ENSG00000075711

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000346964 ENSG00000075711 HEK293_OSMI2_6hA HEK293_TMG_6hB DLG1 protein_coding protein_coding 11.61499 3.810143 21.2762 0.2809093 0.8855481 2.47822 0.75164694 0.55953359 0.6108162 0.29080429 0.6108162 0.1243852 0.08288333 0.13760000 0.03130000 -0.10630000 3.777247e-01 1.721479e-05 FALSE TRUE
ENST00000357674 ENSG00000075711 HEK293_OSMI2_6hA HEK293_TMG_6hB DLG1 protein_coding protein_coding 11.61499 3.810143 21.2762 0.2809093 0.8855481 2.47822 0.41380205 0.00000000 1.2978159 0.00000000 0.6644494 7.0310157 0.02475000 0.00000000 0.05860000 0.05860000 5.280831e-01 1.721479e-05 FALSE TRUE
ENST00000475394 ENSG00000075711 HEK293_OSMI2_6hA HEK293_TMG_6hB DLG1 protein_coding retained_intron 11.61499 3.810143 21.2762 0.2809093 0.8855481 2.47822 0.68783129 0.24253505 1.1221918 0.12557583 0.1210985 2.1645629 0.06122500 0.06816667 0.05306667 -0.01510000 1.000000e+00 1.721479e-05 FALSE FALSE
ENST00000657381 ENSG00000075711 HEK293_OSMI2_6hA HEK293_TMG_6hB DLG1 protein_coding protein_coding 11.61499 3.810143 21.2762 0.2809093 0.8855481 2.47822 0.89688824 0.00000000 2.2782504 0.00000000 0.7159902 7.8381011 0.05085417 0.00000000 0.10566667 0.10566667 5.141748e-05 1.721479e-05 FALSE TRUE
ENST00000659716 ENSG00000075711 HEK293_OSMI2_6hA HEK293_TMG_6hB DLG1 protein_coding protein_coding 11.61499 3.810143 21.2762 0.2809093 0.8855481 2.47822 1.36133312 1.36603537 2.9529133 0.34929023 0.3002849 1.1064989 0.14496667 0.35303333 0.13833333 -0.21470000 5.212078e-02 1.721479e-05 FALSE TRUE
ENST00000660898 ENSG00000075711 HEK293_OSMI2_6hA HEK293_TMG_6hB DLG1 protein_coding protein_coding 11.61499 3.810143 21.2762 0.2809093 0.8855481 2.47822 0.95421380 0.44191153 1.4099821 0.10914585 0.8290192 1.6517604 0.11039167 0.12163333 0.06656667 -0.05506667 8.157744e-01 1.721479e-05 FALSE TRUE
ENST00000661453 ENSG00000075711 HEK293_OSMI2_6hA HEK293_TMG_6hB DLG1 protein_coding protein_coding 11.61499 3.810143 21.2762 0.2809093 0.8855481 2.47822 0.04028867 0.23445595 0.0000000 0.23445595 0.0000000 -4.6115026 0.01179583 0.05726667 0.00000000 -0.05726667 6.499787e-01 1.721479e-05 FALSE TRUE
ENST00000670935 ENSG00000075711 HEK293_OSMI2_6hA HEK293_TMG_6hB DLG1 protein_coding protein_coding 11.61499 3.810143 21.2762 0.2809093 0.8855481 2.47822 1.11158815 0.03596215 1.9729172 0.03596215 0.1887390 5.4310344 0.05802917 0.01106667 0.09286667 0.08180000 3.345466e-02 1.721479e-05 FALSE TRUE
MSTRG.24369.50 ENSG00000075711 HEK293_OSMI2_6hA HEK293_TMG_6hB DLG1 protein_coding   11.61499 3.810143 21.2762 0.2809093 0.8855481 2.47822 1.39432798 0.00000000 3.1992348 0.00000000 1.0049515 8.3260855 0.07214583 0.00000000 0.14956667 0.14956667 1.721479e-05 1.721479e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000075711 E001 0.1308682 0.032649190 0.112033584   3 197042560 197042580 21 - 0.000 0.229 14.411
ENSG00000075711 E002 0.1308682 0.032649190 0.112033584   3 197042581 197042597 17 - 0.000 0.229 14.470
ENSG00000075711 E003 0.1308682 0.032649190 0.112033584   3 197042598 197042599 2 - 0.000 0.229 14.470
ENSG00000075711 E004 0.1308682 0.032649190 0.112033584   3 197042600 197042612 13 - 0.000 0.229 14.470
ENSG00000075711 E005 7.5564171 0.409124625 0.280873333 0.52111559 3 197042613 197042937 325 - 0.739 1.125 1.460
ENSG00000075711 E006 2.7594498 0.086311699 0.023715243 0.10820801 3 197042938 197042942 5 - 0.369 0.855 2.204
ENSG00000075711 E007 2.7594498 0.086311699 0.023715243 0.10820801 3 197042943 197042944 2 - 0.369 0.855 2.204
ENSG00000075711 E008 2.9020844 0.057413806 0.024254877 0.10987319 3 197042945 197042947 3 - 0.396 0.857 2.059
ENSG00000075711 E009 3.3557839 0.159314879 0.070890586 0.22649857 3 197042948 197042954 7 - 0.444 0.889 1.925
ENSG00000075711 E010 3.1943682 0.122400491 0.042471430 0.16116879 3 197042955 197042956 2 - 0.420 0.891 2.057
ENSG00000075711 E011 3.8544564 0.233444171 0.252742262 0.49089551 3 197042957 197042963 7 - 0.523 0.879 1.494
ENSG00000075711 E012 5.4338122 0.249182071 0.185481597 0.41119281 3 197042964 197042984 21 - 0.622 1.012 1.540
ENSG00000075711 E013 5.4416345 0.487836563 0.432737622 0.65328605 3 197042985 197042989 5 - 0.637 0.975 1.340
ENSG00000075711 E014 7.3062596 0.622513780 0.461046867 0.67388229 3 197042990 197043032 43 - 0.737 1.086 1.327
ENSG00000075711 E015 6.1843599 0.527561973 0.416546266 0.64108404 3 197043033 197043034 2 - 0.675 1.034 1.397
ENSG00000075711 E016 8.5978206 0.316853271 0.126831568 0.32674015 3 197043035 197043074 40 - 0.762 1.220 1.706
ENSG00000075711 E017 14.9562152 0.419571907 0.149076412 0.36092329 3 197043075 197043126 52 - 0.990 1.403 1.469
ENSG00000075711 E018 66.3712417 0.860559692 0.193062491 0.42088107 3 197043127 197043588 462 - 1.590 2.049 1.551
ENSG00000075711 E019 4.3249641 0.051677209 0.093750634 0.27073792 3 197043589 197043630 42 - 0.563 0.900 1.386
ENSG00000075711 E020 8.9704971 0.268594633 0.228902512 0.46388914 3 197043631 197043692 62 - 0.835 1.112 1.031
ENSG00000075711 E021 8.8435731 0.301466155 0.251059648 0.48912104 3 197043693 197043700 8 - 0.833 1.096 0.980
ENSG00000075711 E022 65.5706951 0.891933698 0.295434270 0.53590814 3 197043701 197043982 282 - 1.627 1.966 1.144
ENSG00000075711 E023 42.5863869 0.767439799 0.286797241 0.52750078 3 197043983 197044074 92 - 1.448 1.777 1.121
ENSG00000075711 E024 21.3576313 0.513273691 0.178794348 0.40234881 3 197044075 197044094 20 - 1.146 1.523 1.317
ENSG00000075711 E025 37.6762256 0.704557968 0.226065803 0.46066275 3 197044095 197044152 58 - 1.386 1.747 1.234
ENSG00000075711 E026 33.8207258 0.712213754 0.283436603 0.52391349 3 197044153 197044184 32 - 1.355 1.670 1.082
ENSG00000075711 E027 48.5828284 0.832631204 0.374722467 0.60790292 3 197044185 197044259 75 - 1.528 1.774 0.835
ENSG00000075711 E028 27.6116458 0.646775036 0.330873516 0.56978516 3 197044260 197044266 7 - 1.286 1.550 0.911
ENSG00000075711 E029 37.8846806 0.748069702 0.330460583 0.56940318 3 197044267 197044330 64 - 1.416 1.687 0.927
ENSG00000075711 E030 81.0402911 1.253107220 0.455190824 0.66962813 3 197044331 197044550 220 - 1.744 1.996 0.849
ENSG00000075711 E031 38.0477794 0.738779892 0.351338961 0.58850063 3 197044551 197044559 9 - 1.426 1.668 0.827
ENSG00000075711 E032 45.1524682 0.784736982 0.322491068 0.56191887 3 197044560 197044622 63 - 1.488 1.767 0.950
ENSG00000075711 E033 70.6462745 0.922865326 0.340292247 0.57821252 3 197044623 197044729 107 - 1.676 1.961 0.964
ENSG00000075711 E034 0.0000000       3 197046232 197046439 208 -      
ENSG00000075711 E035 0.5117739 0.025928189 0.587500322   3 197046440 197047066 627 - 0.114 0.230 1.220
ENSG00000075711 E036 0.3228314 0.343944639 1.000000000   3 197047067 197047378 312 - 0.114 0.000 -11.073
ENSG00000075711 E037 1.2782695 0.014837022 0.279942984   3 197047379 197049307 1929 - 0.242 0.490 1.483
ENSG00000075711 E038 1.1364427 0.014554366 0.680242608   3 197049308 197050659 1352 - 0.278 0.230 -0.364
ENSG00000075711 E039 79.8836245 0.029949588 0.049798904 0.17916457 3 197051577 197051668 92 - 1.745 1.980 0.792
ENSG00000075711 E040 87.2582359 0.001015329 0.411933797 0.63752115 3 197059889 197059998 110 - 1.811 1.931 0.403
ENSG00000075711 E041 121.5689466 0.013757531 0.493339333 0.69619137 3 197065276 197065439 164 - 1.968 2.015 0.156
ENSG00000075711 E042 55.2416396 0.007934162 0.562117766 0.74475552 3 197065440 197065448 9 - 1.631 1.677 0.155
ENSG00000075711 E043 4.1460840 0.010523282 0.508110874 0.70653740 3 197065449 197065464 16 - 0.632 0.578 -0.239
ENSG00000075711 E044 7.5876232 0.123543558 0.951553480 0.97771975 3 197065465 197065707 243 - 0.824 0.897 0.283
ENSG00000075711 E045 51.2872585 0.004841675 0.825964900 0.91146932 3 197065708 197065708 1 - 1.595 1.665 0.237
ENSG00000075711 E046 91.2653827 0.009231942 0.263502546 0.50275023 3 197065709 197065809 101 - 1.850 1.865 0.050
ENSG00000075711 E047 67.0703950 0.018142334 0.038674779 0.15129848 3 197066704 197066754 51 - 1.737 1.649 -0.300
ENSG00000075711 E048 0.0000000       3 197068502 197068522 21 -      
ENSG00000075711 E049 0.1614157 0.032919726 1.000000000   3 197068523 197068537 15 - 0.061 0.000 -10.068
ENSG00000075711 E050 0.9632605 0.015728112 0.475403510   3 197069217 197069218 2 - 0.204 0.379 1.218
ENSG00000075711 E051 58.7341876 0.073581592 0.210493478 0.44240336 3 197069219 197069260 42 - 1.678 1.608 -0.239
ENSG00000075711 E052 10.3659217 0.009516540 0.645266612 0.80036455 3 197069261 197071003 1743 - 0.928 1.059 0.485
ENSG00000075711 E053 17.9749532 0.024049337 0.192226920 0.41969828 3 197075837 197075870 34 - 1.123 1.362 0.843
ENSG00000075711 E054 0.8545700 0.594302396 0.500244977   3 197075871 197075871 1 - 0.249 0.000 -12.440
ENSG00000075711 E055 50.7382184 0.017100592 0.004916281 0.03417649 3 197076586 197076682 97 - 1.630 1.458 -0.589
ENSG00000075711 E056 14.8191022 0.010949858 0.021077133 0.09959326 3 197076683 197076685 3 - 1.122 0.902 -0.812
ENSG00000075711 E057 0.4466850 0.021768165 0.600827615   3 197078463 197078533 71 - 0.161 0.000 -11.650
ENSG00000075711 E058 1.8457739 0.015484665 0.236798406 0.47290203 3 197080478 197080989 512 - 0.311 0.579 1.417
ENSG00000075711 E059 0.8737109 0.085373812 0.347956899   3 197080990 197081050 61 - 0.161 0.381 1.643
ENSG00000075711 E060 58.7757000 0.010472482 0.533852734 0.72482423 3 197081051 197081117 67 - 1.659 1.701 0.143
ENSG00000075711 E061 0.4764247 0.021768165 0.582114301   3 197085296 197085579 284 - 0.114 0.230 1.222
ENSG00000075711 E062 87.7718939 0.022245256 0.030007861 0.12736242 3 197085580 197085756 177 - 1.853 1.751 -0.344
ENSG00000075711 E063 65.6260168 0.015800744 0.015156222 0.07866847 3 197090912 197091026 115 - 1.730 1.621 -0.371
ENSG00000075711 E064 55.7097203 0.016819084 0.083488724 0.25175442 3 197104903 197104992 90 - 1.654 1.592 -0.211
ENSG00000075711 E065 32.7618319 0.025398355 0.318204746 0.55813349 3 197104993 197105005 13 - 1.423 1.402 -0.072
ENSG00000075711 E066 68.6262906 0.009371851 0.027107646 0.11860416 3 197115927 197116037 111 - 1.744 1.671 -0.249
ENSG00000075711 E067 51.0783950 0.025139583 0.012233053 0.06736455 3 197116038 197116083 46 - 1.629 1.463 -0.569
ENSG00000075711 E068 82.4174280 0.017920254 0.082917226 0.25055665 3 197119410 197119530 121 - 1.818 1.767 -0.170
ENSG00000075711 E069 1.5086893 0.558980367 0.030885792 0.13000664 3 197126134 197126464 331 - 0.061 0.804 5.163
ENSG00000075711 E070 75.5472934 0.015812014 0.357859576 0.59405529 3 197130527 197130671 145 - 1.768 1.788 0.067
ENSG00000075711 E071 0.3228314 0.343944639 1.000000000   3 197136324 197136541 218 - 0.114 0.000 -11.073
ENSG00000075711 E072 72.5840357 0.015474064 0.240727826 0.47741737 3 197136542 197136678 137 - 1.757 1.752 -0.018
ENSG00000075711 E073 0.1779838 0.061203736 1.000000000   3 197138215 197138221 7 - 0.061 0.000 -10.071
ENSG00000075711 E074 78.7789092 0.019409605 0.002029452 0.01725395 3 197138222 197138391 170 - 1.817 1.642 -0.594
ENSG00000075711 E075 27.5680145 0.016972366 0.008298465 0.05069764 3 197140140 197140144 5 - 1.378 1.173 -0.719
ENSG00000075711 E076 64.5814837 0.026480020 0.024335096 0.11012495 3 197140145 197140264 120 - 1.726 1.602 -0.422
ENSG00000075711 E077 0.1614157 0.032919726 1.000000000   3 197141230 197141353 124 - 0.061 0.000 -10.068
ENSG00000075711 E078 55.4461970 0.024583560 0.017002666 0.08547032 3 197142718 197142768 51 - 1.664 1.522 -0.483
ENSG00000075711 E079 0.0000000       3 197142769 197142799 31 -      
ENSG00000075711 E080 34.7880115 0.016424697 0.013465384 0.07224377 3 197149743 197149754 12 - 1.469 1.310 -0.552
ENSG00000075711 E081 45.5319674 0.004668321 0.001204671 0.01146818 3 197149755 197149796 42 - 1.584 1.416 -0.575
ENSG00000075711 E082 0.0000000       3 197155669 197155763 95 -      
ENSG00000075711 E083 29.1957506 0.027459287 0.074527700 0.23387323 3 197161640 197161738 99 - 1.387 1.266 -0.422
ENSG00000075711 E084 0.1779838 0.061203736 1.000000000   3 197183575 197184131 557 - 0.061 0.000 -10.071
ENSG00000075711 E085 0.0000000       3 197194337 197194424 88 -      
ENSG00000075711 E086 78.1778676 0.009235207 0.020039772 0.09600947 3 197194425 197194589 165 - 1.800 1.725 -0.251
ENSG00000075711 E087 0.0000000       3 197222971 197223143 173 -      
ENSG00000075711 E088 0.0000000       3 197225857 197226359 503 -      
ENSG00000075711 E089 0.1779838 0.061203736 1.000000000   3 197260259 197260739 481 - 0.061 0.000 -10.071
ENSG00000075711 E090 0.0000000       3 197270700 197270784 85 -      
ENSG00000075711 E091 0.2922838 0.025931762 0.325181052   3 197282610 197282678 69 - 0.060 0.229 2.217
ENSG00000075711 E092 70.0491748 0.017974269 0.008965059 0.05365733 3 197282679 197282845 167 - 1.763 1.632 -0.445
ENSG00000075711 E093 0.4952057 0.255737807 0.576752301   3 197295314 197295363 50 - 0.114 0.231 1.226
ENSG00000075711 E094 36.8966669 0.018072229 0.046560864 0.17145378 3 197296346 197296389 44 - 1.489 1.377 -0.384
ENSG00000075711 E095 43.9819016 0.006316683 0.040055567 0.15486298 3 197296390 197296477 88 - 1.557 1.480 -0.263
ENSG00000075711 E096 0.0000000       3 197296786 197296889 104 -      
ENSG00000075711 E097 26.4504905 0.001364105 0.107525020 0.29493074 3 197297186 197297235 50 - 1.343 1.281 -0.217
ENSG00000075711 E098 0.3206185 0.024805508 1.000000000   3 197297236 197297352 117 - 0.114 0.000 -11.067
ENSG00000075711 E099 0.9662812 0.065417194 0.222840306   3 197297353 197297426 74 - 0.278 0.000 -12.655
ENSG00000075711 E100 0.5255656 0.250707768 0.579472581   3 197297427 197297543 117 - 0.114 0.233 1.242
ENSG00000075711 E101 5.5127064 0.009161442 0.249803651 0.48765309 3 197297544 197297672 129 - 0.662 0.901 0.956
ENSG00000075711 E102 10.3652681 0.076337832 0.132626736 0.33592456 3 197297673 197297888 216 - 0.868 1.195 1.200
ENSG00000075711 E103 2.3870998 0.024335566 0.020097375 0.09621121 3 197297889 197298072 184 - 0.311 0.771 2.225
ENSG00000075711 E104 0.0000000       3 197298073 197298115 43 -      
ENSG00000075711 E105 4.1230377 0.117865811 0.502889521 0.70276579 3 197298418 197298535 118 - 0.594 0.766 0.725
ENSG00000075711 E106 7.6780262 0.335947252 0.752919497 0.86849323 3 197298536 197298648 113 - 0.834 0.871 0.144
ENSG00000075711 E107 0.0000000       3 197299045 197299330 286 -