.5069716 0.0126053535 0.626243797 0.78807410 10 102401050 102401179 130 + 0.234 0.336 0.709
ENSG00000077150 E036 128.4031225 0.0003822630 0.214736748 0.44720386 10 102401180 102401331 152 + 1.948 1.999 0.170
ENSG00000077150 E037 82.9579973 0.0019745824 0.221168254 0.45489671 10 102401449 102401518 70 + 1.748 1.816 0.230
ENSG00000077150 E038 118.9322166 0.0055047434 0.008542137 0.05180203 10 102401745 102401917 173 + 1.824 1.978 0.517
ENSG00000077150 E039 74.3926715 0.0009561146 0.005363254 0.03651395 10 102402048 102402104 57 + 1.620 1.783 0.553
ENSG00000077150 E040 84.7532835 0.0005704245 0.004761270 0.03333497 10 102402105 102402159 55 + 1.682 1.835 0.516
ENSG00000077150 E041 25.2650521 0.0151255179 0.049025982 0.17727079 10 102402252 102402254 3 + 1.095 1.321 0.800
ENSG00000077150 E042 83.8797714 0.0004923334 0.006335108 0.04138032 10 102402255 102402524 270 + 1.682 1.829 0.497