ENSG00000076356

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367033 ENSG00000076356 HEK293_OSMI2_6hA HEK293_TMG_6hB PLXNA2 protein_coding protein_coding 1.628298 2.07897 1.183388 0.2211359 0.1271788 -0.8077291 1.17261623 1.3087140 0.91153448 0.08867383 0.03981776 -0.5170217 0.73608333 0.6400667 0.78666667 0.14660000 0.671327783 0.002295842 FALSE TRUE
ENST00000460870 ENSG00000076356 HEK293_OSMI2_6hA HEK293_TMG_6hB PLXNA2 protein_coding processed_transcript 1.628298 2.07897 1.183388 0.2211359 0.1271788 -0.8077291 0.03683353 0.0000000 0.12277761 0.00000000 0.12277761 3.7309400 0.02139167 0.0000000 0.08540000 0.08540000 0.751194296 0.002295842 FALSE TRUE
ENST00000463510 ENSG00000076356 HEK293_OSMI2_6hA HEK293_TMG_6hB PLXNA2 protein_coding processed_transcript 1.628298 2.07897 1.183388 0.2211359 0.1271788 -0.8077291 0.06474152 0.2536366 0.00000000 0.02592159 0.00000000 -4.7204787 0.03320000 0.1224667 0.00000000 -0.12246667 0.002295842 0.002295842   FALSE
ENST00000480053 ENSG00000076356 HEK293_OSMI2_6hA HEK293_TMG_6hB PLXNA2 protein_coding processed_transcript 1.628298 2.07897 1.183388 0.2211359 0.1271788 -0.8077291 0.12055531 0.2050844 0.04979560 0.11392767 0.04979560 -1.8467916 0.06523333 0.0932000 0.04663333 -0.04656667 0.833896540 0.002295842   FALSE
ENST00000483048 ENSG00000076356 HEK293_OSMI2_6hA HEK293_TMG_6hB PLXNA2 protein_coding processed_transcript 1.628298 2.07897 1.183388 0.2211359 0.1271788 -0.8077291 0.23355121 0.3115349 0.09927982 0.09633105 0.02627262 -1.5569483 0.14409583 0.1442667 0.08126667 -0.06300000 0.686001504 0.002295842 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000076356 E001 40.6497536 0.013895972 0.91151673 0.95792287 1 208022242 208026103 3862 - 1.599 1.592 -0.024
ENSG00000076356 E002 36.7761707 0.030960171 0.50191135 0.70213404 1 208026104 208027338 1235 - 1.510 1.588 0.267
ENSG00000076356 E003 22.9167941 0.005327944 0.15036992 0.36281357 1 208028009 208028159 151 - 1.280 1.402 0.428
ENSG00000076356 E004 24.8618588 0.002365898 0.61161925 0.77799315 1 208028830 208029042 213 - 1.370 1.412 0.145
ENSG00000076356 E005 7.3940739 0.004762265 0.18927263 0.41607682 1 208029043 208030303 1261 - 0.798 0.967 0.647
ENSG00000076356 E006 1.7772088 0.345693846 0.21371728 0.44603502 1 208031042 208031338 297 - 0.160 0.525 2.402
ENSG00000076356 E007 23.5488779 0.001455520 0.02502928 0.11230286 1 208031590 208031759 170 - 1.248 1.424 0.612
ENSG00000076356 E008 22.2384724 0.002186307 0.01810539 0.08938376 1 208033319 208033509 191 - 1.215 1.408 0.675
ENSG00000076356 E009 13.3308894 0.002641035 0.67725349 0.82098349 1 208034493 208034592 100 - 1.165 1.131 -0.122
ENSG00000076356 E010 13.1841931 0.005326906 0.83298637 0.91546601 1 208038371 208038474 104 - 1.152 1.138 -0.052
ENSG00000076356 E011 10.7621718 0.005835952 0.98803209 0.99583212 1 208038825 208038906 82 - 1.062 1.065 0.010
ENSG00000076356 E012 12.7212656 0.003302138 0.38226230 0.61405169 1 208038907 208038984 78 - 1.178 1.099 -0.281
ENSG00000076356 E013 17.1186912 0.001924738 0.12488632 0.32356059 1 208039621 208039767 147 - 1.318 1.195 -0.431
ENSG00000076356 E014 12.5419113 0.006577932 0.49821565 0.69963474 1 208039992 208040058 67 - 1.151 1.085 -0.240
ENSG00000076356 E015 0.8507255 0.027471672 0.07939149   1 208040059 208040264 206 - 0.000 0.340 10.114
ENSG00000076356 E016 23.3037392 0.001622073 0.28877265 0.52943075 1 208042098 208042366 269 - 1.416 1.343 -0.251
ENSG00000076356 E017 13.1271279 0.007395492 0.10379363 0.28854085 1 208043061 208043203 143 - 1.227 1.074 -0.549
ENSG00000076356 E018 22.5437602 0.002101387 0.71759207 0.84667448 1 208044508 208044742 235 - 1.370 1.348 -0.077
ENSG00000076356 E019 20.7460164 0.001957553 0.88557577 0.94428238 1 208045067 208045210 144 - 1.327 1.319 -0.025
ENSG00000076356 E020 23.0050239 0.002133775 0.29089814 0.53151570 1 208045878 208046117 240 - 1.409 1.334 -0.258
ENSG00000076356 E021 9.7053182 0.006210662 0.06021841 0.20332574 1 208051009 208051102 94 - 1.124 0.922 -0.742
ENSG00000076356 E022 13.1689240 0.004374815 0.20643542 0.43748027 1 208051256 208051423 168 - 1.202 1.084 -0.423
ENSG00000076356 E023 14.6813800 0.003055000 0.48107113 0.68781976 1 208052327 208052463 137 - 1.214 1.154 -0.215
ENSG00000076356 E024 14.8875675 0.002474848 0.29386325 0.53451227 1 208054421 208054538 118 - 1.237 1.147 -0.320
ENSG00000076356 E025 16.1608907 0.031045122 0.45632065 0.67053088 1 208060686 208060837 152 - 1.260 1.175 -0.300
ENSG00000076356 E026 15.2337691 0.010414412 0.82925581 0.91338563 1 208079260 208079450 191 - 1.166 1.190 0.084
ENSG00000076356 E027 9.6887250 0.025725551 0.54405350 0.73198648 1 208082412 208082508 97 - 0.953 1.036 0.308
ENSG00000076356 E028 15.2059093 0.013916598 0.32096502 0.56054918 1 208084380 208084580 201 - 1.110 1.217 0.381
ENSG00000076356 E029 10.7631655 0.003001584 0.49966894 0.70051105 1 208092786 208092900 115 - 1.095 1.029 -0.237
ENSG00000076356 E030 10.4998608 0.004613318 0.21078633 0.44273393 1 208096029 208096125 97 - 0.950 1.091 0.520
ENSG00000076356 E031 10.1305542 0.019622903 0.47656570 0.68467461 1 208096730 208096883 154 - 0.972 1.070 0.360
ENSG00000076356 E032 11.3246775 0.002812142 0.93703543 0.97072750 1 208098846 208098969 124 - 1.063 1.075 0.044
ENSG00000076356 E033 11.9711774 0.003451496 0.73363722 0.85642532 1 208103147 208103247 101 - 1.063 1.101 0.137
ENSG00000076356 E034 14.6318094 0.012021141 0.33070952 0.56966450 1 208142329 208142463 135 - 1.095 1.198 0.368
ENSG00000076356 E035 0.0000000       1 208209987 208210279 293 -      
ENSG00000076356 E036 18.3739715 0.009618517 0.43765700 0.65697488 1 208210280 208210462 183 - 1.214 1.286 0.255
ENSG00000076356 E037 52.6904721 0.000781997 0.08276470 0.25023786 1 208216735 208218002 1268 - 1.761 1.682 -0.269
ENSG00000076356 E038 0.0000000       1 208230191 208230470 280 -      
ENSG00000076356 E039 13.8638252 0.002398950 0.67243444 0.81786864 1 208243643 208244384 742 - 1.124 1.168 0.157