ENSG00000076685

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343289 ENSG00000076685 HEK293_OSMI2_6hA HEK293_TMG_6hB NT5C2 protein_coding protein_coding 18.99501 7.582122 30.829 1.615774 1.763428 2.022181 6.2190243 2.4909665 10.17409962 0.6776765 0.47500950 2.02576082 0.34062917 0.31780000 0.33046667 0.01266667 0.9689272811 0.0004374893 FALSE TRUE
ENST00000404739 ENSG00000076685 HEK293_OSMI2_6hA HEK293_TMG_6hB NT5C2 protein_coding protein_coding 18.99501 7.582122 30.829 1.615774 1.763428 2.022181 3.4157698 1.0939610 6.46701733 0.2687339 0.56117766 2.55264038 0.15527083 0.14150000 0.21116667 0.06966667 0.4083716843 0.0004374893 FALSE TRUE
ENST00000452156 ENSG00000076685 HEK293_OSMI2_6hA HEK293_TMG_6hB NT5C2 protein_coding nonsense_mediated_decay 18.99501 7.582122 30.829 1.615774 1.763428 2.022181 0.6877832 0.0000000 2.11413534 0.0000000 0.73529982 7.73073188 0.02332083 0.00000000 0.07166667 0.07166667 0.0004374893 0.0004374893 FALSE FALSE
ENST00000675645 ENSG00000076685 HEK293_OSMI2_6hA HEK293_TMG_6hB NT5C2 protein_coding protein_coding 18.99501 7.582122 30.829 1.615774 1.763428 2.022181 0.6436339 0.1018633 2.12963118 0.1018633 0.49088564 4.25755402 0.02477083 0.01060000 0.06790000 0.05730000 0.1836763274 0.0004374893 FALSE TRUE
MSTRG.4575.30 ENSG00000076685 HEK293_OSMI2_6hA HEK293_TMG_6hB NT5C2 protein_coding   18.99501 7.582122 30.829 1.615774 1.763428 2.022181 1.3529949 0.5947515 0.60330032 0.3376343 0.33174144 0.02025135 0.09325417 0.06396667 0.01846667 -0.04550000 0.8518449493 0.0004374893   FALSE
MSTRG.4575.32 ENSG00000076685 HEK293_OSMI2_6hA HEK293_TMG_6hB NT5C2 protein_coding   18.99501 7.582122 30.829 1.615774 1.763428 2.022181 0.2418476 0.5166003 0.09271159 0.2705427 0.04642149 -2.35810944 0.02205417 0.07180000 0.00310000 -0.06870000 0.0328396442 0.0004374893   TRUE
MSTRG.4575.6 ENSG00000076685 HEK293_OSMI2_6hA HEK293_TMG_6hB NT5C2 protein_coding   18.99501 7.582122 30.829 1.615774 1.763428 2.022181 2.7698652 1.4706568 4.10669107 0.3937187 0.48784266 1.47524793 0.15448333 0.19740000 0.13280000 -0.06460000 0.5629246676 0.0004374893 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000076685 E001 0.4654660 0.0244411696 4.968784e-01   10 103087185 103087256 72 - 0.174 0.000 -12.866
ENSG00000076685 E002 2.3520084 0.0132677510 1.527430e-01 3.662861e-01 10 103087257 103088017 761 - 0.393 0.682 1.371
ENSG00000076685 E003 0.2852693 0.1662826017 9.216680e-01   10 103088018 103088037 20 - 0.122 0.000 -12.256
ENSG00000076685 E004 0.1426347 0.0311494226 1.000000e+00   10 103088038 103088059 22 - 0.066 0.000 -11.270
ENSG00000076685 E005 1.0242381 0.0194902218 5.732464e-01   10 103088060 103088071 12 - 0.297 0.213 -0.632
ENSG00000076685 E006 6.4961109 0.2890783935 2.454270e-01 4.828726e-01 10 103088072 103088119 48 - 0.717 1.035 1.227
ENSG00000076685 E007 9.9555936 0.2439700639 1.570732e-01 3.723629e-01 10 103088120 103088163 44 - 0.864 1.209 1.267
ENSG00000076685 E008 11.5105245 0.2781560848 2.961048e-01 5.366409e-01 10 103088164 103088170 7 - 0.962 1.180 0.791
ENSG00000076685 E009 13.1003209 0.2702027178 1.100819e-01 2.991453e-01 10 103088171 103088180 10 - 0.962 1.326 1.307
ENSG00000076685 E010 11.7504903 0.2717902600 1.528281e-01 3.663797e-01 10 103088181 103088182 2 - 0.934 1.257 1.170
ENSG00000076685 E011 96.6181376 1.1813426161 2.877641e-01 5.285017e-01 10 103088183 103088481 299 - 1.785 2.177 1.315
ENSG00000076685 E012 32.0660736 0.5437470617 1.222661e-01 3.194206e-01 10 103088482 103088483 2 - 1.297 1.737 1.510
ENSG00000076685 E013 44.1194359 0.6715031308 1.835127e-01 4.084729e-01 10 103088484 103088501 18 - 1.454 1.839 1.310
ENSG00000076685 E014 43.0537199 0.6909395358 2.138602e-01 4.461938e-01 10 103088502 103088516 15 - 1.457 1.807 1.190
ENSG00000076685 E015 74.1508943 0.8574397545 2.308828e-01 4.661806e-01 10 103088517 103088648 132 - 1.682 2.048 1.235
ENSG00000076685 E016 412.6787109 1.7529705848 5.074532e-01 7.059931e-01 10 103088649 103089840 1192 - 2.469 2.696 0.756
ENSG00000076685 E017 75.7352288 0.9168285810 4.492572e-01 6.652036e-01 10 103089841 103089908 68 - 1.749 1.940 0.643
ENSG00000076685 E018 51.5087063 0.1648469552 4.659449e-01 6.772152e-01 10 103090611 103090638 28 - 1.609 1.715 0.361
ENSG00000076685 E019 107.4927998 0.0019487305 9.545721e-01 9.792342e-01 10 103090639 103090787 149 - 1.933 2.004 0.238
ENSG00000076685 E020 89.6287430 0.0060271916 4.948829e-01 6.973418e-01 10 103090936 103090996 61 - 1.862 1.903 0.140
ENSG00000076685 E021 86.4767028 0.0005852913 9.058568e-01 9.550573e-01 10 103091564 103091615 52 - 1.841 1.915 0.248
ENSG00000076685 E022 135.8243013 0.0143807671 3.443736e-01 5.819738e-01 10 103093139 103093272 134 - 2.040 2.069 0.097
ENSG00000076685 E023 72.5864106 0.0251518456 3.951263e-01 6.244742e-01 10 103093273 103093309 37 - 1.775 1.788 0.044
ENSG00000076685 E024 2.1172514 0.0211286755 5.493347e-01 7.358564e-01 10 103093732 103093971 240 - 0.394 0.549 0.786
ENSG00000076685 E025 97.9423790 0.0232211525 1.897791e-01 4.167132e-01 10 103093972 103094038 67 - 1.910 1.893 -0.056
ENSG00000076685 E026 117.0778693 0.0153552280 1.367623e-01 3.425521e-01 10 103094348 103094455 108 - 1.986 1.971 -0.052
ENSG00000076685 E027 0.6190593 0.0193821220 9.402261e-01   10 103094456 103094535 80 - 0.174 0.213 0.369
ENSG00000076685 E028 68.9808944 0.0056964009 1.532329e-01 3.669736e-01 10 103095939 103095980 42 - 1.760 1.750 -0.035
ENSG00000076685 E029 52.1136911 0.0079697804 4.733830e-02 1.733618e-01 10 103097291 103097307 17 - 1.651 1.579 -0.246
ENSG00000076685 E030 76.7414763 0.0132014051 9.852029e-03 5.748303e-02 10 103097308 103097374 67 - 1.823 1.710 -0.382
ENSG00000076685 E031 18.6607564 0.0533386638 5.401489e-01 7.291030e-01 10 103097375 103097971 597 - 1.216 1.193 -0.082
ENSG00000076685 E032 4.8003049 0.0237149622 6.794929e-01 8.224183e-01 10 103097972 103098047 76 - 0.693 0.682 -0.048
ENSG00000076685 E033 4.4715042 0.1180464454 5.698671e-01 7.501938e-01 10 103098048 103098088 41 - 0.680 0.618 -0.263
ENSG00000076685 E034 8.9194052 0.1911530535 8.408691e-01 9.199360e-01 10 103098089 103098391 303 - 0.913 0.930 0.065
ENSG00000076685 E035 14.1317381 0.0542922161 8.851560e-02 2.610309e-01 10 103098392 103098930 539 - 1.131 0.934 -0.722
ENSG00000076685 E036 62.7920213 0.0265881751 8.175022e-03 5.013567e-02 10 103098931 103098970 40 - 1.747 1.573 -0.591
ENSG00000076685 E037 49.6164744 0.0310077076 7.700888e-03 4.793417e-02 10 103098971 103098984 14 - 1.650 1.446 -0.696
ENSG00000076685 E038 97.3400688 0.0381210065 2.352558e-02 1.076318e-01 10 103099926 103100019 94 - 1.930 1.781 -0.502
ENSG00000076685 E039 5.9990146 0.0053947611 4.813210e-02 1.753100e-01 10 103100752 103100867 116 - 0.818 0.549 -1.136
ENSG00000076685 E040 5.7188572 0.0053230259 6.996716e-02 2.247448e-01 10 103100868 103100943 76 - 0.795 0.549 -1.045
ENSG00000076685 E041 1.6620083 0.0118592853 8.091428e-01 9.016799e-01 10 103100944 103100964 21 - 0.364 0.356 -0.048
ENSG00000076685 E042 88.4929673 0.0197382720 2.450043e-04 3.164298e-03 10 103101045 103101102 58 - 1.902 1.675 -0.765
ENSG00000076685 E043 111.3978489 0.0237530973 4.181890e-04 4.908294e-03 10 103101235 103101326 92 - 2.000 1.776 -0.755
ENSG00000076685 E044 12.9069683 0.0105556965 3.283759e-01 5.673963e-01 10 103105358 103105381 24 - 1.072 1.022 -0.181
ENSG00000076685 E045 108.1018590 0.0197234015 8.657027e-04 8.816036e-03 10 103105706 103105801 96 - 1.982 1.797 -0.622
ENSG00000076685 E046 113.3266661 0.0326931970 3.143384e-02 1.316056e-01 10 103106589 103106706 118 - 1.990 1.878 -0.373
ENSG00000076685 E047 0.1426347 0.0311494226 1.000000e+00   10 103111693 103111744 52 - 0.066 0.000 -11.270
ENSG00000076685 E048 2.3462267 0.0355119776 7.347823e-01 8.571611e-01 10 103111745 103111805 61 - 0.447 0.549 0.497
ENSG00000076685 E049 0.1614157 0.0319659590 1.000000e+00   10 103136249 103136372 124 - 0.066 0.000 -11.272
ENSG00000076685 E050 81.1916502 0.0405064562 2.308992e-01 4.661887e-01 10 103139406 103139479 74 - 1.830 1.809 -0.072
ENSG00000076685 E051 0.3337900 0.0335097151 3.806278e-01   10 103140117 103140192 76 - 0.066 0.214 1.952
ENSG00000076685 E052 4.0274102 0.0066554728 1.192608e-04 1.729862e-03 10 103143068 103143168 101 - 0.422 1.022 2.538
ENSG00000076685 E053 0.0000000       10 103153291 103153627 337 -      
ENSG00000076685 E054 1.2921811 0.1749673622 3.638543e-02   10 103169284 103169449 166 - 0.173 0.668 2.896
ENSG00000076685 E055 108.2320054 0.0140599649 3.073588e-01 5.479697e-01 10 103174858 103174982 125 - 1.944 1.965 0.070
ENSG00000076685 E056 2.9216167 0.0224132985 8.906428e-02 2.620256e-01 10 103176486 103176899 414 - 0.448 0.781 1.484
ENSG00000076685 E057 20.3252373 0.0132933170 7.305214e-01 8.545326e-01 10 103181185 103181230 46 - 1.233 1.274 0.145
ENSG00000076685 E058 32.1923368 0.0185761296 4.791140e-01 6.865044e-01 10 103181231 103181328 98 - 1.396 1.544 0.509
ENSG00000076685 E059 0.5008152 0.0512078118 4.945362e-01   10 103187125 103187246 122 - 0.174 0.000 -12.860
ENSG00000076685 E060 38.7947527 0.0204780339 7.078708e-01 8.404898e-01 10 103193236 103193306 71 - 1.502 1.549 0.163
ENSG00000076685 E061 0.0000000       10 103197765 103197857 93 -      
ENSG00000076685 E062 2.6416811 0.0159907820 6.951997e-07 2.071971e-05 10 103199296 103199407 112 - 0.174 0.994 4.173
ENSG00000076685 E063 2.0824317 0.0752997096 2.554445e-05 4.698323e-04 10 103199408 103199505 98 - 0.123 0.927 4.514
ENSG00000076685 E064 0.3503582 0.0674585305 3.919099e-01   10 103276216 103276832 617 - 0.066 0.214 1.950
ENSG00000076685 E065 4.5996390 0.0607292711 7.122394e-10 4.266477e-08 10 103277154 103277662 509 - 0.173 1.250 5.097