ENSG00000076864

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374761 ENSG00000076864 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1GAP protein_coding protein_coding 3.98821 5.155658 1.879543 0.580397 0.1018147 -1.450915 0.7306509 0.8209559 0.3510154 0.3974817 0.3510154 -1.202711 0.18188333 0.14970000 0.16876667 0.01906667 0.73020710 0.01701234 FALSE  
ENST00000374765 ENSG00000076864 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1GAP protein_coding protein_coding 3.98821 5.155658 1.879543 0.580397 0.1018147 -1.450915 2.2560941 3.1236765 0.7573851 0.4072031 0.3818106 -2.029833 0.55482917 0.61860000 0.42526667 -0.19333333 0.86638478 0.01701234 FALSE  
ENST00000471600 ENSG00000076864 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1GAP protein_coding nonsense_mediated_decay 3.98821 5.155658 1.879543 0.580397 0.1018147 -1.450915 0.3095823 0.4442272 0.0000000 0.1747966 0.0000000 -5.505342 0.07107917 0.08203333 0.00000000 -0.08203333 0.01701234 0.01701234 TRUE  
ENST00000495204 ENSG00000076864 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1GAP protein_coding protein_coding 3.98821 5.155658 1.879543 0.580397 0.1018147 -1.450915 0.1332981 0.0000000 0.1649796 0.0000000 0.1649796 4.129114 0.03796250 0.00000000 0.09116667 0.09116667 0.75219147 0.01701234 FALSE  
ENST00000542643 ENSG00000076864 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1GAP protein_coding protein_coding 3.98821 5.155658 1.879543 0.580397 0.1018147 -1.450915 0.2441316 0.3999968 0.0000000 0.1231842 0.0000000 -5.357541 0.05854583 0.08226667 0.00000000 -0.08226667 0.04139181 0.01701234 FALSE  
MSTRG.498.9 ENSG00000076864 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1GAP protein_coding   3.98821 5.155658 1.879543 0.580397 0.1018147 -1.450915 0.1150004 0.1861549 0.4790764 0.1861549 0.2465987 1.318067 0.04461250 0.03340000 0.24906667 0.21566667 0.53847429 0.01701234 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000076864 E001 0.1308682 0.030754040 1.00000000   1 21596221 21596221 1 - 0.000 0.069 9.737
ENSG00000076864 E002 71.4688595 0.577405558 0.31947965 0.55923230 1 21596222 21596970 749 - 1.567 1.823 0.867
ENSG00000076864 E003 14.3446015 0.112420916 0.33781360 0.57613376 1 21596971 21597007 37 - 0.966 1.143 0.647
ENSG00000076864 E004 21.8965350 0.169812667 0.22611326 0.46072628 1 21597008 21597183 176 - 1.082 1.325 0.861
ENSG00000076864 E005 15.6195230 0.112695686 0.38854189 0.61929448 1 21597184 21597264 81 - 0.996 1.177 0.659
ENSG00000076864 E006 14.6141650 0.002737474 0.17303363 0.39452605 1 21597686 21597728 43 - 0.975 1.154 0.651
ENSG00000076864 E007 18.9676788 0.002313966 0.64389651 0.79945378 1 21597961 21598040 80 - 1.173 1.244 0.252
ENSG00000076864 E008 10.7539831 0.003019151 0.34266042 0.58036083 1 21598041 21598064 24 - 0.883 1.027 0.538
ENSG00000076864 E009 1.6650768 0.012703040 0.62792985 0.78917831 1 21598065 21598095 31 - 0.449 0.376 -0.396
ENSG00000076864 E010 19.2283676 0.001983996 0.97857586 0.99107052 1 21598400 21598449 50 - 1.206 1.236 0.103
ENSG00000076864 E011 20.4037885 0.002052649 0.33218288 0.57100930 1 21598450 21598502 53 - 1.295 1.236 -0.207
ENSG00000076864 E012 32.9274958 0.006058753 0.94194853 0.97323704 1 21599494 21599617 124 - 1.430 1.464 0.115
ENSG00000076864 E013 23.1174602 0.015334891 0.57418782 0.75315232 1 21601684 21601797 114 - 1.239 1.329 0.317
ENSG00000076864 E014 23.5015043 0.002735499 0.86836888 0.93504322 1 21602804 21602913 110 - 1.308 1.321 0.047
ENSG00000076864 E015 3.1130617 0.011357462 0.04469645 0.16686420 1 21602914 21603657 744 - 0.766 0.462 -1.350
ENSG00000076864 E016 0.5530924 0.023199633 0.60893295   1 21603658 21603834 177 - 0.205 0.129 -0.806
ENSG00000076864 E017 0.3559677 0.381124671 0.05573533   1 21603835 21603912 78 - 0.349 0.000 -14.421
ENSG00000076864 E018 23.1621024 0.001701397 0.74442271 0.86331887 1 21606066 21606197 132 - 1.308 1.307 -0.001
ENSG00000076864 E019 26.0737569 0.001860644 0.49199624 0.69531293 1 21608213 21608350 138 - 1.368 1.340 -0.098
ENSG00000076864 E020 20.2689633 0.002177502 0.66389330 0.81233118 1 21608850 21608936 87 - 1.253 1.240 -0.046
ENSG00000076864 E021 15.4999028 0.020462980 0.36846894 0.60277913 1 21609575 21609646 72 - 1.192 1.113 -0.284
ENSG00000076864 E022 33.8762743 0.007777176 0.81070415 0.90269102 1 21610120 21610275 156 - 1.451 1.456 0.017
ENSG00000076864 E023 37.3003355 0.001232311 0.88809572 0.94563939 1 21611452 21611581 130 - 1.486 1.503 0.061
ENSG00000076864 E024 34.2616647 0.001877940 0.49344045 0.69623570 1 21611716 21611816 101 - 1.486 1.466 -0.069
ENSG00000076864 E025 33.9814370 0.001466283 0.01026017 0.05922785 1 21612026 21612109 84 - 1.571 1.426 -0.497
ENSG00000076864 E026 0.0000000       1 21613036 21613175 140 -      
ENSG00000076864 E027 30.7466718 0.001486888 0.05231204 0.18506031 1 21613176 21613229 54 - 1.502 1.391 -0.383
ENSG00000076864 E028 32.4285521 0.001200064 0.88726850 0.94522471 1 21613628 21613706 79 - 1.411 1.448 0.129
ENSG00000076864 E029 35.8962132 0.001189922 0.66423091 0.81251665 1 21613986 21614089 104 - 1.440 1.498 0.199
ENSG00000076864 E030 19.3679002 0.002253625 0.33295297 0.57159249 1 21617306 21617306 1 - 1.136 1.257 0.428
ENSG00000076864 E031 37.9656365 0.003199541 0.87460071 0.93850194 1 21617307 21617491 185 - 1.494 1.511 0.057
ENSG00000076864 E032 0.1308682 0.030754040 1.00000000   1 21617932 21617933 2 - 0.000 0.069 9.734
ENSG00000076864 E033 15.5190437 0.013628130 0.60425426 0.77305051 1 21617934 21617972 39 - 1.156 1.124 -0.114
ENSG00000076864 E034 13.9226376 0.005541583 0.72081454 0.84868471 1 21619025 21619072 48 - 1.096 1.082 -0.052
ENSG00000076864 E035 8.5921910 0.004213507 0.33082728 0.56973443 1 21620015 21620040 26 - 0.976 0.878 -0.368
ENSG00000076864 E036 7.1652678 0.005190282 0.30585486 0.54652831 1 21620041 21620050 10 - 0.916 0.803 -0.437
ENSG00000076864 E037 1.3982810 0.025782088 0.80044252 0.89657059 1 21622339 21622568 230 - 0.344 0.309 -0.222
ENSG00000076864 E038 0.0000000       1 21622923 21622981 59 -      
ENSG00000076864 E039 8.6843133 0.004254594 0.55880317 0.74240229 1 21626304 21626397 94 - 0.947 0.898 -0.186
ENSG00000076864 E040 4.4240762 0.006550134 0.06378507 0.21121109 1 21649761 21649796 36 - 0.847 0.595 -1.041
ENSG00000076864 E041 0.0000000       1 21651392 21651778 387 -      
ENSG00000076864 E042 1.5571079 0.446978966 0.47760481 0.68548195 1 21651779 21651903 125 - 0.535 0.280 -1.426
ENSG00000076864 E043 0.0000000       1 21653134 21653307 174 -      
ENSG00000076864 E044 1.5750947 0.161697956 0.98187934 0.99273698 1 21665211 21665317 107 - 0.344 0.374 0.179
ENSG00000076864 E045 0.0000000       1 21667598 21667681 84 -      
ENSG00000076864 E046 0.2617363 0.138003542 1.00000000   1 21668511 21668593 83 - 0.000 0.127 10.711
ENSG00000076864 E047 1.1539680 0.042946433 0.14602725   1 21669254 21669357 104 - 0.000 0.344 12.547