ENSG00000075275

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262738 ENSG00000075275 HEK293_OSMI2_6hA HEK293_TMG_6hB CELSR1 protein_coding protein_coding 7.312414 10.06573 5.611836 0.8455898 0.6872592 -0.841771 1.1792162 1.417955 1.3976825 0.2156940 0.4381094 -0.02062854 0.16452083 0.14206667 0.2398667 0.09780000 0.57840164 0.04315813 FALSE TRUE
ENST00000473624 ENSG00000075275 HEK293_OSMI2_6hA HEK293_TMG_6hB CELSR1 protein_coding protein_coding 7.312414 10.06573 5.611836 0.8455898 0.6872592 -0.841771 2.0359377 2.877451 0.6386386 0.2827348 0.1500746 -2.15430961 0.25529583 0.28916667 0.1136000 -0.17556667 0.04315813 0.04315813 FALSE TRUE
ENST00000674359 ENSG00000075275 HEK293_OSMI2_6hA HEK293_TMG_6hB CELSR1 protein_coding protein_coding 7.312414 10.06573 5.611836 0.8455898 0.6872592 -0.841771 0.5164559 0.825374 0.3646330 0.1141120 0.1042546 -1.15694427 0.06967917 0.08126667 0.0657000 -0.01556667 0.84664929 0.04315813 FALSE TRUE
ENST00000674500 ENSG00000075275 HEK293_OSMI2_6hA HEK293_TMG_6hB CELSR1 protein_coding protein_coding 7.312414 10.06573 5.611836 0.8455898 0.6872592 -0.841771 2.9167743 4.085090 2.3226366 0.4102656 0.4316443 -0.81193356 0.42390000 0.40493333 0.4407000 0.03576667 0.98374482 0.04315813 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000075275 E001 2.0948474 0.6729645182 8.439032e-02 2.535073e-01 22 46360834 46361173 340 - 0.814 0.088 -4.612
ENSG00000075275 E002 240.8032231 0.0026594825 9.017159e-02 2.641070e-01 22 46361174 46361985 812 - 2.318 2.369 0.170
ENSG00000075275 E003 317.2595945 0.0026056126 2.707709e-02 1.185299e-01 22 46361986 46363187 1202 - 2.430 2.493 0.209
ENSG00000075275 E004 24.0430481 0.0453227756 6.359110e-01 7.942247e-01 22 46363188 46363247 60 - 1.336 1.387 0.178
ENSG00000075275 E005 8.9350344 0.0035233838 1.738414e-01 3.956388e-01 22 46363248 46363995 748 - 0.851 1.014 0.613
ENSG00000075275 E006 72.4262572 0.0008396082 7.814504e-01 8.855059e-01 22 46363996 46364251 256 - 1.824 1.835 0.037
ENSG00000075275 E007 44.7048741 0.0009334643 5.924645e-01 7.652310e-01 22 46364512 46364629 118 - 1.611 1.640 0.097
ENSG00000075275 E008 47.1741087 0.0015545689 2.925631e-02 1.251432e-01 22 46364630 46364736 107 - 1.564 1.688 0.423
ENSG00000075275 E009 0.4756169 0.0217681645 2.739824e-01   22 46365225 46365230 6 - 0.000 0.222 10.185
ENSG00000075275 E010 55.5711284 0.0124497637 6.786826e-02 2.202988e-01 22 46365231 46365380 150 - 1.631 1.755 0.423
ENSG00000075275 E011 0.8730907 0.5712684826 7.375178e-01   22 46365381 46365585 205 - 0.294 0.227 -0.499
ENSG00000075275 E012 51.5006112 0.0332438562 7.411564e-01 8.611658e-01 22 46365586 46365689 104 - 1.679 1.694 0.052
ENSG00000075275 E013 49.5871882 0.0009500322 3.708852e-01 6.046226e-01 22 46366386 46366480 95 - 1.640 1.688 0.163
ENSG00000075275 E014 0.0000000       22 46366481 46366549 69 -      
ENSG00000075275 E015 52.2239654 0.0008163479 4.701949e-01 6.802186e-01 22 46366993 46367118 126 - 1.672 1.709 0.126
ENSG00000075275 E016 44.5523525 0.0008338645 8.573584e-01 9.290164e-01 22 46367729 46367855 127 - 1.626 1.635 0.032
ENSG00000075275 E017 2.0444347 0.0224658910 9.292796e-01 9.666719e-01 22 46368859 46369178 320 - 0.459 0.445 -0.075
ENSG00000075275 E018 38.5256711 0.0010277707 2.213709e-01 4.551206e-01 22 46369179 46369258 80 - 1.517 1.591 0.252
ENSG00000075275 E019 47.7936561 0.0008186449 4.601456e-01 6.732231e-01 22 46369692 46369804 113 - 1.631 1.670 0.133
ENSG00000075275 E020 2.7861098 1.0144669036 8.949145e-01 9.491863e-01 22 46369805 46370237 433 - 0.658 0.488 -0.773
ENSG00000075275 E021 27.7684025 0.0012622149 6.992363e-02 2.246469e-01 22 46372883 46372912 30 - 1.511 1.386 -0.430
ENSG00000075275 E022 63.5551936 0.0017352137 4.055427e-01 6.327132e-01 22 46372913 46373057 145 - 1.805 1.763 -0.143
ENSG00000075275 E023 8.5822701 0.0686173961 7.918701e-01 8.915199e-01 22 46373058 46374084 1027 - 0.905 0.970 0.244
ENSG00000075275 E024 74.3693823 0.0005303764 1.760729e-01 3.985661e-01 22 46377061 46377261 201 - 1.889 1.830 -0.199
ENSG00000075275 E025 0.0000000       22 46377348 46377624 277 -      
ENSG00000075275 E026 47.2013064 0.0007992935 2.794992e-01 5.196049e-01 22 46378591 46378717 127 - 1.611 1.670 0.199
ENSG00000075275 E027 59.0873178 0.0056735024 4.844440e-03 3.377385e-02 22 46380788 46380955 168 - 1.622 1.792 0.576
ENSG00000075275 E028 53.5383553 0.0089317824 7.252697e-02 2.298337e-01 22 46381846 46382050 205 - 1.623 1.738 0.389
ENSG00000075275 E029 0.3088520 0.0260529539 5.859422e-01   22 46384501 46384542 42 - 0.167 0.087 -1.082
ENSG00000075275 E030 42.2330813 0.0223549272 6.207460e-01 7.843464e-01 22 46384543 46384686 144 - 1.585 1.610 0.085
ENSG00000075275 E031 53.3869553 0.0148040291 4.822060e-01 6.885295e-01 22 46386402 46386585 184 - 1.672 1.715 0.147
ENSG00000075275 E032 59.0066797 0.0009455022 2.055242e-01 4.365024e-01 22 46389290 46389499 210 - 1.701 1.764 0.213
ENSG00000075275 E033 39.8910846 0.0010000849 1.062021e-01 2.926989e-01 22 46390392 46390486 95 - 1.511 1.608 0.332
ENSG00000075275 E034 5.7637260 0.0054034307 1.999962e-01 4.296731e-01 22 46390528 46390863 336 - 0.677 0.858 0.726
ENSG00000075275 E035 4.8384104 0.0056062086 2.931151e-01 5.338261e-01 22 46390864 46391033 170 - 0.631 0.786 0.638
ENSG00000075275 E036 2.8147931 0.0083439172 4.361966e-01 6.559570e-01 22 46391034 46391075 42 - 0.459 0.590 0.623
ENSG00000075275 E037 45.4561450 0.0009700066 1.692703e-01 3.896263e-01 22 46391186 46391287 102 - 1.580 1.657 0.263
ENSG00000075275 E038 56.8407950 0.0007548500 5.488833e-02 1.911003e-01 22 46391633 46391816 184 - 1.663 1.760 0.330
ENSG00000075275 E039 46.0746903 0.0010565833 1.917109e-01 4.190268e-01 22 46394142 46394262 121 - 1.596 1.669 0.249
ENSG00000075275 E040 46.9825264 0.0015859693 8.126835e-01 9.038127e-01 22 46396605 46396746 142 - 1.645 1.657 0.040
ENSG00000075275 E041 56.6794274 0.0076075336 3.362843e-01 5.747087e-01 22 46397674 46397848 175 - 1.769 1.713 -0.190
ENSG00000075275 E042 49.2918759 0.0238912254 9.223227e-01 9.634540e-01 22 46398524 46398637 114 - 1.671 1.672 0.004
ENSG00000075275 E043 37.0101996 0.0203139610 6.861679e-01 8.266092e-01 22 46399717 46399761 45 - 1.573 1.543 -0.103
ENSG00000075275 E044 55.7581203 0.0014524463 3.883107e-02 1.516936e-01 22 46399762 46399902 141 - 1.795 1.690 -0.356
ENSG00000075275 E045 0.5233527 0.0217681645 2.307100e-01   22 46399903 46399926 24 - 0.287 0.087 -2.075
ENSG00000075275 E046 54.5878195 0.0007406879 1.093807e-01 2.980929e-01 22 46408996 46409162 167 - 1.772 1.692 -0.272
ENSG00000075275 E047 0.1723744 0.0307842021 1.000000e+00   22 46409163 46409276 114 - 0.000 0.087 8.534
ENSG00000075275 E048 51.3434705 0.0018221860 1.232062e-01 3.208330e-01 22 46409755 46409880 126 - 1.740 1.655 -0.287
ENSG00000075275 E049 53.9516006 0.0081142879 1.446050e-01 3.543053e-01 22 46410398 46410561 164 - 1.771 1.672 -0.334
ENSG00000075275 E050 48.4494157 0.0074484575 1.648503e-01 3.838242e-01 22 46411602 46411759 158 - 1.722 1.633 -0.305
ENSG00000075275 E051 37.6801212 0.0020655697 6.607553e-02 2.162734e-01 22 46433393 46433481 89 - 1.631 1.518 -0.384
ENSG00000075275 E052 41.9392365 0.0012915857 6.467652e-02 2.131637e-01 22 46436174 46436289 116 - 1.676 1.570 -0.359
ENSG00000075275 E053 46.1294838 0.0026090228 3.205914e-01 5.602185e-01 22 46439189 46439411 223 - 1.688 1.631 -0.194
ENSG00000075275 E054 0.0000000       22 46462779 46462918 140 -      
ENSG00000075275 E055 81.5983025 0.0004933858 4.546195e-01 6.692341e-01 22 46463707 46464345 639 - 1.909 1.877 -0.108
ENSG00000075275 E056 1.0585918 0.0690209314 5.833709e-01   22 46530308 46530500 193 - 0.381 0.274 -0.672
ENSG00000075275 E057 331.4857801 0.0022840045 2.675823e-07 8.922369e-06 22 46533627 46537620 3994 - 2.585 2.441 -0.479