ENSG00000075785

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265062 ENSG00000075785 HEK293_OSMI2_6hA HEK293_TMG_6hB RAB7A protein_coding protein_coding 119.144 108.7609 123.8934 14.00361 2.881539 0.1879221 103.484349 98.78488 98.10866 12.68115 6.147125 -0.009908757 0.87070417 0.9084667 0.7908 -0.1176667 4.277933e-02 1.846824e-22 FALSE TRUE
ENST00000464496 ENSG00000075785 HEK293_OSMI2_6hA HEK293_TMG_6hB RAB7A protein_coding protein_coding 119.144 108.7609 123.8934 14.00361 2.881539 0.1879221 5.978175 0.00000 16.84513 0.00000 3.178771 10.718971773 0.04820417 0.0000000 0.1367 0.1367000 1.846824e-22 1.846824e-22 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000075785 E001 0.0000000       3 128693669 128693792 124 +      
ENSG00000075785 E002 11.2332165 3.471859e-03 3.405344e-02 1.390158e-01 3 128726136 128726156 21 + 0.948 1.176 0.828
ENSG00000075785 E003 20.8894596 2.305048e-03 7.760855e-02 2.400377e-01 3 128726157 128726162 6 + 1.250 1.398 0.517
ENSG00000075785 E004 74.2884525 7.558418e-03 7.448431e-01 8.635823e-01 3 128726163 128726182 20 + 1.857 1.889 0.109
ENSG00000075785 E005 89.5888101 4.049254e-03 7.375715e-01 8.589923e-01 3 128726183 128726192 10 + 1.940 1.969 0.095
ENSG00000075785 E006 622.3470362 2.154624e-04 3.612874e-06 8.699856e-05 3 128726193 128726351 159 + 2.748 2.829 0.273
ENSG00000075785 E007 443.2165457 1.893657e-04 5.739324e-03 3.843787e-02 3 128726352 128726359 8 + 2.613 2.672 0.197
ENSG00000075785 E008 2.0904239 1.201304e-02 3.292775e-02 1.358673e-01 3 128788914 128789070 157 + 0.227 0.607 2.153
ENSG00000075785 E009 0.0000000       3 128794552 128794783 232 +      
ENSG00000075785 E010 0.0000000       3 128794844 128795193 350 +      
ENSG00000075785 E011 0.1308682 3.264919e-02 5.523501e-01   3 128795243 128795358 116 + 0.001 0.115 8.038
ENSG00000075785 E012 0.9291287 1.537876e-02 1.304245e-01   3 128795359 128795359 1 + 0.128 0.401 2.147
ENSG00000075785 E013 707.0603155 1.140109e-03 6.100406e-01 7.769098e-01 3 128795360 128795420 61 + 2.838 2.858 0.069
ENSG00000075785 E014 609.5080946 1.147198e-03 1.343839e-01 3.387087e-01 3 128797943 128797968 26 + 2.796 2.774 -0.072
ENSG00000075785 E015 846.5702779 9.887733e-05 1.007044e-03 9.967899e-03 3 128797969 128798036 68 + 2.942 2.912 -0.102
ENSG00000075785 E016 714.6208586 8.849175e-05 9.768042e-06 2.054864e-04 3 128798037 128798069 33 + 2.878 2.829 -0.163
ENSG00000075785 E017 1.7623289 1.059613e-02 2.600941e-01 4.990674e-01 3 128798070 128798425 356 + 0.531 0.345 -0.980
ENSG00000075785 E018 0.3807181 2.866266e-02 9.173913e-01   3 128799272 128799430 159 + 0.128 0.115 -0.171
ENSG00000075785 E019 0.6564337 5.338260e-02 8.901459e-01   3 128801992 128802169 178 + 0.227 0.206 -0.173
ENSG00000075785 E020 877.6421873 1.054859e-04 1.450224e-02 7.624141e-02 3 128806372 128806449 78 + 2.951 2.932 -0.066
ENSG00000075785 E021 1191.7754083 1.046226e-04 8.994317e-03 5.379263e-02 3 128806450 128806590 141 + 3.083 3.066 -0.057
ENSG00000075785 E022 4.7883412 2.450186e-01 4.014065e-01 6.294851e-01 3 128806591 128806615 25 + 0.643 0.841 0.807
ENSG00000075785 E023 12.2149740 5.071209e-02 8.173985e-01 9.066053e-01 3 128806616 128807542 927 + 1.125 1.106 -0.066
ENSG00000075785 E024 690.1215793 1.087155e-04 7.180494e-03 4.548521e-02 3 128807543 128807554 12 + 2.851 2.825 -0.089
ENSG00000075785 E025 868.4824656 4.074948e-04 2.285839e-02 1.055031e-01 3 128807555 128807617 63 + 2.949 2.926 -0.075
ENSG00000075785 E026 749.7352402 4.309722e-04 9.523568e-01 9.781551e-01 3 128807618 128807671 54 + 2.867 2.877 0.033
ENSG00000075785 E027 3.1592025 8.733005e-02 8.863218e-01 9.447575e-01 3 128811146 128811257 112 + 0.641 0.608 -0.145
ENSG00000075785 E028 3606.7582792 1.112134e-03 4.667668e-03 3.283260e-02 3 128813327 128814798 1472 + 3.528 3.578 0.166
ENSG00000075785 E029 17.6936308 1.867684e-03 1.545608e-01 3.688276e-01 3 128823718 128825942 2225 + 1.197 1.323 0.446