ENSG00000075651

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351298 ENSG00000075651 HEK293_OSMI2_6hA HEK293_TMG_6hB PLD1 protein_coding protein_coding 1.05239 0.882819 1.226033 0.07738941 0.1616139 0.4692774 0.091643511 0.15072676 0.02689301 0.12346148 0.02689301 -2.1231908 0.093237500 0.17396667 0.01943333 -0.15453333 0.733207910 0.005042395 FALSE TRUE
ENST00000356327 ENSG00000075651 HEK293_OSMI2_6hA HEK293_TMG_6hB PLD1 protein_coding protein_coding 1.05239 0.882819 1.226033 0.07738941 0.1616139 0.4692774 0.346255811 0.22058855 0.54692437 0.08432285 0.02001105 1.2721605 0.347520833 0.23880000 0.46480000 0.22600000 0.420710978 0.005042395 FALSE TRUE
ENST00000418087 ENSG00000075651 HEK293_OSMI2_6hA HEK293_TMG_6hB PLD1 protein_coding protein_coding 1.05239 0.882819 1.226033 0.07738941 0.1616139 0.4692774 0.064045356 0.00000000 0.19704774 0.00000000 0.04245189 4.3718915 0.054441667 0.00000000 0.16020000 0.16020000 0.005042395 0.005042395 FALSE FALSE
ENST00000460926 ENSG00000075651 HEK293_OSMI2_6hA HEK293_TMG_6hB PLD1 protein_coding processed_transcript 1.05239 0.882819 1.226033 0.07738941 0.1616139 0.4692774 0.266560446 0.31091346 0.11362580 0.06275693 0.05744029 -1.3762045 0.262141667 0.37046667 0.10566667 -0.26480000 0.406319007 0.005042395   FALSE
ENST00000465816 ENSG00000075651 HEK293_OSMI2_6hA HEK293_TMG_6hB PLD1 protein_coding processed_transcript 1.05239 0.882819 1.226033 0.07738941 0.1616139 0.4692774 0.082735995 0.05136724 0.00000000 0.05136724 0.00000000 -2.6174687 0.064729167 0.06876667 0.00000000 -0.06876667 0.823084743 0.005042395 FALSE FALSE
ENST00000489995 ENSG00000075651 HEK293_OSMI2_6hA HEK293_TMG_6hB PLD1 protein_coding processed_transcript 1.05239 0.882819 1.226033 0.07738941 0.1616139 0.4692774 0.009443603 0.00000000 0.07554882 0.00000000 0.07554882 3.0967480 0.006825000 0.00000000 0.05460000 0.05460000 0.868734888 0.005042395   FALSE
ENST00000497307 ENSG00000075651 HEK293_OSMI2_6hA HEK293_TMG_6hB PLD1 protein_coding processed_transcript 1.05239 0.882819 1.226033 0.07738941 0.1616139 0.4692774 0.041151962 0.02633273 0.02170836 0.02633273 0.02170836 -0.1964064 0.058916667 0.02593333 0.01570000 -0.01023333 0.984507971 0.005042395 TRUE FALSE
ENST00000498278 ENSG00000075651 HEK293_OSMI2_6hA HEK293_TMG_6hB PLD1 protein_coding retained_intron 1.05239 0.882819 1.226033 0.07738941 0.1616139 0.4692774 0.013795394 0.00000000 0.11036315 0.00000000 0.11036315 3.5893219 0.009966667 0.00000000 0.07973333 0.07973333 0.876122175 0.005042395 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000075651 E001 0.0000000       3 171600404 171600404 1 -      
ENSG00000075651 E002 0.4341107 0.024441170 0.059508772   3 171600405 171600658 254 - 0.000 0.317 11.325
ENSG00000075651 E003 3.2129728 0.008660710 0.650028998 0.80358936 3 171600659 171601046 388 - 0.651 0.588 -0.278
ENSG00000075651 E004 4.6722517 0.008271036 0.331154625 0.57001797 3 171601047 171601206 160 - 0.814 0.693 -0.488
ENSG00000075651 E005 11.2226918 0.004718970 0.963879505 0.98384929 3 171601207 171602058 852 - 1.080 1.096 0.056
ENSG00000075651 E006 5.6657816 0.006555405 0.915977344 0.96016851 3 171602059 171602338 280 - 0.814 0.806 -0.033
ENSG00000075651 E007 19.1923346 0.012435842 0.894608589 0.94903372 3 171602339 171603302 964 - 1.297 1.316 0.064
ENSG00000075651 E008 4.8333215 0.006000946 0.113075535 0.30429478 3 171605299 171605416 118 - 0.651 0.872 0.890
ENSG00000075651 E009 0.0000000       3 171611466 171611634 169 -      
ENSG00000075651 E010 3.2914103 0.008936595 0.018851973 0.09194953 3 171612279 171612306 28 - 0.438 0.804 1.624
ENSG00000075651 E011 6.1409708 0.005480807 0.371901909 0.60556239 3 171612307 171612432 126 - 0.794 0.912 0.456
ENSG00000075651 E012 5.2466413 0.006533929 0.718497965 0.84730291 3 171620386 171620520 135 - 0.773 0.828 0.216
ENSG00000075651 E013 3.3093493 0.008155450 0.835997062 0.91715524 3 171642840 171642889 50 - 0.622 0.661 0.166
ENSG00000075651 E014 0.0000000       3 171642890 171643154 265 -      
ENSG00000075651 E015 4.3986763 0.006933943 0.797313031 0.89477674 3 171644910 171645023 114 - 0.751 0.724 -0.111
ENSG00000075651 E016 0.8569551 0.023429965 0.514181879   3 171653242 171654293 1052 - 0.199 0.318 0.896
ENSG00000075651 E017 2.9825241 0.007971848 0.461513787 0.67420948 3 171659213 171659301 89 - 0.651 0.545 -0.471
ENSG00000075651 E018 2.5955137 0.093140592 0.915688008 0.96001336 3 171662060 171662170 111 - 0.555 0.548 -0.034
ENSG00000075651 E019 0.0000000       3 171666258 171666305 48 -      
ENSG00000075651 E020 1.1304579 0.020454244 0.540940307   3 171674500 171674516 17 - 0.272 0.387 0.724
ENSG00000075651 E021 1.6857632 0.012467112 0.353225824 0.59017002 3 171674517 171674613 97 - 0.334 0.499 0.895
ENSG00000075651 E022 2.3152337 0.009806653 0.724191609 0.85065902 3 171676715 171676833 119 - 0.482 0.546 0.308
ENSG00000075651 E023 2.8432860 0.008256608 0.305584499 0.54622644 3 171677566 171677694 129 - 0.651 0.498 -0.695
ENSG00000075651 E024 0.0000000       3 171677695 171677853 159 -      
ENSG00000075651 E025 0.6258862 0.019387492 0.235164434   3 171686685 171686798 114 - 0.111 0.317 1.891
ENSG00000075651 E026 3.9761445 0.006097108 0.351528723 0.58864726 3 171687371 171687584 214 - 0.751 0.626 -0.524
ENSG00000075651 E027 2.0947636 0.012500488 0.955002369 0.97940931 3 171688676 171688694 19 - 0.482 0.498 0.079
ENSG00000075651 E028 4.2142279 0.005953189 0.489181133 0.69345410 3 171688695 171688876 182 - 0.751 0.662 -0.372
ENSG00000075651 E029 3.4511991 0.008075157 0.199509347 0.42910504 3 171692332 171692442 111 - 0.728 0.545 -0.794
ENSG00000075651 E030 2.8029475 0.013248577 0.307274097 0.54789073 3 171699745 171699826 82 - 0.651 0.498 -0.693
ENSG00000075651 E031 3.6461109 0.022829450 0.568922342 0.74946659 3 171708755 171708838 84 - 0.704 0.626 -0.331
ENSG00000075651 E032 0.0000000       3 171708839 171708870 32 -      
ENSG00000075651 E033 4.0160580 0.007430065 0.182632991 0.40746853 3 171709560 171709709 150 - 0.773 0.588 -0.780
ENSG00000075651 E034 0.0000000       3 171713878 171713892 15 -      
ENSG00000075651 E035 3.5515875 0.008224707 0.030906349 0.13006416 3 171713893 171714045 153 - 0.773 0.446 -1.457
ENSG00000075651 E036 0.0000000       3 171721354 171721545 192 -      
ENSG00000075651 E037 2.5046217 0.167915393 0.673082101 0.81828665 3 171724696 171724788 93 - 0.588 0.498 -0.422
ENSG00000075651 E038 0.0000000       3 171726004 171726017 14 -      
ENSG00000075651 E039 2.9982844 0.008128249 0.858895852 0.92979484 3 171726018 171726076 59 - 0.591 0.626 0.153
ENSG00000075651 E040 3.6468958 0.007287722 0.513177275 0.71036612 3 171733444 171733509 66 - 0.622 0.724 0.432
ENSG00000075651 E041 4.0827962 0.073410477 0.514845926 0.71153764 3 171734865 171734970 106 - 0.753 0.627 -0.523
ENSG00000075651 E042 3.1105456 0.043682588 0.835516038 0.91683794 3 171735492 171735500 9 - 0.624 0.588 -0.160
ENSG00000075651 E043 3.6930880 0.011117658 0.566440774 0.74763085 3 171735501 171735623 123 - 0.705 0.626 -0.334
ENSG00000075651 E044 0.8995767 0.017267182 0.823019530   3 171735624 171735637 14 - 0.272 0.317 0.306
ENSG00000075651 E045 3.1802166 0.076963753 0.486749890 0.69172658 3 171737532 171737659 128 - 0.679 0.578 -0.439
ENSG00000075651 E046 2.1004433 0.018541948 0.454738076 0.66930849 3 171737892 171737932 41 - 0.558 0.445 -0.550
ENSG00000075651 E047 4.8349526 0.006273223 0.188339649 0.41483438 3 171737933 171738051 119 - 0.833 0.661 -0.695
ENSG00000075651 E048 3.4948479 0.008033614 0.277685634 0.51776947 3 171738052 171738082 31 - 0.705 0.546 -0.694
ENSG00000075651 E049 0.3228314 0.344042158 0.370039688   3 171765129 171765495 367 - 0.199 0.000 -13.440
ENSG00000075651 E050 0.6787990 0.021394481 0.060390309   3 171771195 171771359 165 - 0.335 0.000 -14.439
ENSG00000075651 E051 0.0000000       3 171771360 171771385 26 -      
ENSG00000075651 E052 0.0000000       3 171788567 171788580 14 -      
ENSG00000075651 E053 5.4843764 0.090924076 0.005069091 0.03498814 3 171788581 171789535 955 - 0.521 1.014 2.009
ENSG00000075651 E054 0.3032425 0.027442404 0.151625956   3 171789646 171789701 56 - 0.000 0.235 13.553
ENSG00000075651 E055 0.3641499 0.032219039 0.885601101   3 171789841 171789957 117 - 0.111 0.133 0.311
ENSG00000075651 E056 2.1304727 0.010948843 0.245991253 0.48362418 3 171810399 171810437 39 - 0.389 0.588 0.983
ENSG00000075651 E057 0.9624527 0.134280807 0.332085105   3 171810438 171810438 1 - 0.200 0.384 1.280
ENSG00000075651 E058 0.9624527 0.134280807 0.332085105   3 171810439 171810441 3 - 0.200 0.384 1.280
ENSG00000075651 E059 0.7844689 0.026866401 0.117598845   3 171810442 171810462 21 - 0.111 0.386 2.303
ENSG00000075651 E060 0.4341107 0.024441170 0.059508772   3 171810463 171810483 21 - 0.000 0.317 14.038
ENSG00000075651 E061 0.3032425 0.027442404 0.151625956   3 171810484 171810714 231 - 0.000 0.235 13.553
ENSG00000075651 E062 0.0000000       3 171810889 171810950 62 -