ENSG00000076351

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000578217 ENSG00000076351 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC46A1 protein_coding processed_transcript 13.87707 19.3781 9.252477 1.18421 0.281073 -1.065701 0.3598448 0.3726932 0.7763534 0.1359466 0.05187419 1.0389896 0.02852083 0.01900000 0.0840000 0.06500000 0.004811783 0.004811783 FALSE FALSE
ENST00000582590 ENSG00000076351 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC46A1 protein_coding retained_intron 13.87707 19.3781 9.252477 1.18421 0.281073 -1.065701 1.9330658 3.3028603 0.2063099 0.1435808 0.20630988 -3.9369059 0.13100000 0.17083333 0.0223000 -0.14853333 0.126562916 0.004811783 FALSE TRUE
ENST00000582735 ENSG00000076351 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC46A1 protein_coding protein_coding 13.87707 19.3781 9.252477 1.18421 0.281073 -1.065701 2.6489993 2.9045183 1.7633640 0.5942644 0.49729469 -0.7167688 0.19024167 0.14836667 0.1878333 0.03946667 0.909773227 0.004811783 FALSE TRUE
ENST00000612814 ENSG00000076351 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC46A1 protein_coding protein_coding 13.87707 19.3781 9.252477 1.18421 0.281073 -1.065701 4.5996723 5.8147240 3.5407290 0.8063933 0.48016834 -0.7140745 0.33397917 0.29710000 0.3804667 0.08336667 0.672984898 0.004811783 FALSE TRUE
ENST00000618626 ENSG00000076351 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC46A1 protein_coding protein_coding 13.87707 19.3781 9.252477 1.18421 0.281073 -1.065701 2.8184455 4.7962173 2.0629251 0.3712608 0.57144387 -1.2132339 0.20395000 0.24743333 0.2265000 -0.02093333 0.932522929 0.004811783 FALSE TRUE
MSTRG.13951.5 ENSG00000076351 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC46A1 protein_coding   13.87707 19.3781 9.252477 1.18421 0.281073 -1.065701 1.3557666 1.8451723 0.6151798 0.9251412 0.31426559 -1.5692102 0.10028333 0.09966667 0.0671000 -0.03256667 0.986517816 0.004811783 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000076351 E001 92.2202624 0.164899279 5.276757e-02 0.1861630899 17 28394642 28395675 1034 - 2.135 1.766 -1.239
ENSG00000076351 E002 729.8131521 0.403063366 4.329019e-01 0.6534198716 17 28395676 28399345 3670 - 2.821 2.741 -0.268
ENSG00000076351 E003 150.3292606 0.385043290 4.331884e-01 0.6535944912 17 28399346 28399591 246 - 2.141 2.057 -0.283
ENSG00000076351 E004 100.5732304 0.232336519 4.055439e-01 0.6327132139 17 28399592 28399713 122 - 1.957 1.888 -0.233
ENSG00000076351 E005 1.1318630 0.014666763 6.446121e-01   17 28400518 28400609 92 - 0.221 0.288 0.510
ENSG00000076351 E006 94.9605490 0.186560637 3.468941e-01 0.5844705917 17 28400610 28400766 157 - 1.908 1.869 -0.131
ENSG00000076351 E007 2.7013482 0.012753527 2.618362e-01 0.5009424028 17 28400767 28401045 279 - 0.366 0.526 0.832
ENSG00000076351 E008 63.1260284 0.048671266 5.050544e-01 0.7043429373 17 28402238 28402321 84 - 1.759 1.690 -0.233
ENSG00000076351 E009 3.0587439 0.007973238 1.685599e-01 0.3886515063 17 28404240 28404315 76 - 0.751 0.460 -1.297
ENSG00000076351 E010 21.2795177 0.034283157 4.754038e-01 0.6837677234 17 28404316 28404615 300 - 1.359 1.217 -0.500
ENSG00000076351 E011 104.5992164 0.000443399 9.000210e-01 0.9518973765 17 28404616 28404723 108 - 1.989 1.905 -0.284
ENSG00000076351 E012 81.0241428 0.096270777 5.209837e-01 0.7155567210 17 28404724 28404768 45 - 1.889 1.788 -0.343
ENSG00000076351 E013 168.4601966 0.169310257 5.041223e-01 0.7036778496 17 28404769 28405047 279 - 2.213 2.099 -0.379
ENSG00000076351 E014 127.3130981 0.017385225 6.488738e-01 0.8027983176 17 28405048 28405376 329 - 2.023 1.999 -0.078
ENSG00000076351 E015 50.4674240 0.004674832 9.519693e-04 0.0095209815 17 28405377 28405468 92 - 1.487 1.633 0.499
ENSG00000076351 E016 0.5061644 0.309913656 6.615550e-01   17 28405681 28405817 137 - 0.221 0.120 -1.057
ENSG00000076351 E017 48.9702641 0.003268599 8.872043e-06 0.0001892335 17 28405887 28405997 111 - 1.395 1.632 0.813
ENSG00000076351 E018 37.9254227 0.001268936 6.003374e-04 0.0065821610 17 28405998 28406212 215 - 1.346 1.519 0.597
ENSG00000076351 E019 0.3336024 0.024937092 1.000000e+00   17 28406457 28406623 167 - 0.000 0.119 11.050
ENSG00000076351 E020 0.0000000       17 28406624 28406723 100 -      
ENSG00000076351 E021 0.1779838 0.564156155 1.503945e-01   17 28406724 28407197 474 - 0.224 0.000 -14.259