ENSG00000077044

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264057 ENSG00000077044 HEK293_OSMI2_6hA HEK293_TMG_6hB DGKD protein_coding protein_coding 18.81098 27.32685 18.61267 2.476585 0.3439551 -0.553787 9.6381844 15.411105 8.58400712 1.7934099 0.03047997 -0.8435032 0.51745000 0.57290000 0.461566667 -0.11133333 6.839627e-01 9.073474e-05 FALSE TRUE
ENST00000430834 ENSG00000077044 HEK293_OSMI2_6hA HEK293_TMG_6hB DGKD protein_coding nonsense_mediated_decay 18.81098 27.32685 18.61267 2.476585 0.3439551 -0.553787 1.2809189 2.025102 0.02948121 0.4782335 0.02948121 -5.6877910 0.06417917 0.07896667 0.001566667 -0.07740000 9.073474e-05 9.073474e-05 FALSE TRUE
ENST00000471764 ENSG00000077044 HEK293_OSMI2_6hA HEK293_TMG_6hB DGKD protein_coding retained_intron 18.81098 27.32685 18.61267 2.476585 0.3439551 -0.553787 2.0827285 2.278664 2.71016683 1.3692583 0.53956672 0.2491895 0.10759583 0.07590000 0.144666667 0.06876667 7.642762e-01 9.073474e-05   FALSE
ENST00000480535 ENSG00000077044 HEK293_OSMI2_6hA HEK293_TMG_6hB DGKD protein_coding processed_transcript 18.81098 27.32685 18.61267 2.476585 0.3439551 -0.553787 1.2865280 1.930433 1.57024584 0.5170253 0.59786085 -0.2962298 0.06710417 0.06873333 0.085533333 0.01680000 9.724418e-01 9.073474e-05   FALSE
ENST00000490764 ENSG00000077044 HEK293_OSMI2_6hA HEK293_TMG_6hB DGKD protein_coding retained_intron 18.81098 27.32685 18.61267 2.476585 0.3439551 -0.553787 0.9784568 1.054807 1.46602197 0.4668661 0.33435075 0.4711222 0.05233333 0.03640000 0.078666667 0.04226667 4.765751e-01 9.073474e-05 FALSE TRUE
ENST00000495901 ENSG00000077044 HEK293_OSMI2_6hA HEK293_TMG_6hB DGKD protein_coding retained_intron 18.81098 27.32685 18.61267 2.476585 0.3439551 -0.553787 1.2423470 1.321072 1.81660166 0.4378399 0.06219899 0.4565729 0.06617917 0.04840000 0.097566667 0.04916667 3.503609e-01 9.073474e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000077044 E001 0.7254668 0.0732245970 7.611223e-01   2 233354494 233354507 14 + 0.164 0.227 0.578
ENSG00000077044 E002 14.7471053 0.0024130857 9.583780e-02 2.744840e-01 2 233354508 233354571 64 + 1.045 1.227 0.651
ENSG00000077044 E003 46.3973620 0.0068283127 1.063928e-02 6.085123e-02 2 233354572 233354674 103 + 1.744 1.595 -0.506
ENSG00000077044 E004 0.0000000       2 233385945 233386010 66 +      
ENSG00000077044 E005 0.0000000       2 233386054 233386214 161 +      
ENSG00000077044 E006 0.1723744 0.0336464856 1.000000e+00   2 233388154 233388256 103 + 0.000 0.089 8.432
ENSG00000077044 E007 86.1498368 0.0057764776 1.427247e-04 2.012951e-03 2 233388257 233388367 111 + 2.028 1.843 -0.620
ENSG00000077044 E008 0.2922838 0.0264292286 5.830861e-01   2 233388368 233388985 618 + 0.164 0.089 -1.019
ENSG00000077044 E009 94.0037536 0.0005532936 2.562112e-09 1.374741e-07 2 233390403 233390483 81 + 2.077 1.871 -0.693
ENSG00000077044 E010 5.8561138 0.0151806586 5.766251e-01 7.548367e-01 2 233392070 233392399 330 + 0.843 0.779 -0.254
ENSG00000077044 E011 0.0000000       2 233408891 233409051 161 +      
ENSG00000077044 E012 0.0000000       2 233419241 233419421 181 +      
ENSG00000077044 E013 85.6086880 0.0006142382 1.021446e-08 4.785240e-07 2 233434380 233434466 87 + 2.040 1.833 -0.696
ENSG00000077044 E014 55.8744068 0.0008454091 3.566038e-05 6.249693e-04 2 233434467 233434484 18 + 1.841 1.658 -0.621
ENSG00000077044 E015 87.2627215 0.0004786685 7.303565e-07 2.160825e-05 2 233434769 233434901 133 + 2.031 1.858 -0.581
ENSG00000077044 E016 73.7105946 0.0004880781 9.297928e-03 5.507890e-02 2 233435818 233435924 107 + 1.908 1.816 -0.310
ENSG00000077044 E017 73.6540700 0.0005934504 5.264016e-01 7.194660e-01 2 233436316 233436441 126 + 1.858 1.850 -0.027
ENSG00000077044 E018 74.6245611 0.0008340714 2.720536e-02 1.188970e-01 2 233437377 233437479 103 + 1.908 1.831 -0.257
ENSG00000077044 E019 73.6301052 0.0006506772 4.978560e-03 3.450773e-02 2 233438217 233438312 96 + 1.917 1.816 -0.340
ENSG00000077044 E020 64.4060493 0.0005914025 6.367257e-03 4.153281e-02 2 233438313 233438379 67 + 1.861 1.756 -0.354
ENSG00000077044 E021 93.8218537 0.0045239048 1.056928e-01 2.918504e-01 2 233441887 233441995 109 + 1.995 1.931 -0.214
ENSG00000077044 E022 5.7362848 0.1990856515 4.995797e-01 7.004777e-01 2 233441996 233442591 596 + 0.874 0.777 -0.377
ENSG00000077044 E023 106.6563519 0.0012795054 6.910563e-01 8.297624e-01 2 233445623 233445762 140 + 2.008 2.011 0.010
ENSG00000077044 E024 82.4458380 0.0047726676 6.126478e-01 7.786793e-01 2 233446712 233446796 85 + 1.904 1.891 -0.042
ENSG00000077044 E025 21.6499704 0.0837169222 3.926417e-01 6.225163e-01 2 233447701 233447905 205 + 1.394 1.288 -0.368
ENSG00000077044 E026 11.0054001 0.0807193162 7.583422e-01 8.715929e-01 2 233448030 233448086 57 + 0.986 1.085 0.360
ENSG00000077044 E027 92.9548252 0.0004995660 5.374819e-01 7.272877e-01 2 233448087 233448181 95 + 1.920 1.963 0.146
ENSG00000077044 E028 95.8145913 0.0004732356 5.546837e-01 7.395507e-01 2 233448276 233448375 100 + 1.934 1.976 0.141
ENSG00000077044 E029 161.1319044 0.0002959510 2.572738e-01 4.960322e-01 2 233449103 233449376 274 + 2.196 2.182 -0.048
ENSG00000077044 E030 122.0492718 0.0004052722 1.857658e-01 4.115653e-01 2 233449982 233450131 150 + 2.084 2.058 -0.086
ENSG00000077044 E031 117.6565504 0.0004721843 9.505827e-01 9.772549e-01 2 233450922 233451050 129 + 2.040 2.058 0.058
ENSG00000077044 E032 115.0038261 0.0036514227 8.516321e-01 9.259725e-01 2 233451964 233452060 97 + 2.022 2.050 0.095
ENSG00000077044 E033 1.5540872 0.0126868096 5.144949e-01 7.113564e-01 2 233454357 233454464 108 + 0.283 0.413 0.793
ENSG00000077044 E034 119.9933088 0.0039620217 9.061126e-01 9.551518e-01 2 233454763 233454873 111 + 2.042 2.067 0.083
ENSG00000077044 E035 113.4624857 0.0020043080 9.191641e-01 9.617941e-01 2 233456899 233456995 97 + 2.025 2.040 0.049
ENSG00000077044 E036 112.8574475 0.0016385697 8.243481e-01 9.104957e-01 2 233457221 233457328 108 + 2.016 2.045 0.096
ENSG00000077044 E037 35.8000343 0.1700882598 1.411562e-01 3.492462e-01 2 233457329 233457817 489 + 1.679 1.450 -0.782
ENSG00000077044 E038 6.8038778 0.1734916775 1.710359e-01 3.919128e-01 2 233458239 233458283 45 + 1.009 0.786 -0.852
ENSG00000077044 E039 106.6578802 0.0010086219 8.765200e-01 9.394544e-01 2 233458284 233458397 114 + 1.994 2.020 0.086
ENSG00000077044 E040 117.9523821 0.0015824993 9.259098e-02 2.685673e-01 2 233459757 233459891 135 + 1.992 2.077 0.282
ENSG00000077044 E041 10.1775249 0.0782312761 9.645748e-01 9.842041e-01 2 233460105 233460193 89 + 1.005 1.029 0.090
ENSG00000077044 E042 141.4201424 0.0003379294 3.332368e-03 2.538522e-02 2 233460194 233460345 152 + 2.048 2.163 0.387
ENSG00000077044 E043 142.5081306 0.0003669198 1.658046e-01 3.848571e-01 2 233462348 233462459 112 + 2.087 2.151 0.214
ENSG00000077044 E044 116.2147856 0.0004237089 9.419856e-01 9.732419e-01 2 233462643 233462735 93 + 2.027 2.049 0.071
ENSG00000077044 E045 15.8732876 0.0795723529 1.400745e-02 7.436853e-02 2 233463814 233464163 350 + 1.398 1.051 -1.230
ENSG00000077044 E046 118.5801904 0.0007215929 4.452362e-01 6.622292e-01 2 233464164 233464283 120 + 2.020 2.066 0.155
ENSG00000077044 E047 120.7586019 0.0004135042 6.348712e-01 7.934790e-01 2 233467086 233467203 118 + 2.037 2.072 0.120
ENSG00000077044 E048 108.3922829 0.0003794444 5.271712e-03 3.603808e-02 2 233468423 233468553 131 + 1.927 2.050 0.415
ENSG00000077044 E049 1077.2170411 0.0023064805 1.467497e-09 8.307160e-08 2 233469371 233472104 2734 + 2.905 3.046 0.471