ENSG00000076201

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265562 ENSG00000076201 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN23 protein_coding protein_coding 24.97648 35.10192 19.82038 4.316716 0.4965179 -0.8242481 12.552369 21.478762 11.694882 4.0406223 0.8765900 -0.8764719 0.49912917 0.60316667 0.59016667 -0.0130000 0.9867459963 0.0004171573 FALSE TRUE
ENST00000602307 ENSG00000076201 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN23 protein_coding nonsense_mediated_decay 24.97648 35.10192 19.82038 4.316716 0.4965179 -0.8242481 2.717632 2.493950 1.688790 0.8970883 0.4229351 -0.5596980 0.11129167 0.07386667 0.08456667 0.0107000 0.9365119639 0.0004171573 FALSE TRUE
ENST00000683566 ENSG00000076201 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN23 protein_coding retained_intron 24.97648 35.10192 19.82038 4.316716 0.4965179 -0.8242481 1.797637 1.339549 2.252667 0.5644355 0.1345747 0.7455467 0.07760833 0.04306667 0.11346667 0.0704000 0.2259553855 0.0004171573 FALSE TRUE
ENST00000683708 ENSG00000076201 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN23 protein_coding processed_transcript 24.97648 35.10192 19.82038 4.316716 0.4965179 -0.8242481 4.907033 6.719563 1.324490 1.5301567 0.1013352 -2.3342245 0.18724167 0.18720000 0.06713333 -0.1200667 0.0004171573 0.0004171573 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000076201 E001 4.4002381 0.0060894308 4.282056e-01 6.495975e-01 3 47379559 47381010 1452 + 0.631 0.753 0.513
ENSG00000076201 E002 5.1183305 0.0049601541 7.825567e-01 8.861691e-01 3 47381011 47381013 3 + 0.788 0.754 -0.139
ENSG00000076201 E003 6.8851330 0.0042497246 3.249059e-01 5.641135e-01 3 47381014 47381020 7 + 0.788 0.921 0.511
ENSG00000076201 E004 28.0010060 0.0069372692 7.479314e-01 8.654671e-01 3 47381021 47381035 15 + 1.456 1.438 -0.063
ENSG00000076201 E005 48.9525749 0.0011974298 9.945311e-01 9.988719e-01 3 47381036 47381069 34 + 1.675 1.680 0.017
ENSG00000076201 E006 118.1082286 0.0003796533 3.996775e-01 6.279844e-01 3 47381070 47381180 111 + 2.068 2.043 -0.085
ENSG00000076201 E007 126.9172593 0.0008465447 2.120520e-01 4.441718e-01 3 47396143 47396217 75 + 2.109 2.068 -0.136
ENSG00000076201 E008 0.1723744 0.0417683672 1.000000e+00   3 47396218 47396291 74 + 0.000 0.087 8.219
ENSG00000076201 E009 142.1747468 0.0038098092 9.153923e-01 9.598382e-01 3 47404652 47404779 128 + 2.128 2.125 -0.010
ENSG00000076201 E010 125.1975952 0.0018164107 6.330750e-03 4.135504e-02 3 47405005 47405081 77 + 2.138 2.035 -0.346
ENSG00000076201 E011 6.5429494 0.2683823700 1.066320e-01 2.933583e-01 3 47405082 47405279 198 + 1.053 0.714 -1.302
ENSG00000076201 E012 9.6768851 0.1916806693 7.879372e-02 2.424048e-01 3 47405280 47405748 469 + 1.208 0.852 -1.309
ENSG00000076201 E013 122.5450533 0.0004622458 2.787331e-05 5.059107e-04 3 47405749 47405798 50 + 2.151 2.013 -0.463
ENSG00000076201 E014 87.0442419 0.0004317247 3.445150e-04 4.183822e-03 3 47405915 47405944 30 + 2.007 1.870 -0.459
ENSG00000076201 E015 167.2841367 0.0003191988 1.221734e-04 1.764423e-03 3 47405945 47406046 102 + 2.268 2.160 -0.359
ENSG00000076201 E016 145.4654051 0.0053587392 1.497848e-01 3.619778e-01 3 47406325 47406405 81 + 2.182 2.111 -0.235
ENSG00000076201 E017 194.9121764 0.0006000783 1.191083e-01 3.144015e-01 3 47406481 47406612 132 + 2.292 2.251 -0.139
ENSG00000076201 E018 137.6748025 0.0003026204 3.027765e-01 5.433513e-01 3 47406703 47406750 48 + 2.135 2.106 -0.098
ENSG00000076201 E019 14.2315038 0.1736664184 2.407742e-02 1.093220e-01 3 47406892 47407129 238 + 1.401 0.957 -1.586
ENSG00000076201 E020 135.5312122 0.0003000751 2.114869e-01 4.435416e-01 3 47407130 47407186 57 + 2.133 2.096 -0.121
ENSG00000076201 E021 150.7430845 0.0002910441 9.665169e-02 2.759146e-01 3 47407309 47407367 59 + 2.185 2.138 -0.157
ENSG00000076201 E022 160.8546759 0.0002846925 1.283143e-02 6.975345e-02 3 47407505 47407584 80 + 2.229 2.160 -0.232
ENSG00000076201 E023 224.6759768 0.0003166060 1.123196e-05 2.317392e-04 3 47407697 47407811 115 + 2.395 2.288 -0.358
ENSG00000076201 E024 188.7038593 0.0013064863 4.795200e-05 8.030128e-04 3 47407890 47407955 66 + 2.329 2.203 -0.421
ENSG00000076201 E025 18.3228514 0.1528862347 7.558922e-02 2.360063e-01 3 47407956 47408332 377 + 1.450 1.127 -1.131
ENSG00000076201 E026 246.4900433 0.0002851289 6.057307e-08 2.368570e-06 3 47408345 47408490 146 + 2.447 2.320 -0.421
ENSG00000076201 E027 317.9562617 0.0001885684 1.859250e-02 9.103695e-02 3 47408776 47409087 312 + 2.506 2.460 -0.153
ENSG00000076201 E028 178.4158843 0.0002899404 4.440556e-01 6.614290e-01 3 47409163 47409297 135 + 2.209 2.235 0.087
ENSG00000076201 E029 96.8463313 0.0005433835 1.433304e-01 3.524433e-01 3 47409298 47409317 20 + 2.001 1.949 -0.172
ENSG00000076201 E030 2.0937632 0.6001918300 6.025892e-01 7.719380e-01 3 47409318 47409416 99 + 0.535 0.422 -0.563
ENSG00000076201 E031 159.4879935 0.0029077619 6.933707e-01 8.312719e-01 3 47409417 47409545 129 + 2.164 2.183 0.064
ENSG00000076201 E032 84.0440268 0.0125593317 8.950039e-01 9.492041e-01 3 47409546 47409568 23 + 1.895 1.903 0.027
ENSG00000076201 E033 13.1600898 0.0388413825 1.021949e-02 5.906206e-02 3 47409569 47409654 86 + 1.316 0.980 -1.204
ENSG00000076201 E034 173.6113290 0.0003529645 4.824656e-02 1.755861e-01 3 47409655 47409834 180 + 2.171 2.234 0.210
ENSG00000076201 E035 452.6498284 0.0013070858 9.811742e-03 5.731295e-02 3 47409928 47411038 1111 + 2.585 2.648 0.210
ENSG00000076201 E036 468.4688216 0.0007981307 3.582541e-07 1.153580e-05 3 47411039 47411686 648 + 2.565 2.678 0.377
ENSG00000076201 E037 273.9689818 0.0002495823 1.728639e-02 8.648844e-02 3 47411783 47411967 185 + 2.372 2.433 0.201
ENSG00000076201 E038 195.9960411 0.0007850663 2.019939e-03 1.719287e-02 3 47412094 47412198 105 + 2.202 2.299 0.325
ENSG00000076201 E039 195.6221131 0.0003188824 2.475015e-07 8.324707e-06 3 47412283 47412421 139 + 2.159 2.311 0.510
ENSG00000076201 E040 165.4047285 0.0027793826 7.556762e-03 4.729186e-02 3 47412514 47412627 114 + 2.116 2.225 0.366
ENSG00000076201 E041 23.2259536 0.0031626629 3.306346e-01 5.695817e-01 3 47412628 47412705 78 + 1.305 1.389 0.292
ENSG00000076201 E042 484.9507503 0.0007915533 3.673068e-17 7.434702e-15 3 47412706 47413471 766 + 2.523 2.711 0.626